Hunting for better biomarkers of response: where is real progress being made in understanding why patients do and don’t respond to I-O therapeutics?

2021 ◽  
Vol 2 (3) ◽  
pp. 133-102
Author(s):  
Dr Adil Daud ◽  
Steven Fling ◽  
John Rossi ◽  
Dr Majid Ghoddusi
Keyword(s):  
2021 ◽  
Vol 2 (3) ◽  
pp. 133-102
Author(s):  
Dr Adil Daud ◽  
Steven Fling ◽  
John Rossi ◽  
Dr Majid Ghoddusi
Keyword(s):  

1885 ◽  
Vol 176 ◽  
pp. 679-689

In offering to the Royal Society some results deduced from the systems of magnetic observation and magnetic self-registration established several years since at the Royal Observatory, Greenwich, during a portion of the time in which I presided over that institution, I think it desirable to premise a short statement on the origin of the Magnetic Department of the Royal Observatory, and on the successive steps in its constitution. It appears to have been recognised many years ago, that magnetic determinations would form a proper part of the business of the Royal Observatory. When I commenced residence at the Royal Observatory, at the end of 1835, I found in the garden a small wooden building, evidently intended for the examination of compasses, perhaps of the size of those used in the Royal Navy. But the locality was inconvenient, and the structure was totally unfit for any delicate magnetic purpose; for instance, the balance-weights of the sliding windows were of iron. For some preliminary experiments a small observatory was borrowed from Captain Fitzroy, but no real progress was made in magnetism.


2006 ◽  
Vol 30 (2) ◽  
pp. 144 ◽  
Author(s):  
Tom Trauer ◽  
Lisa Gill ◽  
Glenda Pedwell ◽  
Peta Slattery

IN ORDER TO FULLY EVALUATE and manage a service, one should be able to answer all parts of the question ?Who receives what services, from whom, at what cost, and with what effect??1 While there is good information on the first four elements, mental health services generally do less well in demonstrating the effectiveness of what they do, and it is here that routine outcome measurement (ROM) can make a contribution. Despite the very real progress that has been made in implementing ROM in Australia it is evident from a variety of sources, formal and informal, that not everyone is convinced of its necessity or value.


1950 ◽  
Vol 43 (4) ◽  
pp. 165-168
Author(s):  
Ben A. Sueltz

Three new courses of study in arithmetic are reviewed. These represent California, New York, and Pennsylvania. They indicate that real progress is being made in the teaching of arithmetic. This is particularly true on the curriculum level. However, the most important task is that of bringing our best thinking into the classrooms. How can this be done? It is interesting to note that each of the courses of study was prepared by a comparatively few people but in each case this was done after wide consultation with teachers and supervisors. Many curriculum workers believe that the wider the participation in the preparation of syllabi and courses of study the more real value to the teachers and to the boys and girls. Do we need many special workshops and institutes in order that our teachers in service might gain the benefit of our best thinking about aims, methods, procedures, materials, and modes of evaluation in arithmetic?


Immanuel Kant ◽  
2009 ◽  
pp. 337-424 ◽  
Author(s):  
Henry Allison ◽  
Immanuel Kant ◽  
Henry Allison ◽  
Peter Heath ◽  
Gary Hatfield ◽  
...  
Keyword(s):  

1981 ◽  
Vol 47 (6) ◽  
pp. 427-434 ◽  
Author(s):  
James B. Duffey ◽  
John Salvia ◽  
James Tucker ◽  
James Ysseldyke

The current technical history of nonbiased assessment is highlighted. Definitions of fairness and experts' attempts to alleviate problems associated with bias in assessment are reviewed. Factors relating to nonbiased assessment are emphasized that normally do not receive sufficient attention. Decisions currently made as a result of the assessment process are reviewed and an examination made of how decisions based on inappropriate evaluation can negate the validity of the assessment process. Finally, the utility of many recent efforts to resolve the problems of bias in assessment is questioned and it is suggested that very basic systematic changes are needed before real progress can be made in reducing bias in assessment.


2017 ◽  
Vol 4 (02) ◽  
pp. 169-188
Author(s):  
Andree HAHMANN

Kant famously criticizes Leibniz for his apparent neglect to observe the difference between two sources of cognition: understanding and intuition. This is the reason that Leibniz supposedly intellectualized the phenomena by identifying them with things in themselves. In Kantian terms, Leibniz fell prey to an amphiboly of concepts which, in the case of his understanding of substance, has led him to assume monads—that is to say, ideal unities which exist in a state of pre-established harmony; for this is the only possible form of community between ideal substances. Distinct versions of this argument can be found in Kant’s Critique of Pure Reason, notably in the notoriously difficult passage entitled “On the amphiboly of concepts of reflections”, and in some later writings, such as the Kantian reply to the self-declared Leibnizian Johann August Eberhard (On a Discovery whereby any New Critique of Pure Reason is to be made Superfluous by an Older One, from 1790) or the late fragment What Real Progress has Metaphysics made in Germany since the Time of Leibniz and Wolff? (originally from 1793, but published post mortem in 1804).


1966 ◽  
Vol 24 ◽  
pp. 118-119
Author(s):  
Th. Schmidt-Kaler

I should like to give you a very condensed progress report on some spectrophotometric measurements of objective-prism spectra made in collaboration with H. Leicher at Bonn. The procedure used is almost completely automatic. The measurements are made with the help of a semi-automatic fully digitized registering microphotometer constructed by Hög-Hamburg. The reductions are carried out with the aid of a number of interconnected programmes written for the computer IBM 7090, beginning with the output of the photometer in the form of punched cards and ending with the printing-out of the final two-dimensional classifications.


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