scholarly journals Study of Relationship Between Dry Eye and Expressions of CXCR3 and CCR5 After Ocular Acid Burn

2021 ◽  
Author(s):  
Bo Jiang ◽  
Qianqian Hu ◽  
Tao Li ◽  
Man She ◽  
Xiaodong Zhou
Keyword(s):  
Dry Eye ◽  
Corneal Thickness ◽  
Control Group ◽  
Observation Group ◽  
Ccr5 Expression ◽  
Meniscus Height ◽  
Group 3 ◽  
Tear Meniscus ◽  
Tear Meniscus Height ◽  
Control Study

Abstract Objective To investigate the manifestation of dry eye and its relationship with CXCR3 and CCR5 expression in patients with ocular acid burns. Methods This is a case-control study. A total of 27 eyes of 22 cases ocular with acid burns of I-V degrees from Jan.2020 to Feb.2021 in this hospital were selected as observation group, and 8 eyes of 8 cases of normal people were selected as control group. The followed up time was 3 months. The visual acuity, intraocular pressure, BUT, Schirmer Ⅰ test, corneal thickness and tear meniscus height (TMH) were observed at 1 day, 1 and 3 months after injury. The protein expression of CXCR3 and CCR5 were examined by ELISA and were compared among groups at each time point. Results BUT and Schirmer I tests value in the observation group were lower than those in the control group 3 months after injury (all p < 0.05). The corneal thickness and the tear meniscus height 1 day after injury were higher than those in the control group (p < 0.05), and also higher than those at 1 month and 3 months after injury (p < 0.05). The expression levels of CXCR3 and CCR5 protein were significantly negatively correlated with BUT (p < 0.05), and CXCR3 and CCR5 were also significantly negatively correlated with Schirmer I test value (p < 0.05). Conclusion Ocular acid burns can cause dry eye, and the expression of CXCR3 and CCR5 protein in tears may be related to the occurrence of dry eye after ocular acid burn.

scholarly journals Diagnostic value of three simple and rapid dry eye tests: Lid parallel conjunctival folds, tear meniscus height and tear ferning

2021 ◽  
pp. 24-24
Author(s):  
Bojana Dacic-Krnjaja ◽  
Milan Hadzi-Milic ◽  
Jelena Potic ◽  
Danijela Raonic ◽  
Milenko Stojkovic
Keyword(s):  
Dry Eye ◽  
High Specificity ◽  
Diagnostic Value ◽  
Control Group ◽  
Ocular Surface Disease Index ◽  
Mean Values ◽  
Meniscus Height ◽  
Tear Meniscus ◽  
Tear Meniscus Height ◽  
Low Sensitivity

Introduction/Objective. The objective of this paper was to assess the diagnostic value of three simple dry eye (DE) tests: lid parallel conjunctival folds (LIPCOF), tear meniscus height (TMH), and tear ferning (TF). Methods. Diagnostic DE tests LIPCOF, TMH and TF tests were performed in 100 patients. Eighty of them were referred to us by rheumatologists and general practitioners either during evaluation for Sj?gren?s syndrome, or because of DE symptoms. Control group was made of 20 patients, with no DE relating symptoms. Ocular Surface Disease Index (OSDI) questionnaire was used for DE symptoms? evaluation. Results of LIPCOF, TMH and TF tests were compared with results of Copenhagen criteria (CC) DE tests i.e., tear fluorescein break up time, Schirmer I and Rose Bengal tests. Ability of tests to recognize DE in various grades according to Dry Eye Work Shop (DEWS) report score system was assessed. Results. Compared to CC, sensitivity of LIPCOF and TMH was high: 92.8% and 83.5%, while specificity was low: 34.4% and 49.2%, respectively. TF had low sensitivity of 59.1% but high specificity of 82.7%. Mean values of both LIPCOF and TMH differed significantly (F = 7.222, p < 0.001 and F = 11.802, p < 0.001) between control group and all DEWS DE grades, but not among different grades of DE. Conclusions. Diagnostic tests TMH and LIPCOF showed high sensitivity which makes them excellent screening DE tests. Low sensitivity of TF suggests that it is not truly a good screening test on its own, but its high specificity is of definite value.

SCREENING FOR DRY EYE IN TYPE II DIABETIC PATIENTS IN A TERITIARY EYE CARE HOSPITAL

2021 ◽  
pp. 23-25
Author(s):  
Vepa Meenakshi ◽  
Maridi Aparna ◽  
Tammana v
Keyword(s):  
Dry Eye ◽  
Structural Damage ◽  
Screening Tests ◽  
Diabetic Patients ◽  
Care Hospital ◽  
Meniscus Height ◽  
Tear Meniscus ◽  
Break Up ◽  
Tear Meniscus Height

