scholarly journals Central Corneal Thickness in an Adult Non-Glaucomatous Ethnic Population in Nigeria

Author(s):  
Nkechinyere Judith Uche ◽  
Nkiru Kizor karaiwe ◽  
Suhanya Okeke ◽  
Jude Shiweobi

Abstract Purpose: To determine the mean central corneal thickness (CCT) of healthy adult Nigerians from the Igbo ethnic population in southeastern Nigeria which has the highest prevalence of glaucoma and to evaluate the relationship if any between mean CCT and patients’ demographics.Methods: A cross sectional study conducted at an eye screening center in Enugu Southeastern Nigeria. Subjects with healthy eyes from the Igbo ethnic population were recruited. Central corneal thickness was measured with ultrasound pachymetry (Sonomed PacScan plus, model 300AP+) on eligible subjects. Topical anesthetic was instilled and 3 measurements of corneal thickness were taken. The average thickness for each eye was calculated and the relationship between mean CCT, age and gender were studied.Results: 706 eyes of 353 participants were examined. 52.7% of the subjects were females while 47.3% were males. The mean age of participants was 50.29 ± 16.58 years. The mean central corneal thickness (CCT) for RE was 527.68 ± 36.88μm (95% CI: 523.83 –531.55μm) and 527.45 ± 38.01μm for LE (95% CI: 523.47 – 531.43μm). There was a decrease in CCT values with increasing age (p= 0.016, p= 0.05 for RE and left eyes respectively). Males had a significantly higher CCT compared to females for both right and left eyes (p=0.004, p=0.007).Conclusion: Central corneal thickness values in the Igbo ethnic population of Southeast Nigeria, an ethnic group with the reported highest prevalence of glaucoma in Nigeria from our study is thinner than those reported from other regions both within Nigeria as well as some Sub-Saharan populations, Caucasians, Asians, and Hispanics but it is however comparable with values reported among Cameroonians and African Americans. CCT among Nigerian Igbos, seems to decrease with age and appears thicker in males compared with females.

2016 ◽  
Vol 15 (2) ◽  
Author(s):  
Satheesh Solomon T Selvin ◽  
Chris Elsa Samson Jacob ◽  
Thomas Kuriakose

Purpose: Goldmann applanation tonometry (GAT) is considered the gold standard for Intraocular Pressure (IOP) measurement. It has the disadvantages of being a contact device, need for a slit-lamp, non-portability and need of a skilled examiner. Many hospitals are using a Non Contact Tonometry (NCT) as a screening device to save clinician time, however the usefulness is not proved in terms of reliability. This study was aimed to determine the usefulness of the Air-puff tonometer (TONOREF NIDEK II, NIDEK CO., LTD., JAPAN) over a GAT in a tertiary care center. Design: Cross-sectional Study Methods: This was a cross-sectional, non interventional observational study conducted on 224 eyes (right eye) from 224 patients. All patients underwent the IOP measurement with both methods and a central corneal thickness (CCT) measured. The data was analyzed using SPSS 20.0 software. Results: The mean age of the patients was 40.3±11.29 years. There was a statistically significant difference (p<0.001) between the mean NCT and GAT readings which persisted even after correction for central corneal thickness. The correlation between NCT and GAT using Pearson’s correlation coefficient was strong irrespective of the corrections for their corneal thickness (r = 0.751 and 0.718 for uncorrected and corrected values respectively). The correlation of the individual clinicians for the readings varied from moderate to strong. The ROC curve showed the best sensitivity and specificity to occur at around 13 to 14 mmHg. Conclusion: NCT seems to overestimate the IOP at low ranges as compared to the GAT and underestimate at higher ranges. The crossover of the values is seen between 12 to 13 mmHg.  The clinician should do an individualized analysis of his/her GAT measurements to the readings of the NCT machine at the clinic to obtain clinician specific nomogram. 


