scholarly journals Karakterisasi Sistem Dispersi Padat Meloksikam Dengan Matriks PEG 6000 Dan Poloxamer 188 Dibuat Dengan Menggunakan Metode Peleburan

2021 ◽  
Vol 6 (1) ◽  
pp. 46-51
Author(s):  
Yuli Ainun Najih ◽  
Yuyun Nailufa ◽  
Dita Nurlita Rakhma ◽  
Bambang Widjaja ◽  
Lailatul Silviyah ◽  
...  
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2020 ◽  
Vol 23 (1) ◽  
pp. 26-31
Author(s):  
Joya Boidya ◽  
Ikramul Hasan ◽  
Md Selim Reza

The present study was conducted for preparing and assessing different in-vitro characteristics of hydrophilic polymer based matrix tablets of carvedilol. Nine formulations of matrix tablet were prepared using three hydrophilic polymers having 1% of three different dissolution enhancers. The matrix formers were sodium-carboxy methyl cellulose, Methocel K4M CR, Methocel K100M CR and the dissolution enhancers were PEG 6000, Poloxamer 188 and Kollidon-CLSF. Formulations F-10, F- 13 and F-16 contained PEG 6000 as dissolution enhancer, formulations F-11, F-14 and F-17 contained Poloxamer 188 and formulations F-12, F-15 and F-18 contained Kollidon-CLSF. Tablet granules were evaluated for bulk density (0.293 ± 0.012 to 0.310 ± 0.004 g/ml), tapped bulk density (0.368 ± 0.013 to 0.380 ± 0.012 g/ml) and compressibility index (16.612 ± 1.868 to 22.834 ± 5.426). The data indicated satisfactory flow properties of granules during compression. The tablets were subjected to thickness (1.79±0.04mm), hardness (11.46 ± 1.06 kg/cm), and friability (0.26 ± 0.06%) measurements. The in vitro dissolution study was carried out for 12 hrs using USP type II dissolution apparatus in 6.8 buffer as the dissolution medium where release mechanisms were subjected to zero order, first order, Korsmeyer-Peppas, Hixson-Crowell and Higuchi kinetic studies. The order of dissolution enhancing power was PEG 6000 > Poloxamer 188 >Kllidon-CLSF. The drug release from the tablets followed erosion mechanisms. Among all the formulation F-13, F-14 and F-17 exhibited USP complied in vitro dissolution profiles. Bangladesh Pharmaceutical Journal 23(1): 26-31, 2020


2016 ◽  
Vol 5 (1) ◽  
pp. 6
Author(s):  
Budi Setiawan ◽  
Erizal Zaini ◽  
Salman Umar

Sebuah penelitian tentang sistem dispersi padat dari asiklovir dengan poloxamer 188 telah dilakukan formulasi dengan pencampuran secara fisika dengan rasio 1 : 1, 1 : 3, 1 : 5 dan dispersi padat 1 : 1, 1 : 3, 1 : 5 dan penggilingan 1:1 sebagai pembanding. Dispersi padat dibuat menggunakan metode pencairan (fusi), yang digabung dengan poloxamer 188 pada hotplate kemudian asiklovir dimasukkan ke dalam hasil poloxamer 188 lalu di kocok hingga membentuk masa homogen. Semua formula yang terbentuk termasuk asiklovir poloxamer 188 murni dianalisis karakterisasinya dengan Differential Thermal Analysis (DTA), X-ray Diffraction, Scanning Electron Microscopy (SEM), dan Fourier Transform Infrared (FTIR), kemudian pengambilan dilakukan  (penentuan kadar) mengunakan spektrofotometer UV pada panjang gelombang 257,08 nm dan uji laju disolusi dengan aquadest bebas CO2 menggunakan metode dayung. Hasil pengambilan  (penentuan kadar) menunjukkan bahwa semua formula memenuhi persyaratan farmakope Amerika edisi 30 dan farmakope Indonesia edisi 4 yaitu 95-110%. Sedangkan hasil uji laju disolusi untuk campuran fisik 1: 1, dan dispersi padat 1: 1, dan penggilingan 1: 1 menunjukkan peningkatan yang nyata dibandingkan asiklovir murni. Hal ini juga dapat dilihat dari hasil perhitungan statistik  menggunakan analisis varian satu arah  SPSS 17.


2021 ◽  
pp. 51612
Author(s):  
Swanya Yakaew ◽  
Kunlathida Luangpradikun ◽  
Preeyawass Phimnuan ◽  
Nitra Nuengchamnong ◽  
Nuntaporn Kamonsutthipaijit ◽  
...  

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