scholarly journals Prevalence of the polymorphic H-ficolin (FCN3) genes and mannosebinding lectin-associated serine protease-2 (MASP2) in indigenous populations from the Russian Arctic regions

2022 ◽  
Vol 25 (8) ◽  
pp. 847-854
Author(s):  
M. V. Smolnikova ◽  
S. Yu. Tereshchenko
Keyword(s):  
Serine Protease ◽  
Point Mutations ◽  
Total Sample ◽  
Indigenous Populations ◽  
Lectin Pathway ◽  
Genotype Distribution ◽  
Russian Arctic ◽  
Homozygous Variant ◽  
Total Absence ◽  
Arctic Regions

Lectins, being the main proteins of the lectin pathway activating the complement system, are encoded by polymorphic genes, wherein point mutations cause the protein conformation and expression to change, which turns out to have an effect on the functionality and ability to respond to the pathogen. In the current study, largescale data on the population genotype distribution of the genes for H-ficolin FCN3 rs28357092 and mannose-binding lectin-associated serine protease MASP2 rs72550870 among the indigenous peoples of the Russian Arctic regions (Nenets, Dolgans and Nganasans, a mixed population and Russians: a total sample was about 1000 newborns) have been obtained for the first time. Genotyping was carried out using RT-PCR. The frequency of the homozygous variant del/del FCN3 rs28357092 associated with the total absence of the most powerful activator of the lectin complement pathway, N-ficolin, was revealed; 0 % in the Nenets, 0.8 % in the Dolgans and Nganasans, and 3.5 % among the Russians ( p < 0.01). Analysis of the prevalence of the MASP2 genotypes has shown the predominance of the homozygous variant AA in all studied populations, which agrees with the available world data. The heterozygous genotype AG rs72550870 associated with a reduced level of protease was found to occur rarely in the Nenets, Dolgans and Nganasans compared to newborns of Caucasoid origin from Krasnoyarsk: 0.5 % versus 3.3 %, respectively. Moreover, among 323 examined Nenets, one AG carrier was identified, whereas in Russians, 16 out of 242 examined newborns were found to be AG carriers ( p < 0.001). A homozygous variant (GG) in total absence of protease with impaired binding of both MBL and ficolins was not detected in any of the 980 examined newborns. An additional analysis of infectious morbidity in Arctic populations allows one to find phenotypic characteristics related to a high functional activity of the lectin pathway of complement activation as an most important factor for the first-line of anti-infectious defense, including such new viral diseases as COVID-19.

THE STRUCTURE OF THE ECONOMIC SPACE OF THE RUSSIAN ARCTIC

2021 ◽  
Vol 1 (7) ◽  
pp. 132-140
Author(s):  
E. A. KORCHAK ◽  
Keyword(s):  
Economic Development ◽  
Natural Resources ◽  
National Policy ◽  
The Arctic ◽  
Russian Arctic ◽  
Economic Space ◽  
Arctic Regions ◽  
Dominant Direction ◽  
Integrated Structures

The purpose of the study was to analyze the structure of the economic space of the Russian Arctic within the framework of determining the prospects for the economic development of the Arctic regions. The unevenness of the economic space of the Russian Arctic and the focus on the extraction and export of natural resources are determined. It is revealed that vertically integrated structures play a key role in the Russian Arctic. It is determined that the specific feature of this region is the ethnoeconomics, the long-term development of which is the dominant direction of the national policy in the field of agriculture of the Russian Arctic.

scholarly journals The rumen bacterial community of reindeer in different age periods from Russian arctic regions

2018 ◽  
Author(s):  
Larisa Ilina ◽  
Valentina Filippova ◽  
Andrey Dubrovin ◽  
Elena Yildirim ◽  
Timur Dunyashev ◽  
...  
Keyword(s):  
Bacterial Community ◽  
Russian Arctic ◽  
Arctic Regions

scholarly journals L-Ficolin/Mannose-Binding Lectin-Associated Serine Protease Complexes Bind to Group B Streptococci Primarily through N-Acetylneuraminic Acid of Capsular Polysaccharide and Activate the Complement Pathway

