scholarly journals Acceptability and practicability of self-management for patients with Parkinson's disease based on smartphone applications in China

2019 ◽  
Author(s):  
Jie Hu ◽  
Dezhi Yuan ◽  
Qiuye Zhao ◽  
Xuefei Wang ◽  
Xiaotian Zhang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Chronic Condition ◽  
Positive Attitude ◽  
Medication Compliance ◽  
Self Management ◽  
Smartphone Apps ◽  
Smartphone Applications ◽  
Promising Strategy ◽  
Initial Stage

Abstract Background China has had about 1.2 billion mobile-phone users, and usage continues to grow. However, mobile-health services (mHealth) are currently in the initial stage, and have not yet prevailed in China. Additionally, the prevalence of Parkinson's disease (PD) in China is 190/100,000. Indeed, these PD patients would benefit from mHealth to manage their disease. Therefore, we designed a study to determine attitudes toward smartphone applications (apps) for chronic condition self-management, and to discover the practicality of these apps among PD patients in China.Methods We selected 204 participants with PD between 52 and 87 years old and surveyed their attitudes concerning the use of smartphone apps for chronic condition management via questionnaires.Results Among the participants, 65.19％ had smartphones. Among these smartphone users, 82.84％ expressed a preference for using apps for PD management. This group tended to be younger and more frequent web users with higher education and better medication compliance, and they tended to have a longer PD course and worse conditions (P < 0.001, P = 0.001, P < 0.001, P = 0.041, P < 0.001, P = 0.013.) Additionally, the willingness to apply apps for PD self-management was positively related to education (P < 0.001) and negatively related to age and PD course (P = 0.017, P < 0.001).Conclusion In China, patients with PD have a generally positive attitude towards self-management through smartphone apps. Consequently, improving the coverage of smartphones with practical and handy apps is a promising strategy for PD self-management.

scholarly journals Acceptability and practicability of self-management for patients with Parkinson's disease based on smartphone applications in China

2020 ◽  
Author(s):  
Jie Hu ◽  
Dezhi Yuan ◽  
Qiuye Zhao ◽  
Xuefei Wang ◽  
Xiaotian Zhang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Chronic Condition ◽  
Positive Attitude ◽  
Medication Compliance ◽  
Self Management ◽  
Smartphone Apps ◽  
Smartphone Applications ◽  
Promising Strategy ◽  
Initial Stage

Abstract Background China has had about 1.2 billion mobile-phone users, and this number continues to grow. However, mobile-health services (mHealth) are currently in the initial stage, and have not yet prevailed in China. Additionally, the prevalence of Parkinson's disease (PD) in China is 1700/100,000 (≥65 years). Indeed, these PD patients would benefit from mHealth to manage their disease. Therefore, we designed a study to determine attitudes toward smartphone applications (apps) for chronic condition self-management, and to discover the practicality of these apps among PD patients in China.Methods We selected 204 participants with PD between 52 and 87 years old and surveyed their attitudes concerning the use of smartphone apps for chronic condition management via questionnaires. Results Among the participants, 65.19％ had smartphones. Among these smartphone users, 82.84％ expressed a preference for using apps for PD management. This group tended to be younger and more frequent web users with higher education and better medication compliance, and they tended to have a longer PD course and worse conditions (P < 0.001, P = 0.001, P < 0.001, P = 0.041, P < 0.001, P = 0.013) .Additionally, the willingness to apply apps for PD self-management was positively related to education (P < 0.001) and negatively related to age and PD course (P = 0.017, P < 0.001). Conclusion In China, patients with PD have a generally positive attitude towards self-management through smartphone apps. Consequently, improving the coverage of smartphones with practical and handy apps is a promising strategy for PD self-management.

scholarly journals Acceptability and practicability of self-management for patients with Parkinson's disease based on smartphone applications in China

2020 ◽  
Author(s):  
Jie Hu ◽  
Dezhi Yuan ◽  
Qiuye Zhao ◽  
Xuefei Wang ◽  
Xiaotian Zhang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Chronic Condition ◽  
Positive Attitude ◽  
Medication Compliance ◽  
Self Management ◽  
Smartphone Apps ◽  
Smartphone Applications ◽  
Promising Strategy ◽  
Initial Stage