2020 ◽  
Author(s):  
Amr A. Gab-Alla

Abstract Background: To generate reference values of the central corneal thickness (CCT) with different refractive errors for the adult Egyptian population. Methods: A retrospective, observational, and cross-sectional study of 2200 eyes in 1166 subjects scheduled for LASIK, who came to private refractive eye center, Ismailia, Egypt. The study period was from January 2018 to January 2020. The subjects were divided into a broad range of myopia with spherical equivalent (SE) <-0.5D and hyperopia SE> +0.5D. Then, the myopic eyes divided into low (SE>-3.0D), moderate (SE-3.0D to >-6.0D), and high (SE<-6.0D). Similarly, the hyperopic eyes were divided into low (SE<+3.0 D) and moderate (SE+3.0D to <+6.0D) and high >+6.0D. The refractive error was measured by an auto-refractometer (Topcon, Tokyo Optical Co., Ltd., Japan), and CCT was measured using Sirius (CSO, Florence, Italy). Results: The data of 1100 myopic eyes in 556 subjects (30.5% males and 69.5% females) and 1100 hyperopic eyes in 610 subjects (33.6% males and 66.4% females). The mean+SD of CCT for the total myopic subjects was 531.98+32.92μm, range (406 to 636μm). The mean+SD of SE was -4.1±2.5D, range (-0.5 to -12.0D). The mean+SD of CCT for the total hyperopic subjects was 529±38.8μm, range (448 to 619 μm). The mean+SD of SE was +3.65+1.97D, range (+0.5 to +8.5D).Conclusion: In this study, the mean of CCT of the Egyptian population was 531.9 μm for myopic and 529μm for hyperopic subjects respectively. The myopic and hyperopic subjects show a reduction in CCT with age. Females have a thinner cornea than males, 23.6% of the myopic eyes, and 16.5% of the hyperopic eyes have CCT less than 500μm.


2021 ◽  
Vol 13 ◽  
pp. 251584142110201
Author(s):  
Anuradha Raj ◽  
Renu Dhasmana ◽  
Harsh Bahadur

Purpose: To evaluate the relationship between measurements and various morphometric parameters of primary pterygium on anterior segment optical coherence tomography(AS-OCT) and refractive and keratometric astigmatism. Methods: In this cross-sectional study, patients with primary pterygium were included. The AS-OCT parameters of pterygium consisting of epithelial thickness near apex(µm), apical or head thickness(µm), its thickness at limbus(µm), horizontal length of pterygium(mm), central corneal thickness (µm) and maximum pterygium thickness(mm) were evaluated. Results: Sixty three patients comprising of 63 eyes with a primary pterygium were studied. The mean keratometric and refractive astigmatism were 1.69 ± 3.15 Diopter(D) and0.5 ± 1.4D, respectively. There was a significant association between pterygium grade and stocker’s line with keratometric astigmatism ( p = 0.02, 0.00) respectively. Vertical and horizontal length on slit lamp and horizontal length on AS-OCT showed significant association with keratometric astigmatism ( p = 0.05, 0.00,0.00), respectively. Limbal thickness on AS-OCT showed significant positive correlation with refractive astigmatism ( r = 0.29, p = 0.02). Conclusion: The pterygium grade influences the keratometric astigmatism. Increased limbal thickness of pterygium on AS-OCT leads to more refractive astigmatism.


2021 ◽  
Vol 35 (3) ◽  
Author(s):  
Dr Ronak afza Memon ◽  
Dr munira Shakir ◽  
Dr Sahira Wasim

Abstract Objective: The objective is to determine the mean difference of central corneal thickness measurements by using ultrasound pachymeter and oculus Wavelight Occulyzer II. Patients & Methods: This prospective cross-sectional comparative study was conducted at Department of Ophthalmology, Liaquat National Hospital, Karachi for 6 months duration, after the approval from ethical committee. Patients were included in our study on the basis of inclusion & exclusion criteria. Central corneal thickness measurements was taken by using ultrasound pachymeter & oculus Wavelight Occulyzer II. All the data was collected by single researcher. The results were plotted, compared & analyzed. Results: 130 patients attending ophthalmology department and fulfilling the inclusion criteria were assessed. One eye of each patient was measured (65 were right eye and 65 were left eye). 73(56.2%) were male and 57(43.8%) were females. Mean age of these patients was 33.9 ±8.9 years. The mean ± SD thinnest oculus Wavelight Occulyzer II measurement was 538.61±23.46 ?m and ranged between 476.0 and 619.0 ?m whereas the mean thinnest ultrasound pachymeter measurement was 535.1±21.816?m and ranged between 482 and 601 ?m. There was highly significant correlation of central corneal thickness between both the instruments. (r=0.96, p<0.001)  Conclusion: According to the results of our study there is a highly correlation of central corneal thickness was found between the readings obtained from both UP and oculus Wavelight Occulyzer II. So we concluded that oculus Wavelight Occulyzer II can be used as an alternative technique to ultrasound pachymetry while assessing CCT in clinical settings to  decrease the risk of procedure associated problems with UP like epithelial trauma and infection, to decrease the frequent use of topical anesthetic agents, for early detection and management of glaucoma & in anxious patients also. Keywords: Central corneal thickness, ultrasound pachymeter, oculus Wavelight Occulyzer II  