2007 ◽  
Vol 76 (1) ◽  
pp. 179-188 ◽  
Author(s):  
Youko Aoyagi ◽  
Elisabeth E. Adderson ◽  
Craig E. Rubens ◽  
John F. Bohnsack ◽  
Jin G. Min ◽  
...  
Keyword(s):  
Serine Protease ◽  
Specific Antibody ◽  
Capsular Polysaccharide ◽  
Mannose Binding Lectin ◽  
Lectin Pathway ◽  
Group B Streptococci ◽  
Acetylneuraminic Acid ◽  
Mannose Binding ◽  
Group B ◽  
Binding Lectin

ABSTRACT Group B streptococci (GBS) are the most common cause of neonatal sepsis and meningitis. Most infants who are colonized with GBS at birth do not develop invasive disease, although many of these uninfected infants lack protective levels of capsular polysaccharide (CPS)-specific antibody. The lectin pathway of complement is a potential mechanism for initiating opsonization of GBS with CPS-specific antibody-deficient serum. In this study, we determined whether mannose-binding lectin (MBL)/MBL-associated serine protease (MASP) complexes and L-ficolin/MASP complexes bind to different strains of GBS to activate the lectin pathway, and we identified the molecules recognized by lectins on the GBS surface. We found that MBL did not bind to any GBS examined, whereas L-ficolin bound to GBS cells of many serotypes. L-ficolin binding to GBS cells correlated with the CPS content in serotypes Ib, III (restriction digestion pattern types III-2 and III-3), and V but not with the group B-specific polysaccharide (GBPS) content or with the lipoteichoic acid (LTA) content. L-ficolin bound to purified CPS and GBPS in a concentration-dependent manner but not to purified LTA. All strains to which L-ficolin/MASP complexes bound consumed C4. When N-acetylneuraminic acid (NeuNAc) was selectively removed from GBS cells by treatment with neuraminidase, the reduction in L-ficolin binding was correlated with the amount of NeuNAc removed. Additionally, L-ficolin was able to bind to wild-type strains but was able to bind only weakly to unencapsulated mutants and a mutant strain in which the CPS lacks NeuNAc. We concluded that L-ficolin/MASP complexes bind to GBS primarily through an interaction with NeuNAc of CPS.

Pan-arctic glaciers volume changes over 1975-2019

2021 ◽  
Author(s):  
Amaury Dehecq ◽  
Alex Gardner ◽  
Romain Hugonnet ◽  
Joaquin Belart
Keyword(s):  
Canadian Arctic ◽  
Aerial Images ◽  
The Arctic ◽  
Glacier Mass Balance ◽  
Russian Arctic ◽  
Elevation Change ◽  
Volume Changes ◽  
Arctic Regions ◽  
Digital Elevation

&lt;p&gt;Glaciers retreat contributed to about 1/3 of the observed sea level rise since 1971 (IPCC). However, long term estimates of glaciers volume changes rely on sparse field observations and region-wide satellite observations are available mostly after 2000. The now declassified images from the American reconnaissance satellite series Hexagon (KH-9), that acquired 6 m resolution stereoscopic images from 1971 to 1986, open new possibilities for glaciers observation.&lt;/p&gt;&lt;p&gt;Based on recently published methodology (Dehecq et al., 2020, doi: 10.3389/feart.2020.566802), we process all available KH-9 images over the Arctic (Canadian arctic, Iceland, Svalbard, Russian arctic) to generate Digital Elevation Models (DEMs) and ortho-images for the period 1974-1980. We validate the KH-9 DEMs over Iceland against elevation derived from historical aerial images acquired within a month from the satellite acquisition.&lt;/p&gt;&lt;p&gt;Finally, we calculate the glacier elevation change between the historical DEMs and modern elevation obtained from a time series of ASTER stereo images and validated against ICESat-2 elevation. The geodetic glacier mass balance is calculated for all pan-Arctic regions and analyzed with reference to the last 20 years evolution.&lt;/p&gt;

Determination of anthropogenic contamination by 137Cs, 240Pu/239Pu and 235U/238U in lichens and mosses from Russian Arctic areas 

