scholarly journals Quadriceps Physiological Response During the 1-minute Sit-to-stand Test in People with Severe COPD and Healthy Controls

2021 ◽  
Author(s):  
Sarah Gephine ◽  
Patrick Mucci ◽  
Mathieu Bielmann ◽  
Mickael Martin ◽  
Laurent Bouyer ◽  
...  
Keyword(s):  
Physiological Response ◽  
Near Infrared ◽  
Healthy Controls ◽  
Total Work ◽  
Time Duration ◽  
Contraction Pattern ◽  
Sit To Stand ◽  
Cardiorespiratory Response ◽  
Severe Copd ◽  
Semg Signals

Abstract We compared quadriceps oxygenation and surface electromyography (sEMG) responses during the 1-min sit-to-stand (1STS) in 14 people with severe COPD and 12 controls, in whom cardiorespiratory response, near-infrared spectroscopy signals (oxy [Hb-Mb], deoxy [Hb-Mb], total [Hb-Mb], and SmO2) and sEMG signals of the quadriceps were recorded. Time duration of each sit-to-stand cycle and the total work performed during the 1STS were measured. The quadriceps oxygenation parameters were normalized by reporting their values according to the total work during 1STS. The rate of sit-to-stand maneuvers decelerated in people with COPD leading to smaller total work compared with controls. The pattern of quadriceps oxygenation response during 1STS was similar between groups. However, in COPD, the recovery after 1STS was characterized by larger overshoots in oxy [Hb-Mb], total [Hb-Mb], and SmO2. When corrected for the cumulative total work, the increase in muscle O2 extraction (deoxy [Hb-Mb]) during the first 30 seconds of recovery was greater in people with COPD compared to controls. Quadriceps sEMG changes suggestive of a fatiguing contraction pattern was observed only in people with COPD. All together, these results highlighted physiological misadaptation of people with severe COPD to the 1STS.

scholarly journals Comparison of Brain Activation Patterns during Olfactory Stimuli between Recovered COVID-19 Patients and Healthy Controls: A Functional Near-Infrared Spectroscopy (fNIRS) Study

2021 ◽  
Vol 11 (8) ◽  
pp. 968
Author(s):  
Roger C. Ho ◽  
Vijay K. Sharma ◽  
Benjamin Y. Q. Tan ◽  
Alison Y. Y. Ng ◽  
Yit-Shiang Lui ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Time Interval ◽  
Healthy Controls ◽  
Functional Near Infrared Spectroscopy ◽  
Activation Patterns ◽  
Identification Test ◽  
Olfactory Stimuli ◽  
Preliminary Study

Impaired sense of smell occurs in a fraction of patients with COVID-19 infection, but its effect on cerebral activity is unknown. Thus, this case report investigated the effect of COVID-19 infection on frontotemporal cortex activity during olfactory stimuli. In this preliminary study, patients who recovered from COVID-19 infection (n = 6) and healthy controls who never contracted COVID-19 (n = 6) were recruited. Relative changes in frontotemporal cortex oxy-hemoglobin during olfactory stimuli was acquired using functional near-infrared spectroscopy (fNIRS). The area under curve (AUC) of oxy-hemoglobin for the time interval 5 s before and 15 s after olfactory stimuli was derived. In addition, olfactory function was assessed using the Sniffin’ Sticks 12-identification test (SIT-12). Patients had lower SIT-12 scores than healthy controls (p = 0.026), but there were no differences in oxy-hemoglobin AUC between healthy controls and patients (p > 0.05). This suggests that past COVID-19 infection may not affect frontotemporal cortex function, and these preliminary results need to be verified in larger samples.

