Changes in the Prevalence of Hyperuricemia in Clients of Health Examination in Eastern China, 2009 to 2019

Abstract Background: With the continuous improvement of people's living standards, the incidence of hyperuricemia (HUA) is increasing globally. The prevalence of HUA ranged in terms of region, race, and age. This study aims to investigate the changes in the prevalence of HUA in clients of health examination in Eastern China between 2009 and 2019. Methods: Chinese men and women aged 20-79 years (n = 4847 in the 2009 cohort and n = 12188 in 2019) who had received health examinations were enrolled. Serum uric acid (UA) levels and biochemical parameters, including fasting blood-glucose (FBG), triglyceride (TG), total cholesterol (CHOL), high-density lipoprotein (HDL), low-density lipoprotein (LDL), creatinine (Cr) and blood urea nitrogen (BUN) were evaluated. The prevalence of HUA in different age groups were measured, and the correlation of biochemical parameters with the onset of HUA were analyzed. Results: The prevalence of HUA was 18.7% in the 2019 cohort, which was significantly higher than that in 2009 (13.3%). In females, the prevalence of HUA was significantly higher in 2019 than 2009 for age groups of 20-29 and 30-39 years. In male population, 2019 cohort had significantly higher age-specific prevalence for all age groups than 2009 cohort. Young men aged 20-29 years became the main population of HUA in the 2019 male cohort, whereas middle-aged men aged 40-49 years had the highest prevalence of HUA in the 2009 male cohort. The prevalence rates of HUA in all BMI groups in 2019 cohort were significantly higher than those in 2009 cohort. Spearmen’s correlation analysis and Logistic regression analysis indicated that BMI was positively correlated with the onset of HUA. The receiver-operating characteristic curve (ROC) analysis showed BMI＞24.48kg/m2 and BMI＞23.84 kg/m2 displayed good capacities to discriminate the population with HUA from those without HUA in 2009 and 2019 cohort, respectively. Conclusions: In recent 10 years, the prevalence of HUA was increased rapidly in Chinese adults, especially in males. Young men aged 20-29 years in the 2019 cohort replaced the middle-aged males (40-49 years old) in the 2009 cohort, and became the main population of male HUA in the 2019 cohort. BMI was positively correlated with HUA, and might be a potential risk factors to predict the onset of HUA.

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Association of Triglyceride Glucose (TyG) Index With Leukoaraiosis in Middle-aged and Older Adults: A Cross-sectional Study

10.21203/rs.3.rs-124306/v1 ◽

2020 ◽

Author(s):

Dong-Hyuk Jung ◽

Byoung Jin Park ◽

Yong-Jae Lee

Keyword(s):

Older Adults ◽

Brain Mri ◽

Multiple Logistic Regression Analysis ◽

Fasting Blood Glucose ◽

Cross Sectional Study ◽

Health Examination ◽

Sectional Study ◽

Middle Aged ◽

Cross Sectional ◽

Tyg Index

Abstract Background: Leukoaraiosis refers to lesions of high signal intensity in the periventricular and subcortical white matter that result from chronic microvascular ischemic damage to the brain. Increasing evidence suggests that the triglyceride glucose (TyG) index is associated with arterial stiffness and cardiovascular disease, which are both closely related to ischemic arterial damage. We hypothesized that the serum TyG index could be associated with cerebrovascular microangiopathy as measured by leukoaraiosis among middle-aged and older adults.Methods: This cross-sectional study included 2,162 Korean adults aged ≥45 years who participated in a health examination program between 2010 and 2011. TyG index was calculated as Ln (fasting triglycerides (mg/dl) × fasting blood glucose (mg/dl)/2). TyG index quartiles were categorized as follows: Q1, ≤8.12; Q2, 8.13-8.50 Q2, 8.51-8.89; and Q4, ≥8.90. The odds ratios (ORs) and 95% confidence intervals (95% CIs) for leukoaraiosis based on brain MRI scans were calculated across TyG index quartiles using multiple logistic regression analysis.Results: The overall prevalence of leukoaraiosis was 5.4% and increased with serum TyG index quartiles. Compared to the lowest quartile, the ORs (95% CIs) of the highest TyG index quartile for leukoaraiosis was 2.37 (1.17-4.79) after adjusting for age, sex, body mass index, smoking status, alcohol intake, regular exercise, mean arterial pressure, total cholesterol, HDL cholesterol levels, hypertension, and type 2 diabetes.Conclusions: The serum TyG index was positively and independently associated with leukoaraiosis. Our findings indicate that the TyG index might be a useful additional measure for assessing cerebrovascular microangiopathy in clinical settings.

