Cardiac troponins in hypertension: mechanisms of increase and diagnostic value

The understanding of the diagnostic and prognostic value of many biomarkers of cardiovascular diseases (CVD), including cardiac troponins (cTnT and cTnI), is changing significantly with the development of methods for their determination. New highly sensitive immunoassays can detect minimal concentrations of cardiac troponin protein molecules in biological fluids (several ng/L or less), allowing the detection of cTnT and cTnI in all healthy individuals. Along with this, there are opportunities to use cTnT and cTnI both to assess the risk of developing CVD in healthy people, and to identify and monitor many early pathological conditions that pose a risk to the cardiovascular system and the life of patients. These pathological conditions include hypertension (HTN), which is the direct cause leading to coronary heart disease, acute myocardial infarction, stroke, and other CVD. A number of recent studies reported the possibility of using highly sensitive cTnT and cTnI in the management of HTN patients. In this article, we consider in detail the diagnostic and prognostic value of cardiac troponins in HTN, we also discuss the main possible mechanisms underlying the increase in cTnT and cTnI in human body fluids.

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Polyamines of biological fluids of the body and the diagnostic value of their determination in clinical and laboratory researches (review of literature)

Russian Clinical Laboratory Diagnostics ◽

10.51620/0869-2084-2021-66-4-197-204 ◽

2021 ◽

Vol 66 (4) ◽

pp. 197-204

Author(s):

M. V. Ploskonos

Keyword(s):

Prognostic Value ◽

Web Of Science ◽

Seminal Fluid ◽

Biological Fluids ◽

Practical Interest ◽

Diagnostic Value ◽

The Body ◽

Review Of Literature ◽

Early Markers ◽

Diagnostic And Prognostic Value

The review provides the analysis of the content of the main polyamines (PA) - spermine, spermidine and putrescine in the most important biological fluids of the human body (blood, urine, seminal fluid, etc.). The assessment of their diagnostic and prognostic value in clinical practice is carried out. The novelty and value of assessing of the level of PA metabolites as new diagnostic markers of various diseases has been shown. Among such diseases as cancer, stroke, renal failure, for which the search for early markers is especially relevant. This survey data can be of practical interest and taken into account in estimating the level of PA and its derivatives in clinical and laboratory reseaches. The literature search for the review was carried out using the Scopus, Web of Science, MedLine, RSCI databases.

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Diagnostic and prognostic value of miRNAs in hepatoblastoma: A systematic review with meta-analysis

10.37766/inplasy2021.11.0045 ◽

2021 ◽

Author(s):

Bin Wu ◽

◽

Lixia Guo ◽

Kaikai Zhen ◽

Chao Sun

Keyword(s):