AIM: To screen for dry eye among type 2 diabetic patients ,determine the prevalence and correlate with blood sugar levels. METHODS: 100 patients who were diagnosed cases of type 2 diabetes were included in the study .Detailed history regarding ocular symptoms, diabetes and its duration was taken. A thorough ocular examination using Slit lamp bio microscopy was done and visual acuity tested with Snellen's chart.Tear lm status evaluated by Schirmer's I test, Tear lm break up time(TBUT),Tear meniscus height. Two or all of the above performed tests was positive in a given patient, the patient was deemed to be suffering from dry eye. RESULTS:Out of 100 patients, males were 48 and females were 52. 39 patients were found to show positive screening tests for dry eye.38% (out of 39 patients) had major symptom of foreign body sensation. 23 out of 39 patients were females. 14 out of 39 patients were in age group 51 to 60 years.Most of the diabetics with dry eye had duration of disease 5 to 10 years .39 patients had Tear Break Up time <10 sec, 25 patients had Tear Meniscus Height <0.25mm and 36 patients had Schirmers I test<10mm.Diabetics with dry eyes had average RBS of 179.63+57.28 and PPBS of 247.75+88.39 mg/dl. These values were more when compared to diabetics with no dry eye. CONCLUSION: Early ocular examination in Diabetic patients and good glycemic control should be done considering increased incidence of dry eyes.This should be an integral part of the assessment of diabetic eye disease so as to improve the patient's comfort and to prevent or minimize further structural damage to the ocular surface.

scholarly journals Automated Measurement of Tear Meniscus Height with the Kowa DR-1α Tear Interferometer in Both Healthy Subjects and Dry Eye Patients

2019 ◽  
Vol 60 (6) ◽  
pp. 2092 ◽  
Author(s):  
Reiko Arita ◽  
Katsumi Yabusaki ◽  
Taisuke Hirono ◽  
Takanori Yamauchi ◽  
Tadashi Ichihashi ◽  
...  
Keyword(s):  
Dry Eye ◽  
Healthy Subjects ◽  
Automated Measurement ◽  
Meniscus Height ◽  
Tear Meniscus ◽  
Tear Meniscus Height

Application of Visante Optical Coherence Tomography Tear Meniscus Height Measurement in the Diagnosis of Dry Eye Disease

Ophthalmology ◽  
2010 ◽  
Vol 117 (10) ◽  
pp. 1923-1929 ◽  
Author(s):  
Osama M.A. Ibrahim ◽  
Murat Dogru ◽  
Yoji Takano ◽  
Yoshiyuki Satake ◽  
Tais Hitomi Wakamatsu ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Optical Coherence ◽  
Height Measurement ◽  
Meniscus Height ◽  
Tear Meniscus ◽  
Tear Meniscus Height

scholarly journals Treatment of Dry Eye With Intracanalicular Injection of Hydroxybutyl Chitosan: A Prospective Randomized Clinical Trial

2021 ◽  
Vol 8 ◽  
Author(s):  
Tong Lin ◽  
Wushuang Wang ◽  
Yang Lu ◽  
Lan Gong
Keyword(s):  
Clinical Trial ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Phenol Red ◽  
Efficacy And Safety ◽  
Fluorescence Staining ◽  
Meniscus Height ◽  
Tear Meniscus ◽  
Tear Meniscus Height

Background: Punctal/intracanalicular plugs on the market nowadays are all designed before clinical use in treating dry eye disease (DED). To provide an individualized lacrimal drainage system occlusion method and reduce the complications, we developed a “liquid plug” strategy by intracanalicular injection of hydroxybutyl chitosan (HBC) solution, a thermosensitive, phase-changing biomaterial. This study evaluated the efficacy and safety of the HBC plug in treating dry eye disease by comparing it with the VisiPlug absorbable intracanalicular plug.Methods: A monocenter, randomized, controlled clinical trial was performed. Fifty patients with DED were randomized 1:1 to undergo either the HBC injection treatment or the VisiPlug treatment. Ocular Surface Disease Index (OSDI) questionnaire, tear break-up time (TBUT), corneal fluorescence staining (CFS), tear meniscus height (TMH), and phenol red thread test were evaluated at Day 0 (baseline, before treatment) and Weeks 1, 4, and 12.Results: The two groups had a balanced baseline of age, gender, and DED-related characteristics. Both occlusion methods could relieve the symptoms and signs of DED. Significant improvement was found in OSDI, phenol red thread test, and tear meniscus height (P &lt; 0.05 compared to baseline) but not in corneal fluorescence staining and tear break-up time (P &gt; 0.05). There is no statistically significant difference between HBC injection and VisiPlug at Weeks 1 and 4 (P &gt; 0.05). However, at week 12, the HBC injection was not as effective as the VisiPlug in maintaining phenol red thread test (HBC: 5.35 ± 3.22 mm, VisiPlug: 8.59 ± 4.35 mm, P = 0.009) and tear meniscus height (HBC: 206.9 ± 47.95 μm, VisiPlug: 242.59 ± 60.30 μm, P = 0.041). The numbers of ocular adverse events were relatively low in both groups.Conclusions: The HBC injection showed similar efficacy and safety compared to VisiPlug. The intracanalicular injection of HBC solution proves to be a promising, individualizing method to treat DED.Clinical Trial Registration: This study is registered with the Chinese Clinical Trial Registry (https://www.chictr.org.cn/enindex.aspx), Identifier: ChiCTR1800016603.

Evaluation of strip meniscometry, tear meniscus height and depth in the diagnosis of dry eye disease in asian Indian eyes

2019 ◽  
Vol 17 (4) ◽  
pp. 747-752 ◽  
Author(s):  
Archita Singh ◽  
Murugesan Vanathi ◽  
Alisha Kishore ◽  
Noopur Gupta ◽  
Radhika Tandon
Keyword(s):  
Asian Indian ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Meniscus Height ◽  
Tear Meniscus ◽  
Tear Meniscus Height
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