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Metabolic syndrome in middle-aged and older women: A cross-sectional study

Women s Health ◽

10.1177/17455065211070673 ◽

2022 ◽

Vol 18 ◽

pp. 174550652110706

Author(s):

Mayle Andrade Moreira ◽

Saionara Maria Aires da Câmara ◽

Sabrina Gabrielle Gomes Fernandes ◽

Ingrid Guerra Azevedo ◽

Álvaro Campos Cavalcanti Maciel

Keyword(s):

Metabolic Syndrome ◽

Older Women ◽

Abdominal Obesity ◽

Menopausal Status ◽

Age Groups ◽

Density Lipoprotein ◽

Cross Sectional Study ◽

Age At Menarche ◽

Middle Aged ◽

Cross Sectional

Objective: This study aims to compare the prevalence of metabolic syndrome between different age groups of middle-aged and older women and to assess whether these differences are independent of potential covariates. Methods: Study conducted with 510 women divided into three age groups: 45–54, 55–64 and 65–74 years. Socioeconomic, reproductive and lifestyle variables were self-reported. We defined metabolic syndrome using the National Cholesterol Education Program Adult Treatment Panel III criteria (abdominal obesity, diabetes, reduced high-density lipoprotein, elevated triglycerides, and hypertension). Logistic regression assessed the association between age groups, and metabolic syndrome was adjusted for covariates (socioeconomic variables, age at menarche and at first childbirth, parity, menopausal status, physical activity variables and smoking). Results: Women aged 55–64 years presented higher prevalence of all metabolic syndrome criteria than the other groups, except for abdominal obesity, which was higher in the oldest group. In the fully adjusted analysis, the 55–64 years age group continues to exhibit significantly higher odds of presenting metabolic syndrome when compared to the youngest group (45–54 years) (OR = 2.257; 95% CI = 1.20:4.24). There was no statistical difference in the odds of presenting metabolic syndrome when comparing the oldest and the youngest groups (OR = 1.500; 95% CI = 0.85:2.65). Conclusion: The higher prevalence of metabolic syndrome among those aged 55–64 years may indicate that middle-aged women become unhealthy earlier in the life course and that many of them may die prematurely. This result highlights the importance of screening metabolic syndrome earlier in the midlife and the need for public health policies aimed at reducing adverse effects in later years.

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Relationship between Smoking and Concentrations of Some Biochemical Parameters in Blood of Young Smokers

Earthline Journal of Chemical Sciences ◽

10.34198/ejcs.1119.6570 ◽

2019 ◽

pp. 65-70

Author(s):

Khalid Shaalan Sahab

Keyword(s):

Cigarette Smoking ◽

Total Cholesterol ◽

Biochemical Parameters ◽

Low Density Lipoprotein ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Total Serum ◽

Control Group ◽

Low Density ◽

Young Smokers

Cigarette smoking is main cause of lung cancer and one of the major causes for cardiovascular problems. Smoking causes changes to some blood contents. The study aimed to identifying the influence of cigarette smoking on concentrations of glucose, total cholesterol, triglycerides, high density lipoprotein (HDL-C), glucose, low density lipoprotein (LDL-C) and bilirubin in blood of young smokers. The study conducted among 30 subjects of young smokers and compared with 20 non-smoker volunteers as control group. The biochemical parameters of blood among all subjects have been determined by using available commercial kits. The results have been showed that the mean of the total serum bilirubin levels were lower in smokers when compared with controls but with significant (P > 0.05). Serum fasting blood glucose (FBG) and total cholesterol (TC) levels were found to be higher in smokers as compared to controls (P ≤ 0.05). The comparison between the estimated levels of triglycerides (TG) and low density lipoprotein-c (LDL-C) in smokers and healthy controls subjects showed no significant increased (P > 0.05). Also there are no significant decrease in levels of HDL-C in smoking subjects as compared to controls Conclusion: The conclusion from results, that smoke of cigarette can influence on biochemical parameters such as glucose, total cholesterol and bilirubin in early stages of smoking and produce a problems to cardiovascular system in early ages.

