scholarly journals Increasing Incidence of Juvenile Idiopathic Arthritis: A Trend Over 31 Years in Southern Sweden

2022 ◽  
Author(s):  
Elisabet Berthold ◽  
Alma Dahlberg ◽  
Helena Tydén ◽  
Bengt Månsson ◽  
Robin Kahn
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Juvenile Chronic Arthritis ◽  
Population Based ◽  
Geographic Region ◽  
Chronic Arthritis ◽  
Annual Incidence ◽  
Juvenile Arthritis ◽  
Significant Difference ◽  
The Mean ◽  
Rate Ratios

Abstract Background The reported incidence of juvenile idiopathic arthritis (JIA) varies from studies around the world, depending on patient collection techniques, geographic region, and time. Our aim was to study the mean annual incidence of juvenile arthritis in a population-based setting using two regional cohorts of children diagnosed with juvenile chronic arthritis (JCA) and JIA over a period of 31 years.Findings The study population was 651 children diagnosed 1980-2010. The mean annual incidence over the period was 9.9 per 100,000 children, with a range from 4.2 per 100,000 in 1980 to 17.1 per 100,000 children in 2010. When comparing incidence rate between the decade of diagnosis using rate ratios, there is a significant difference with diagnosis 1980-1989 as comparator.Conclusions We show a statistically significant increase in the incidence of JIA over three decades in a population-based cohort of children with juvenile arthritis.

Juvenile idiopathic arthritis

2011 ◽  
pp. 303-320
Author(s):  
Alan J. Hakim ◽  
Gavin P.R. Clunie ◽  
Inam Haq
Keyword(s):  
Rheumatoid Arthritis ◽  
Juvenile Idiopathic Arthritis ◽  
Rheumatoid Factor ◽  
Juvenile Rheumatoid Arthritis ◽  
Juvenile Chronic Arthritis ◽  
Chronic Arthritis ◽  
Juvenile Arthritis ◽  
Childhood Onset ◽  
International League

Introduction 304 Oligoarthritis 306 Systemic arthritis 310 Rheumatoid factor negative polyarthritis in childhood 316 Chronic, infantile, neurological, cutaneous, and articular syndrome 319 • The classification of childhood onset arthritis has seen several changes over recent years. In this chapter we will discuss juvenile arthritis using headings and criteria from the International League of Associations for Rheumatology (ILAR.) The terms ‘juvenile rheumatoid arthritis’ (JIA) and ‘juvenile chronic arthritis’ (JCA) were discarded in the ILAR classification. The term ‘juvenile idiopathic arthritis’ was adopted to indicate arthritis present for at least 6 weeks and currently of no known cause in a patient <16 years....

Total hip arthroplasty in skeletal dysplasia

2003 ◽  
Vol 13 (3) ◽  
pp. 177-183 ◽  
Author(s):  
S.I.M. Umarji ◽  
M.B. Lee ◽  
M.F. Gargan ◽  
N.M.A. Portinaro ◽  
I.D. Learmonth
Keyword(s):  
Revision Surgery ◽  
Juvenile Chronic Arthritis ◽  
Chronic Arthritis ◽  
Developmental Dysplasia ◽  
Harris Hip Score ◽  
Hip Prostheses ◽  
Replacement Surgery ◽  
Hip Replacement Surgery ◽  
The Mean

This study presents the results of 38 hip prostheses in 24 people of short stature (under 152 cm). A retrospective clinical and radiological study recording the diagnosis, age at reconstruction, height, weight, type of prostheses, length of follow-up, radiological appearances and patient satisfaction was performed. Harris hip scores were used to assess activities of daily living (1). All patients were under 152cm and their diagnoses included achondroplasia, spondyloepiphyseal dysplasia, multiple epiphyseal dysplasia, developmental dysplasia of the hip and juvenile chronic arthritis. The mean height of these patients was 135 cm (range: 109cm to 150cm). The mean age was 38 years (range: 19 to 75 years) with mean follow-up 67 months (range: 12 to 406 months). Only one patient, who is now aged 69 years (though 65 years at revision surgery), has required revision surgery to date. The results were excellent for 33 hips (Harris hip score between 80–100), good in three (Harris hip score between 70–80), satisfactory in one (score 60–70) and poor for one (Harris hip score <50). The mean Harris hip score to date is 89. Hip replacement surgery is difficult in this challenging group of patients but can nonetheless yield gratifying results in over 90% of cases.

