scholarly journals A Head-to-head Comparison of the EQ-5D-3L Index Scores Derived from the Two EQ-5D-3L Value Sets for China

2022 ◽  
Author(s):  
Ruo-Yu Zhang ◽  
Wei Wang ◽  
Hui-Jun Zhou ◽  
Jianwei Xuan ◽  
Nan Luo ◽  
...  
Keyword(s):  
Index Score ◽  
Altman Plot ◽  
Health States ◽  
Minimum Important Difference ◽  
Absolute Level ◽  
Bland Altman Plot ◽  
Health Gains ◽  
The Mean ◽  
Two Indices ◽  
Value Sets

Abstract Background: Two EQ-5D-3L (3L) value sets (developed in 2014 and 2018) co-exist in China. The study examined the level of agreement between index scores for all the 243 health states derived from them at both absolute and relative levels and compared the responsiveness of the two indices. Methods: Intraclass correlations coefficient (ICC) and Bland-Altman plot were adopted to assess the degree of agreement between the two indices at the absolute level. Health gains for 29,403 possible transitions between pairs of 3L health states were calculated to assess the agreement at the relative level. Their responsiveness for the transitions was assessed using Cohen effect size.Results：The mean (standard deviation, SD) value was 0.427 (0.206) and 0.649 (0.189) for the 3L2014 and 3L2018 index scores, respectively. Although the ICC value showed good agreement (i.e., 0.896), 88.9% (216/243) of the points were beyond the minimum important difference limit according to the Bland-Altman plot. The mean health gains for the 29,403 health transitions was 0.234 (3L2014 index score) and 0.216 (3L2018 index score). The two indices predicted consistent transitions in 23,720 (80.7%) of 29,403 pairs. For the consistent pairs, Cohen effective size value was 1.05 (3L2014 index score) or 1.06 (3L2018 index score); and the 3L2014 index score only yielded 0.007 more utility gains. However, the results based on the two measures varied substantially according to the direction and magnitude of health change. Conclusion：The 3L2014 and 3L2018 index scores are not interchangeable. The choice between them is likely to influence QALYs estimations.

Effect of manual eyelid manipulation on intraocular pressure measurement by rebound tonometry

2018 ◽  
Vol 102 (11) ◽  
pp. 1515-1519 ◽  
Author(s):  
Sung Uk Baek ◽  
Ahnul Ha ◽  
Young Kook Kim ◽  
Jin Wook Jeoung ◽  
Ki Ho Park
Keyword(s):  
Intraocular Pressure ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Mean Value ◽  
Applanation Tonometry ◽  
Palpebral Fissure ◽  
Altman Plot ◽  
Bland Altman Plot ◽  
Rebound Tonometry ◽  
The Mean

Background/aimsTo investigate the effect of eyelid manipulation on the measurement of intraocular pressure (IOP) using two different tonometries (rebound tonometry (RT) vs Goldmann applanation tonometry (GAT)).Methods103 patients with primary open-angle glaucoma were prospectively enrolled. For all of the patients, IOP measurements were performed in three different ways: (1) RT with lid manipulation (LM), (2) RT without LM and (3) GAT. The order of the three measurements was randomly selected. Additionally, the palpebral fissure height (PFH; elliptical space between upper and lower eyelids) was measured.ResultsThe mean value of IOP measured by GAT was 13.97±2.80 mm Hg, which was not significantly different from that by RT without LM (13.75±2.44 mm Hg; P=0.096), but which was significantly lower than that by RT with LM (15.21±2.91 mm Hg; P<0.001). On a Bland-Altman plot, RT with LM was overestimated relative to GAT (mean: −1.5) and RT without LM (mean: −1.2). Among the high IOPs (>20 mm Hg), interestingly, those measured by RT without LM were significantly lower than those measured by GAT (P<0.001). In the subgroup analysis of PFH, the smaller the PFH, the more exaggerated the IOP difference between GAT (P=0.014) and RT with LM (P<0.001).ConclusionRT-measured IOP was significantly exaggerated when manipulation was applied to the eyelid. This overall trend was more pronounced when PFH was small. GAT-measured IOP, meanwhile, showed a good correlation with IOP measured using RT without LM.