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Urbanization-gradient-, gender- and age-specific prevalence of metabolic syndrome abnormal components and their accumulation in adults in Burkina Faso: analysis of the first national data

10.21203/rs.3.rs-74451/v1 ◽

2020 ◽

Author(s):

Jeoffray Diendéré ◽

Ahmed Kaboré ◽

Jean Kaboré ◽

Hermann Lanou ◽

Habib Fofana ◽

...

Keyword(s):

Metabolic Syndrome ◽

Burkina Faso ◽

Fasting Blood Glucose ◽

Age Groups ◽

International Diabetes Federation ◽

Density Lipoprotein ◽

Cumulative Number ◽

Urbanization Gradient ◽

Gender And Age ◽

Low Hdl

Abstract Background: Accumulation of metabolic syndrome abnormal components dramatically increases the risk for cardiovascular diseases. This study aimed to assess the specific prevalence of abnormal components according to the urbanization gradient, gender and age, with the cumulative number of abnormalities in Burkinabè, using nationally representative data.Methods: Data of 4365 participants to the Burkina Faso 2013 Stepwise approach to Surveillance study were analysed, including sociodemographic parameters (with age-groups of 25-34; 35-44; 45-54 and 55-64y), components defined with the International Diabetes Federation criteria (waist circumference [WC], blood pressure [BP], high-density lipoprotein cholesterol [HDL-C], fasting blood glucose [FBG]). The urbanization gradient was the four quartiles of the regional urbanization rates.Results: Between quartiles, prevalences (%) of abnormal components significantly differed and the extremes were: 71.1-81.2 in men(♂), 75.9-81.2 in women(♀) for low HDL-C; 32.8-48.2(♂), 21.5-51.6(♀) for elevated BP; 3.4-7.3(♂), 30.8-45.5(♀) for high WC; 6.2-11.0(♂), 6.7-14.2(♀) for high FBG; 2.8-7.3(♂), 9.6-24.0(♀) for individuals who cumulated at least three abnormalities; and the extreme means in cumulative number of abnormalities were 1.3-1.5(♂), 1.4-1.9(♀). Between age-groups, prevalences significantly differed and the extremes were: 71.9-81.6(♂), 71.8-83.1(♀) for low HDL-C; 32.3-49.1(♂), 23.8-30.3(♀) for elevated BP; 2.0-14.0(♂), 24.8-65.3(♀) for high WC; 6.4-13.0(♂), 5.5-10.4(♀) for high FBG; 2.5-12.0(♂), 8.5-25.8(♀) for individuals who cumulated at least three abnormalities; and the extreme means in number of abnormalities were 1.2-1.4(♂), 1.4-1.9(♀).Conclusion: The low HDL-C was nationally prevalent and could serve as a background to the metabolic abnormalities’ accumulation, which worsened with the process of urbanization and demographic transition, and more severely in women.

