scholarly journals Cognitive reserve estimated with a life experience questionnaire outperforms education in predicting performance on MoCA: Italian normative data

Author(s):  
Sonia Montemurro ◽  
Roberta Daini ◽  
Chiara Tagliabue ◽  
Sabrina Guzzetti ◽  
Giulia Gualco ◽  
...  

Abstract Normative data of neuropsychological tests typically take into account the effect of demographic variables like age and education on performance. However, a broad literature has shown that, after the school age, other cognitively stimulating experiences (e.g., occupational attainment and a variety of leisure-time activities) may increase and build up cognitive reserve (CR), which is positively associated with better performance in neuropsychological tests. With these premises, we investigated the predictive ability of education and a life-experience proxy of CR on a widely used cognitive screening, i.e., the Montreal Cognitive Assessment (MoCA). Results show that including the more comprehensive life-experience CR proxy is better than considering only education in predicting expected cognitive performance. Based on the results of our analyses we provide normative data and cut-offs on 440 Italian individuals aged 50-90 years, by taking into account, for the first time for the Italian population, a CR index, together with demographic variables and Education, in the calculation of regression-based norms. Accounting for life-experience CR proxies can improve the accuracy of normative data and allow a finer estimation of cognitive performance, which lead to a more tailored approach to patient assessment.

2018 ◽  
Vol 31 (2) ◽  
pp. 241-249 ◽  
Author(s):  
Martina Pigliautile ◽  
Francesca Chiesi ◽  
Franca Stablum ◽  
Sonia Rossetti ◽  
Caterina Primi ◽  
...  

ABSTRACTObjectives:Addenbrooke's Cognitive Examination III (ACE-III) is a brief cognitive screening tool to assess five cognitive domains: attention/orientation, verbal fluency, memory, language, and visuospatial abilities. This study aimed to provide normative data (for total score and subscale scores) of the Italian version of ACE-III for gender, age, and education.Methods:A total of 574 healthy Italian participants (mean age 68.70 ± 9.65; mean education 9.15 ± 4.04) were recruited from the community and included in the study. Linear regression analysis was performed to evaluate the effects of age, gender, and education on the ACE-III total performance score.Results:Age and education exerted a significant effect on total and subscale ACE-III scores, whereas gender was on attention/orientation, language, and visuospatial subscale scores. From the derived linear equation, correction grids to adjust raw scores and equivalent scores (ESs) with cut-off values were provided.Conclusions:The present study provided normative data, correction grids, and ESs for ACE-III in an Italian population.


2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 285-285
Author(s):  
Monica Nelson ◽  
Ross Andel ◽  
Julie Martinkova ◽  
Kateřina Čechová ◽  
Hana Marková ◽  
...  

Abstract Dementia is arguably the most devastating condition of older adulthood with treatment options still elusive. Alzheimer’s is the most prevalent form of dementia where cognitive deficits relate strongly to underlying brain pathology. However, there exist cases in which cognitive performance does not match the corresponding level of neuropathology. Attempts to explain this phenomenon often include the concept of cognitive reserve (CR), whereby greater CR (e.g., more education or higher occupational position) presumably results in less impairment relative to the extent of pathology early in disease progression but also greater impairment once cognitive symptoms manifest. We examined the influence of CR proxy variables (education and occupation) on the relationship between hippocampal volume and cognitive performance on tests of executive control and memory using data from the Czech Brain Aging Study (CBAS). Participants were cognitively normal/with subjective cognitive decline but without actual impairment (CN; n=115; M(age)=66.43; M(education)=15.90; 37 men) or had amnestic mild cognitive impairment (aMCI; n=165; M(age)=71.37; M(education)=14.92; 85 men). We found that hippocampal volume was significantly related to executive control (b=-.0001, p=.03) and memory (b=.0002, p<.001) for participants with aMCI, but only memory (b=.0002, p=.03) for CN participants. Occupational position moderated the association between memory and hippocampal volume in aMCI, with the result approaching significance (p=.07), whereby a greater link between memory problems and hippocampal atrophy was present in those previously in high occupational positions. No other moderations for occupational position or education emerged (ps>.25). We found evidence for the concept of CR using occupational position as proxy.