scholarly journals Outcome in juvenile idiopathic arthritis: a population-based study from Sweden

2019 ◽  
Vol 21 (1) ◽  
Author(s):  
Elisabet Berthold ◽  
Bengt Månsson ◽  
Robin Kahn
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Disease Activity ◽  
Orthopedic Surgery ◽  
Population Based ◽  
Annual Incidence ◽  
Common Disease ◽  
Necrosis Factor Alpha ◽  
Systemic Jia ◽  
Record Review

Abstract Background As the treatment arsenal for children with juvenile idiopathic arthritis (JIA) has expanded during the last decades, follow-up studies are needed on children diagnosed in the era of biological treatment to evaluate if this has improved the outcome. Our aim was to study the epidemiology and outcome of JIA in southern Sweden using a population-based cohort of children with a validated diagnosis of JIA collected over 9 years. Methods Potential cases of JIA between 2002 and 2010 were collected after a database search, using the ICD codes M08-M09. The study area was Skåne, the southernmost county of Sweden (population 1.24 million; 17.6% aged < 16 years). The JIA diagnosis was validated and subcategorized through medical record review based on the criteria defined by the International League of Associations for Rheumatism (ILAR). Parameters on disease activity and pharmacologic treatment were recorded annually until the end of the study period (December 31, 2015). Results In total, 251 cases of JIA were confirmed. The mean annual incidence rate for JIA was estimated to be 12.8/100,000 children < 16 years, with the highest age-specific annual incidence at the age of 2 years (36/100,000). Oligoarthritis was the largest subgroup (44.7%), and systemic JIA was the smallest subgroup (2.8%). Methotrexate was the most common disease-modifying anti-rheumatic drug prescribed (60.6%). Tumor necrosis factor alpha inhibitors were used as treatment for 23.9% of the children. Only 40.0% of the follow-up years, with a median follow-up time of 8 years, were free of arthritis or uveitis. Uveitis occurred in 10.8% of the children (8.0% chronic uveitis), and the need for joint corrective orthopedic surgery was 9.2%. Conclusions The incidence of JIA in this well-defined, population-based cohort is slightly lower than in previously published studies from Scandinavia. The need for orthopedic surgery and the presence of uveitis are diminished compared to studies with patients diagnosed more than 20 years ago. Children with JIA however still experience disease activity more than 50% of the time. In conclusion, we still have long-term challenges in the care for children with JIA, in spite of state-of-the-art treatment.

Sociodemographic factors influencing Breslow thickness at diagnosis for patients with melanoma

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 6552-6552
Author(s):  
K. B. Stitzenberg ◽  
N. E. Thomas ◽  
M. Berwick ◽  
H. Anton-Culver ◽  
U. J. Mujumdar ◽  
...  
Keyword(s):  
Rural Areas ◽  
Secondary Data ◽  
Sociodemographic Factors ◽  
Population Based ◽  
Geographic Region ◽  
Breslow Thickness ◽  
Outcome Variable ◽  
Effective Measure ◽  
Significant Difference ◽  
Incident Cases