Systematic Review ◽

Prognostic Value ◽

Meta Analysis ◽

Area Under The Curve ◽

Prognostic Indicator ◽

Diagnostic Odds Ratio ◽

Diagnostic Value ◽

Likelihood Ratios ◽

Clinical Value ◽

Diagnostic And Prognostic Value

Review question / Objective: Background and aim: Increasing evidence has revealed the valuable diagnostic and prognostic applications of dysregulated microRNAs (miRNAs) in hepatoblastoma (HB), the most common hepatic malignancy during childhood. However, these results are inconsistent and remain to be elucidated. In the present study, we aimed to systematically compile up-to-date information regarding the clinical value of miRNAs in HB. Methods: Articles concerning the diagnostic and prognostic value of single miRNAs for HB were searched from databases. The sensitivity (SEN), specificity (SPE), positive and negative likelihood ratios (PLR and NLR), diagnostic odds ratio (DOR), area under the curve (AUC), and hazard ratios (HRs) were separately pooled to explore the diagnostic and prognostic performance of miRNA. Subgroup and meta-regression analyses were further carried out only in the event of heterogeneity. Results: In all, 20 studies, involving 264 HB patients and 206 healthy individuals, met the inclusion criteria in the six included literature articles. For the diagnostic analysis of miRNAs in HB, the pooled SEN and SPE were 0.76 (95% CI: 0.72–0.80) and 0.75 (95% CI: 0.70–0.80), respectively. Moreover, the pooled PLR was 2.79 (95% CI: 2.12–3.66), NLR was 0.34 (95% CI: 0.26–0.45), DOR was 10.24 (95% CI: 6.55–16.00), and AUC was 0.83, indicating that miRNAs had moderate diagnostic value in HB. For the prognostic analysis of miRNAs in HB, the abnormal expressions of miR-21, miR-34a, miR-34b, miR-34c, miR-492, miR-193, miR-222, and miR-224 in patients were confirmed to be associated with a worse prognosis. The pooled HR was 1.74 (95% CI: 1.20–2.29) for overall survival (OS) and 1.74 (95% CI: 1.31–2.18) for event-free survival (EFS), suggesting its potential as a prognostic indicator for HB. Conclusion: To the best of our knowledge, this is the first comprehensive systematic review and meta-analysis that examines the diagnostic and prognostic role of dysregulated miRNAs in HB patients. The combined meta-analysis results supported the previous individual finds that miRNAs might provide a new, noninvasive method for the diagnostic and prognostic analyses ofHB.

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The diagnostic and prognostic value of H2AFY in hepatocellular carcinoma

10.21203/rs.3.rs-17889/v2 ◽

2020 ◽

Author(s):

xuyang ma ◽

Ying Ding ◽

Li Zeng

Keyword(s):

Gene Expression ◽

Hepatocellular Carcinoma ◽

Poor Prognosis ◽

Prognostic Value ◽

Clinical Characteristics ◽

Cox Regression ◽

Normal Liver ◽

Diagnostic Value ◽

The Relationship ◽

Diagnostic And Prognostic Value

Abstract Background: The potential correlation between H2AFY (also known as MacroH2A1) and the clinical characteristics of hepatocellular carcinoma (HCC) patients was analysed through gene expression profiles and clinical data in The Cancer Genome Atlas (TCGA) database, and the diagnostic and prognostic value of H2AFY in HCC was discussed. Methods: The gene expression data of HCC and the corresponding clinical characteristics of HCC patients were downloaded from the TCGA database. The differences in H2AFY in normal liver tissues and HCC were analysed. The relationship between H2AFY and clinical characteristics was analysed by Wilcoxon signed-rank test, logistic regression and Kruskal-Wallis test. The Kaplan-Meier method and the Cox regression method were used to analyse the relationship between overall survival and clinical characteristics of the patients. An ROC curve was used to predict the diagnostic value of H2AFY in HCC. Gene set enrichment analysis (GSEA) was used to analyse the pathway enrichment of H2AFY. Result: Compared with normal liver tissues, H2AFY was significantly highly expressed in HCC. H2AFY was positively correlated with the age, clinical stage, G stage (grade) and T stage (tumor stage) of liver cancer patients. Higher H2AFY expression predicted a poor prognosis in HCC patients. Cox regression analysis suggested that H2AFY was an independent risk factor for the prognosis of HCC patients. The ROC curve suggested that H2AFY had certain diagnostic value in HCC. GSEA suggested that H2AFY was correlated with lipid metabolism and a variety of tumour pathways. Conclusion: Our study showed that H2AFY was significantly overexpressed in HCC. H2AFY may be a potential diagnostic and prognostic marker for HCC, and high expression of H2AFY predicts a poor prognosis in patients with HCC.

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Diagnostic Value of sST2 in Cardiovascular Diseases: A Systematic Review and Meta-Analysis

Frontiers in Cardiovascular Medicine ◽

10.3389/fcvm.2021.697837 ◽

2021 ◽

Vol 8 ◽

Author(s):

Tianyi Zhang ◽

Chengyang Xu ◽

Rui Zhao ◽

Zhipeng Cao

Keyword(s):