2019 ◽  
Vol 16 (3) ◽  
pp. 144-152
Author(s):  
Tanie Natung ◽  
Prasanta Kumar Goswami ◽  
Avonuo Keditsu ◽  
Wakaru Shullai

Purpose: To compare the intraocular pressure (IOP) and central corneal thickness (CCT) of non-glaucomatous North-East (NE) Indian tribals and general Indians.  Materials and methods: In a prospective, cross-sectional study, the IOP and CCT of non-glaucomatous NE Indian tribals (n = 50) and non-glaucomatous general Indians (n = 50) were compared. Glaucoma was ruled out by history, detailed ocular examinations, and investigations. Results: There was very good correlation between the CCT and IOP values of right and left eyes (p = 0.940 and 0.847, respectively). The difference in the IOP values in the two groups was not statistically significant (p = 0.312 for Oculus Dexter [OD], p = 0.400 for Oculus Sinister [OS]). Similarly, the difference in the CCT values in the two groups was not statistically significant (p = 0.736 for OD and 0.613 for OS). The mean CCT and IOP OD for the whole population was 530.50 ± 35.42 μm and 13.80 ± 2.760 mmHg, respectively. By linear regression analysis, the IOP OD of the whole population had good correlation with CCT OD of the whole population (adjusted r2 = 0.084, p = 0.002), but not with age (adjusted r2=0.000, p=0.314) and sex (adjusted r2 = 0.010, p = 0.163). Similarly, CCT OD for the whole population did not have good correlation with age (adjusted r2 = -0.009, p = 0.762) and sex (adjusted r2 = -0.007, p = 0.603). Conclusions: In this study of individuals with normal corneas and without glaucoma, no racial variation was found in the CCT and IOP values of the two groups. The IOP OD of whole population had good correlation with CCT, but not with age and sex. There was good correlation between OD and OS values of IOP and CCT.


2016 ◽  
Vol 15 (2) ◽  
Author(s):  
Paaraj Dave ◽  
Jitendra Jethani

Purpose: To report the repeatability of Pattern Electrotretinogram (PERG) and its findings in ocular hypertension (OHT) and normal eyes.Methods: A cross-sectional study where PERG responses were compared between the study group comprising of 80 eyes of 80 patients with intraocular pressure (IOP)>21 mmHg and the control group with 80 eyes of 80 normal individuals (IOP≤21mmHg). The optic disc and the visual fields were normal with a visual acuity of ≥ 0.8 in both groups. PERG was recorded twice for each individual in the control group by a single operator on 2 consecutive days to assess the repeatability.Results: The mean age in the study and control groups was 50.05±10.03 and 54.8±7.66 years(p=0.44) respectively. The mean IOP was 26.55±3.9 mmHg for the study group as opposed to 14.45±2.9 mmHg for the controls (p<0.001). The central corneal thickness and the cup-disc ratio was similar between the groups (p>.05). The P50-N95 amplitude (p=0.01) and the P50 latency (p<0.001) was statistically significantly different between both the groups. The intra-class correlation coefficient (ICC) showed poor agreement for all parameters except for N35-P50 0.8 to 16 degree check size amplitude ratio (PERG ratio).Conclusion:  Increase in P50 latency emerges as a new candidate for early glaucoma indicator in addition to reduction in P50-N95 amplitude. PERG parameters suffer from high test-retest variability. Deterioration in PERG recordings should be interpreted with caution. The variability is lesser for the PERG ratio which maybe more meaningful while monitoring for change over time.


2021 ◽  
Vol 9 (2) ◽  
pp. 127-133
Author(s):  
Annamary Stanislaus ◽  
Ntsilane Susan Mosenene ◽  
Celina Mhina ◽  
John Stanslaus Kisimbi ◽  
Frederick Robert Burgess ◽  
...  

