Hydrodynamics in the Morganza Floodway and Atchafalaya Basin, report 3 : phase 3; a report for the US Army Corps of Engineers, MRG&P

2022 ◽  
Author(s):  
Gary Bell ◽  
David Abraham ◽  
Gaurav Savant ◽  
Anthony G. Emiren
Keyword(s):  
Mississippi River ◽  
Phase 1 ◽  
Army Corps ◽  
Study Phase ◽  
Vegetation Density ◽  
Design Flood ◽  
Phase 3 ◽  
Us Army ◽  
Model Studies ◽  
Inundation Maps

The Morganza Floodway and the Atchafalaya Basin, located in Louisiana west of the Mississippi River, were evaluated using a two-dimensional Adaptive Hydraulics model. Prior to this study, Phase 1 and 2 model studies were performed that indicated that the existing floodway may not be able to pass the Project Design Flood discharge of 600,000 cubic feet per second due to levee overtopping. In this study, all elevations of exterior and interior levees were updated with current crest elevations. In addition, the Phase 3 effort evaluated the sensitivity of the floodway’s flow capacity to variations in tree/vegetation density conditions. These adjustments in roughness will improve the understanding of the role of land cover characteristics in the simulated water surfaces. This study also provides a number of inundation maps corresponding to certain flows through the Morganza Control Structure.

scholarly journals Performance of a multisensory implantable cardioverter-defibrillator algorithm for remote heart failure management: the RE-HEART registry

2021 ◽  
Vol 2 (4) ◽  
Author(s):  
J De Juan Baguda ◽  
M Pachon Iglesias ◽  
J J Gavira Gomez ◽  
V Martinez Mateo ◽  
M F Arcocha Torres ◽  
...  
Keyword(s):  
Heart Failure ◽  
Clinical Practice ◽  
Implantable Cardioverter Defibrillator ◽  
Phase 1 ◽  
Study Phase ◽  
Phase 2 ◽  
Office Visits ◽  
Phase 3 ◽  
Cardioverter Defibrillator ◽  
Clinical Events

Abstract Background The HeartLogic algorithm measures data from multiple implantable cardioverter-defibrillator-based (ICD) sensors and combines them into a single index. The associated alert has proved to be a sensitive and timely predictor of impending heart failure (HF) decompensation. Objective To analyze the association between HeartLogic alerts and clinical events and to describe the implementation in clinical practice of the algorithm for remote management of HF patients. Methods The association between HeartLogic alerts and clinical events has been analyzed in the blinded study Phase 1 (from ICD implantation to HeartLogic alert activation) and in the following unblinded Phase 2 and 3 (after HeartLogic activation). During Phase 1, patients were managed according to the standard clinical practice and physicians were blinded to the alert status. During Phase 2 physicians reacted to alerts according to their clinical practice, while during Phase 3 they followed a standardized protocol in response to alerts. Results We enrolled 288 patients who received HeartLogic-enabled ICD or CRT-D at 15 centers. 101 patients contributed to Phase 1. During a median observation period of 10 [95% CI: 5 – 19] months, the HeartLogic index crossed the alert-threshold value 73 times (0.72 alerts/patient-year) in 39 patients. 8 HF hospitalizations and 2 emergency room admissions occurred in 9 patients (0.10 events/patient-year) during HeartLogic IN alert state. Other 10 minor events (HF in-office visits and non-HF hospitalization) were associated with HeartLogic alerts. During the active phases 267 patients were observed for a median follow-up of 16 [95% CI: 15 – 22] months. 277 HeartLogic alerts (0.89 alerts/patient-year) occurred in 136 patients. Thirty-three HeartLogic alerts were associated with hospitalizations for HF or with HF death (n=6), and 46 alerts were associated with unplanned in-office visits for HF. In 78 cases, HeartLogic alerts were associated with other clinically relevant events. The rate of unexplained alerts was low (0.39 alerts/patient-year). During the active phases, one HF hospitalization and one unplanned in-office visit for HF occurred when patients were in OUT of alert state. Patient phone contacts or in-person assessments were performed more frequently in Phase 3 (85%) than in Phase 2 (73%; p=0.047), while alert-triggered actions were similar in the two phases. Most alerts in both Phases (82% in 2 and 81% in 3; p=0.861) were managed remotely. The total number of patient phone contacts performed during Phase 2 was 35 (0.65 contacts/patient-year) and during Phase 3 was 287 (1.12 contacts/patient-year; p=0.002). Conclusions HeartLogic index was frequently associated with HF-related clinical events, with a low rate of unexplained events. The HeartLogic alert and a standardize protocol of actions allowed to remotely detect impending decompensation events and to implement clinical actions with a low workload for the centers. Funding Acknowledgement Type of funding sources: None.