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Annual Health Examination Didn’t Perform a Positive Effect in the Prevention of Hyperlipidemia and Hyperglycemia Through an Eight-Year Study in China

10.21203/rs.3.rs-955188/v2 ◽

2022 ◽

Author(s):

Xiaohong Zhang ◽

Xiaokui He ◽

Xuehong Zhou ◽

Hongyan Geng ◽

Xiangyi Liu

Keyword(s):

Health Management ◽

Age Groups ◽

Density Lipoprotein ◽

Serum Levels ◽

Lipoprotein Cholesterol ◽

Clinical Samples ◽

Control Group ◽

Health Examination ◽

Positive Effect

Abstract Background: Annual health examination is recommended for the prevention and treatment of cardiovascular diseases and diabetes. However, whether it is effective for the prevention of hyperlipidemia and hyperglycemia remains unclear. Methods: A retrospective analysis of clinical samples using the laboratory information system was performed. From 2012 to 2019, 5043 participants (1755 males and 3288 females) have completed the annual health examination for 8 consecutive years, which was the follow-up group. In the same period, 136,994 participants (the control group) had a health examination only 1 time. Serum levels of fasting triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and glucose (GLU) were measured.Results: Compared with 2019 of the control group, serum TC and GLU in the 8th year of the follow-up group increased markedly in some of age groups (p < 0.001). Serum TG and TC in the 8th year were much higher compared with the 1st year of the follow-up group, especially for the female (p < 0.001). Moreover, the prevalence of hyperlipidemia and hyperglycemia in the 8th year showed significant increase compared with the 1st year of the follow-up group and 2019 of the control group (all p < 0.05).Conclusions: Annual health examination didn’t perform a positive effect in the prevention of hyperlipidemia and hyperglycemia. Health management should be paid more attention to prevent cardiovascular disease and diabetes.

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Association of Sleep Duration and Insomnia Symptoms with Components of Metabolic Syndrome and Inflammation in Middle-Aged and Older Adults with Metabolic Syndrome in Taiwan

Nutrients ◽

10.3390/nu11081848 ◽

2019 ◽

Vol 11 (8) ◽

pp. 1848 ◽

Cited By ~ 4

Author(s):

Ahmad Syauqy ◽

Chien-Yeh Hsu ◽

Hsiao-Hsien Rau ◽

Adi Lukas Kurniawan ◽

Jane C-J Chao

Keyword(s):

Older Adults ◽

Metabolic Syndrome ◽

Sleep Duration ◽

Fasting Blood Glucose ◽

International Diabetes Federation ◽

Density Lipoprotein ◽

Middle Aged ◽

Cross Sectional ◽

Long Sleep ◽

Insomnia Symptoms

The study determined the association of sleep duration and insomnia symptoms with the components of metabolic syndrome and inflammation in middle-aged and older adults with metabolic syndrome in Taiwan. This cross-sectional study used the database compiled in Taiwan between 2004–2013. A total of 26,016 volunteers aged 35 years and above were selected. Metabolic syndrome was defined according to the International Diabetes Federation. Compared with regular sleep duration (6–8 h/day), short (<6 h/day) or long sleep duration (>8 h/day) and insomnia symptoms significantly increased the odds ratios of high waist circumference, high blood pressure, low high-density lipoprotein-cholesterol, high triglycerides, high fasting blood glucose, and high C-reactive protein. Insomnia symptoms did not modify the effects of sleep duration on the components of metabolic syndrome and inflammation. Our study suggests that short or long sleep duration and insomnia symptoms may have an adverse effect on metabolic syndrome and inflammation.

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Visceral adipose tissue and low-density lipoprotein particle size in middle-aged versus young men

Metabolism ◽

10.1016/s0026-0495(99)90275-5 ◽

1999 ◽

Vol 48 (10) ◽

pp. 1322-1327 ◽

Cited By ~ 13

Author(s):

Isabelle Lemieux ◽

Agnès Pascot ◽

André Tchernof ◽

Jean Bergeron ◽

Denis Prud'homme ◽

...

Keyword(s):

Particle Size ◽

Adipose Tissue ◽

Visceral Adipose Tissue ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Young Men ◽

Low Density ◽

Middle Aged ◽

Lipoprotein Particle Size ◽

Visceral Adipose

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Sex Differences in the Nonlinear Association Between BMI and LDL Cholesterol in Middle-Aged and Older Adults: Results from two Nationally Representative Surveys of China

10.21203/rs.3.rs-779196/v1 ◽

2021 ◽

Author(s):

Haibin Li ◽

Jiahui Ma ◽

Deqiang Zheng ◽

Xia Li ◽

Xiuhua Guo ◽

...