Background: Central Corneal Thickness (CCT) is an indicator of corneal health status as well as being an essential tool in assessment and management of corneal diseases. It is an important factor in the diagnosis and management of glaucoma as it affects the measurement of intraocular pressure. However, the pattern of central corneal thickness in our population is not known. Our study aimed to describe the CCT measurements and their variation with age and sex among patients attending the eye clinic at Muhimbili National Hospital (MNH), in Dar es Salaam, Tanzania. Methodology: A hospital-based descriptive, cross-sectional study used convenient sampling to recruit adult patients aged 18 years and above, presenting to the MNH between August 2016 and January 2017.Visual acuity assessment, Goldman applanation tonometry and CCT assessment using an ultrasound pachymeter were performed. Patients with previous intraocular surgery were excluded. Results: A total of 398 patients (208 males and 190 females) were recruited. The mean CCT was 526.64±38.30 µm; being 523.99±38.20 µm for males and 529.7±38.3 µm for females. 226 (56.85%) had CCT of less than 520 µm.There was no statistically significant difference in CCT between gender. The proportion of patients with thinner CCT increased with increasing age from 25.8% in those < 30 years to 75% in those aged 71years and above. The mean CCT decreased with increasing age with P-value<0.001. Conclusion: The average CCT in patients attending Muhimbili National Hospital is 526.64 µm (SD 38.30) which is generally thin, inversely proportion to age and similar that of other Africans and African-Americans. This finding has implications for the management of glaucoma in this population.


2017 ◽  
Vol 157 (4) ◽  
pp. 690-695 ◽  
Author(s):  
Onyinyechi C. Ukaegbe ◽  
Foster T. Orji ◽  
Basil C. Ezeanolue ◽  
James O. Akpeh ◽  
Ijeoma A. Okorafor

Objectives To evaluate the quality of life of patients with ongoing tinnitus. Study Design This was a cross-sectional study of patients with ongoing tinnitus. Setting The study was carried out in a tertiary hospital in southeastern Nigeria. Subjects and Methods Subjects are adults who presented to the otorhinolaryngology clinic with tinnitus as their primary complaint. Pure-tone audiometry, tinnitus pitch, and loudness matching were done. The Tinnitus Handicap Inventory (THI) questionnaire was used in assessing their quality of life. Results There were 63 participants within the age range of 16 to 74 years; 20 (31.7%) were male and 43 (68.3%) were female. The mean duration of tinnitus was 26.7 ± 38.1 months. Nineteen (30.2%) participants had bilateral tinnitus while 44 (69.8%) had unilateral tinnitus. The mean THI score was 36.6 ± 19.7. The most reported handicap was anxiety and difficulty with concentration followed by depression and irritability. There was no correlation between the disability shown by the THI score and the age, sex, duration of the tinnitus, the tinnitus pitch, tinnitus loudness, or the laterality of the tinnitus. There was a significant positive correlation between the grade of hearing loss and the level of disability reported in the THI ( P = .01). Conclusion Tinnitus sufferers appear to have poorer quality of life compared with nonsufferers. This quality-of-life affectation is likely to be worse in those with disabling hearing loss but does not appear to be related to their age, sex, symptom duration, or the loudness and pitch of their tinnitus.


2016 ◽  
Vol 33 (2) ◽  
pp. 116-120 ◽  
Author(s):  
Pongdhep Theerawit ◽  
Chalermpon Na Petvicharn ◽  
Viratch Tangsujaritvijit ◽  
Yuda Sutherasan

Background: Applying peripheral venous lactate instead of arterial lactate in clinical practice is questionable because of deviation between both values. We aimed to find the relationship between the arterial lactate and the peripheral venous lactate before reasoned that the venous lactate could be used in substitution to the arterial lactate in sepsis. Methods: We conducted a prospective, cross-sectional study at a university hospital. The patients with sepsis in ICU who required lactate level monitoring were enrolled in this research. The correlation and agreement between arterial lactate (A-LACT) and peripheral venous lactate (V-LACT) were the primary outcomes. Results: A total of 63 paired samples were collected. The A-LACT and V-LACT were strongly correlated ( r = .934, P < .0001, r2 = .873). The regression equation was A-LACT = (0.934 × V-LACT) − 0.236. The mean difference between V-LACT and A-LACT was 0.66 ± 1.53 mmol/L. The 95% limits of agreement were between −3.66 and 2.33 mmol/L. The V-LACT ≥ 4 mmol/L can predict A-LACT level ≥ 4 mmol/L with 87.5% sensitivity and 91.5% specificity, and the area under receiver operating characteristic curve was 0.948. Conclusion: The present study demonstrated a strong correlation between A-LACT and V-LACT, but an agreement between both parameters was poor. We suggest not to use the V-LACT in substitution to the A-LACT in sepsis regarding the absolute value and clearance rate, but the V-LACT ≥ 4.5 mmol/L may be used for predicting the A-LACT ≥ 4 mmol/L.


Sign in / Sign up

Export Citation Format

Share Document