scholarly journals Pharmacokinetic and Pharmacodynamic Analyses To Determine the Optimal Fixed Dosing Regimen of Iclaprim for Treatment of Patients with Serious Infections Caused by Gram-Positive Pathogens

2017 ◽  
Vol 62 (2) ◽  
Author(s):  
Thomas P. Lodise ◽  
John Bosso ◽  
Colleen Kelly ◽  
Paul J. Williams ◽  
James R. Lane ◽  
...  
Keyword(s):  
Steady State ◽  
Phase 1 ◽  
Infection Model ◽  
Phase 3 ◽  
Two Phase ◽  
Time Curve ◽  
Skin Structure ◽  
Model Studies ◽  
Complicated Skin ◽  
Animal Infection

ABSTRACT Iclaprim is a bacterial dihydrofolate reductase inhibitor that is currently being evaluated in two phase 3 trials for the treatment of patients with acute bacterial skin and skin structure infections (ABSSSI). Prior animal infection model studies suggest that the pharmacokinetic/pharmacodynamic (PK/PD) drivers for efficacy are area under the concentration-time curve from 0 to 24 h at steady state (AUC0–24ss), AUC/MIC, and time above the MIC during the dosing interval (T > MIC), while QTc prolongation was associated with the maximal concentration at steady state (C maxss) in a thorough QTc phase 1 study. Using PK data collected from 470 patients from the previously conducted phase 3 complicated skin and skin structure infection (cSSSI) trials, population PK modeling and Monte Carlo simulation (MCS) were used to identify a fixed iclaprim dosage regimen for the ongoing phase 3 ABSSSI studies that maximizes AUC0–24ss, AUC/MIC, and T > MIC while minimizing the probability of a C maxss of ≥800 ng/ml relative to the values for the previously employed cSSSI regimen of 0.8 mg/kg of body weight infused intravenously over 0.5 h every 12 h. The MCS analyses indicated that administration of 80 mg as a 2-h infusion every 12 h provides 28%, 28%, and 32% increases in AUC0–24ss, AUC/MIC, and T > MIC, respectively, compared to values for the 0.8-mg/kg cSSSI regimen, while decreasing the probability of a C maxss of ≥800 ng/ml, by 9%. Based on PK/PD analyses, 80 mg iclaprim administered over 2 h every 12 h was selected as the dosing scheme for subsequent phase 3 clinical trials.

Water level management for enhanced fish and wildlife habitat production in Upper Mississippi River navigation pools : an Engineering with Nature® review of practice

2021 ◽  
Author(s):  
Charles Theiling ◽  
Benjamin McGuire ◽  
Gretchen Benjamin ◽  
Dave Busse ◽  
Jon Hendrickson ◽  
...  
Keyword(s):  
Wildlife Management ◽  
Mississippi River ◽  
Habitat Management ◽  
River System ◽  
Lessons Learned ◽  
Wildlife Habitat ◽  
Army Corps ◽  
Upper Mississippi River ◽  
Army Corps Of Engineers ◽  
Us Army

There is a long history of fish and wildlife management associated with Upper Mississippi River navigation dams owned and operated by the US Army Corps of Engineers (USACE). Many operational changes have been made to improve aquatic habitat, with recent emphasis on pool-scale drawdowns to enhance wetland benefits without affecting navigation or other uses. This special report describes projects successfully incorporating Engineering With Nature® principles in a review of the physical setting and historical fish and wildlife habitat management efforts using Upper Mississippi River System navigation dams. We reviewed 80 years of adaptation and lessons learned about how to integrate navigation operations and wildlife management. Several experiments have revealed the capacity to produce thousands of hectares of emergent and submersed aquatic plants, restoring much-needed riparian habitat for a variety of aquatic, wetland, and avian species.

