scholarly journals Risk Factors for Postoperative Hydrocephalus Following Subependymal Giant Cell Astrocytoma Resection: A Study of Under 18-Year-Old Patients in China

Author(s):  
Fangjie Shen ◽  
Jia Wang ◽  
Loren Skudder Hill ◽  
Gang Cui ◽  
Xu Kang ◽  
...  

Abstract Background: Hydrocephalus may occur after subependymal giant cell astrocytoma (SEGA) resection. In existing literatures, SEGA almost always occurred in patients with tuberous sclerosis complex (TSC), however, many SEGA also occurred alone in our Chinese pediatric patients. Objective: To discuss the risk factors of postoperative hydrocephalus following SEGA resection and the relationship between SEGA and TSC in Chinese children.Materials and methods: A total of 35 children (≤18-year-old) who underwent SEGA resection were selected. From 3 months postoperatively until December 2020 all patients received telephone or clinical follow-up. Related risk factors were first screened by univariate analysis and then analyzed by multivariate logistic regression.Results: The ratio of males to females was 3:2 and the mean age was 11.6 years. Twenty cases were associated with TSC and 15 were not. The mean maximum diameter of the SEGA for patients with and without associated TSC was 49.7mm and 30.5mm, respectively (Z=-3.293, P=0.001). Twenty-eight patients had preoperative hydrocephalus. Sixteen patients developed postoperative hydrocephalus, and amongst these, 2 did not have hydrocephalus before surgery. Multivariate analysis showed that association with TSC [odds ratio (OR), 18.81, P=0.048] and tumor resection rate (OR, 0.042, P=0.025) were independent risk factors for postoperative hydrocephalus. Conclusion:SEGA could be associated with TSC or appear alone. The maximum diameter of SEGA associated with TSC is larger than that without TSC. Hydrocephalus is a common onset symptom and might recur following SEGA resection. Association with TSC and tumor resection rate are risk factors for postoperative hydrocephalus.

Neurosurgery ◽  
1994 ◽  
Vol 35 (4) ◽  
pp. 748-750 ◽  
Author(s):  
Susumu Oikawa ◽  
Keizo Sakamoto ◽  
Norio Kobayashi

2005 ◽  
Vol 7 (4) ◽  
pp. 544-549 ◽  
Author(s):  
Tomotsugu Ichikawa ◽  
Akiko Wakisaka ◽  
Shigeru Daido ◽  
Soichiro Takao ◽  
Takashi Tamiya ◽  
...  

2016 ◽  
Vol 41 (4) ◽  
pp. E9 ◽  
Author(s):  
David Y. A. Dadey ◽  
Ashwin A. Kamath ◽  
Eric C. Leuthardt ◽  
Matthew D. Smyth

Subependymal giant cell astrocytoma (SEGA) is a rare tumor occurring almost exclusively in patients with tuberous sclerosis complex. Although open resection remains the standard therapy, complication rates remain high. To minimize morbidity, less invasive approaches, such as endoscope-assisted resection, radiosurgery, and chemotherapy with mTOR pathway inhibitors, are also used to treat these lesions. Laser interstitial thermal therapy (LITT) is a relatively new modality that is increasingly used to treat a variety of intracranial lesions. In this report, the authors describe two pediatric cases of SEGA that were treated with LITT. In both patients the lesion responded well to this treatment modality, with tumor shrinkage observed on follow-up MRI. These cases highlight the potential of LITT to serve as a viable minimally invasive therapeutic approach to the management of SEGAs in the pediatric population.


Neurosurgery ◽  
1991 ◽  
pp. 864 ◽  
Author(s):  
C W Shepherd ◽  
B W Scheithauer ◽  
M R Gomez ◽  
H J Altermatt ◽  
J A Katzmann

1979 ◽  
Vol 50 (1) ◽  
pp. 106-109 ◽  
Author(s):  
G. Michael Halmagyi ◽  
Leon P. Bignold ◽  
John L. Allsop

✓ A case is described of a subependymal giant-cell astrocytoma that occurred as a mural nodule within a cyst in the parietal lobe. The tumor recurred twice over a period of 47 years despite two extensive surgical resections. Neither the patient nor any of his children suffered tuberous sclerosis, a disease with which this type of astrocytoma is associated.


2018 ◽  
Vol 40 (5) ◽  
pp. 415-420 ◽  
Author(s):  
Ichiro Kuki ◽  
Hisashi Kawawaki ◽  
Shin Okazaki ◽  
Eiji Ehara ◽  
Yoko Yoshida ◽  
...  

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