Reliability of Shoulder Symptom Recall after 1 Year in a Retrospective Application of the Oxford Shoulder Score

2012 ◽  
Vol 4 (4) ◽  
pp. 255-258
Author(s):  
Michael Held ◽  
Steve Roche ◽  
Basil Vrettos ◽  
Maritz Laubscher ◽  
Johan Walters
Keyword(s):  
Shoulder Function ◽  
Test Pair ◽  
Altman Plot ◽  
Bland Altman Plot ◽  
Individual Level ◽  
Oxford Shoulder Score ◽  
The Mean ◽  
One Year ◽  
The Individual ◽  
Shoulder Score

Background The accuracy of retrospective recall of shoulder symptoms has not been well documented. This prospective study assesses the ability of patients to recall their preoperative shoulder function one year after a surgical intervention, using the Oxford Shoulder Score (OSS). Methods 35 patients completed an OSS before undergoing shoulder surgery. One year later, patients were asked to recall their symptoms prior to their surgery. The recalled OSS of the patients as a group was compared to their preoperative score. The recall bias of each test pair was assessed with a Bland – Altman plot. Results On recall after a mean of 12.6 months, the mean OSS from the index assessment increased from 36.25 to 38.25 points. The mean difference of 2 points for the patients as a group was not significant (p = 0.14). The statistical limits of agreement of the Bland – Altman plot were set at +/-2 SD = 14.079 points. The plotted points showed fair correlation between each individual test pair. Conclusion The recall of symptoms of a large group of patients at 1 year after the index intervention appears to have a moderate correlation with the preoperative scoring. Although statistically acceptable, this limit of agreement is much larger than the 4.5-point difference, established to be clinically relevant in prior studies. The variation seen within the scores at the individual level suggests that these data cannot be used as a retrospective tool.

scholarly journals Original article. Repeatability assessment of the New Numbers Contrast Sensitivity Chart

2014 ◽  
Vol 8 (3) ◽  
pp. 361-369
Author(s):  
Bharkbhum Khambhiphant ◽  
Sunee Chansangpetch ◽  
Wasee Tulvatana ◽  
Mathu Busayarat
Keyword(s):  
Contrast Sensitivity ◽  
Narrow Range ◽  
Primary Language ◽  
Altman Plot ◽  
Bland Altman Plot ◽  
Plot Analysis ◽  
Good Repeatability ◽  
The Mean ◽  
Mean Differences ◽  
The Right

Abstract Background: The validity and agreement of the New Numbers Contrast Sensitivity Chart with the original Mars chart have been found to be good. The two charts can be used interchangeably; however, evidence of the repeatability of the new chart remains to be sought. This study was to assess the repeatability of the New Numbers Contrast Sensitivity Chart. Objectives: We assessed the repeatability of the Numbers Contrast Sensitivity Chart. Methods: Two hundred subjects from the ophthalmic clinic of the King Chulalongkorn Memorial Hospital, who were able to communicate and read Arabic numerals were recruited. The contrast sensitivity (CS) scores were collected by reading the same Numbers Contrast Sensitivity Chart in the same environment with each eye and both eyes ten minutes apart. The repeatability of the CS score was assessed by Bland-Altman plot analysis. Results: The visual acuity of subjects with variety in diagnoses ranged from 20/480 to 20/20. The mean differences were -0.006, -0.008, -0.002 log CS and the coefficients of repeatability were 0.155, 0.141, and 0.093 for the right eye, left eye, and both eyes, respectively. The plots showed a narrow range of 95% limit of agreement, which were (+0.146, -0.159) in the right eye, (+0.130, -0.147) in the left eye, and (+0.089, -0.093) in both eyes. Conclusions: The New Numbers Contrast Sensitivity Chart has good repeatability. With proven good validity and repeatability, this easy and convenient numbers chart is beneficial for practical use in a clinical setting where English is not used as the primary language.