scholarly journals Empirical analysis of effects of dike systems on channel morphology and flowlines

2021 ◽  
Author(s):  
Casey Mayne ◽  
David May ◽  
David Biedenharn
Keyword(s):  
Mississippi River ◽  
Channel Morphology ◽  
Army Corps ◽  
Army Corps Of Engineers ◽  
Us Army ◽  
The Us ◽  
River Geomorphology ◽  
Lower Mississippi River ◽  
Insight Into

A phased study of the dike fields within the Vicksburg and Memphis Districts of the US Army Corps of Engineers was conducted to document the channel morphology trends since dike construction on the Lower Mississippi River (LMR). This included the development of the hydrographic survey database and methodology utilized to identify changes in channel geometry in response to dike construction. A subsequent report will provide further refinements to the approach and results of the comprehensive assessment. Recent Mississippi River Geomorphology and Potamology program efforts have employed the database developed by Mr. Steve Cobb to assess the geomorphic changes in 21 dike systems along the LMR. Previous studies using this database have indicated that the dike fields have not caused a loss of channel capacity. Furthermore, these efforts suggested that the trends in the dike fields are closely related to the long-term geomorphic trends along the LMR. Previous efforts using the Cobb database provided considerable insight into the dike effects on the LMR, but they were limited spatially and temporally. In this study, a database and protocols were developed to allow for a more robust assessment of dike field impacts and to extend the spatial and temporal extents of the analysis.

scholarly journals Vertical and horizontal datums used in the Lower Mississippi Valley for US Army Corps of Engineers projects

2022 ◽  
Author(s):  
Joseph Dunbar
Keyword(s):  
Mississippi River ◽  
Technical Note ◽  
Background Information ◽  
Army Corps ◽  
Mississippi Valley ◽  
Army Corps Of Engineers ◽  
Lower Mississippi Valley ◽  
Us Army ◽  
Vertical Datum ◽  
The Mean

Six geodetic datums have been used by the US Army Corps of Engineers (USACE), Mississippi River Commission (MRC), for river surveys in the Lower Mississippi Valley (LMV). These legacy elevation datums are the Cairo datum, the Memphis datum, the Mean Gulf Level (MGL), the Mean Sea Level (MSL), the National Geodetic Vertical Datum (NGVD) 1929, and the North American Vertical Datum 1988 (NAVD88). The official geodetic datum currently prescribed by the USACE is NAVD88 (USACE 2010). In addition to these different geodetic datums, hydraulic datums are in use by the USACE for rivers, lakes, and reservoir systems. Hydrographic surveys from the Mississippi River are typically based on a low water pool or discharge reference, such as a low water reference plane (LWRP), an average low water plane (ALWP), or a low water (LW) plane. The following technical note is intended to provide background information about legacy datums used in the LMV to permit comparison of historic maps, charts, and surveys pertaining to the Mississippi River in the LMV. The purpose of this report is to provide background information and history of different published horizontal and vertical datums used for presentation of hydrographic survey data from the Mississippi River. The goal is to facilitate understanding of differences with comparison to other historic surveys for change-detection studies along the river. Conversion values are identified herein for the earlier surveys where appropriate, and methods are presented here to evaluate the differences between earlier and later charts and maps. This report is solely intended to address the LMV area and historic surveys made there. This note is not applicable to areas outside of the LMV. Throughout this technical note, historic hydrographic surveys and data from the Memphis, TN, to Rosedale, MS, reach will be used as examples of features of interest for discussion purposes. Selected historic hydrographic survey sheets at Helena, AR, are included as Plates 1 to 3 (Appendix C) of this document and will be used as examples for discussion purposes.