Abstract Background China has had about 1.2 billion mobile-phone users, and this number continues to grow. However, mobile-health services (mHealth) are currently in the initial stage, and have not yet prevailed in China. Additionally, the prevalence of Parkinson's disease (PD) in China is 1700/100,000 (≥65 years). Indeed, these PD patients would benefit from mHealth to manage their disease. Therefore, we designed a study to determine attitudes toward smartphone applications (apps) for chronic condition self-management, and to discover the practicality of these apps among PD patients in China. Methods We selected 204 participants with PD between 52 and 87 years old and surveyed their attitudes concerning the use of smartphone apps for chronic condition management via questionnaires. Results Among the participants, 65.19％ had smartphones. Among these smartphone users, 82.84％ expressed a preference for using apps for PD management. This group tended to be younger and more frequent web users with higher education and better medication compliance, and they tended to have a longer PD course and worse conditions ( P < 0.001, P = 0.001, P < 0.001, P = 0.041, P < 0.001, P = 0.013.) Additionally, the willingness to apply apps for PD self-management was positively related to education ( P < 0.001) and negatively related to age and PD course ( P = 0.017, P < 0.001). Conclusion In China, patients with PD have a generally positive attitude towards self-management through smartphone apps. Consequently, improving the coverage of smartphones with practical and handy apps is a promising strategy for PD self-management.

scholarly journals Acceptability and practicability of self-management for patients with Parkinson's disease based on smartphone applications in China

2020 ◽  
Author(s):  
Jie Hu ◽  
Dezhi Yuan ◽  
Qiuye Zhao ◽  
Xuefei Wang ◽  
Xiaotian Zhang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Chronic Condition ◽  
Positive Attitude ◽  
Medication Compliance ◽  
Self Management ◽  
Smartphone Apps ◽  
Smartphone Applications ◽  
Promising Strategy ◽  
Initial Stage

Abstract Background China has had about 1.2 billion mobile-phone users, and this number continues to grow. However, mobile-health services (mHealth) are currently in the initial stage, and have not yet prevailed in China. Additionally, the prevalence of Parkinson's disease (PD) in China is 1700/100,000 (≥65 years). Indeed, these PD patients would benefit from mHealth to manage their disease. Therefore, we designed a study to determine attitudes toward smartphone applications (apps) for chronic condition self-management, and to discover the practicality of these apps among PD patients in China. Methods We selected 204 participants with PD between 52 and 87 years old and surveyed their attitudes concerning the use of smartphone apps for chronic condition management via questionnaires. Results Among the participants, 65.19％ had smartphones. Among these smartphone users, 82.84％ expressed a preference for using apps for PD management. This group tended to be younger and more frequent web users with higher education and better medication compliance, and they tended to have a longer PD course and worse conditions ( P < 0.001, P = 0.001, P < 0.001, P = 0.041, P < 0.001, P = 0.013.) Additionally, the willingness to apply apps for PD self-management was positively related to education ( P < 0.001) and negatively related to age and PD course ( P = 0.017, P < 0.001). Conclusion In China, patients with PD have a generally positive attitude towards self-management through smartphone apps. Consequently, improving the coverage of smartphones with practical and handy apps is a promising strategy for PD self-management.

scholarly journals Acceptability and practicability of self-management for patients with Parkinson's disease based on smartphone applications in China

2020 ◽  
Author(s):  
Jie Hu ◽  
Dezhi Yuan ◽  
Qiuye Zhao ◽  
Xuefei Wang ◽  
Xiaotian Zhang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Chronic Condition ◽  
Positive Attitude ◽  
Medication Compliance ◽  
Self Management ◽  
Smartphone Apps ◽  
Smartphone Applications ◽  
Promising Strategy ◽  
Initial Stage

Abstract Background: China has had about 1.2 billion mobile-phone users, and this number continues to grow. However, mobile-health services (mHealth) are currently in the initial stage, and have not yet prevailed in China. Additionally, the prevalence of Parkinson's disease (PD) in China is 1700/100,000 (≥65 years). Indeed, these PD patients would benefit from mHealth to manage their disease. Therefore, we designed a study to determine attitudes toward smartphone applications (apps) for chronic condition self-management, and to discover the practicality of these apps among PD patients in China.Methods: We selected 204 participants with PD between 52 and 87 years old and surveyed their attitudes concerning the use of smartphone apps for chronic condition management via questionnaires. Results: Among the participants, 65.19％ had smartphones. Among these smartphone users, 82.84％ expressed a preference for using apps for PD management. This group tended to be younger and more frequent web users with higher education and better medication compliance, and they tended to have a longer PD course and worse conditions (P < 0.001, P = 0.001, P < 0.001, P = 0.041, P < 0.001, P = 0.013) .Additionally, the willingness to apply apps for PD self-management was positively related to education (P < 0.001) and negatively related to age and PD course (P = 0.017, P < 0.001). Conclusion: In China, patients with PD have a generally positive attitude towards self-management through smartphone apps. Consequently, improving the coverage of smartphones with practical and handy apps is a promising strategy for PD self-management.

scholarly journals Acceptability and practicability of self-management for patients with Parkinson's disease based on smartphone applications in China

2019 ◽  
Author(s):  
Jie Hu ◽  
Dezhi Yuan ◽  
Qiuye Zhao ◽  
Xuefei Wang ◽  
Xiaotian Zhang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Chronic Condition ◽  
Medication Compliance ◽  
Self Management ◽  
Smartphone Apps ◽  
Smartphone Applications ◽  
Education Standards ◽  
Promising Strategy ◽  
Initial Stage