2021 ◽  
Author(s):  
Susanna Salminen-Paatero ◽  
Paul Dutheil ◽  
Timo Sundström ◽  
Ilia Rodushkin ◽  
Jussi Paatero
Keyword(s):  
Gamma Spectrometry ◽  
Russian Arctic ◽  
Anthropogenic Contamination ◽  
Terrestrial Environment ◽  
Arctic Regions ◽  
Franz Josef Land ◽  
Icp Ms ◽  
Nuclear Events ◽  
Hpge Gamma Spectrometry

&lt;p&gt;Lichen and moss samples were collected from Russian Arctic areas (Kola Peninsula, Franz Josef Land and few other locations) in the 1990s. In 2020, &lt;sup&gt;137&lt;/sup&gt;Cs was determined by HPGe gamma spectrometry from these samples after which isotopes of Pu and U were radiochemically separated from the samples. Mass ratios &lt;sup&gt;240&lt;/sup&gt;Pu/&lt;sup&gt;239&lt;/sup&gt;Pu and &lt;sup&gt;235&lt;/sup&gt;U/&lt;sup&gt;238&lt;/sup&gt;U were determined by ICP-MS for utilizing the characteristic isotopic fingerprints of different nuclear events. The aim of the work was to survey radioactive contamination sources in terrestrial environment in Russian Arctic regions, which have not yet been completely explored in respect to anthropogenic isotopes and their origin in the environment.&lt;/p&gt;

scholarly journals Regions of the Russian Arctic Zone: State and Problems at the Beginning of the New Development Stage

2018 ◽  
Vol 7 (3.14) ◽  
pp. 369 ◽  
Author(s):  
Lyubov Vasilievna Larchenko ◽  
Roman Aleksandrovich Kolesnikov
Keyword(s):  
Socioeconomic Development ◽  
Regional Policy ◽  
Raw Materials ◽  
Development Stage ◽  
The State ◽  
The Arctic ◽  
Russian Arctic ◽  
Arctic Zone ◽  
Arctic Regions ◽  
Regions Of Russia

In recent years, a new market trading in cryptocurrencies and instruments based on them has been formed. The market of This paper The goal of the study is to analyze the degree of differentiation of the Arctic regions of Russia by the key indicators of socioeconomic development, dependence of their economic development on the raw materials industries, which should be accounted to shape an efficient regional policy by the state and achieve the strategic goals for the reclamation and development of the Russian Arctic zone. The methodology of the study is based on a systematic approach to assessing the socioeconomic and sectoral differentiation of the Arctic regions of Russia. A set of general scientific and special research methods was used. The conducted analysis indicates that all the Arctic regions under study have a narrow raw materials nature of the economy, the sectoral structure is poorly differentiated. The policy of equalizing the per capita income and the cost of living in the Arctic regions with other regions of Russia largely determined the outflow of population from the northern regions. The state regional policy in relation to the Arctic regions should take into account their heterogeneity in order to achieve the results outlined in the strategic documents. 

Development of Tourism in the Arctic Zone and Its Impact on Environment

2019 ◽  
Vol 9 (8) ◽  
pp. 1642
Author(s):  
Marina L. BELONOZHKO ◽  
Oleg M. BARBAKOV ◽  
Anton L. ABRAMOVSKY
Keyword(s):  
Human Life ◽  
The Arctic ◽  
Russian Arctic ◽  
Arctic Zone ◽  
The Past ◽  
The North ◽  
Arctic Regions ◽  
Long Time ◽  
Historical Resources ◽  
Almost All

For a long time, the Arctic was considered a territory not adapted for human life (“dead earth”), impassable either by water or by land due to the climate. Currently, not only scientists, but also ordinary travelers and tourists are going to the North Pole. Today, tourism in the Arctic is one of the rapidly developing areas in the past few years. Therefore, the authors studied the development of tourism in the Arctic and its impact on the environment. It has been established that the development of ecological, cultural, scientific, extreme tourism, sport hunting, fishing and cruises is relevant for the Arctic regions. It was determined that the main problem in the development of tourism in the Russian Arctic is the transport and logistics underdevelopment of the region. But, these territories are so rich in natural, cultural, historical resources that there is the possibility of developing almost all types of tourism.

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