6552 Background: In previous work, we demonstrated that Breslow thickness at diagnosis is significantly related to distance to provider for patients with melanoma in North Carolina (NC). Expanding the study population to include patients in New Jersey (NJ) and southern California (CA), we hypothesize that distance to provider is an effective measure of access to melanoma care regardless of geographic region. Methods: An IRB-approved secondary data analysis was performed of all incident cases of invasive cutaneous melanoma in 2000 from 3 population-based ascertainment areas (CA, NC, NJ). Patients and providers were geocoded to street address; Euclidian distances between patients and providers were calculated. The outcome variable, Breslow thickness at diagnosis, was logged for analysis. Simple and multiple linear regression were used to test associations between Breslow thickness and multiple sociodemographic factors. Results: Of 1,408 eligible cases, 16% were excluded for missing Breslow data. Median Breslow thickness was 0.6 mm (range 0.01–30.0 mm). Median distance to provider was 7 miles (range 0–372 miles). There was no significant difference in Breslow between the 3 geographic regions. Males had on average 15.5% thicker tumors than females, p=0.009. Patients 51–80 years old had 15.3% thicker tumors than patients =50, p=0.015, and those >80 had 64.3% thicker tumors than patients =50, p<0.001. For all patients, Breslow thickness increased only 2% for each 10 mile increase in distance, p=0.047. However, when limited to patients from rural areas, each 10 mile increase in distance corresponded to an 8% increase in Breslow, p<0.001. Meanwhile, Breslow was not associated with any area-based measures of rurality or provider supply. Each 1% increase in poverty rate corresponded to a 1% increase in Breslow, p=0.036. Conclusion: Breslow thickness at diagnosis is strongly correlated with distance to provider, especially for patients from rural areas. Distance to provider is a better measure of access to melanoma care than area-based measures of rurality. No significant financial relationships to disclose.

scholarly journals Growth-Related Differences in Maximum Laterotrusion and Retrusion between Children and Adults

2009 ◽  
Vol 79 (2) ◽  
pp. 265-270 ◽  
Author(s):  
Claudia A. Reicheneder ◽  
Peter Proff ◽  
Uwe Baumert ◽  
Tomas Gedrange
Keyword(s):  
Temporomandibular Joint ◽  
Null Hypothesis ◽  
Population Based ◽  
Adult Group ◽  
Population Based Study ◽  
Significant Difference ◽  
Left And Right ◽  
The Mean ◽  
The Right

Abstract Objective: To test the null hypothesis that there are no differences between children and adults in maximum laterotrusion and maximum retrusion on the right and left sides. Materials and Methods: This population-based study included 81 randomly selected children between the ages of 6 and 10 years and 67 adults. Kinematic variables were measured with the ultrasonic JMA-System for registration. Results: The mean maximum laterotrusion of the children's group (10.6 ± 1.5 mm on the left, 11.0 ± 1.7 mm on the right) was significantly smaller than that of the adult group (11.7 ± 2.0 mm on the left, 12.2 ± 1.7 mm on the right). The maximum laterotrusion of the children's group corresponded to about 90% on the left and right sides of that of the adult group. The mean maximum retrusion of the children's group was significantly bigger than that of the adult group. There, the adult values corresponded to 66.7% on the left and 50% on the right side of the children's values. No significant difference in maximum laterotrusion and retrusion was noted on the right and left sides, and no significant differences according to gender specificities were observed in either group. Conclusions: The hypothesis is rejected. In development of the temporomandibular joint, maximum laterotrusion on the right and left sides increases significantly with age, and maximum retrusion decreases significantly with age.

scholarly journals The Pattern of Juvenile Idiopathic Arthritis in a Single Tertiary Center in Saudi Arabia

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Mohammad H. Al-Hemairi ◽  
Shatha M. Albokhari ◽  
Mohammed A. Muzaffer
Keyword(s):  
Saudi Arabia ◽  
Juvenile Idiopathic Arthritis ◽  
Population Based ◽  
Chronic Arthritis ◽  
Rheumatology Clinic ◽  
Single Center Study ◽  
Tertiary Center ◽  
Systemic Onset ◽  
Pediatric Rheumatology Clinic

