scholarly journals Clinical Analysis of 44 Cases of Atypical Polypoid Adenomyoma of the Uterus

2022 ◽  
Author(s):  
Xin Wang ◽  
Yinshu Guo
Keyword(s):  
Benign Lesion ◽  
Polypoid Lesion ◽  
Treatment Method ◽  
Clinical Analysis ◽  
Endometrial Biopsy ◽  
High Rate ◽  
Diagnosis And Treatment ◽  
Complete Excision ◽  
Atypical Polypoid Adenomyoma

Abstract Background: Atypical polypoid adenomyoma (APA) is a rare intrauterine polypoid lesion that occurs predominantly in premenopausal women. Although, it is considered as a benign lesion and treated conservatively previously, more and more cases show that APA has a high rate of recurrence or residual, and is found to precede the development of carcinoma. The clinical management of APA remains to be established. The aim of this study was to analyse the clinicopathological features of APA and discuss its diagnosis and prognosis.Methods: Forty-four patients with APA were admitted to Beijing Obstetrics and Gynecology Hospital from 2005-2019, and their clinical and histopathologic features were evaluated. B-ultrasound was performed, and all patients (n=44) underwent hysteroscopy. Endometrium excision was performed by means of the “Four-step diagnosis and treatment” method. Hysteroscopic transcervical resection (TCR) was performed in 5 cases with APA-H and 11 with APA-L. Except for one patient who underwent transcervical endometrial resection, all patients underwent hysterectomy and salpingectomy or salpingo-oophorectomy. Data from a median follow-up of 42 months (ranging from 3 to 174 months) were available for these patients.Results: Pathological diagnoses were made according to the degree of abnormality of APA surface glands, resulting in APA-L in 36 cases and APA-H in 8 cases. Among these cases, 28 (25 APA-L and 3 APA-H) were treated conservatively. “Four-step diagnosis and treatment” method performed a excellent effect for APA therapy. During the follow-up no evidence of recurrence was found.Conclusions: For cases with intracavitary lesions > 1 cm, hysteroscopic “four-step diagnosis and treatment” and pathological diagnosis are the basis of clinical treatment. More than 30% of APA surface glands have complex structures, characterized by branching and budding, or other high-risk factors, such as endometrial hyperplasia, which are indications for hysterectomy. For patients with the desire to become pregnant or for uterine preservation, hysteroscopy with complete excision of the lesions should be the preferred treatment method. The patients should be treated individually, followed up closely, and followed up by regular hysteroscopy and endometrial biopsy.

Pro-COL11A1: A biomarker to predict malignant relapse of breast intraductal papillomas.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 540-540
Author(s):  
Javier Freire ◽  
Lucia Garcia-Berbel ◽  
Saioa Dominguez-Hormaetxe ◽  
Saray Pereda ◽  
Ana De Juan ◽  
...  
Keyword(s):  
Benign Lesion ◽  
Intraductal Papilloma ◽  
High Rate ◽  
Positive Staining ◽  
Complete Excision ◽  
Formalin Fixed Paraffin ◽  
Highly Sensitive ◽  
Formalin Fixed Paraffin Embedded ◽  
Formalin Fixed

540 Background: Breast cancer is currently the most frequent tumor among women. Despite the huge progress achieved in its early diagnosis, there are still many unsolved clinical issues, being the diagnosis, prognosis and treatment of papillary diseases (and specifically intraductal papilloma), one of the highest challenges. Because of its unpredictable clinical behavior, treatment of intraductal papilloma has generated a great controversy. Even though considered as a benign lesion, it presents high rate of malignant recurrence. This is the reason why there are clinicians supporting a complete excision of the papillary lesion, while others support an only expectant follow up. Previous results of our group have suggested that pro-Collagen 11 alpha 1 (pro-COL11A1) expression in cancer associated fibroblasts (CAFs) correlates with an infiltrating phenotype in breast lesions. We have analyzed the correlation between the differential expression of pro-COL11A1 in intraductal papilloma and their risk of malignant recurrence. Methods: Immunohistochemistry of pro-COL11A1 (clone 1E8.33, ONCOMATRIX, Bilbao, SPAIN) was performed in formalin fixed, paraffin embedded Core Needle Biopsy samples of 51 patients with intraductal papilloma. All patients had a minimum follow-up of 5 years. Results: Twenty-three out of 51 cases showed positive staining for COL11A1. Nine patients out of the positive cases relapsed as infiltrating carcinoma, two as intraductal papilloma and the rest had not recurred after five years of follow up. Only one case out of the 28 negative cases relapsed as invasive carcinoma. There were significant differences (p=0.0013) when comparing staining of individuals with malignant recurrence versus non recurrence and benign relapse patients, with a sensitivity of 90% and specificity of 66%. Conclusions: These data suggest that COL11A1 expression in CAFs is a highly sensitive biomarker to predict malignant relapse of intraductal papilloma. The low specificity might be biased by the complete excision of this lesion as the routine treatment or by a short follow-up of the patients.