Abstract Background China has had about 1.2 billion mobile-phone users and the usage has been still growing, however, mobile-health(m-Health) services are currently in the initial stage and have not yet prevailed. Additionally, the prevalence of Parkinson's disease (PD) is 190/100,000 in China, and patients need m-Health to manage their PD. Therefore, this study was designed to determine the attitudes and practicability towards about smartphone applications (APPs) of self-management of chronic condition among the elderly with PD in China.Methods Total 204 participants with PD were selected, from 52 to 87 years, and conducted by attitude surveys concerning using APPs for managing chronic condition via questionnaires.Results Among the total participants, 65.19% subjects had smartphones, and 82.84% ones preferred to use APPs for PD management, who were younger and more frequent web users with higher education standards and better medication compliance as well as longer PD courses and worse conditions of PD, compared with the rest of subjects( P < 0.001, P = 0.001, P < 0.001, P = 0.041, P < 0.001, P = 0.013. Additionally, the preference of patients for the use of the APPs is positively related to education standards( P < 0.001), while negatively related to age and PD course ( P = 0.017, P < 0.001).Conclusion Patients with PD are positive about self-management of smartphone APPs in China. Consequently, improving the coverage of smartphones developing practical and handy APPs would become a novel and promising strategy for PD self-management.

scholarly journals The acceptability and practicability of smartphone applications in self- management of Parkinson's disease patients in China

2019 ◽  
Author(s):  
Dezhi Yuan ◽  
Qiuye Zhao ◽  
Jie Hu ◽  
Xuefei Wang ◽  
Xiaotian Zhang ◽  
...  
Keyword(s):  
Higher Education ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Chronic Condition ◽  
The Elderly ◽  
Education Level ◽  
Self Management ◽  
Smartphone Applications ◽  
Ownership Rate ◽  
Practicable Method

Abstract Objective：To determine the practicability and attitudes among the elderly with Parkinson's disease (PD) in China unto the use of smartphone applications (APPs) for self-management of chronic condition. Methods：Patients with PD who participated in the study ranged in age from 52 to 87 years. Questionnaires were collected for attitudes towards using APPs for chronic condition from 204 PD patients, and the results were statistically analyzed. Results：The surveyed population had a smartphone ownership rate of about 65.19%; Among all patients, 82.84% were willing to use an APP for PD managing; among these patients, those who were inclined to use APPs were at younger ages, web users and with higher education, better medication adherence, longer PD courses, and worse conditions of PD（P＜0.001, P＝0.001, P＜0.001, P＝0.041, P<0.001, P＝0.013）. Additionally, the willingness of patients to use APPs for PD self-management is positively related to education level(P<0.001) while the age and PD course are negatively related to it (P=0.017, P<0.001). Conclusion：Patients with PD have relatively low smartphone coverage. They are positive about using APP to manage PD and thus using APPs to help manage PD is a practicable method. Consequently, it is still necessary to improve the smartphones’ coverage and develop practical and handy APPs for PD self-management.

scholarly journals TFE3-Mediated Autophagy is Involved in Dopaminergic Neurodegeneration in Parkinson’s Disease

2021 ◽  
Vol 9 ◽  
Author(s):  
Xin He ◽  
Yue Xie ◽  
Qiongping Zheng ◽  
Zeyu Zhang ◽  
Shanshan Ma ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cell Death ◽  
Transcription Factor ◽  
Dopaminergic Neurons ◽  
Essential Role ◽  
Dopaminergic Neurodegeneration ◽  
Promising Strategy ◽  
Progressive Loss ◽  
Mptp Model

Impairment of autophagy has been strongly implicated in the progressive loss of nigral dopaminergic neurons in Parkinson’s disease (PD). Transcription factor E3 (TFE3), an MiTF/TFE family transcription factor, has been identified as a master regulator of the genes that are associated with lysosomal biogenesis and autophagy. However, whether TFE3 is involved in parkinsonian neurodegeneration remains to be determined. In this study, we found decreased TFE3 expression in the nuclei of the dopaminergic neurons of postmortem human PD brains. Next, we demonstrated that TFE3 knockdown led to autophagy dysfunction and neurodegeneration of dopaminergic neurons in mice, implying that reduction of nuclear TFE3 may contribute to autophagy dysfunction-mediated cell death in PD. Further, we showed that enhancement of autophagy by TFE3 overexpression dramatically reversed autophagy downregulation and dopaminergic neurons loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD. Taken together, these findings demonstrate that TFE3 plays an essential role in maintaining autophagy and the survival of dopaminergic neurons, suggesting TFE3 activation may serve as a promising strategy for PD therapy.

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