Introduction.Juvenile Idiopathic Arthritis (JIA) is the most common chronic arthritis in children. Our aim is to describe demographic, clinical, and laboratory characteristics and treatment of JIA patients followed up in Pediatric Rheumatology clinic in a tertiary center in Saudi Arabia.Methods. Medical records of all patients who are followed up between January 2007 and January 2015 were retrospectively reviewed. Data were collected about demographic, clinical, and laboratory features and treatment.Results.Total patients were 82, males were 31 (37.8%), and mean age of JIA onset was 7.1 ± 3.6 yr. Mean follow-up duration was 2.67±1.6 yr. Systemic onset JIA (SoJIA) was the commonest (36.5%), followed by polyarticular in 29.2% and oligoarticular in 28%. Large and small joints are involved in 76 (92%) and 30 (36.6%), respectively. Main extra-articular feature was fever in 34 (41.4%). Uveitis was diagnosed in 7 (8.5%) and in 5 (21.7%) of oligoarticular JIA. Anemia was found in 49 (59.7%), high ESR in 45 (54.8%), and leukocytosis and thrombocytosis in 33 (40.2%). Positive ANA was found in 30 (36.5%) mainly in oligoarticular subtype as 12 (52%) patients (out of 23) had this positive test. 9 patients (10.9%) required NSAIDs only, 6 patients (7.3%) required NSAIDs and intra-articular steroids only, and 19 (23%) required NSAIDs, methotrexate, steroids, and biologics.Conclusion.SoJIA is the most common JIA subtype in our study. A population based rather than a single center study will give more details about JIA characteristics in Saudi Arabia

Accuracy of Wallace Criteria for Clinical Remission in Juvenile Idiopathic Arthritis: a Cohort Study of 761 Consecutive Cases

2009 ◽  
Vol 36 (7) ◽  
pp. 1532-1535 ◽  
Author(s):  
ALFREDOMARIA LURATI ◽  
ALESSANDRA SALMASO ◽  
VALERIA GERLONI ◽  
MAURIZIO GATTINARA ◽  
FLAVIO FANTINI
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Clinical Laboratory ◽  
Survival Function ◽  
Disease Onset ◽  
Remission Status ◽  
Kaplan Meier ◽  
Significant Difference ◽  
Laboratory Variables ◽  
The Mean ◽  
Seronegative Polyarthritis

Objective.To evaluate disease course and clinical usefulness in some categories of juvenile idiopathic arthritis (JIA) by applying newly developed Wallace definitions of remission off drugs.Methods.In a retrospective study, charts of patients with chronic form of primary (idiopathic) arthritis followed from our center since 1970 were reviewed and clinical/laboratory variables were collected for further analysis.Results.The cohort included 761 eligible patients [516 (67.8%) female, 245 (32.2%) male] with JIA. Mean disease onset age (± standard deviation) was 6.25 ± 4.4 years (range 0.5–15.9). Disease mean duration to last visit was 10.02 ± 4.31 years. Followup mean period was 7.6 ± 6.4 years (range 1.5–35 yrs). A total of 247 (32.46%) patients achieved remission according to criteria [persistent oligoarthritis 153 (42.9%); extended oligoarthritis 15 (13.1%); seronegative polyarthritis 21 (22.4%); systemic arthritis 33 (33.7%); enthesitis related arthritis (ERA) plus juvenile psoriatic arthritis (JPsA) 25 (33.4%)]. No patients with seropositive polyarthritis achieved remission status (p < 0.001). In remitted patients the mean survival function (± standard error of the mean) before relapse calculated by Kaplan-Meier was of 20.9 (± 1.3) months overall: 21.7 (± 0.46) in persistent oligoarthritis, 25.0 (± 6.6) in extended oligoarthritis, 26.7 (± 13.2) in seronegative polyarthritis, and 17.6 (± 2.44) in ERA+JPsA (p > 0.1).Conclusion.In our cohort about one-third of cases obtained a remission episode in 4 decades of observation, with a significant difference between oligoarthritis and other categories (p < 0.001) using the Kaplan-Meier method; the remission status duration before a relapse has been about 20 months, without a significant difference between JIA categories.