scholarly journals Collagen Type XI Alpha 1 Expression in Intraductal Papillomas Predicts Malignant Recurrence

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Javier Freire ◽  
Lucia García-Berbel ◽  
Pilar García-Berbel ◽  
Saray Pereda ◽  
Ainara Azueta ◽  
...  
Keyword(s):  
Collagen Type ◽  
Benign Lesion ◽  
Intraductal Papilloma ◽  
High Rate ◽  
Positive Staining ◽  
Breast Lesions ◽  
Complete Excision ◽  
Clinical Behavior ◽  
Highly Sensitive

Despite the progress achieved in the treatment of breast cancer, there are still many unsolved clinical issues, being the diagnosis, prognosis, and treatment of papillary diseases, one of the highest challenges. Because of its unpredictable clinical behavior, treatment of intraductal papilloma has generated a great controversy. Even though considered as a benign lesion, it presents high rate of malignant recurrence. This is the reason why there are clinicians supporting a complete excision of the lesion, while others support an only expectant follow-up. Previous results of our group suggested that procollagen 11 alpha 1 (pro-COL11A1) expression correlates with infiltrating phenotype in breast lesions. We analyzed the correlation between expression of pro-COL11A1 in intraductal papilloma and their risk of malignant recurrence. Immunohistochemistry of pro-COL11A1 was performed in 62 samples of intraductal papilloma. Ten out 11 cases relapsed as carcinoma presents positive staining for COL11A1, while just 17 out of 51 cases with benign behaviour present immunostaining. There were significant differences (P<0.0001) when comparing patients with malignant recurrence versus nonmalignant relapse patients. These data suggest that pro-COL11A1 expression is a highly sensitive biomarker to predict malignant relapse of intraductal papilloma and it can be used as indicative factor for prevention programs.

Stent-assisted coil embolization followed by a stent-within-a-stent technique for ruptured dissecting aneurysms of the intracranial vertebrobasilar artery

2009 ◽  
Vol 111 (1) ◽  
pp. 48-52 ◽  
Author(s):  
Sang Hyun Suh ◽  
Byung Moon Kim ◽  
Sung Il Park ◽  
Dong Ik Kim ◽  
Yong Sam Shin ◽  
...  
Keyword(s):  
Coil Embolization ◽  
Therapeutic Option ◽  
Direct Consequence ◽  
Treatment Method ◽  
Dissecting Aneurysm ◽  
High Rate ◽  
Parent Artery ◽  
Vertebrobasilar Artery ◽  
Complete Obliteration

Object A ruptured dissecting aneurysm of the vertebrobasilar artery (VBA-DA) is a well-known cause of acute subarachnoid hemorrhage (SAH) with a high rate of early rebleeding. Internal trapping of the parent artery, including the dissected segment, is one of the most reliable techniques to prevent rebleeding. However, for a ruptured VBA-DA not suitable for internal trapping, the optimal treatment method has not been well established. The authors describe their experience in treating ruptured VBA-DAs not amenable to internal trapping of the parent artery with stent-assisted coil embolization (SAC) followed by a stent-within-a-stent (SWS) technique. Methods Eleven patients—6 men and 5 women with a mean age of 48 years and each with a ruptured VBA-DA not amenable to internal trapping of the parent artery—underwent an SAC-SWS between November 2005 and October 2007. The feasibility and clinical and angiographic outcomes of this combined procedure were retrospectively evaluated. Results The SAC-SWS was successful without any treatment-related complications in all 11 patients. Immediate posttreatment angiograms revealed complete obliteration of the DA sac in 3 patients, near-complete obliteration in 7, and partial obliteration in 1. One patient died as a direct consequence of the initial SAH. All 10 surviving patients had excellent clinical outcomes (Glasgow Outcome Scale Score 5) without posttreatment rebleeding during a follow-up period of 8–24 months (mean follow-up 15 months). Angiographic follow-up at 6–12 months after treatment was possible at least once in all surviving patients. Nine VBA-DAs showed complete obliteration; the other aneurysm, which had appeared partially obliterated immediately after treatment, demonstrated progressive obliteration on 2 consecutive follow-up angiography studies. There was no in-stent stenosis or occlusion of the branch or perforating vessels. Conclusions The SAC-SWS technique seems to be a feasible and effective reconstructive treatment option for a ruptured VBA-DA. The technique may be considered as an alternative therapeutic option in selected patients with ruptured VBA-DAs unsuitable for internal trapping of the parent artery.

