scholarly journals Adverse effects of nicotine on endometrium receptivity markers: and protective effect of caffeic acid phenyl ester

2020 ◽  
Keyword(s):  
Adverse Effects ◽  
Protective Effect ◽  
Caffeic Acid ◽  
Phenyl Ester ◽  
Endometrium Receptivity

Abstract The authors have requested that this preprint be withdrawn due to erroneous posting.

scholarly journals Adverse effects of nicotine on endometrium receptivity markers: and protective effect of caffeic acid phenyl ester

2020 ◽  
Author(s):  
AMIN NAMDARI ◽  
FARIDEH MOHAMMADIAN ◽  
Fatemeh KHAJEH ◽  
SOUDABEH KAVOUSIPOUR ◽  
behnoosh miladpour
Keyword(s):  
Protective Effect ◽  
Caffeic Acid ◽  
Stromal Cells ◽  
Reproductive System ◽  
Quantitative Polymerase Chain Reaction ◽  
Protective Effects ◽  
Uterine Receptivity ◽  
Endometrial Stromal Cells ◽  
Genes Expression ◽  
Endometrium Receptivity

Abstract Background nicotine adversely affects the female reproductive system and changes the methylation pattern of some genes in the placenta. In contrast, caffeic acid phenylethyl ester) CAPE (, as a potent antioxidant, has protective effects against the harmful effects of oxygen free radical molecules, methotrexate, and pesticides on the reproductive system. To find the effect of nicotine on the endometrium, we investigated three markers of endometrium receptivity including fibroblast growth factor 2, vascular endothelial growth factors A, and C-X-C motif chemokine ligand 12 and also changes in methylation levels of CXCL-12 gene promoter. In addition, we evaluated the protective effect of CAPE against nicotine. Methods the appropriate treatment dose was selected based on the literature, the endometrial stromal cells were divided into 4 groups, including control, treated with nicotine, CAPE, and nicotine followed by CAPE. Finally, the quantitative polymerase chain reaction and Methylation-Specific PCR were carried out. Results The results showed that treatment of endometrial stromal cells with nicotine (10− 6 µM) for 24 h significantly reduced expression of CXCL-12, FGF, and VEGFA genes. However, a decrease in CXCL-12 expression was not associated with increased methylation levels in the studied promoter region. In contrast, endometrial stromal cells treated with CAPE (4 µg/ml) for 24 h adverse significantly nicotine-induced reduction of CXCL-12, FGF, and VEGFA genes expression. Conclusion Exposure to nicotine has negative effects on uterine receptivity, implantation, and fertility, via reducing the expression of VEGFA, CXCL-12, and FGF2 genes. In contrast, CAPE has a protective effects and improves these genes expression.

scholarly journals The protective effect of Capheic acid phenyl ester on hepatic ischemia-reperfusion injury in cholestatic rats

2018 ◽  
Author(s):  
Arif Aslaner ◽  
Tugrul Cakir
Keyword(s):  
Protective Effect ◽  
Reperfusion Injury ◽  
Caffeic Acid ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Intraperitoneal Administration ◽  
Albino Rats ◽  
Myeloperoxidase Activity ◽  
Phenyl Ester ◽  
Hepatic Ischemia

PURPOSE: Caffeic acid phenyl ester (CAPE), which is an active component of propolis, has antioxidant, antiproliferative, immunomodulatory and anti-inflammatory properties and has been used for many years. The protective effect against ischemic reperfusion injury in the cholestatic liver is unknown and it is aimed to determine its effect in this study. MATERIALS AND METHODS: Three groups of 18 Wistar albino rats were divided into cholestasis, control and study groups with bile duct attachment. Intraperitoneal administration of caffeic acid phenyl ester at the dose of 30 mg/kg/ day started 15 days ago and continued until the second operation in the study group. On the seventh day, hepatic ischemia was performed for 30 minutes followed by reperfusion for 60 minutes. Serum, plasma and liver samples were taken. Laboratory analysis, tissue glutathione, malondialdehyde, and myeloperoxidase levels were evaluated. RESULTS: Significant reduction in the level of liver glutathione and a marked increase in malondialdehyde level and myeloperoxidase activity were observed in the cholestatic I / R group. After treatment, all parameters except serum bilirubin levels were reversed. CONCLUSIONS: Intraperitoneal administration of CAPE may improve liver function and may reduce inflammation and oxidative stress in cholestatic I / R injury.

scholarly journals Caffeic Acid - Potential Antioxidant in Cultured Human Retinal Pigment Epithelial Cells