Oxygen delivery-utilization mismatch in contracting locomotor muscle in COPD: peripheral factors

2015 ◽  
Vol 308 (2) ◽  
pp. R105-R111 ◽  
Author(s):  
Wladimir M. Medeiros ◽  
Mari C. T. Fernandes ◽  
Diogo P. Azevedo ◽  
Flavia F. M. de Freitas ◽  
Beatriz C. Amorim ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Near Infrared ◽  
Neuromuscular Electrical Stimulation ◽  
Muscle Oxygenation ◽  
Whole Body ◽  
Chronic Obstructive ◽  
Copd Patients ◽  
Skeletal Muscle Oxygenation ◽  
Severe Copd

Central cardiorespiratory and gas exchange limitations imposed by chronic obstructive pulmonary disease (COPD) impair ambulatory skeletal muscle oxygenation during whole body exercise. This investigation tested the hypothesis that peripheral factors per se contribute to impaired contracting lower limb muscle oxygenation in COPD patients. Submaximal neuromuscular electrical stimulation (NMES; 30, 40, and 50 mA at 50 Hz) of the quadriceps femoris was employed to evaluate contracting skeletal muscle oxygenation while minimizing the influence of COPD-related central cardiorespiratory constraints. Fractional O2 extraction was estimated by near-infrared spectroscopy (deoxyhemoglobin/myoglobin concentration; deoxy-[Hb/Mb]), and torque output was measured by isokinetic dynamometry in 15 nonhypoxemic patients with moderate-to-severe COPD (SpO2 = 94 ± 2%; FEV1 = 46.4 ± 10.1%; GOLD II and III) and in 10 age- and gender-matched sedentary controls. COPD patients had lower leg muscle mass than controls (LMM = 8.0 ± 0.7 kg vs. 8.9 ± 1.0 kg, respectively; P < 0.05) and produced relatively lower absolute and LMM-normalized torque across the range of NMES intensities ( P < 0.05 for all). Despite producing less torque, COPD patients had similar deoxy-[Hb/Mb] amplitudes at 30 and 40 mA ( P > 0.05 for both) and higher deoxy-[Hb/Mb] amplitude at 50 mA ( P < 0.05). Further analysis indicated that COPD patients required greater fractional O2 extraction to produce torque (i.e., ↑Δdeoxy-[Hb/Mb]/torque) relative to controls ( P < 0.05 for 40 and 50 mA) and as a function of NMES intensity ( P < 0.05 for all). The present data obtained during submaximal NMES of small muscle mass indicate that peripheral abnormalities contribute mechanistically to impaired contracting skeletal muscle oxygenation in nonhypoxemic, moderate-to-severe COPD patients.

scholarly journals Paraoxonase 1 and Chronic Obstructive Pulmonary Disease: A Meta-Analysis

Antioxidants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1891
Author(s):  
Jun Watanabe ◽  
Kazuhiko Kotani ◽  
Alejandro Gugliucci
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Meta Analysis ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Chronic Obstructive ◽  
Healthy Controls ◽  
Obstructive Pulmonary Disease ◽  
Paraoxonase Activity ◽  
Severe Copd

Oxidative stress is a driving factor in the pathophysiology of chronic obstructive pulmonary disease (COPD). While paraoxonase 1 (PON1) is an antioxidant enzyme and a potential biomarker of this disease, data regarding the status of PON-1 in COPD are inconclusive. In this regard, to shed light on this issue, we performed a meta-analysis of data on PON1 activity in COPD. Electronic databases (MEDLINE, Embase and CENTRAL) were searched for available studies on PON1 activity in patients with stable COPD published before October 2021. A meta-analysis was performed using random-effects models. Twelve studies (12 studies on paraoxonase and three on arylesterase) were identified. Patients with COPD had lower levels of paraoxonase activity (standard mean difference [SMD] −0.77, 95% confidence interval [CI] −1.35 to −0.18) and arylesterase activity (SMD −1.15, 95% CI −1.95 to −0.36) in comparison to healthy controls. In subgroup analyses, paraoxonase activity was lower in patients of studies as consisted of mainly non-severe COPD (SMD −1.42, 95% CI −2.04 to −0.79) and, by contrast, slightly higher in patients of studies including severe COPD (SMD 0.33, 95% CI 0.02 to 0.64) in comparison to healthy controls. Arylesterase activity showed a similar trend. Overall, PON1 activity was lower in patients with COPD, suggesting that PON1-related antioxidant defense is impaired in COPD. Future studies are warranted.