scholarly journals Trichofolliculoma of the Nose: A Rare Disease

2013 ◽  
Vol 6 (3) ◽  
pp. 152-153
Author(s):  
AK Agarwal ◽  
JC Passey ◽  
Tripti Brar ◽  
Shilpi Dabas ◽  
Nikhil Arora
Keyword(s):  
Rare Disease ◽  
Rare Case ◽  
Clinical Presentation ◽  
Benign Lesion ◽  
Diagnosis And Treatment ◽  
Histopathological Diagnosis ◽  
Total Removal ◽  
Histopathological Findings ◽  
Plastic Reconstruction

ABSTRACT Purpose The author wants to present a rare case of trichofolliculoma of nose. Patients and methods Clinical presentation, radiology, histopathological findings and management of the case has been presented. Results Patient has been on regular follow-up and planned for plastic reconstruction. Conclusion Trichofolliculoma, a benign hamortomatous lesion that develops at any age, usually presenting as a skin-colored nodule, correct histopathological diagnosis and treatment therefore, can lead to total removal of the benign lesion. How to cite this article Brar T, Passey JC, Dabas S, Agarwal AK, Arora N. Trichofolliculoma of the Nose: A Rare Disease. Clin Rhinol An Int J 2013;6(3):152-153.

scholarly journals Pigmented epithelioid melanocytoma: A rare tumor

2021 ◽  
Vol 12 (e) ◽  
pp. 1-3
Author(s):  
Meryem Khalidi ◽  
Hasna Kerrouch ◽  
Mohammed El Amraoui ◽  
Naoufal Hjira ◽  
Mohammed Boui
Keyword(s):  
Skin Tumor ◽  
Diagnosis And Treatment ◽  
Left Cheek ◽  
Rare Tumor ◽  
Blue Nevus ◽  
Complete Excision ◽  
Nodular Melanoma ◽  
Sudden Appearance

Pigmented epithelioid melanocytoma is a poorly understood and rarely reported skin tumor which mimics melanoma and whose diagnosis is based on clinical, histological and immunohistochemical arguments. We report the case of a young 24-year-old patient who consulted for the sudden appearance of a plaque and then a black nodule on the left cheek, gradually increasing in size, painless and slightly infiltrated. Dermoscopy could not decide between a nodular melanoma or a blue nevus given the intensity of the pigmentation. Anatomopathological examination of the piece revealed a pigmented epithelioid melanocytoma or animal-type melanocytoma. The consequences of the complete excision were simple without recurrence after a follow-up of 9 months. It is a borderline affection, its diagnosis and treatment are necessary in order to avoid any unforeseeable malignant evolution.

Lipomas of the larynx and hypopharynx: a review of the literature with the addition of three new cases

1995 ◽  
Vol 109 (4) ◽  
pp. 353-357 ◽  
Author(s):  
Bruce M. Wenig
Keyword(s):  
Polypoid Lesion ◽  
Pyriform Sinus ◽  
Review Of The Literature ◽  
Complete Excision ◽  
The Third ◽  
Mesenchymal Neoplasms ◽  
One Year ◽  
Initial Resection ◽  
Supraglottic Larynx

AbstractLipomas of the larynx and hypopharynx are uncommon mesenchymal neoplasms. This report discusses the clinical and pathological features of three cases of laryngeal and hypopharyngeal lipomas. Two of the cases occurred in females and one in a male. The ages of the patients were 28, 51 and 51 years respectively. Two of the cases involved the supraglottic larynx (left arytenoid and left vestibular fold); the third involved the pyriform sinus. Symptoms included airway obstruction. dysphagia, throat discomfort, a sensation of excessive secretions in the throat and an increase in snoring. The complaints occurred over periods ranging from several months to one year in duration. Clinically, a polypoid lesion described as yellow in appearance was seen. Histologically. the tumours were composed of mature adipocytes without evidence of pleomorphism, lipoblasts or infiltrative growth. Surgery was the treatment of choice and included simple but complete excision in two of the cases. In these two cases, surgery proved curative with follow-up periods of 11 and seven years, respectively. In one case. the initial tumour was removed in pieces. This lesion recurred 15 years after the initial resection and was totally excised at that time. This patient has been free of tumour for more than five years.

Respiratory epithelial adenomatoid hamartoma in the nasopharynx

2005 ◽  
Vol 119 (6) ◽  
pp. 476-478 ◽  
Author(s):  
R M Metselaar ◽  
H V Stel ◽  
S van der Baan
Keyword(s):  
Case Report ◽  
Female Patient ◽  
Nasal Obstruction ◽  
Benign Lesion ◽  
Pathological Features ◽  
Complete Excision ◽  
Respiratory Epithelial Adenomatoid Hamartoma ◽  
Respiratory Epithelial ◽  
Clinical And Pathological Features

We present a case report of a female patient with complaints of single-sided nasal obstruction. A polypoid structure was seen in the nasopharynx. Histologic examination showed a respiratory epithelial adenomatoid hamartoma – a rare, benign lesion. Therapy consisted of complete excision. In line with previous reports, the lesion did not recur during 13 months of follow up. The clinical and pathological features of this abnormality are discussed.