1970 ◽  
Vol 66 (2) ◽  
Author(s):  
Dumitriţa RUGINǍ ◽  
Adela PINTEA ◽  
Raluca PÂRLOG ◽  
Andreea VARGA
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Protective Effect ◽  
Caffeic Acid ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Antioxidant Defence ◽  
Rpe Cells ◽  
In Cells

Oxidative stress causes biological changes responsible for carcinogenesis and aging in human cells. The retinal pigmented epithelium is continuously exposed to oxidative stress. Therefore reactive oxygen species (ROS) and products of lipid peroxidation accumulate in RPE. Neutralization of ROS occurs in retina by the action of antioxidant defence systems. In the present study, the protective effect of caffeic acid (3,4-dihydroxy cinnamic acid), a dietary phenolic compound, has been examined in normal and in oxidative stress conditions (500 µM peroxide oxygen) in cultures human epithelial pigment retinal cells (Nowak, M. et al.). The cell viability, the antioxidant enzymes activity (CAT, GPx, SOD) and the level of intracellular reactive oxygen species (ROS) were determined. Exposure to l00 µM caffeic acid for 24 h induced cellular changes indicating the protective effect of caffeic acid in RPE cells. Caffeic acid did not show any cytotoxic effect at concentrations lower than 200 μM in culture medium. Treatment of RPE cells with caffeic acid causes an increase of catalase, glutathione peroxidase and superoxide dismutase activity, especially in cells treated with hydrogen peroxide. Caffeic acid causes a decrease of ROS level in cells treated with hydrogen peroxide. This study proved that caffeic acid or food that contain high levels of this phenolic acid may have beneficial effects in prevention of retinal diseases associated with oxidative stress by improving antioxidant defence systems.

scholarly journals Synthesis of caffeic acid sulfonamide derivatives and their protective effect against H2O2 induced oxidative damage in A549 cells

RSC Advances ◽  
2020 ◽  
Vol 10 (17) ◽  
pp. 9924-9933 ◽  
Author(s):  
Xiaoyu Peng ◽  
Tingjun Hu ◽  
Yuxue Zhang ◽  
Anran Zhao ◽  
Bharathi Natarajan ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Protective Effect ◽  
Caffeic Acid ◽  
A549 Cells ◽  
Oxidative Injury ◽  
Caffeic Acid Derivatives ◽  
Nrf2 Pathway

Synthesized caffeic acid derivatives exhibit protective effect on H2O2 induced oxidative injury in A549 cells via Nrf2 pathway.

scholarly journals Caffeic Acid Phenethyl Ester as a Protective Agent against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review

2014 ◽  
Vol 2014 ◽  
pp. 1-16 ◽  
Author(s):  
Sumeyya Akyol ◽  
Veli Ugurcu ◽  
Aynur Altuntas ◽  
Rukiye Hasgul ◽  
Ozlem Cakmak ◽  
...  
Keyword(s):  
Systematic Review ◽  
Protective Effect ◽  
Caffeic Acid ◽  
Renal Injury ◽  
Active Component ◽  
Current Knowledge ◽  
Ischemia Reperfusion ◽  
Oxidative Injury ◽  
Caffeic Acid Phenethyl Ester ◽  
Protective Agent

Caffeic acid phenethyl ester (CAPE), an active component of propolis, has been attracting the attention of different medical and pharmaceutical disciplines in recent years because of its antioxidant, anti-inflammatory, antiproliferative, cytotoxic, antiviral, antifungal, and antineoplastic properties. One of the most studied organs for the effects of CAPE is the kidney, particularly in the capacity of this ester to decrease the nephrotoxicity induced by several drugs and the oxidative injury after ischemia/reperfusion (I/R). In this review, we summarized and critically evaluated the current knowledge regarding the protective effect of CAPE in nephrotoxicity induced by several special medicines such as cisplatin, doxorubicin, cyclosporine, gentamycin, methotrexate, and other causes leading to oxidative renal injury, namely, I/R models and senility.

LC with Electrochemical Detection for Analysis of Caffeic Acid and Caffeic Acid Phenyl Ester in Propolis

2011 ◽  
Vol 73 (3-4) ◽  
pp. 411-414 ◽  
Author(s):  
Wei Cao ◽  
Hai-Feng Liu ◽  
Ni Cheng ◽  
Hui Gao ◽  
Bi-Ni Wang ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Electrochemical Detection ◽  
Phenyl Ester
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