scholarly journals Comparison of the EQ-5D-5L and the EQ-5D-3L using individual patient data from the REFORM trial

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 974
Author(s):  
Belen Corbacho ◽  
Ada Keding ◽  
Ling-Hsiang Chuang ◽  
Juan Manuel Ramos-Goni ◽  
Kalpita Joshi ◽  
...  
Keyword(s):  
Convergent Validity ◽  
Missing Values ◽  
Individual Patient Data ◽  
Patient Data ◽  
Ceiling Effect ◽  
Mean Difference ◽  
Discriminatory Power ◽  
Health States ◽  
The Mean ◽  
Value Sets

Background: This study compares the 5-level version of the EQ-5D (5L) with the 3-level version EQ-5D (3L) in older adults using individual patient data from the REFORM (REducing Falls with Orthoses and a Multifaceted podiatry intervention) trial. Methods: EQ-5D-5L and EQ-5D-3L were administered to men and women (n=151) over the age of 65 years alongside the REFORM trial. The two versions of the EQ-5D were assessed in terms of feasibility, level of consistency, ceiling effect and discriminatory power. We also undertook a comparison of the performance of different EQ-5D-3L and EQ-5D-5L value sets. Results: The proportion of participants that returned a complete questionnaire was higher for the 5L (96.7%) than for the 3L (92.7%). Missing values among dimensions were on average 1.59% (5L) and 1.45% (3L). The ceiling effect was reduced from 18.2% (3L) to 6% (5L). On average the proportion of inconsistent responses between both descriptive systems was 3.25%. Redistribution from 3L to 5L showed valid results for the majority of consistent level combinations, with slight inconsistency in the case of Anxiety/Depression. For the 5L, 67 unique health states were observed for the 5L compared to 27 for the 3L. The absolute informatively improved with the new classification system (5.48 for 5L versus 3.91 for 3L) and relative discriminatory power improved slightly on average (0.90 for 5L versus 0.84 for 3L). The mean difference between the EQ-5D-5L and EQ-5D-3L values was 0.091 (range -0.345 to 0.505); whilst the mean difference between the EQ-5D-5L and the crosswalk values was 0.082 (range -0.035 to 0.293). Conclusion: In the REFORM clinical trial involving an elderly population, our study supported the feasibility and convergent validity of both EQ-5D-3L and EQ-5D-5L. Results suggest that the 5L improves the ceiling effect and discriminatory power. The EQ-5D-5L scores were significantly higher than both EQ-5D-3L and crosswalk.

Cervical length at 31–34 weeks of gestation: transvaginal vs. transperineal ultrasonographic approach

2019 ◽  
Vol 47 (8) ◽  
pp. 817-821 ◽  
Author(s):  
Ioannis Tsakiridis ◽  
Themistoklis Dagklis ◽  
Apostolos Mamopoulos ◽  
Angeliki Gerede ◽  
Apostolos Athanasiadis
Keyword(s):  
Correlation Coefficient ◽  
Pearson Correlation ◽  
Close Correlation ◽  
Cervical Length ◽  
Tolerance Interval ◽  
Pearson Correlation Coefficient ◽  
Altman Plot ◽  
Bland Altman Plot ◽  
Paired Samples ◽  
The Mean

