scholarly journals Serum Cytokine Levels for Predicting Immune-Related Adverse Events and the Clinical Response in Lung Cancer Treated with Immunotherapy

Author(s):  
Ni Zhao ◽  
Ye Yi ◽  
Wen Cao ◽  
Nan Mei ◽  
Xiao Fu ◽  
...  

Abstract Analyses of the composition of peripheral cytokines hold promise for providing a basis for determining the prognosis of lung cancer treated with immunotherapy. In this study, we assessed correlations between interleukins in peripheral blood and the disease prognosis in patients with lung cancer. We retrospectively collected eligible adult patients with histologically confirmed lung cancer. Patients with immune-related adverse events (AE) from immunotherapy had higher pretreatment levels of IL-2 (p=0.002), IL-17 (p=0.01), and IFN-α (p=0.02) than patients with nonimmune-related adverse events (NAE). Univariate analysis showed that changes in IL-2 (p=0.04), IL-5 (p=0.007), IFN-α (p=0.003), IFN-γ (p=0.012) and TNF-α (p=0.049) levels were significantly increased in patients with AE compared with those with NAE before the second cycle of therapy. Patients with a clinical benefit had higher levels of IL-17 before the third cycle than patients without a clinical benefit. No significant cytokine differences were observed between patients with and without a clinical benefit undergoing ICI pretreatment or in the first two cycles of therapy. Plasma cytokines are related to immune-related adverse events and clinical responses, which are potential predictive markers for anti-PD-1/PD-L1 therapy in lung cancer patients and may play an important role in selecting patients who would benefit from PD-1/PD-L1 inhibitors.

2017 ◽  
Vol 12 (11) ◽  
pp. S2417 ◽  
Author(s):  
Y. Toi ◽  
S. Sugawara ◽  
Y. Kawashima ◽  
T. Aiba ◽  
K. Tsurumi ◽  
...  

2018 ◽  
Vol 34 ◽  
pp. 113-115 ◽  
Author(s):  
Wen-Juan Liu ◽  
Xiao-Dan Wang ◽  
Wei Wu ◽  
Xiao Huang

Objective: To study the correlation between depression and blood cytokine levels in lung cancer patients.Methods: 92 patients with advanced lung cancer were evaluated for depression using the scoring index of depression self-rating scale. Lack of depression (n=24), mild depression (n=45), and moderate depression (n=23) were found in the cohort. Meanwhile, 40 healthy subjects were selected as the control group. The levels of IL-10, IL-6, IL-8, and TNF-α in each group were detected by sandwich enzyme-linked immunosorbent assays, and their correlation with the degree of depression was analyzed.Results: The levels of IL-10, IL-6, IL-8, and TNF-α were all higher than those in the control group (P<0.05). Moreover, the depression statuses of patients with lung cancer were positively correlated with IL-10, IL-6, and TNF-α levels (r = 0.705, 0.301, and 0.446, P<0.01); however, the level of IL-8 was not relevant (r=0.136, p>0.05).Conclusion: Serum levels of IL-10, IL-6, and TNF-α are associated with depression scoring in patients with lung cancer.


Author(s):  
M. Trovo ◽  
T.M. Bortolin ◽  
C. Furlan ◽  
R. Tedeschi ◽  
J. Polesel ◽  
...  

2017 ◽  
Vol 99 (2) ◽  
pp. S150-S151
Author(s):  
H. Hubbeling ◽  
E. Schapira ◽  
A. Shaw ◽  
K.S. Oh ◽  
J. Gainor ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document