scholarly journals Mechanisms of beta-blockers antihypertensive action

2021 ◽  
Vol 27 (3) ◽  
pp. 291-299
Author(s):  
E. V. Kuleshova ◽  
N. V. Kuzmenko ◽  
M. G. Pliss ◽  
V. A. Tsyrlin
Keyword(s):  
Blood Circulation ◽  
Beta Blockers ◽  
Smooth Muscles ◽  
Plasma Renin ◽  
Short Term ◽  
Receptor Blockers ◽  
Β Blockers ◽  
Β Adrenergic Receptors ◽  
Channel Currents

This article presents an analysis of data on the mechanisms of antihypertensive effect of β-adrenergic receptor blockers. The article describes the effectiveness of cardiotropic action of drugs to reduce high blood pressure (BP) with short-term and long-term action of compounds, the effect of blockers on the activity of plasma renin. The influence of β-blockers on the central mechanisms of blood circulation regulation is considered. Information on the effect of β-blockers on myogenic mechanisms of vascular tone regulation is presented. The possibilities of blockade of β-adrenergic receptors of endothelium-dependent hyperpolarization of smooth muscles of resistive arteries, violation of the NO-cGMP pathway and blockade of Ca2+ channel currents as factors providing expansion of resistive vessels and reduction of high BP are analyzed.

scholarly journals Role of antihypertensive drugs in the treatment of migraine

2015 ◽  
Vol 156 (5) ◽  
pp. 179-185 ◽  
Author(s):  
Gergely Fehér ◽  
Gabriella Pusch
Keyword(s):  
Enzyme Inhibitors ◽  
Beta Blockers ◽  
Angiotensin Receptor Blockers ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Channel Blockers ◽  
Migraine Prevention ◽  
Angiotensin Receptor ◽  
Converting Enzyme Inhibitors ◽  
Receptor Blockers

The treatment of migraine depends on the frequency, severity and concomitant diseases. There are several specific drugs developed for migraine prevention in addition to the additive antimigraine effects of some other non-specific drugs. The aim of this literature-based review is to summarize the possible antimigraine properties of different antihypertensive agents (beta-blockers, calcium channel blockers, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, etc.) focusing on the possible side effects (avoidance of beta blockers in the absence of heart disease, possible antiparkinson effect of calcium channel blockers, additive effect of drugs modifying the renin-angiotensin system activity, etc.). Current evidence supports the use of angiotensin converting enzyme inhibitors (mainly lisinopril) and angiotensin receptor blockers (mainly candesartan) for long-term migraine prevention and blood pressure control. Long-term beta-blocker treatment should be avoided in the absence of ischemic heart disease due to possible unfavourable cardiovascular effects. Orv. Hetil., 2015, 156(5), 179–185.

scholarly journals A case of the development of Dressler syndrome in a patient with acute diffuse myocarditis

2020 ◽  
Vol 27 (4) ◽  
pp. 69-77
Author(s):  
O. V. Onyshchenko ◽  
O. A. Yepanchintseva ◽  
D. V. Riabenko ◽  
B. M. Todurov
Keyword(s):  
Young Patient ◽  
Mineralocorticoid Receptor ◽  
Clinical Case ◽  
Beta Blockers ◽  
Underlying Disease ◽  
Rapid Recovery ◽  
Timely Diagnosis ◽  
Complex Therapy ◽  
Receptor Blockers

A clinical case of the development of classic Dressler syndrome in a young patient with acute diffuse myocarditis is described. Timely diagnosis, administration of glucocorticoid and long-term complex therapy using beta-blockers (carvedilol), mineralocorticoid receptor blockers (eplerenone) not only led to the disappearance of Dressler’s syndrome, but also to a fairly rapid recovery of the patient from the underlying disease.

scholarly journals Upaya Meningkatkan Daya Ingat Melalui Olahraga Ringan

2019 ◽  
Author(s):  
cika suteja
Keyword(s):  
Blood Circulation ◽  
Daily Life ◽  
Young Age ◽  
Long Term Memory ◽  
Memory Recall ◽  
Short Term ◽  
Term Memory ◽  
The Brain ◽  
Rule Out

In daily life, humans can not be separated from the name of learning and remembering. Learning and remembering is the basis for someone to adapt their behavior to the environment. The brain is the organ that regulates learning and memory. The brain will store and bring back the information needed. Decline in memory usually occurs during old age but does not rule out the possibility of happening at a young age too. Decreasing memory recall at a young age is usually caused by a lack of physical activity. Sports is one of the factors that can improve memory. Exercise can improve blood circulation so that the brain can be well-nourished and will work optimally. To make our memories into long-term memories can be done by repeating the information obtained. Because repetition can accelerate and increase consolidation. Information entered in long-term memory will be grouped according to the type of information. This grouping serves to facilitate the search for the desired information. Short-term information will forever be forgotten, but long-term information can last up to a lifetime.

