scholarly journals The Correlation of Papanicolaou Smears and Clinical Features to Identify the Common Risk Factors for Cervical Cancer: a Retrospective and Descriptive Study From a Tertiary Care Hospital in Trinidad

Author(s):  
Srikanth Umakanthan ◽  
Saudah Ghany ◽  
La Donna Gay ◽  
Tia Gilkes ◽  
Jamila Freeman ◽  
...  

Abstract Background: Cervical cancer, the fourth most frequent cancer in women, is associated with the human papilloma virus (HPV). This study focuses on identifying any risk factors and clinical findings for abnormal cervical cytology and histopathology in relation to the Trinidad and Tobago population. Some risk factors include early age of first coitus, high number of sexual partners, high parity, smoking, and use of certain medications such as oral contraception. This study is aimed to identify the significance of Papanicolaou (pap) smears and to identify the common risk factors that contribute to the development of premalignant and malignant cervical lesions. Method: A three-year retrospective, descriptive study of cervical cancer was conducted at the Eric Williams Medical Sciences Complex to assess the risk factors and clinical findings using cervical cytology and histopathology data of patients with premalignant lesions. The subject population included 215 female patients aged 18 years and older who had the following documented abnormal cervical cytology: (ASCUS), ASC-H, LSIL, HSIL, Atypical Glandular cells, HPV, Adenocarcinoma, Invasive Squamous Cell Carcinoma. Histopathology records were analysed for thirty-three of these patients. Patients’ information were recorded on data collection sheets adapted from the North Central Regional Health Authority’s cytology laboratory standardised reporting format request form (Appendix I). Results and findings: The data were analysed via Statistical Package for Social Sciences (SPSS) software edition 23 using frequency tables and descriptive analysis. The sample mean age of the population was 36.7 years, first age of coitus was 18.1 years, number of sexual partners was 3.8 and number of live births was 2. LSIL was the most popular abnormal finding, 32.6 %, followed by HSIL, 28.8% and ASCUS, 27.4%. Most histopathological reports resulted in CIN I and II.Conclusion: The major risk factors observed for cytology abnormalities and premalignant lesions were early age of coitus, high number of sexual partners, and no use of contraception.Patients mostly presented as asymptomatic despite obtaining abnormal cytology results. Hence, regular pap smear screening should continue to be highly encouraged.

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
K. Torres-Poveda ◽  
I. Ruiz-Fraga ◽  
V. Madrid-Marina ◽  
M. Chavez ◽  
V. Richardson

Abstract Background Cervical cancer is the second cause leading of malignancy-related death among Mexican women. The present study determined the population-based prevalence of high risk Human Papillomavirus (HR-HPV) infection and associated cofactors in female beneficiaries of the Institute of Security and Social Services for State Workers (ISSSTE) attending the Program for HPV Screening and Early Detection of Cervical Cancer and registered in the Women’s Cancer Detection System (SIDECAM). Methods In a cross-sectional study, cervical samples from 115,651 female users of the program for HPV screening and early detection of cervical cancer recruited in 23 ISSSTE care centers were analyzed for HR-HPV. Logistic regression analyses, adjusting for potential confounders, were performed to determine the association of HR-HPV infection with sexual health and behavior variables and with positivity to cervical premalignant lesions by cytology. Results The overall prevalence of HR-HPV infection among female ISSSTE beneficiaries in the 2013–2015 period was 13%. A bivariate analysis of relevant variables for HR-HPV infection showed a statistically significant association for age, number of sexual partners, use of hormonal contraceptives and smoking. A statistical association was found between infection by HR-HPV with the use of hormonal contraceptives, number of sexual partners and smoking and association of HPV 16 and other non-16/18 HR-HPV infection with number of lifetime sexual partners and tobacco use adjusted for age, history of hormonal contraception, number of sexual partners and tobacco use with the exception of exposition variable itself. Similarly, an association was found between HR-HPV infection, regardless of the virus genotype, with positivity to cervical premalignant lesions adjusted for age, number of lifetime sexual partners, history of hormonal contraception and tobacco use. Conclusions HR-HPV prevalence in female ISSSTE Women’s Cancer Program users is similar to the population-based prevalence previously reported in Mexican women without cervical alterations. The ISSSTE robust screening and early detection program, based on cytology studies and HPV co-testing, allows us to know the prevalence of HR-HPV infection among female users of the service.


2012 ◽  
Vol 32 (4) ◽  
pp. 177-185 ◽  
Author(s):  
A.A. Demers ◽  
B. Shearer ◽  
A. Severini ◽  
R. Lotocki ◽  
E.V. Kliewer ◽  
...  

