scholarly journals Radiation Methods in the Diagnosis and Determination of Surgical Treatment Tactics for Primary Multiple Lung Carcinoid

2021 ◽  
Vol 102 (4) ◽  
pp. 227-231
Author(s):  
N. V. Nudnov ◽  
V. D. Сhkhikvadze ◽  
D. S. Kontorovich
Keyword(s):  
Surgical Treatment ◽  
Early Diagnosis ◽  
Clinical Oncology ◽  
Neuroendocrine Tumors ◽  
Who Classification ◽  
Carcinoid Tumors ◽  
Typical Carcinoid ◽  
Organ Sparing ◽  
Lung Carcinoid

The early and complete diagnosis of lung carcinoid tumors is of great interest in clinical oncology, since this is the basis for the possibility of using options for organ-sparing surgical treatment. According to the 2015 WHO classification, carcinoids belong to the group of neuroendocrine tumors and are divided into two types: a typical carcinoid and an atypical one. Based on the data available in the literature, there are from 0.2 to 2 cases per 100,000 population. The paper considers the possibilities of radiation studies in the early diagnosis of this tumor, as well as those of determining the tactics, type, and scope of surgical treatment.

scholarly journals Radiation methods in the diagnosis and determination of the tactics of surgical treatment of multiple primary lung carcinoid on clinical observation

2021 ◽  
Vol 25 (1) ◽  
pp. 159-163
Author(s):  
N. V. Nudnov ◽  
V. D. Сhkhikvadze ◽  
D. S. Kontorovich
Keyword(s):  
Surgical Treatment ◽  
Early Diagnosis ◽  
Clinical Oncology ◽  
Neuroendocrine Tumors ◽  
Who Classification ◽  
Clinical Observation ◽  
Multiple Primary ◽  
Radiation Research ◽  
Lung Carcinoid

Early and complete diagnosis of carcinoid lung tumors is of great interest in the clinical oncology, since this is the basis for the possibility of using options for organ-preserving surgical treatment. According to the 2015 WHO classification, carcinoids of the group of neuroendocrine tumors are divided into two types: typical and atypical carcinoids. Based on literature data, there are 0.2–2 cases per 100,000 people. This article discusses the possibilities of radiation research methods in the early diagnosis of this tumor, as well as the assessment of surgical treatment using them. 

Neuroendocrine Tumors of the Lung: An Update

2010 ◽  
Vol 134 (11) ◽  
pp. 1628-1638 ◽  
Author(s):  
Natasha Rekhtman
Keyword(s):  
Neuroendocrine Tumors ◽  
Who Classification ◽  
Large Cell ◽  
Mitotic Rate ◽  
World Health ◽  
Diagnostic Tools ◽  
Ki 67 ◽  
Typical Carcinoid ◽  
Pathologic Features ◽  
Health Organization

AbstractContext.—The 2004 World Health Organization (WHO) classification recognizes 4 major types of lung neuroendocrine tumors: typical carcinoid, atypical carcinoid, small cell lung cancer, and large cell neuroendocrine carcinoma. Markedly different prognostic implications and treatment paradigms for these tumors underscore the importance of accurate pathologic diagnosis.Objective.—To detail the clinical and pathologic features of lung neuroendocrine tumors, with emphasis on diagnostic criteria, differential diagnoses, and application of immunohistochemistry. The emerging evidence for the utility of Ki-67 (MIB1) in the diagnosis of lung neuroendocrine tumors, particularly in small biopsy and cytology, is emphasized.Data Sources.—The 2004 WHO classification, other published literature, and primary material from the author's institution.Conclusions.—The current WHO classification of neuroendocrine tumors is based on morphologic features in combination with precisely defined mitotic rate and absence or presence of necrosis. Ki-67 (MIB1) is emerging as a useful ancillary tool in the diagnosis of these tumors. Continued research efforts are needed to identify additional immunohistochemical and molecular biomarkers that can serve as ancillary diagnostic tools and as potential therapeutic targets for these diseases.

scholarly journals Case report of atypical carcinoid tumors of the larynx

2018 ◽  
Vol 5 (9) ◽  
pp. 4155
Author(s):  
Fatimah S. Alkhaliah ◽  
Ibrahim A. Almajed ◽  
Anwar S. Alkhalifah ◽  
Abdulltaif S. Alkhalifah ◽  
Khalid A. AlYahya ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Neuroendocrine Tumors ◽  
Histopathological Examination ◽  
Small Cell ◽  
Carcinoid Tumors ◽  
High Rate ◽  
Atypical Carcinoid ◽  
Typical Carcinoid ◽  
Laryngeal Tumors

Neuroendocrine tumors (NET) of the larynx are considered one of the rare disease; they represent only 1% of the laryngeal tumors. These tumors are very aggressive with a high rate of metastases. Diagnosis is done by computed tomography and confirmed by histopathological examination. Neuroendocrine tumors can be classified into four types based on histopathology: typical carcinoid tumors, atypical carcinoid tumors, small cell neuroendocrine tumors and paragangliomas. Atypical carcinoid tumor of the larynx is considered rare in occurrence. We report a rare laryngeal neuroendocrine tumor case.