scholarly journals Bedside hyperspectral imaging for the evaluation of microcirculatory alterations in perioperative intensive care medicine: a study protocol for an observational clinical pilot study (HySpI-ICU)

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e035742 ◽  
Author(s):  
Maximilian Dietrich ◽  
Sebastian Marx ◽  
Thomas Bruckner ◽  
Felix Nickel ◽  
Beat Peter Müller-Stich ◽  
...  
Keyword(s):  
Hyperspectral Imaging ◽  
Organ Dysfunction ◽  
Pancreatic Surgery ◽  
Near Infrared ◽  
Haemodynamic Monitoring ◽  
Healthy Controls ◽  
Study Results ◽  
Infrared Spectral ◽  
Registration Number ◽  
Tissue System

IntroductionNormalisation of macrocirculatory parameters during resuscitation therapy does not guarantee the restoration of microcirculatory perfusion in critical illness due to haemodynamic incoherence. Persistent microcirculatory abnormalities are associated with severity of organ dysfunction and mandate the development of bedside microcirculatory monitoring. A novel hyperspectral imaging (HSI) system can visualise changes in skin perfusion, oxygenation and water content at the bedside. We aim to evaluate the effectiveness of HSI for bedside monitoring of skin microcirculation and the association of HSI parameters with organ dysfunction in patients with sepsis and major abdominal surgery.Methods and analysisThree independent groups will be assessed and separately analysed within a clinical prospective observational study: (1) 25 patients with sepsis or septic shock (according to sepsis-3 criteria), (2) 25 patients undergoing pancreatic surgery and (3) 25 healthy controls. Patients with sepsis and patients undergoing pancreatic surgery will receive standard therapy according to local protocols derived from international guidelines. In addition, cardiac output of perioperative patients and patients with sepsis will be measured. Healthy controls undergo one standardised evaluation. The TIVITA Tissue System is a novel HSI system that uses the visible and near-infrared spectral light region to determine tissue microcirculatory parameters. HSI analysis (hand/knee) will be done in parallel to haemodynamic monitoring within defined intervals during a 72-hour observation period. HSI data will be correlated with the Sequential Organ Failure Assessment score, global haemodynamics, inflammation and glycocalyx markers, surgical complications and 30-day outcome.Ethics and disseminationThe protocol has been approved by the local ethics committee of the University of Heidelberg (S-148/2019). Study results will be submitted to peer-reviewed journals and medical conferences.Trial registration numberDRKS00017313; Pre-results.

Impact of Fibromyalgia in the Sit-to-Stand-to-Sit Performance Compared With Healthy Controls

PM&R ◽  
2016 ◽  
Vol 9 (6) ◽  
pp. 588-595 ◽  
Author(s):  
Daniel Collado-Mateo ◽  
Jose C. Adsuar ◽  
Francisco J. Dominguez-Muñoz ◽  
Pedro R. Olivares ◽  
Narcis Gusi
Keyword(s):  
Healthy Controls ◽  
Sit To Stand

Preserved muscle metaboreflex in chronic obstructive pulmonary disease

2011 ◽  
Vol 36 (6) ◽  
pp. 821-830 ◽  
Author(s):  
Megan F.B. Sherman ◽  
Jeremy D. Road ◽  
Donald C. McKenzie ◽  
A. William Sheel
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Heart Rate ◽  
Blood Flow ◽  
Pulmonary Disease ◽  
Exercise Capacity ◽  
Chronic Obstructive ◽  
Healthy Controls ◽  
Obstructive Pulmonary Disease ◽  
Muscle Metaboreflex ◽  
Severe Copd

The objective of this study was to measure the magnitude of the muscle metaboreflex in people with chronic obstructive pulmonary disease (COPD) compared with healthy controls and to assess the relationships between disease severity, exercise capacity, and the magnitude of the muscle metaboreflex. Nine people with mild-to-severe COPD and 11 age- and gender-matched healthy controls performed isometric handgrip exercise (IHG), followed by postexercise circulatory occlusion (PECO) while hemodynamic changes were measured. Continuous measures of heart rate, arterial pressure, leg blood flow, leg vascular resistance, and total peripheral resistance were obtained. Participants then performed a cycle test to exhaustion. Heart rate, blood pressure, and blood flow responses during IHG and PECO were similar between the COPD group and healthy controls (p > 0.05). There was no association between disease severity or exercise capacity and the magnitude of the muscle metaboreflex. We observed a preserved muscle metaboreflex in mild-to-severe COPD, suggesting the metaboreflex is not a contributing factor to the development of exercise intolerance in this population.