Objectives We conducted a study to investigate the prevalence of human papillomavirus (HPV) infections in an opportunistic sample of women in Manitoba, Canada. We inquired about risk factors associated with HPV infections and linked the HPV typing results with the cervical cancer screening history of the participants. Methods The study population included 592 women attending Papanicolaou (Pap) test clinics. After signing a consent form, participants were given a self-administered questionnaire on risk factors and received a conventional Pap test. Residual cells from the Pap tests were collected and sent for HPV typing. Results The mean age of the population was 43 years. A total of 115 participants (19.4%) had an HPV infection, 89 of whom had a normal Pap test. Of those who were HPV-positive, 61 (10.3%) had high-risk (Group 1) HPV. HPV-16 was the most prevalent type (15/115: 13.0% of infections). The most consistent risk factors for HPV infection were young age, Aboriginal ethnicity, higher lifetime number of sexual partners and higher number of sexual partners in the previous year. Conclusion The prevalence of HPV types in Manitoba is consistent with the distributions reported in other jurisdictions. These data provide baseline information on type-specific HPV prevalence in an unvaccinated population and can be useful in evaluating the effectiveness of the HPV immunization program. An added benefit is in the validation of a proof of concept which links a population-based Pap registry to laboratory test results and a risk behaviour survey to assess early and late outcomes of HPV infection. This methodology could be applied to other jurisdictions across Canada where such capacities exist.


2021 ◽  
Vol 74 (6) ◽  
pp. 1428-1432
Author(s):  
Vyacheslav M. Zhdan ◽  
Iryna A. Holovanova ◽  
Orest Ya. Vovk ◽  
Maksym V. Korosh

The aim: Of this study is to determine the relationship between the development of cervical cancer and the level ofconducting of preventive oncological examinations. To identify risk factors of cervical cancer, we considered seven prognostic variables, that are associated with the development of cervical cancer. Matherials and methods: We conducted a survey of 120 women, among them 40 (33.3%) women had a confirmed diagnosis of cervical cancer, and 80 (66.7%) women were healthy. Results: We find, that factors that increase risk of cervical canser is age after 40 years increases the chances of cervical cancer by 14 times; untimely medical examinations increase by 5,4 times; the number of sexual partners, more than 4 - in 6 times. Conclusions: A comprehensive medical and social study has established a reliable relationship between the development of cervical cancer and the level of preventive cancer examinations.


Author(s):  
Li Zhang ◽  
Jie Hou ◽  
Fu-Zhe Ma ◽  
Jia Li ◽  
Shuai Xue ◽  
...  

2019 ◽  
Author(s):  
Li Song ◽  
Yuanjing Lyu ◽  
Ling Ding ◽  
Xiaoxue Li ◽  
Wen Gao ◽  
...  

Abstract Background: High-risk human papillomavirus (HR-HPV) infection is widely known as the major cause of cervical intraepithelial neoplasia (CIN) and cervical cancer and it’s characteristics vary greatly in different population. Women with abnormal cervical cytology could increase the risk of cervical cancer, however, HR-HPV infection characteristics in women with abnormal cervical cytology remains unclear. Methods: This study was based on baseline survey of the CIN Cohort established in Shanxi Province, China. A total number of 2300 women with cervical abnormalities were enrolled in this study. All participants gave informed consent and agreed to HPV and thinprepcytologic test (TCT). Each individual completed a questionnaire about characteristics related to HPV infection. Results: The overall prevalence of HR-HPV in 2300 women was 32.0%, and the proportion of single and multiple HR-HPV infections were 70.2% and 29.8% in HR-HPV infection women, respectively. The top five HR-HPV genotypes were ranked as HPV16, HPV58, HPV52, HPV53 and HPV51. The prevalence of HR-HPV in atypical squamous cells of undetermined significance (ASC-US), low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion and above(HSIL+) were 30.8%, 36.5% and 54.9%, respectively, showing an increasing trend with the severity of cervical cytology ( χ 2 trend =13.952; p <0.001). The women aged 35~45 years, with lower education level, less frequency of bathing, multiple gravidity, multiple parity, history of gynecological diseases and premenopausal women were prone to HR-HPV infection. Conclusions: We defined the characteristics related to HR-HPV infection in abnormal cervical cytology women, and provided an insight for the development and deeply research of HPV vaccine.


