scholarly journals Relation Between Leukocyte Count and CRP (C-Reactive Protein) Levels in Typhoid Fever Patients

Academia Open ◽  
2021 ◽  
Vol 4 ◽  
Author(s):  
Alda Megawati ◽  
Andika Aliviameita
Keyword(s):  
Typhoid Fever ◽  
Protein C ◽  
Protein Production ◽  
Leukocyte Count ◽  
White Blood Cells ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Spearman Correlation Test ◽  
The Relationship

Typhoid fever is a systemic infectious disease characterized by the patient experiencing fever and abdominal pain due to the spread of Salmonella bacteria. Typhoid fever sufferers cause the immune system to decline which can affect changes in the number of white blood cells and in an infection, an inflammatory process occurs that produces cytokines which are the core stimulators of acute phase protein production, including C-reactive protein (C-reactive protein = CRP). This study was conducted in April 2021 with the aim of knowing the relationship between the number of leukocytes and CRP levels in typhoid fever patients at RA Basoeni Mojokerto Hospital. The design carried out in this study was a laboratory experimental, the sample needed in this study was 30 typhoid fever patients at RA Basoeni Hospital. Examination of the leukocyte count uses an automatic method with a Hematology analyzer, while CRP examination uses a semi-quantitative method. In the Spearman correlation test, it was found that there was no significant relationship between the number of leukocytes and the level of CRP p = 0.460.

scholarly journals C-Reactive Protein Levels and Gadolinium-Enhancing Lesions Are Associated With the Degree of Depressive Symptoms in Newly Diagnosed Multiple Sclerosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Yavor Yalachkov ◽  
Victoria Anschuetz ◽  
Jasmin Jakob ◽  
Martin A. Schaller-Paule ◽  
Jan Hendrik Schaefer ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Depressive Symptoms ◽  
White Blood Cells ◽  
Newly Diagnosed ◽  
Linear Regression Models ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Relapsing Remitting ◽  
Mental Symptoms

Background: Inflammation is essential for the pathogenesis of multiple sclerosis (MS). While the immune system contribution to the development of neurological symptoms has been intensively studied, inflammatory biomarkers for mental symptoms such as depression are poorly understood in the context of MS. Here, we test if depression correlates with peripheral and central inflammation markers in MS patients as soon as the diagnosis is established.Methods: Forty-four patients were newly diagnosed with relapsing-remitting MS, primary progressive MS or clinically isolated syndrome. Age, gender, EDSS, C-reactive protein (CRP), albumin, white blood cells count in cerebrospinal fluid (CSF WBC), presence of gadolinium enhanced lesions (GE) on T1-weighted images and total number of typical MS lesion locations were included in linear regression models to predict Beck Depression Inventory (BDI) score and the depression dimension of the Symptoms Checklist 90-Revised (SCL90RD).Results: CRP elevation and GE predicted significantly BDI (CRP: p = 0.007; GE: p = 0.019) and SCL90RD (CRP: p = 0.004; GE: p = 0.049). The combination of both factors resulted in more pronounced depressive symptoms (p = 0.04). CSF WBC and EDSS as well as the other variables were not correlated with depressive symptoms.Conclusions: CRP elevation and GE are associated with depressive symptoms in newly diagnosed MS patients. These markers can be used to identify MS patients exhibiting a high risk for the development of depressive symptoms in early phases of the disease.

scholarly journals Hubungan Jumlah Leukosit dan C-Reactive Protein (CRP) dengan Luaran Pasien Cedera Otak Traumatik (COT) berdasarkan Skor Glasgow Coma Scale (GCS) di RSUD Ulin Banjarmasin

2021 ◽  
Vol 10 (1) ◽  
pp. 8-15
Author(s):  
Irvan Maulana ◽  
◽  
Kenanga Marwan Sikumbang ◽  
Asnawati Asnawati ◽  
Keyword(s):  
Glasgow Coma Scale ◽  
Leukocyte Count ◽  
The Body ◽  
Outcome Analysis ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Coma Scale ◽  
Reactive Protein ◽  
Spearman Correlation Test ◽  
Severe Tbi