A Multivariate NIR Study of Skin Alterations in Diabetic Patients as Compared to Control Subjects

2000 ◽  
Vol 8 (4) ◽  
pp. 217-227 ◽  
Author(s):  
Paul Geladi ◽  
Josefina Nyström ◽  
Jan W. Eriksson ◽  
Anders Nilsson ◽  
Folke Lithner ◽  
...  
Keyword(s):  
Diabetes Complications ◽  
Near Infrared ◽  
Nir Spectroscopy ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Skin Changes ◽  
Skin Reflectance ◽  
Fibre Optic Probe ◽  
Optic Probe ◽  
Skin Conditions

A group of 15 diabetic persons with different degrees of diabetes complications, including skin changes, was studied by Fourier Transform Near Infrared (FT-NIR) spectroscopy. Skin reflectance spectra were measured with a fibre-optic probe in four locations (sites): hand, arm, leg and foot. For reference, a group of 28 healthy controls was also measured. Multivariate analysis of the NIR spectra obtained shows a high potential for classification and discrimination of the skin conditions. Valuable indications for future experiments can be observed.

scholarly journals Impact of Rest-Redistribution on Fatigue During Maximal Eccentric Knee Extensions

2020 ◽  
Vol 74 (1) ◽  
pp. 205-214
Author(s):  
Justin J. Merrigan ◽  
Margaret T. Jones ◽  
Jan Padecky ◽  
Jan Malecek ◽  
Dan Omcirk ◽  
...  
Keyword(s):  
Eccentric Exercise ◽  
Perceived Exertion ◽  
Near Infrared ◽  
Peak Torque ◽  
Rating Of Perceived Exertion ◽  
Total Work ◽  
Oxygen Utilization ◽  
Rest Periods ◽  
Eccentric Actions ◽  
Rest Intervals

Abstract Redistributing long inter-set rest intervals into shorter but more frequent rest intervals generally maintains concentric performance, possibly due to improved energy store maintenance. However, eccentric actions require less energy than concentric actions, meaning that shorter but more frequent sets may not affect eccentric actions to the same degree as concentric actions. Considering the increased popularity of eccentric exercise, the current study evaluated the effects of redistributing long inter-set rest periods into shorter but more frequent rest periods during eccentric only knee extensions. Eleven resistance-trained men performed 40 isokinetic unilateral knee extensions at 60°·s−1 with 285 s of total rest using traditional sets (TS; 4 sets of 10 with 95 s inter-set rest) and rest-redistribution (RR; 20 sets of 2 with 15 s inter-set rest). Before and during exercise, muscle oxygenation was measured via near-infrared spectroscopy, and rating of perceived exertion (RPE) was recorded after every 10th repetition. There were no differences between protocols for peak torque (RR, 241.58±47.20 N; TS, 231.64±48.87 N; p=0.396) or total work (RR, 215.26±41.47 J; TS, 209.71±36.02 J; p=0.601), but moderate to large effect sizes existed in later repetitions (6,8,10) with greater peak torque during RR (d=0.66-1.19). For the entire session, RR had moderate effects on RPE (RR, 5.73±1.42; TS, 6.09±1.30; p=0.307; d=0.53) and large effects on oxygen saturation (RR, 5857.4±310.0; TS, 6495.8±273.8; p=0.002, d=2.13). Therefore, RR may maintain peak torque or total work during eccentric exercise, improve oxygen utilization at the muscle, and reduce the perceived effort.

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