2004 ◽  
Vol 14 (5) ◽  
pp. 721-740 ◽  
Author(s):  
G. C. Zografos ◽  
M. Panou ◽  
N. Panou

Clinicians, epidemiologists, and public health specialists tend to examine breast and ovarian cancer separately. Although this seems fairly rational and expected, both malignancies are estrogen related and thus share many risk factors. In this review, we investigate the common familial, reproductive, anthropometric, nutritional, and lifestyle risk factors of breast and ovarian cancer. We believe that the parallel examination of the two cancer types could significantly contribute to an improved prevention of “gynecological cancer” as a whole.


2017 ◽  
Vol 02 (03) ◽  
pp. 056-062
Author(s):  
Shibba Chhabra ◽  
Ruhani Bali ◽  
Tripat Kaur ◽  
Bhupinder Singh ◽  
Abhishek Goyal ◽  
...  

AbstractPregnancy is a normal physiologic state in a woman's life, and according to traditional beliefs, it may not be predictive of future cardiovascular disease (CVD) lest it is complicated by some adverse events. Contrary to the previous beliefs, the complications are not limited to pregnancy period and may leave permanent vascular and metabolic damage. Factors such as lipid inflammatory pathways and vascular functions play a vital role in determining the cardiovascular risk in pregnancy. In addition to modifiable and nonmodifiable risk factors, emerging factors like genetics and epigenetics risk, obesity, metabolic syndrome, lifestyle, inflammatory and hypertensive disorders, and endothelial dysfunction with gestational diabetes help in determining the future CVD.The present debate is an effort to study that besides the common risk factors such as gestational hypertension, gestational diabetes, and preeclampsia, preterm delivery, assisted reproductive technology–related pregnancy events, and arrhythmias also have a bearing on future cardiovascular risk of a woman. The awareness in the medical community especially obstetricians, physicians, and cardiologists may play a pivotal role in detecting these complications and appropriate follow-up.


2016 ◽  
Vol 38 (05) ◽  
pp. 523-529 ◽  
Author(s):  
Jeire Steinbuch ◽  
Anouk van Dijk ◽  
Floris Schreuder ◽  
Martine Truijman ◽  
Alexandra de Rotte ◽  
...  

Abstract Purpose Inhomogeneity of arterial wall thickness may be indicative of distal plaques. This study investigates the intra-subject association between relative spatial intima-media thickness (IMT) inhomogeneity of the common carotid artery (CCA) and the degree of stenosis of plaques in the internal carotid artery (ICA). Materials and Methods We included 240 patients with a recent ischemic stroke or transient ischemic attack and mild-to-moderate stenosis in the ipsilateral ICA. IMT inhomogeneity was extracted from B-mode ultrasound recordings. The degree of ICA stenosis was assessed on CT angiography according to the European Carotid Surgery Trial method. Patients were divided into groups with a low (≤ 2 %) and a high (> 2 %) IMT inhomogeneity scaled with respect to the local end-diastolic diameter. Results 182 patients had suitable CT and ultrasound measurements. Relative CCA-IMT inhomogeneity was similar for the symptomatic and asymptomatic side (difference: 0.02 %, p = 0.85). High relative IMT inhomogeneity was associated with a larger IMT (difference: 235 µm, p < 0.001) and larger degree of ICA stenosis (difference: 5 %, p = 0.023) which remained significant (p = 0.016) after adjustment for common risk factors. Conclusion Regardless of common risk factors, high relative CCA-IMT inhomogeneity is associated with a greater degree of ICA stenosis and is therefore indicative of atherosclerotic disease. The predictive value of CCA-IMT inhomogeneity for plaque progression and recurrence of cerebrovascular symptoms will be determined in the follow-up phase of PARISK.


2017 ◽  
Vol 24 (11) ◽  
pp. 1675-1679
Author(s):  
Frahat Jaleel ◽  
Khalid Rashid ◽  
Nighat Bakhtiar ◽  
Masood Jawaid

Objectives: To find out the frequency of already recognized risk factor ofGallstones in population of Pakistan. Methods: A total of 50 patients diagnosed as cholelithiasison ultrasonography were included in the study. Data collection through interview included age,sex, marital status, parity, height and weight. On the basis of height and weight Quetelet’s bodymass index (weight in kg/height in m2) was calculated. Data collected also included Lipid profileData was analyzed by SPSS version 17 for descriptive statistics. Setting and Period: Thisstudy was done at Department of Surgery, Dow University Hospital for a period of 6 monthsfrom February to July 2015. Results: 70% of patients were above 40 years of age, 88% werefemale, and 83.3% were multiparous while only 32% had BMI above 23. Conclusion: Femalegender, fertility, middle age and flatulence are the common risk factors of gallstone formationwhile obesity is not a definite risk factor in Pakistan.


Sign in / Sign up

Export Citation Format

Share Document