Myocardial Infarction ◽

Cardiac Troponin ◽

Weighted Mean Difference ◽

Meta Analysis ◽

Diagnostic Value ◽

Mean Difference ◽

Diagnostic Biomarker ◽

Healthy Individuals ◽

Weighted Mean ◽

Standard Mean Difference

Biomarkers such as B-type natriuretic peptide (BNP), N-terminal pro-BNP (NT-proBNP), cardiac troponin (cTn), and CK-MB contribute significantly to the diagnosis of cardiovascular disease (CVD). Recent studies have demonstrated that suppression of tumorigenicity 2 (ST2) is associated with CVD, but a meta-analysis of ST2 levels in different CVDs has yet to be conducted. Therefore, the present study aimed to investigate soluble ST2 (sST2) levels in patients with ischemic heart disease (IHD), myocardial infarction (MI), and heart failure (HF). A total of 1,425 studies were searched across four databases, of which 16 studies were included in the meta-analysis. The Newcastle–Ottawa Quality Assessment Scale (NOS) values of all 16 studies were ≥7. The meta-analysis results indicated that the sST2 level was not correlated with IHD (standard mean difference [SMD] = 0.58, 95% confidence interval [95% CI] = 0.00 to 1.16, p = 0.05) or MI (weighted mean difference [WMD] = 0.17, 95% CI = −0.22 to 0.55, p = 0.40) but was significantly associated with HF (WMD = 0.21, 95% CI = 0.04 to 0.38, p = 0.02; I2 = 99%, p < 0.00001). sST2 levels did not differ significantly between patients with IHD or MI and healthy individuals; however, we believe that ST2 could be used as an auxiliary diagnostic biomarker of HF.

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Diagnostic and Prognostic Value of High-sensitivity Cardiac Troponin T in Patients with Syncope

The American Journal of Medicine ◽

10.1016/j.amjmed.2014.09.021 ◽

2015 ◽

Vol 128 (2) ◽

pp. 161-170.e1 ◽

Cited By ~ 8

Author(s):

Michael Christ ◽

Felicitas Geier ◽

Steffen Popp ◽

Katrin Singler ◽

Alexander Smolarsky ◽

...

Keyword(s):

Cardiac Troponin ◽

Prognostic Value ◽

Troponin T ◽

High Sensitivity ◽

Cardiac Troponin T ◽

Diagnostic And Prognostic Value

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Extracellular Vesicles as Innovative Tools for AssessingAdverse Effects of Immunosuppressant Drugs

Current Medicinal Chemistry ◽

10.2174/0929867328666211208114022 ◽

2021 ◽

Vol 28 ◽

Author(s):

Marianna Lucafò ◽

Serena De Biasi ◽

Debora Curci ◽

Alessia Norbedo ◽

Gabriele Stocco ◽

...

Keyword(s):

Extracellular Vesicles ◽

Biological Fluids ◽

Relevant Information ◽

Immunosuppressive Drugs ◽

Reciprocal Interactions ◽

Pathological Conditions ◽

Therapeutic Uses ◽

Donor Cells ◽

Signal Mediators ◽

Diagnostic And Prognostic Value

Background: Extracellular vesicles (EVs) are a heterogeneous family of small vesicles released by donor cells and absorbed by recipient cells, which represent important mediators with fundamental roles in both physiological and pathological conditions. EVs are present in a large variety of biological fluids and have a great diagnostic and prognostic value. They have gained the interest of the scientific community due to their extreme versatility. In fact, they allow us to hypothesize new therapeutic strategies since, in addition to being cell signal mediators, they play an important role as biomarkers, drug vehicles, and potential new therapeutic agents. They are also involved in immunoregulation, have the ability to transmit resistance to a drug from one cell to a more sensitive one, and can act as drug delivery systems. Objective: The main reciprocal interactions between EVs and immunosuppressive drugs will be presented. Results: The known interactions between EVs and immunosuppressive drugs, in particular, cyclosporin, glucocorticoids, rapamycin, methotrexate, cyclophosphamide, eculizumab, infliximab, certolizumab, etanercept, glatiramer acetate, and fingolimod are presented. Conclusion: This review provides relevant information on the links between EVs and immunosuppressive drugs with a focus on EVs' role as tools to assess effects of immunosuppressants, suggesting innovative properties and new possible therapeutic uses.

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