Background and Objective: The severity of traumatic brain injury (TBI) can be assessed using the Glasgow Coma Scale (GCS). When head injury occurs, the body releases various inflammatory mediators, leukocytes and inflammatory markers, namely c-reactive protein (CRP). The purpose of this study was to determine whether there is a correlation between the leukocyte count and CRP levels with the outcome of TBI patients based on GCS scores in Ulin Hospital Banjarmasin. Subject and Method: This research is an analytic observational with cross-sectional approach. Data acquired with consecutive sampling method. Result: We Obtained 45 subjects with the highest mean of leukocytes count and the highest CRP levels in patients with severe TBI followed by moderate TBI and mild TBI. On the 7th day, 41 patients had good outcome and 4 patients had bad outcome. Analysis using the Spearman correlation test showed that there was a relationship between the leukocyte count (p = 0.004; r = 0.424) and CRP levels with the outcome of TBI patients (p = 0.043; r = 0.361). Conclusion: It was concluded that there is a correlation between leukocyte count and CRP levels with the outcome of TBI patients based on GCS scores

scholarly journals Biomarkers, Inflammation, and Bipolar Disorder: Association Between the Improvement of Bipolar Disorder Severity and the Improvement in C-Reactive Protein Levels After 7 Days of Inpatient Treatment

2021 ◽  
Vol 12 ◽  
Author(s):  
Alessandro Cuomo ◽  
Despoina Koukouna ◽  
Alessandro Spiti ◽  
Giovanni Barillà ◽  
Arianna Goracci ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Inpatient Treatment ◽  
Inflammatory Marker ◽  
C Reactive Protein ◽  
Disease Symptoms ◽  
Mortality And Morbidity ◽  
Protein Levels ◽  
Reactive Protein ◽  
Inflammatory Processes ◽  
The Relationship

Introduction: Compared to the general population, people with severe mental illness (SMI) have a poorer health status and a higher mortality rate, with a 10–20-year reduction in life expectancy. Excess mortality and morbidity in SMI have been explained by intertwined components. Inflammatory processes could increase the morbidity and mortality risk in patients with bipolar disorder (BD) because of a bidirectional interaction between BD and conditions related to inflammation. This pilot study aimed to evaluate the relationship between C-Reactive-Protein (CRP) and bipolar disorder severity.Methods: A retrospective observational study was conducted on 61 hospitalized patients with bipolar disorder. CRP was measured at admission to inpatient treatment (T0) and after seven days from the admission (T1). Clinical Global Impression for Depression, Mania and Overall Bipolar Illness were recorded at T0 and T1. Comparisons among the recorded CRP values were determined through the paired t-test. Correlations between CRP and CGI scores were determined through Spearman's correlation coefficient at T0 and T1.Results: A statistically significant decrease in CRP values was observed after 7 days of hospitalization (p < 0.001) and positive significant correlations emerged between CRP and CGI scores at T0 and T1.Conclusion: Patients admitted to the inpatient unit reported a statistically significant decrease of CRP values during the first 7 days of treatment. Although the direction of the relationship between BP severity and inflammation status continues to remain unclear, this study showed a relationship between the improvement of bipolar disease symptoms and the improvement of the inflammatory marker CRP.

The Relationship Between Plasma C-Reactive Protein Levels and Presence and Severity of Coronary Stenosis in Patients With Stable Angina

Angiology ◽  
2007 ◽  
Vol 58 (6) ◽  
pp. 657-662 ◽  
Author(s):  
Abdullah Ulucay ◽  
Recep Demirbag ◽  
Remzi Yilmaz ◽  
Durmus Unlu ◽  
Mustafa Gur ◽  
...  
Keyword(s):  
Stable Angina ◽  
Coronary Stenosis ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
The Relationship

scholarly journals STUDIES ON INFECTION AND IMMUNITY IN EXPERIMENTAL TYPHOID FEVER

1960 ◽  
Vol 112 (6) ◽  
pp. 1023-1036 ◽  
Author(s):  
Sidney Gaines ◽  
Joseph G. Tully ◽  
William D. Tigertt
Keyword(s):  
Typhoid Fever ◽  
Phage Type ◽  
Clinical Findings ◽  
The Other ◽  
Sedimentation Rates ◽  
C Reactive Protein ◽  
Strain Control ◽  
Protein Levels ◽  
Reactive Protein ◽  
Large Numbers