Abstract Objectives To investigate the correlation between transperineal (TP) and transvaginal (TV) ultrasonography in the measurement of cervical length (CL) in the third trimester of pregnancy. Methods In this prospective study, CL measurements were conducted in women between 31 and 34 weeks of gestation by both the TP and TV approaches. A comparison of the measurements was made between the two techniques. The Pearson correlation coefficient, the paired samples t-test and Bland-Altman plot were used. Results In total, 240 women participated in the study. The CL was successfully measured transvaginally in all cases and transperineally in 229 (95.4%) of the cases. The mean TV CL was 32.8 ± 8.2 mm and the mean TP CL was 32.5 ± 8.1 mm. In the 229 cases with paired measurements, the Pearson correlation coefficient was 0.964. No significant differences in mean CL were identified between the two methods (t = 1.805; P = 0.072). In the Bland-Altman plot, the difference between the paired means was 0.26 mm and the 95% tolerance interval for any given paired observation (TV CL–TP CL) was −4.05 to 4.57 mm. Conclusion The findings of this study suggest that at 31–34 weeks of gestation the cervix can be visualized adequately by both the TV and TP sonography in about 95% of cases. The TP CL measurements demonstrate a close correlation with the TV measurements. TP ultrasound is a feasible alternative, especially in cases where the use of the vaginal transducer should be minimized or is not acceptable by women.

Level of agreement between sPRO and Kubios software in the analysis of R-R intervals obtained by a chest strap

2021 ◽  
pp. 175433712110311
Author(s):  
José Pino-Ortega ◽  
Markel Rico-González ◽  
Petrus Gantois ◽  
Fabio Y Nakamura
Keyword(s):  
Time Domain ◽  
Time Course ◽  
Intraclass Correlation ◽  
Systematic Bias ◽  
Altman Plot ◽  
Bland Altman Plot ◽  
Software Packages ◽  
The Mean ◽  
Improved Performance ◽  
Level Of Agreement

Heart rate variability (HRV) is becoming one of the most commonly used tools for tracking the time course of training adaptation/maladaptation of athletes and setting optimal training loads, leading to improved performance. The aim of this study was to compare Realtrack Systems manufacturer software (sPRO) with the Kubios HRV Standard. R-R intervals were recorded from 48 athletes using a chest strap synchronized to WIMU PRO™ device for 10 min to analyze time-domain HRV indices, located between the scapulae. Time-domain HRV indices analyzed included the square root of the mean squared differences of successive R-R intervals (RMSSD), standard deviation of normal R-R intervals (SDNN), and percentage of adjacent R-R intervals that differ from each other by more than 50 ms (pNN50). The intraclass correlation test and Bland-Altman plot were used to verify the agreement between the sPRO and the Kubios HRV Standard software for examining time-domain HRV indices. The intraclass correlation coefficient showed high values of agreement of R-R intervals and time-domain HRV indices between the two software options (RMSSD, SDNN, and pNN50; ICC > 0.951). The Bland-Altman plot showed low bias for all the HRV indices analyzed (bias = −0.11 to −1.08). In addition, no systematic bias was found between the residual of the mean difference and the average values of the two software packages ( p > 0.05). Therefore, both software options can be used interchangeably for analyzing time-domain HRV records.

scholarly journals Validity assessment of a portable anthropometer to measure length in 24-month children from the 2015 Pelotas Birth Cohort

2020 ◽  
Vol 23 (15) ◽  
pp. 2711-2716
Author(s):  
Thaynã R Flores ◽  
Andréa D Bertoldi ◽  
Luiza IC Ricardo ◽  
Cauane Blumenberg ◽  
Laísa R Moreira ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Cohort ◽  
Gold Standard ◽  
Mean Difference ◽  
Birth Cohort Study ◽  
Altman Plot ◽  
Bland Altman Plot ◽  
Validity Assessment ◽  
The Mean