PENERAPAN MODEL QUANTUM LEARNING UNTUK MENINGKATKAN HASIL BELAJAR AUTOCAD SISWA KELAS X TEKNIK PEMESINAN SMK NEGERI 1 STABAT

2013 ◽  
Vol 5 (1) ◽  
Author(s):  
Abdul Hasan Saragih
Keyword(s):  
Positive Response ◽  
Phase 1 ◽  
First Grade ◽  
Learning Model ◽  
Second Phase ◽  
Phase 2 ◽  
Phase 3 ◽  
The Third ◽  
Third Phase ◽  
Quantum Learning

This classroom research was conducted on the autocad instructions to the first grade of mechinary class of SMK Negeri 1 Stabat aiming at : (1) improving the student’ archievementon autocad instructional to the student of mechinary architecture class of SMK Negeri 1 Stabat, (2) applying Quantum Learning Model to the students of mechinary class of SMK Negeri 1 Stabat, arising the positive response to autocad subject by applying Quantum Learning Model of the students of mechinary class of SMK Negeri 1 Stabat. The result shows that (1) by applying quantum learning model, the students’ achievement improves significantly. The improvement ofthe achievement of the 34 students is very satisfactory; on the first phase, 27 students passed (70.59%), 10 students failed (29.41%). On the second phase 27 students (79.41%) passed and 7 students (20.59%) failed. On the third phase 30 students (88.24%) passed and 4 students (11.76%) failed. The application of quantum learning model in SMK Negeri 1 Stabat proved satisfying. This was visible from the activeness of the students from phase 1 to 3. The activeness average of the students was 74.31% on phase 1,81.35% on phase 2, and 83.63% on phase 3. (3) The application of the quantum learning model on teaching autocad was very positively welcome by the students of mechinary class of SMK Negeri 1 Stabat. On phase 1 the improvement was 81.53% . It improved to 86.15% on phase 3. Therefore, The improvement ofstudent’ response can be categorized good.

Clinical Drug Development for the Treatment of Pulmonary Arterial Hypertension: Collaboration With the Pharmaceutical Industry and Regulatory Agencies

2010 ◽  
Vol 9 (4) ◽  
pp. 214-219
Author(s):  
Robyn J. Barst
Keyword(s):  
Clinical Trials ◽  
Pulmonary Arterial Hypertension ◽  
Drug Development ◽  
Phase 1 ◽  
Preclinical Studies ◽  
Phase 2 ◽  
Phase 3 ◽  
Preclinical Testing ◽  
New Drug ◽  
Pulmonary Arterial

Drug development is the entire process of introducing a new drug to the market. It involves drug discovery, screening, preclinical testing, an Investigational New Drug (IND) application in the US or a Clinical Trial Application (CTA) in the EU, phase 1–3 clinical trials, a New Drug Application (NDA), Food and Drug Administration (FDA) review and approval, and postapproval studies required for continuing safety evaluation. Preclinical testing assesses safety and biologic activity, phase 1 determines safety and dosage, phase 2 evaluates efficacy and side effects, and phase 3 confirms efficacy and monitors adverse effects in a larger number of patients. Postapproval studies provide additional postmarketing data. On average, it takes 15 years from preclinical studies to regulatory approval by the FDA: about 3.5–6.5 years for preclinical, 1–1.5 years for phase 1, 2 years for phase 2, 3–3.5 years for phase 3, and 1.5–2.5 years for filing the NDA and completing the FDA review process. Of approximately 5000 compounds evaluated in preclinical studies, about 5 compounds enter clinical trials, and 1 compound is approved (Tufts Center for the Study of Drug Development, 2011). Most drug development programs include approximately 35–40 phase 1 studies, 15 phase 2 studies, and 3–5 pivotal trials with more than 5000 patients enrolled. Thus, to produce safe and effective drugs in a regulated environment is a highly complex process. Against this backdrop, what is the best way to develop drugs for pulmonary arterial hypertension (PAH), an orphan disease often rapidly fatal within several years of diagnosis and in which spontaneous regression does not occur?

scholarly journals How to improve emergency care to adults discharged within 24 hours? Acute Care planning in Emergency departments (The ACE study): a protocol of a participatory design study

BMJ Open ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. e041743
Author(s):  
Christina Østervang ◽  
Annmarie Touborg Lassen ◽  
Charlotte Myhre Jensen ◽  
Elisabeth Coyne ◽  
Karin Brochstedt Dieperink
Keyword(s):  
Patient Outcomes ◽  
Participatory Design ◽  
Hospital Admissions ◽  
Phase 1 ◽  
Family Needs ◽  
Focus Group Interviews ◽  
Phase 3 ◽  
Ace Study ◽  
Group Interviews ◽  
Improve Patient