scholarly journals Descriptive epidemiology and survival analysis of acromegaly in Korea

2021 ◽  
Author(s):  
Soo Jin Yun ◽  
Jung Kuk Lee ◽  
Jinsun Park ◽  
So Young Park ◽  
Sang Ouk Chin
Keyword(s):  
Treatment Options ◽  
Population Data ◽  
Population Based ◽  
Annual Incidence ◽  
Treatment Modalities ◽  
Newly Diagnosed ◽  
Korean Patients ◽  
Significant Difference ◽  
Average Annual Incidence ◽  
Using Data

Abstract Acromegaly is a rare, slowly progressive disease. Its mechanism is not fully understood, and epidemiological research on Korean patients with acromegaly is scarce. To determine the incidence and prevalence of acromegaly and assess the comorbidities and survival benefits based on treatment options. This nationwide population-based cohort study was conducted using data of the Korean Health Insurance Review and Assessment claims database to evaluate the incidence of newly diagnosed acromegaly cases during 2013–2017. During the 5-year period, 1,093 patients were newly diagnosed with acromegaly. The average annual incidence was 4.2 cases per million per year, and the prevalence was 32.1 cases per million during this period. The incidence of hypertension was low after medical treatment (hazard ratio 0.257, 95% confidence interval: 0.082–0.808, P = 0.0201), but the incidence of diabetes showed no significant difference across treatment modalities. Over a period of 6 years since diagnosis, we found that patients treated for acromegaly had a significantly higher survival rate than those untreated (P = 0.0003). The annual incidence rate of Korean patients with acromegaly was similar to that reported in previous studies. Using nationwide population data, our study emphasized the importance of treatment in acromegaly patients.

scholarly journals Temporal and Geographical Trends of Incidence of Thyroid Cancer in Golestan, Iran, 2004-2013

2021 ◽  
Vol 24 (1) ◽  
pp. 1-6
Author(s):  
Fatemeh Salamat ◽  
Ali Aryannia ◽  
Siamak Rajaei ◽  
Mohammad Naeimi-Tabiei ◽  
Reza Afghani ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Population Based ◽  
Incidence Rates ◽  
Common Type ◽  
Cancer Data ◽  
Significant Difference ◽  
Golestan Province ◽  
Males And Females ◽  
The Mean ◽  
Increasing Trends

Background: Thyroid cancer is the most common type of endocrine cancer. We aimed to determine the incidence rates of thyroid cancer across a 10-year period (2004-2013) in Golestan, Iran. Methods: We obtained the thyroid cancer data from Golestan Population-Based Cancer Registry (GPCR). Age-standardized incidence rates (ASR) were calculated and reported per 100000 person-years. The Joinpoint software was used to assess time trends, and average annual percent changes (AAPCs) and their corresponding 95% confidence intervals (CIs) were reported. Results: Of 326 registered patients, 83 (25.5%) were men and 243 (74.5%) were women. The mean age was 51.3 and 42.6 years for males and females, respectively. Overall, the ASR of thyroid cancer was 2.2 per 100000 person-year (AAPC = 2.76; 95% CI: -3.68 to 9.64). The test of co-incidence showed a statistically significant difference in the incidence of thyroid cancer between men (1.3) and women (3.2) (P < 0.001). According to our results, the ASR of thyroid cancer in western parts of Golestan is higher, including Gorgan and Aliabad cities. Conclusion: Increasing trends in incidence rates of thyroid cancer were found in the Golestan province during the study period, especially in women. We found significantly higher rates of thyroid cancer in women. Geographical diversities were seen in incidence rates of thyroid cancer in the Golestan province. Our results may be helpful for designing further researches to investigate the epidemiological aspects of thyroid cancer in the Golestan province.

Sign in / Sign up

Export Citation Format

Share Document