Surgical Treatment of Neuroendocrine Tumors of the Pancreas

2010 ◽  
Vol 82 (7) ◽  
Author(s):  
Sebastian Dobrowolski ◽  
Zbigniew Śledziński ◽  
Krzysztof Sworczak ◽  
Małgorzata Hellmann ◽  
Anna Babińska
Keyword(s):  
Surgical Treatment ◽  
Neuroendocrine Tumors

Clinical Experience in Surgical Treatment of Gastrointestinal Neuroendocrine Tumors

2010 ◽  
Vol 82 (4) ◽  
Author(s):  
Adam Durczyński ◽  
Stanisław Sporny ◽  
Dariusz Szymański ◽  
Michał Nowicki ◽  
Piotr Hogendorf ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Neuroendocrine Tumors ◽  
Clinical Experience

scholarly journals Molecular Pathology of Well-Differentiated Pulmonary and Thymic Neuroendocrine Tumors: What Do Pathologists Need to Know?

2021 ◽  
Vol 32 (1) ◽  
pp. 154-168 ◽  
Author(s):  
Marco Volante ◽  
Ozgur Mete ◽  
Giuseppe Pelosi ◽  
Anja C. Roden ◽  
Ernst Jan M. Speel ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Young Patients ◽  
Carcinoid Tumors ◽  
Neuroendocrine Neoplasms ◽  
Grey Zone ◽  
Cell Hyperplasia ◽  
Ki 67 ◽  
Familial Form ◽  
Well Differentiated ◽  
Neuroendocrine Carcinomas

AbstractThoracic (pulmonary and thymic) neuroendocrine tumors are well-differentiated epithelial neuroendocrine neoplasms that are classified into typical and atypical carcinoid tumors based on mitotic index cut offs and presence or absence of necrosis. This classification scheme is of great prognostic value but designed for surgical specimens, only. Deep molecular characterization of thoracic neuroendocrine tumors highlighted their difference with neuroendocrine carcinomas. Neuroendocrine tumors of the lung are characterized by a low mutational burden, and a high prevalence of mutations in chromatin remodeling and histone modification-related genes, whereas mutations in genes frequently altered in neuroendocrine carcinomas are rare. Molecular profiling divided thymic neuroendocrine tumors into three clusters with distinct clinical outcomes and characterized by a different average of copy number instability. Moreover, integrated histopathological, molecular and clinical evidence supports the existence of a grey zone category between neuroendocrine tumors (carcinoid tumors) and neuroendocrine carcinomas. Indeed, cases with well differentiated morphology but mitotic/Ki-67 indexes close to neuroendocrine carcinomas have been increasingly recognized. These are characterized by specific molecular profiles and have an aggressive clinical behavior. Finally, thoracic neuroendocrine tumors may arise in the background of genetic susceptibility, being MEN1 syndrome the well-defined familial form. However, pathologists should be aware of rarer germline variants that are associated with the concurrence of neuroendocrine tumors of the lung or their precursors (such as DIPNECH) with other neoplasms, including but not limited to breast carcinomas. Therefore, genetic counseling for all young patients with thoracic neuroendocrine neoplasia and/or any patient with pathological evidence of neuroendocrine cell hyperplasia-to-neoplasia progression sequence or multifocal disease should be considered.

Diffuse Idiopathic Neuroendocrine Cell Hyperplasia, Tumorlets and Typical Carcinoid Tumors

2016 ◽  
Vol 52 (12) ◽  
pp. 623-625
Author(s):  
Jorge Lima Álvarez ◽  
Javier Muñoz Gutiérrez ◽  
Antonio J. Cruz Medina ◽  
Nuria Reyes Núñez ◽  
Enrique Rodríguez Zarco
Keyword(s):  
Carcinoid Tumors ◽  
Neuroendocrine Cell ◽  
Cell Hyperplasia ◽  
Typical Carcinoid
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