IntroductionThe development of acute symptoms or changes in diseases led to feelings of fear and vulnerability and the need for health professional support. Therefore, the care provided in the acute medical and surgical areas of the emergency department (ED) is highly important as it influences the confidence of patients and families in managing everyday life after discharge. There is an increase in short-episode (<24 hours) hospital admissions, related to demographic changes and a focus on outpatient care. Clear discharge information and inclusion in treatment decisions increase the patient’s and family’s ability to understand and manage health needs after discharge, reduces the risk of readmission. This study aims to identify the needs for ED care and develop a solution to improve outcomes of patients discharged within 24 hours of admission.Methods and analysisThe study comprises the three phases of a participatory design (PD). Phase 1 aims to understand and identify patient and family needs when discharged within 24 hours of admission. A qualitative observational study will be conducted in two different EDs, followed by 20 joint interviews with patients and their families. Four focus group interviews with healthcare professionals will provide understanding of the short pathways. Findings from phase 1 will inform phase 2, which aims to develop a solution to improve patient outcomes. Three workshops gathering relevant stakeholders are arranged in the design plus development of a solution with specific outcomes. The solution will be implemented and tested in phase 3. Here we report the study protocol of phase 1 and 2.Ethics and disseminationThe study is registered with the Danish Data Protection Agency (19/22672). Approval of the project has been granted by the Regional Committees on Health Research Ethics for Southern Denmark (S-20192000–111). Findings will be published in suitable international journals and disseminated through conferences.

scholarly journals PSVI-3 Dietary supplementation with coated omega-3 fatty acids has positive effects on growth performance and nutrients digestibility in weaned pigs

2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 196-197
Author(s):  
Woo Jung Seok ◽  
Je min Ahn ◽  
Jing Hu ◽  
Dexin Dang ◽  
Yanjiao Li ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Growth Performance ◽  
Phase 1 ◽  
Dietary Supplementation ◽  
Basal Diet ◽  
Phase 2 ◽  
Omega 3 ◽  
Phase 3 ◽  
Linear Effect ◽  
Weaning Pigs

Abstract The objective of this study was to evaluate the effects of dietary supplementation of coated omega-3 fatty acid (n-3 CFA) by corn cob power silica on performance of weaning pigs. A total of 200 weaned pigs [(Landrace x Yorkshire) x Duroc, average initial body weight at 6.97 ± 1.22 kg] were randomly assigned to four experimental treatments in a 6-week experiment in 3 phases as follows: CON, basal diet; 2) 0.3CFA, CON + phase 1(0.3% n-3CFA), phase 2(0.2% n-3CFA), phase 3(0.1% n-3CFA); 3) 0.6CFA, CON + phase 1(0.6% n-3CFA), phase 2(0.4% n-3CFA), phase 3(0.2% n-3CFA); 4) 0.9CFA, CON + phase 1(0.9% n-3CFA), phase 2(0.6% n-3CFA), phase 3 (0.3% n-3CFA). Each treatment had 10 replicates with 5 pigs (three gilts and two barrows) per replicate. The data were analyzed using the GLM procedure of SAS as a randomized complete block design. Pen served as the experimental unit. Linear, quadratic and cubic polynomial contrasts were used to examine effect of dietary treatment with coated n-3FA in the basal diet. Variability in the data was expressed as the standard error of means and P&lt; 0.05 was considered to statistically significant. Increasing the level of n-3CFA in the diet linearly increased ADG and G/F of pigs (Table 1). Increasing the level of n-3CFA showed a linear increment in the digestibility of DM (83.59, 84.38, 85.13, 85.89 %) whereas nitrogen digestibility (81.79, 82.38, 82.96, 83.64 %) showed a trend (linear effect, p=0.0594) at the end of experiment. The fecal lactobacillus count was increased (7.22, 7.27, 7.33, 7.35 log10cfu/g) with the increase in the supplemental level of n-3CFA (linear effect; p&lt; 0.05). However, there were no differences in the concentration of serum haptoglobin, or fecal E. coli, Clostridium and Salmonella counts despite the increase in n-3CFA levels in the diet. Supplementation of the diet with coated n-3 fatty acids positively affected growth performance and digestibility of dry matter and nitrogen, and enhanced the count of lactobacillus in weaning pigs.

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