scholarly journals Role of Brain-Derived Neurotrophic Factor in Cognitive Function and Exercise

2020 ◽  
Vol 4 (1) ◽  
pp. 61-66
Author(s):  
Mya Mya Thwin ◽  
Ma Saung Oo ◽  
Mohd Nasir Mat Nor ◽  
San Thitsa Aung ◽  
Aung Myo Oo
Keyword(s):  
Nervous System ◽  
Cognitive Function ◽  
Neurotrophic Factor ◽  
Blood Circulation ◽  
Brain Plasticity ◽  
Brain Derived Neurotrophic Factor ◽  
Short Term ◽  
Neurocognitive Functions

Brain-Derived Neurotrophic Factor (BDNF) is a member of neurotrophins and it plays important role in both peripheral nervous system (PNS) and short-term, as well as long-term plasticity in central nervous system. Physical exercise fosters neurocognitive functions and brain plasticity at all ages. However, there was an interesting finding stated that BDNF concentration was found to be lower in the trained athletes compared to that of control. Platelet BDNF is found to be acquired from the blood circulation rather than the megakaryocyte precursor cells. This review directs attention to the role of BDNF on cognitive function intensified by exercise for future perspectives.       Keywords: BDNF, cognitive function, exercise

Forces Induced by Peak Systolic Flows in Asymmetric Endovascular Grafts

2003 ◽  
Author(s):  
Ender A. Finol ◽  
Cristina H. Amon
Keyword(s):  
Blood Circulation ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Short Term ◽  
Abdominal Aortic ◽  
Endovascular Grafts ◽  
Incomplete Occlusion ◽  
Analytical Tools ◽  
Graft Migration

Endovascular repair (EVAR) has emerged as an alternative, less-invasive surgical technique for the treatment of patients diagnosed with abdominal aortic aneurysms (AAAs). The anatomical pathway of blood flow in the abdominal aorta is restored by the implantation of an endovascular graft (EVG), effectively depressurizing the aneurysm and initiating a remodeling process of the diseased aorta. The short-term results of endovascular grafting are promising, but its long-term success has been compromised by the occurrence of graft migration and detachment, which induce endoleaks or incomplete occlusion of the aneurysm from the blood circulation. The forces induced by the blood as it flows through the graft are believed to be a factor of probable cause in the partial detachment from its proximal and distal anchoring points and the migration of the graft downstream. The purpose of this study is to utilize analytical tools to provide an estimation of the forces required to secure the graft proximally when relying only on stresses induced by the flow.

Short-term depression and long-term enhancement of ACh-gated channel currents induced by linoleic and linolenic acid

1997 ◽  
Vol 751 (2) ◽  
pp. 253-258 ◽  
Author(s):  
Tomoyuki Nishizaki ◽  
Youji Ikeuchi ◽  
Toshiyuki Matsuoka ◽  
Katumi Sumikawa
Keyword(s):  
Linolenic Acid ◽  
Short Term ◽  
Gated Channel ◽  
Channel Currents

scholarly journals Why Nicorandil is not Considered to be the First-line Antianginal Drug

Medicina ◽  
2020 ◽  
pp. 25-47
Author(s):  
S. N. Bel'diev ◽  
◽  
E. V. Andreeva ◽  
E. I. Berezina ◽  
I. V. Egorova ◽  
...  
Keyword(s):  
Beta Blockers ◽  
Channel Blockers ◽  
Concomitant Treatment ◽  
First Line ◽  
Short Term ◽  
Term Trial ◽  
Antianginal Drugs ◽  
Long Acting ◽  
Antianginal Efficacy

According to the results of several short-term randomized controlled trials (RCTs), nicorandil is not inferior in its antianginal efficacy to beta-blockers (BB), calcium channel blockers (CCB) and long-acting nitrates (LAN). At the same time, in some short-term RCTs, as well as in the long-term RCT IONA (2002), it was shown that antianginal efficacy of nicorandil as monotherapy or in combination with other antianginal drugs did not differ from placebo. Ability of nicorandil to reduce the risk of adverse cardiovascular events, demonstrated in the RCT IONA, requires confirmation in a long-term trial with a stronger primary endpoint and concomitant treatment that would meet the current guidelines for the management of patients with chronic coronary syndromes. In this regard, and also taking into account the proven ability of nicorandil to cause gastrointestinal ulcerations, European experts currently consider nicorandil as a drug that is inferior in priority of choice to the first-line antianginal drugs (BB, CCB) and, in some cases, to the second-line drugs (LAN, ivabradine, ranolazine, trimetazidine).

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