AbstractObjective:This study aimed to assess the validity of a portable anthropometer against the gold standard among 2-year-old infants from the 2015 Pelotas (Brazil) Birth Cohort.Design:Birth cohort study.Setting:A fixed Harpenden® infant anthropometer was considered as the gold standard for measuring infant length due to its greater precision and stability. The portable SANNY® (model ES2000) anthropometer was the instrument to be validated. The acceptable mean difference in length between the anthropometers was 0·5 cm. In order to compare length estimates, the interviewers carried out two length measures for each of the anthropometers (fixed and portable) and for each child. The mean of the two lengths was calculated for each anthropometer, and their difference was calculated.Participants:A subsample of 252 24-month-old members of the 2015 Pelotas (Brazil) birth cohort study.Results:Children’s mean age was 23·5 months. According to Bland–Altman plot, there were no differences in overall lengths between the portable and the fixed anthropometers, or in lengths according to sex. There was a high overall concordance between the length estimates of the fixed and portable anthropometers (ρ = 0·94; 95 % CI 0·92, 0·95).Conclusions:The portable anthropometer proved to be accurate to measure the length of 24-month-old infants, being applicable to studies using the same standardised protocol used in the present study.

Validity and repeatability of goniometry in normal horses

2016 ◽  
Vol 29 (04) ◽  
pp. 314-319 ◽  
Author(s):  
Henry Adair ◽  
David Levine ◽  
Denis Marcellin-Little
Keyword(s):  
Range Of Motion ◽  
Correlation Coefficients ◽  
Mean Difference ◽  
Altman Plot ◽  
Intra Class Correlation ◽  
Bland Altman Plot ◽  
Radiographic Measurements ◽  
The Mean ◽  
Metatarsophalangeal Joints ◽  
Flexion And Extension

SummaryPurpose: To assess validity and inter- and intra-tester reliability of equine goniometry and to establish values for carpal, meta -carpophalangeal, tarsal, and metatarsophalangeal flexion and extension in horses.Subjects: Seventeen healthy equine subjects of varied breeds were used.Methods: Three investigators blindly and independently measured in triplicate the extension and flexion of carpal, metacarpo -phalangeal, tarsal, and metatarsophalangeal joints of 17 horses after sedation. Radiographs of these joints in flexion and extension were acquired while under sedation. Goniometric and radiographic measurements were compared statistically and were correlated. A Bland-Altman plot was constructed. Inter- and intra-tester repeatability of goniometry were evaluated by calculating intra-class correlation coefficients (ICC). Mean flexion and extension of carpal, metacarpo -phalangeal, tarsal, and metatarsophalangeal joints were calculated.Results: Goniometric and radiographic measurements did not differ statistically and were significantly correlated (correlation coefficients ranged from 0.59 - 0.89). The mean difference between goniometric and radiographic measurements was 0.4°. Triplicate measurements collected by the three raters did not differ significantly within raters (ICC ranging from 0.950 - 0.995) and between raters (ICC ranging from 0.942 - 0.989).Conclusion: Goniometry is a valid and repeatable tool for evaluation of the range of motion of carpal, metacarpophalangeal, tarsal, and metatarsophalangeal joints in standing, sedated healthy horses.

Comparison of Tumor Volume Between PET and MRI in Cervical Cancer With Hybrid PET/MR

2014 ◽  
Vol 24 (4) ◽  
pp. 744-750 ◽  
Author(s):  
Shaomin Zhang ◽  
Jun Xin ◽  
Qiyong Guo ◽  
Jietao Ma ◽  
Quanmei Ma ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cervical Cancer ◽  
Magnetic Resonance ◽  
Tumor Volume ◽  
Standardized Uptake Value ◽  
Resonance Imaging ◽  
Altman Plot ◽  
Bland Altman Plot ◽  
Positron Emission ◽  
The Mean

