scholarly journals Cell-free supernatants of lactobacilli inhibit methicilin-resistant staphylococcus aureus, vancomycin-resistant enterococcus and carbapenem-resistant klebsiella strains

2021 ◽  
pp. 332-339
Author(s):  
Fatma KALAYCI YÜKSEK ◽  
Defne GÜMÜŞ ◽  
Derya Bayırlı Turan BAYIRLI TURAN ◽  
Yaşar NAKİPOĞLU ◽  
Rıza ADALETİ ◽  
...  
Antibiotics ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 126
Author(s):  
Salvatore Princiotto ◽  
Stefania Mazzini ◽  
Loana Musso ◽  
Fabio Arena ◽  
Sabrina Dallavalle ◽  
...  

The global increase in infections by multi-drug resistant (MDR) pathogens is severely impacting our ability to successfully treat common infections. Herein, we report the antibacterial activity against S. aureus and E. faecalis (including some MDR strains) of a panel of adarotene-related synthetic retinoids. In many cases, these compounds showed, together with favorable MICs, a detectable bactericidal effect. We found that the pattern of substitution on adarotene could be modulated to obtain selectivity for antibacterial over the known anticancer activity of these compounds. NMR experiments allowed us to define the interaction between adarotene and a model of microorganism membrane. Biological assessment confirmed that the scaffold of adarotene is promising for further developments of non-toxic antimicrobials active on MDR strains.


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