scholarly journals Outcomes of Naviculectomy for Severe Recurrent Clubfoot Deformity

2021 ◽  
Vol 6 (2) ◽  
pp. 247301142110081
Author(s):  
David E. Westberry ◽  
Ashley M. Carpenter ◽  
Katherine Brown ◽  
Samuel B. Hilton
Keyword(s):  
Case Series ◽  
High Rate ◽  
Salvage Procedure ◽  
Level Of Evidence ◽  
Complete Excision ◽  
Congenital Vertical Talus ◽  
Operative Outcomes ◽  
Current Series ◽  
Talipes Equinovarus

Background: Naviculectomy was originally described for resistant congenital vertical talus deformity but was later expanded to use in rigid cavus deformity. This study reviews the operative outcomes of complete excision of the navicular for recurrent deformity in the talipes equinovarus (TEV) population. Methods: After institutional review board approval, all patients undergoing naviculectomy at a single institution were identified. Clinical, radiographic, and pedobarographic data (minimum 2 years’ follow-up) were reviewed. Results: Twelve patients (14 feet) with TEV from 1984 to 2019 were included. All feet had minimum 1 prior operative intervention on the affected foot (mean age = 4.0 years, range 0.2-14.5), with 8/14 having at least 3 prior operative procedures. Complete navicular excision with concomitant procedures was performed in all patients (mean age = 11.7 years, range 5.5-16.1). Mean clinical follow-up from naviculectomy was 5.1 years (range, 2.2-11.2). During follow-up, 6 patients required subsequent surgery, most often secondary to pain and progressive deformity. One patient underwent elective below-knee amputation of the affected extremity. Of the remaining 11 patients, 7 of 11 reported continued pain and 8 of 11 maintained adequate range of motion at the ankle at the most recent follow-up. Conclusion: Clinical follow-up demonstrated deteriorating results in a large percentage of patients. The high rate of additional procedures and continued pain in the current series suggests that even as a salvage procedure, naviculectomy may not provide adequate results for patients. Level of Evidence: Level IV, case series.

scholarly journals Adrenal cavernous hemangioma misdiagnosed as pheochromocytoma: a case report

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ting Huang ◽  
Qing Yang ◽  
Yang Hu ◽  
Hai-Xiao Wu
Keyword(s):  
Computed Tomography ◽  
Adrenal Gland ◽  
Cavernous Hemangioma ◽  
Treatment Method ◽  
High Rate ◽  
Adrenal Tumors ◽  
Computed Tomography Urography ◽  
Benign Adrenal Tumor ◽  
The Right

Abstract Background Adrenal hemangioma is a rare benign adrenal tumor that is usually misdiagnosed preoperatively. We here present a case of adrenal cavernous hemangioma that was successfully treated with retroperitoneal laparoscopic adrenalectomy. Case presentation A 67-year-old man with dull right back pain attended our clinic for examination of a mass on the right adrenal gland for 1 week. Pheochromocytoma was considered according to the preoperative computed tomography angiography + computed tomography urography findings and was subsequently corrected to adrenal gland hemangioma according to postoperative pathological findings. The patient showed no recurrence of adrenal hemangioma during the 1-year follow-up period after surgery. Conclusion Adrenal gland hemangioma is rare with a high rate of misdiagnosis, and it should be considered in imaging findings of adrenal tumors with typical hemangioma. Surgery is an effective treatment method.

DIGITAL FIBROMYXOMA: A CASE REPORT

2021 ◽  
pp. 2172001
Author(s):  
Mahmood Ajawi ◽  
Irfan Abdulkareem ◽  
Abdullah H. Darwish ◽  
Iftikhar A. Mukhtar ◽  
Noora Iftikhar
Keyword(s):  
Case Report ◽  
Tissue Sample ◽  
Ring Finger ◽  
High Rate ◽  
Excision Biopsy ◽  
Histopathological Analysis ◽  
Complete Excision ◽  
The Right ◽  
Hands And Feet

Digital fibromyxoma is a rare soft tissue tumor with a propensity to grow in the digits of the hands and feet. While mostly asymptomatic, the tumors can grow and cause discomfort and eventually pain. It is a benign tumor, with treatment revolving around complete excision to prevent recurrence. In this case report, we discuss the case of a 11-year old boy presented with a swelling in the right ring finger that had been increasing in size for over a year. Despite the lack of pain or limitation of movement in the finger, the swelling caused concern to the patient and family due to cosmetic appearance. An excision biopsy with histopathological analysis of the tissue sample suggested the diagnosis of digital fibromyxoma. The high rate of recurrence is due to incomplete excision, and therefore regular follow up is recommended to monitor for recurrence.

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