ObjectiveThis study aimed to compare the tumor volume between magnetic resonance imaging–defined gross tumor volume (MR-GTV) and positron emission tomography–defined GTV (PET-GTV) in cervical cancer with hybrid PET/MR.Materials and MethodsTwenty-seven patients with cervical cancer underwent PET/MR pelvic examination before radiotherapy. The MR-GTV was manually outlined on T2-weighted MR images. The PET-GTV was autocontoured on PET images using a 40% maximum standardized uptake value threshold. Results were analyzed by Pearson analysis, Bland-Altman plot, and 1-way analysis of variance.ResultsMagnetic resonance imaging–GTV significantly correlated with PET-GTV (r2 = 0.797, P < 0.001). The Bland-Altman plot showed a bad agreement between MR-GTV and PET-GTV. The PET-GTV underestimated the MR-GTV in 23 of 27 tumors. Patients were divided into the following 3 groups according to MR-GTV: less than 14 mL (n = 6), 14 to 62 mL (n = 12), and 62 mL or more (n = 9). The mean (SD) MR-GTV, PET-GTV, ratio, and overlap between MR-GTV and PET-GTV for the less than 14 mL cohort were 9.6 (2.6) mL, 16.7 (10.1) mL, 0.77 (0.40), and 0.47 (0.20), respectively. The PET-GTV overestimated MR-GTV in 4 of the 6 lesions by a mean (SD) of 11.1 (9.4) mL. Among the 14 to 62 mL cohort, the mean (SD) MR-GTV, PET-GTV, ratio, and overlap were 38.6 (14.5) mL, 24.9 (8.6 mL), 1.54 (0.25), and 0.87 (0.08), respectively. The PET-GTV underestimated MR-GTV for 12 tumors by a mean (SD) of 13.7 (8.4) mL. In the 62 mL or more cohort, the mean (SD) MR-GTV, PET-GTV, ratio, and overlap were 85.9 (25.8) mL, 54.3 (14.1) mL, 1.61 (0.35), and 0.87 (0.09), respectively. The PET-GTV underestimated MR-GTV 9 tumors by a mean (SD) of 31.6 (19.5) mL. The ratio and overlap differences were statistically significant among groups (F = 14.619, P < 0.001; F = 25.134, P < 0.001).ConclusionsTumor volume discrepancies were observed between MR-GTV and PET-GTV for cervical cancer. With an increasing tumor volume, there was an increase in the difference between MR-GTV and PET-GTV. In addition, larger tumors had a higher degree of overlap compared with small tumors.

Estimating Utility Values for Health States of DFU Patients Using EQ-5D-5L and cTTO

2021 ◽  
pp. 153473462110143
Author(s):  
Morteza Arab-Zozani ◽  
Hossein Safari ◽  
Zoha Dori ◽  
Somayeh Afshari ◽  
Hosein Ameri ◽  
...  
Keyword(s):  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Economic Modeling ◽  
Health State ◽  
Health States ◽  
Utility Values ◽  
The Mean ◽  
The Difference ◽  
Diabetes Center ◽  
Health State Utility Values

Health-state utility values of diabetic foot ulcer (DFU) patients are necessary for clinical praxis and economic modeling. The purpose of this study was to estimate utility values in DFU patients using the EuroQol-5-dimension-5-level (EQ-5D-5L) and composite time trade-off (cTTO). The EQ-5D-5L and cTTO were used for estimating utility values. Data were collected from 228 patients referred to the largest governmental diabetes center in the South of Iran, Yazd province. When appropriate, independent sample t-test or analysis of variance test was used to test the difference in the utility values in each of the demographic and clinical characteristics of the patients. Finally, the BetaMix was used to identify predictors of the utility values. The means of EQ-5D-5L and cTTO values were 0.55( SD 0.21) and 0.67( SD 0.23), respectively. Anxiety and pain were the most common problems reported by the patients. The difference between the mean EQ-5D-5L values was significant for age, grade of ulcer, number of comorbidities, and having complications. In addition, variables of gender, age, grade of ulcer, and having complications were significant predictors of the EQ-5D-5L. The difference between the mean cTTO values was significant for age, employment status, grade of ulcer, number of comorbidities, and having complications. Moreover, variables of gender, age, grade of ulcer, number of comorbidities, and developing complications were significant predictors of cTTO. The current study provided estimates of utility values for DFU patients for clinical praxis and economic modeling. These estimates, similar to utilities reported in other studies, were low. Identifying strategies to decrease anxiety/depression and pain in patients is important to improve the utility values.

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