Prevalence and Distribution of Hepatitis C Virus in Iranian Drug User: Systematic Review and Meta-Analysis Study

2020 ◽  
Author(s):  
Alireza Najimi-Varzaneh ◽  
Mohammad Gholami-Fesharaki
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Drug User ◽  
Drug Users ◽  
Meta Analysis ◽  
Scientific Information ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Analysis Study ◽  
Hcv Prevalence

Context: Hepatitis C, as a major public health problem, has serious complications and drug users are the highest risk group for it.Objectives: As the importance of this subject, the current study has been done to estimate the pooled prevalence  and distribution of hepatitis c virus in Iranian Drug User.Evidence Acquisition: Articles were identified through international searching databases including PubMed, Scopus, Elsevier, Google Scholar and Web of Science and Iranian scientific information database (SID), Health. barakatkns, IranDoc, Civilica and MagIran. We reviewed systematically all studies reporting the prevalence of HCV Iranian Drug User.Results: 227 records were identified by the electronic search, of which 62 studies were identified as relevant  papers which were meta-analyzed for the pooled HCV prevalence. Overall, prevalence of HCV  was 42.01 %( 36.83%-47.20%) in Iranian drug user.Conclusion: Our meta-analysis study showed that HCV prevalence is high in drug users in Iran. With respect to the high prevalence of Hepatitis C among Drug User, ongoing preventive actions for this group are recommended.

Interleukin-10 gene polymorphisms in association with susceptibility to chronic hepatitis C virus infection: a meta-analysis study

2010 ◽  
Vol 155 (11) ◽  
pp. 1839-1842 ◽  
Author(s):  
Li-Zhou Zhang ◽  
Tian-Chen Zhang ◽  
Fa-Ming Pan ◽  
Zhen-Hua Zhang ◽  
Xu Li
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Interleukin 10 ◽  
Hepatitis C Virus Infection ◽  
Analysis Study ◽  
Chronic Hepatitis C Virus

Epidemiology of hepatitis C virus infection among injection drug users in China: Systematic review and meta-analysis

Public Health ◽  
2008 ◽  
Vol 122 (10) ◽  
pp. 990-1003 ◽  
Author(s):  
Xian Xia ◽  
Jun Luo ◽  
Jianling Bai ◽  
Rongbin Yu
Keyword(s):  
Systematic Review ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Injection Drug Users ◽  
Drug Users ◽  
Meta Analysis ◽  
Injection Drug ◽  
Hepatitis C Virus Infection

scholarly journals High hepatitis C virus prevalence among drug users in Iran: systematic review and meta-analysis of epidemiological evidence (2001–2012)

2015 ◽  
Vol 40 ◽  
pp. 116-130 ◽  
Author(s):  
Mohsen Malekinejad ◽  
Soodabeh Navadeh ◽  
Ali Lotfizadeh ◽  
Afarin Rahimi-Movaghar ◽  
Masoumeh Amin-Esmaeili ◽  
...  
Keyword(s):  
Systematic Review ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Drug Users ◽  
Meta Analysis ◽  
Epidemiological Evidence ◽  
Virus Prevalence

scholarly journals Protocol for a systematic review and meta-analysis of hepatitis C virus (HCV) prevalence and incidence in the Horn of Africa sub-region of the Middle East and North Africa

2014 ◽  
Vol 3 (1) ◽  
Author(s):  
Karima Chaabna ◽  
Yousra A Mohamoud ◽  
Hiam Chemaitelly ◽  
Ghina R Mumtaz ◽  
Laith J Abu-Raddad
Keyword(s):  
Systematic Review ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Middle East ◽  
North Africa ◽  
Meta Analysis ◽  
Horn Of Africa ◽  
Hcv Prevalence

scholarly journals Factors Correlating to the Development of Hepatitis C Virus Infection among Drug Users—Findings from a Systematic Review and Meta-Analysis

2019 ◽  
Vol 16 (13) ◽  
pp. 2345 ◽  
Author(s):  
Biao Zhou ◽  
Gao Feng Cai ◽  
Hua Kun Lv ◽  
Shuang Fei Xu ◽  
Zheng Ting Wang ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Drug Use ◽  
Drug Users ◽  
Methadone Maintenance ◽  
Meta Analysis ◽  
Injecting Drug Use ◽  
Hcv Infection ◽  
Increased Risk

Hepatitis C remains a significant public health threat. However, the main routes of transmission have changed since the early 1990s. Currently, drug use is the main source of hepatitis C virus (HCV) infection, and some measures have been successively implemented and additional studies have been published. However, the factors correlating with HCV infection failed to clearly define. Our study pooled the odds ratios (ORs) with 95% confidence intervals (CIs) and analyzed sensitivity by searching data in the PubMed, Elsevier, Springer, Wiley, and EBSCO databases. Publication bias was determined by Egger’s test. In our meta-analysis, HCV-infected and non-HCV-infected patients from 49 studies were analyzed. The pooled ORs with 95% CIs for study factors were as follows: Injecting drug use 10.11 (8.54, 11.97); sharing needles and syringes 2.24 (1.78, 2.83); duration of drug use >5 years 2.39 (1.54, 3.71); unemployment 1.50 (1.22, 1.85); commercial sexual behavior 1.00 (0.73, 1.38); married or cohabiting with a regular partner 0.88 (0.79, 0.98), and sexual behavior without a condom 1.72 (1.07, 2.78). This study found that drug users with histories of injecting drug use, sharing needles and syringes, drug use duration of >5 years, and unemployment, were at increased risk of HCV infection. Our findings indicate that sterile needles and syringes should be made available to ensure safe injection. In view of that, methadone maintenance treatment can reduce or put an end to risky drug-use behaviors, and should be scaled up further, thereby reducing HCV infection.