Chimpanzees recovered from typhoid fever induced by ingestion of large numbers of phage-type T S. typhosa were rechallenged approximately a year and a half later with a like number of a phage-type E1 strain. Control animals exhibited febrile responses, bacteriemia, and other significant laboratory and clinical findings, including increases in C-reactive protein levels and sedimentation rates. All of the previously infected and recovered chimpanzees were negative with respect to the aforementioned observations, and appeared to have resisted significant re-infection. On the other hand, recovery from typhoid fever induced by smaller numbers of S. typhosa failed to protect completely against rechallenge with larger numbers of these organisms. These findings indicate that chimpanzees recovered from typhoid fever may be protected against re-infection, even though the re-infecting organism is of a different phage type. Differences in the magnitude of the original and subsequent infecting inocula appear to influence the response to rechallenge.

scholarly journals Transient leukocytosis in Emergency Room: an overlooked issue

2017 ◽  
Vol 11 (1) ◽  
pp. 41
Author(s):  
Giampiera Bertolino ◽  
Federica Quaglia ◽  
Luigia Scudeller ◽  
Iride Ceresa ◽  
Carlo L. Balduini
Keyword(s):  
Differential Diagnosis ◽  
Emergency Room ◽  
Blood Cells ◽  
Leukocyte Count ◽  
White Blood Cells ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Reliable Marker ◽  
Wbc Count ◽  
Clinical Records

Leukocytosis is regarded as a reliable marker of a serious disorder requiring hospitalization. However, leukocytosis often disappears once the patient is admitted to a medical ward; differential diagnosis of leukocytosis is often overlooked in the busy Emergency Room (ER) routine. We retrospectively evaluated the clinical records of 565 consecutive patients admitted to the Department of Internal Medicine (DIM) after examination in ER. Mean leukocyte count was 11.4×109/L in ER and 10.1×109/L in DIM (P<0.001). Leukocytosis was found in 53.1% of patients in ER, but in 33% of these it was no longer evident on the following day, unrelated to baseline white blood cells (WBC) count, age, sex, diagnosis, C-reactive protein level and early antibiotic treatment. A reduction in WBC count larger than 40% from baseline occurred in 13.6% of all subjects, and in 31.7% of those with transient leukocytosis. Leukocytosis in ER is frequent, but it is often transient and not associated with an infectious cause. Other causes, including psychological stress caused by the ER access itself, should be considered in the differential diagnosis.

Serum Endothelial Cell–Specific Molecule 1 (Endocan) Levels in Patients With Acute Myocardial Infarction and Its Clinical Significance

Angiology ◽  
2016 ◽  
Vol 68 (4) ◽  
pp. 354-359 ◽  
Author(s):  
Chong-Rong Qiu ◽  
Qiang Fu ◽  
Jian Sui ◽  
Qian Zhang ◽  
Peng Wei ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Endothelial Cell ◽  
Endothelial Dysfunction ◽  
High Sensitivity ◽  
Control Group ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
The Relationship

Endothelial dysfunction is involved in the process of acute myocardial infarction (AMI), that is, the endothelial cell–specific molecule 1 (ESM-1; endocan) is a novel endothelial dysfunction marker. However, the relationship between patients with AMI and serum ESM-1 levels is not very clear. Patients with AMI (n = 216) and a control group (n = 60) without AMI were included in the study. High-sensitivity C-reactive protein (hsCRP) was measured, and the severity of AMI was assessed by a modified Gensini stenosis scoring system. Serum ESM-1 levels were significantly higher in the AMI group ( P < .05). High-sensitivity C-reactive protein levels were also significantly higher in the AMI group ( P < .05). In patients with AMI, serum ESM-1 levels were not significantly correlated with hsCRP levels. There was no significant correlation between serum ESM-1 level and Gensini score. Our findings suggest that serum ESM-1 levels may be a novel biomarker of endothelial dysfunction in patients with AMI.

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