2018 ◽  
Vol 75 (6) ◽  
pp. 1199-1205
Author(s):  
Fanny Vallet ◽  
Nathalie Mella ◽  
Andreas Ihle ◽  
Marine Beaudoin ◽  
Delphine Fagot ◽  
...  

Abstract Objectives Interindividual differences in cognitive aging may be explained by differences in cognitive reserve (CR) that are built up across the life span. A plausible but underresearched mechanism for these differences is that CR helps compensating cognitive decline by enhancing motivation to cope with challenging cognitive situations. Theories of motivation on cognition suggest that perceived capacity and intrinsic motivation may be key mediators in this respect. Method In 506 older adults, we assessed CR proxies (education, occupation, leisure activities), motivation (perceived capacity, intrinsic motivation), and a global measure of cognitive functioning. Results Perceived capacity, but not intrinsic motivation, significantly mediated the relation between CR and cognitive performance. Discussion Complementary with neurobiological and cognitive processes, our results suggest a more comprehensive view of the role of motivational aspects built up across the life span in determining differences in cognitive performance in old age.


2001 ◽  
Vol 88 (1) ◽  
pp. 183-188 ◽  
Author(s):  
Shane J. Lopez ◽  
Joseph J. Ryan ◽  
Scott W. Sumerall ◽  
James W. Lichtenberg ◽  
Doug Glasnapp ◽  
...  

The associations of demographic variables with cognitive performance, as measured by the MicroCog ability domain scores, were assessed with 222 substance abusers who were patients in a VA medical center. Analysis indicated that age was negatively related to all five outcomes scores, and education was positively related to measures assessing Attention/Mental Control and Reasoning/Calculation. These findings are consistent with past theoretical and applied research. The demographic variables, as a group, accounted for a total of 17% to 37% of the variance in the five domain scores.


2015 ◽  
Vol 94 (3) ◽  
pp. 136
Author(s):  
João Gabriel Magalhães Dias ◽  
Pablo Rodrigo Andrade da Silva ◽  
Tânia Corrêa de Toledo Ferraz Alvez

The elderly population is growing worldwide, and therefore cognitive decline and dementia is a major problem for healthcare system. However, many elders do not develop dementia or significant cognitive impairment even though present brain lesions, such as cortical atrophy and/or lesions, leading to the concept of Cognitive Reserve (CR). The main objective of this review is to establish the recent findings of CR in elderly cognition and explore some of the cognitive markers related to CR. In order to accomplish that we carried out a search for papers published either in English or Portuguese language in the last 5 years in the Medline database using as keywords cognitive reserve, elderly and aging/ageing. We filtered 14 studies that specifically approached the neuropsychological aspects (e.g, memory, attention, orientation, executive function) and reviewed them in detail. Based on these papers regarding old-aged individuals, education appears to have several implications on CR by strengthening cognitive abilities, however does not appear to impact on cognitive decline. Besides, we realized that cognitive performance is one of the form to measure CR, even though the methods cannot be standardized, which may be the cause of some varied conclusions. Regarding CR, education was the most prevalent measure, and CR seems to have a beneficial effect on executive function and episodic memory and it seems to act by both neural reserve and neural compensation. Print exposure appears as a potential variable positively related to cognitive performance and CR.


2020 ◽  
Vol 274 ◽  
pp. 813-818
Author(s):  
André Ponsoni ◽  
Laura Damiani Branco ◽  
Charles Cotrena ◽  
Flávio Milman Shansis ◽  
Rochele Paz Fonseca

2020 ◽  
Vol 11 ◽  
Author(s):  
Elisabet Lopez-Soley ◽  
Elisabeth Solana ◽  
Eloy Martínez-Heras ◽  
Magi Andorra ◽  
Joaquim Radua ◽  
...  

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