Hepatitis C virus resistance to interferon therapy: an alarming situation

2014 ◽  
Vol 9 (12) ◽  
pp. 1155-1167
Author(s):  
Sobia Kanwal ◽  
Tariq Mahmood
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Social Factors ◽  
Molecular Mechanisms ◽  
Public Health Problem ◽  
Pegylated Interferon ◽  
Host Factors ◽  
Interferon Α ◽  
Major Public Health Problem ◽  
Choice Of Treatment

AbstractHepatitis C virus is presently a major public health problem across the globe. The main objective in treating hepatitis C virus (HCV) infection is to achieve a sustained virological response (SVR). Interferon-α (IFN-α) and pegylated interferon (PegIFN) in combination with Ribavirin (RBV) are the choice of treatment nowadays against chronic hepatitis C. There are several mechanisms evolved by the hepatitis C virus that facilitate the persistence of virus and further lead the patient’s status as non responder. Various factors involved in patient’s lack ofresponse to the therapy include: (1) viral factors, (2) host factors, (3) molecular mechanisms related to the lack of response and (4) social factors. Herein we have made an attempt to summarize all the related predictors of drug resistance in one article so that the future polices can be planned to overcome this obstacle and potential therapies can be designed by considering these factors.

scholarly journals Determinants of Hepatitis C Virus Treatment Completion and Efficacy in Drug Users Assessed by Meta-analysis

2012 ◽  
Vol 56 (6) ◽  
pp. 806-816 ◽  
Author(s):  
Rositsa B. Dimova ◽  
Marija Zeremski ◽  
Ira M. Jacobson ◽  
Holly Hagan ◽  
Don C. Des Jarlais ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Drug Users ◽  
Meta Analysis ◽  
Treatment Completion

scholarly journals Two Successive Hepatitis C Virus Infections in an Intravenous Drug User

2000 ◽  
Vol 38 (8) ◽  
pp. 3125-3127 ◽  
Author(s):  
Barbara Proust ◽  
Frederic Dubois ◽  
Yannick Bacq ◽  
Sophie Le Pogam ◽  
Sylvie Rogez ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Drug User ◽  
Drug Users ◽  
Intravenous Drug User ◽  
Hcv Infection ◽  
Intravenous Drug ◽  
Hcv Rna ◽  
Virus Infections ◽  
Serotype 1

We report the case of an occasional intravenous drug user who developed two successive hepatitis C virus (HCV) infections. The first infection led to seroconversion (anti-HCV antibodies detected) and the detection of HCV RNA in serum. After a spontaneous recovery (normalization of alanine aminotransferase levels and HCV RNA clearance), a second HCV infection was observed, with the recurrence of HCV viremia. Antibody directed against HCV serotype 1 was detected throughout the follow-up monitoring, but two different HCV strains were identified during the two infectious episodes: genotype 1a for the first and genotype 3a for the second. This observation shows that primary HCV infection does not confer protective immunity against subsequent infection with viruses of other genotypes. This may hamper the development of a vaccine. Conflicting results were obtained in genotyping and serotyping assays, suggesting that the serotyping method cannot be used to identify the HCV type in patients, such as intravenous drug users, who are exposed to successive HCV infections.

Molecular Detection of Hepatitis C Virus amongst Patients in Five Selected Hospitals in Niger State, Nigeria

2019 ◽  
Vol 2 (1) ◽  
pp. 60-69
Author(s):  
M U Iduh ◽  
F A Kuta ◽  
M E Abalaka ◽  
K O Shitu
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Direct Sequencing ◽  
Rna Extraction ◽  
Public Health Problem ◽  
Developed Countries ◽  
Response To Treatment ◽  
Hcv Rna ◽  
Major Public Health Problem ◽  
Polymerase Chain

Hepatitis C Virus (HCV) is a major public health problem in developing and developed countries worldwide. It is responsible for liver diseases and hepatocellular carcinoma in chronically-infected patients. This study therefore aimed to identify the strain of HCV among HCV seropositive subjects in Niger State. A total of 44 HCV seropositive blood samples which consisted of 27 males and 17 females were analyzed (after Viral RNA extraction) for the presence of HCV-RNA by Reverse Transcriptase Polymerase Chain Reaction (RT-PCR). Nine (20.5%) of the samples were positive for HCV RNA. HCV-RNA positive samples were genotyped by direct sequencing at 5’UTR region genomes; sequences were aligned on MEGA 6.0 and confirmed by phylogenetic analysis. HCV genotype 1b was the only one distributed among the participants. The findings are relevant as predictors for using antiviral therapy in this population because the response to treatment varies according to the genotype.

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