Keyword(s):

Metabolic Syndrome ◽

Sex Differences ◽

Generalized Additive Models ◽

Low Density Lipoprotein ◽

Age Groups ◽

Density Lipoprotein ◽

Additive Models ◽

Middle Aged ◽

Nutrition Survey ◽

Nationally Representative

Abstract Background: The association between body mass index (BMI) and low-density lipoprotein cholesterol (LDL-C) in middle-aged and older man and women was understudied. We aimed to explore whether there were sex differences in this relationship in a large sample of Chinese adults.Methods: Participants in the China Health and Retirement Longitudinal Study (CHARLS, 2011-2012) (n=7485) and the China Health and Nutrition Survey (CHNS, 2009) (n=4788) were cross-sectionally investigated. Generalized additive models with a smooth function for BMI and a smooth-factor interaction for BMI with sex were performed and stratified by age and metabolic syndrome. Segment linear splines regressions were fitted to calculate the slopes with the different breakpoints.Results: Among the 12273 participants aged 45 to 75 years, 5780 (47.1%) were males. The nonlinear relationship between BMI and LDL-C was observed in females and males (P interaction <0.001). The slopes of the BMI and LDL-C association changed (P <0.001) at BMI 22.5 kg/m2 in females and 27.5 kg/m2 in males. Below these BMI breakpoints, LDL-C increased 2.14 (95% CI: 1.42 to 2.86) and 1.77 (95% CI: 1.43 to 2.11) mg/dL per kg/m2, respectively. In females, there was a plateau at BMI values of 22.5-27.5 kg/m2, and then gradually increased after a BMI of 27.5 kg/m2. However, LDL-C declined -1.84 (95% CI: -3.01 to -0.66) mg/dL per kg/m2 above BMI of 27.5 kg/m2 in males. The pattern of sex and BMI-LDL-C association was similar in all age groups but modified by the number of metabolic syndrome criteria.Conclusions: The BMI and LDL-C relationship was inverted U-shaped in males and approximately linear in females.

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Annual Health Examination Didn’t Perform a Positive Effect in the Prevention of Hyperlipidemia and Hyperglycemia Through an Eightyear Study in China

10.21203/rs.3.rs-955188/v1 ◽

2021 ◽

Author(s):

xiaohong zhang ◽

xiaokui he ◽

xuehong zhou ◽

hongyan geng ◽

xiangyi liu

Keyword(s):

Health Management ◽

Age Groups ◽

Density Lipoprotein ◽

Serum Levels ◽

Lipoprotein Cholesterol ◽

Clinical Samples ◽

Control Group ◽

Health Examination ◽

Positive Effect

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Effect of a Physical Activity Program on Serum Biochemical Parameters among the Elderly Women

Reviews on Recent Clinical Trials ◽

10.2174/1574887114666190201113809 ◽

2019 ◽

Vol 14 (3) ◽

pp. 209-216 ◽

Cited By ~ 2

Author(s):

Seyedeh Ameneh Motalebi ◽

Jamileh Amirzadeh Iranagh ◽

Fatemeh Mohammadi

Keyword(s):

Physical Activity ◽

Biochemical Parameters ◽

Elderly Women ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

The Elderly ◽

Community Dwelling ◽

Lipoprotein Cholesterol ◽

Control Group ◽

Significant Difference

Background: The present study examined the efficacy of the walking program on biochemical parameters among the elderly women. Methods: A total of one hundred elderly women participated in this randomized clinical trial study. The intervention group attended a 24-week walking exercise meeting five times per week. The control group continued with their routine activities. The subjects were assessed in Fasting blood glucose (FBS) and lipid profile before and after 12 and 24 weeks of the program. Results: The mean age of the elderly participants in the study was 68.33 ± 4.55 years. The results of repeated measures ANOVA showed a significant difference between the intervention and the control group in FBS, total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol after completing the program (for all p < 0.001). Conclusion: The low-cost physical activity intervention could be effective for reducing chronic vascular disease risk factors among community-dwelling elderly women.

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