Electrodiagnostic Signs of Carpal Tunnel Syndrome in Ocular Pseudoexfoliation Syndrome: A Case-Control Study

Abstract Purpose To assess the occurrence and severity of electrodiagnostic signs of carpal tunnel syndrome (ED-CTS) in patients with ocular pseudoexfoliation (PEX) and compare them with normal subjects.Method A 1:1 case-control study was designed and 60 patients with PEX were recruited from May 2019 to February 2021, and the findings were compared with 59 age- and gender-matched healthy controls. All patients underwent complete ophthalmologic examination and nerve conduction velocity test at the median nerve was used to assess the occurrence and severity of ED-CTS in both hands.Results The mean age of participants was 59.8 ± 4.5 years. Occurrence of ED-CTS was 38.3% in PEX patients and 20.3% in control subjects (P = 0.025). There was also a significant difference in the severity, and presence of asymptomatic CTS (P < 0.05). Adjusting other variables, including; age, sex and job difficulty, having severe ED-CTS showed a 3.49-fold higher chance in the PEX group (P = 0.002). Conclusion There is a direct relation between PEX and the occurrence, as well as severity of ED-CTS.

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Are Carpal Tunnel Syndrome and Regional Degenerative Osteoarthritis Linked? Results of a Case-Control Study

The Journal of Hand Surgery (Asian-Pacific Volume) ◽

10.1142/s2424835518500054 ◽

2018 ◽

Vol 23 (01) ◽

pp. 41-46 ◽

Cited By ~ 1

Author(s):

Guillaume Bacle ◽

Emilie Marteau ◽

Philippe Corcia ◽

Pascal Garaud ◽

Jacky Laulan

Keyword(s):

Carpal Tunnel Syndrome ◽

Carpal Tunnel ◽

Case Control Study ◽

Causal Relation ◽

Case Control ◽

Degenerative Osteoarthritis ◽

Significant Difference ◽

Osteoarthritis Of The Wrist ◽

Tunnel Syndrome ◽

Control Study

Background: Causality has not been formally demonstrated between carpal tunnel syndrome and osteoarthritis of the wrist or at the base of the thumb. The purpose of this study was to assess the relationship between carpal tunnel syndrome and concomitant degenerative osteoarthritis of the wrist or basal thumb joint. We hypothesised that wrist osteoarthritis by reducing the free volume of the carpal tunnel would be associated with carpal tunnel syndrome, while basal thumb osteoarthritis would show no direct correlation with carpal tunnel syndrome. Methods: A case-control study including 95 cases and 99 control subjects, has been carried out. Sixty-eight per group were matched for age and sex. Posterior-anterior and lateral plain wrist radiographs for the two matched groups were analysed. Results: Except for scaphotrapeziotrapezoid location, degenerative osteoarthritis of the wrist was significantly linked with carpal tunnel syndrome, whereas there was no significant difference between case and control groups for prevalence of basal osteoarthritis of the thumb. Conclusions: These results suggest that basal osteoarthritis of the thumb is not a causal factor in carpal tunnel syndrome. In contrast, degenerative osteoarthritis of the wrist was strongly associated with carpal tunnel syndrome, suggesting a causal relation.

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Palmar Musculature: Does It Affect the Development of Carpal Tunnel Syndrome? A Pilot Study

Journal of Wrist Surgery ◽

10.1055/s-0040-1721437 ◽

2021 ◽

Author(s):

Trevor Simcox ◽

Lauren Seo ◽

Kevin Dunham ◽

Shengnan Huang ◽

Catherine Petchprapa ◽

...

Keyword(s):

Carpal Tunnel Syndrome ◽

Correlation Coefficient ◽

Carpal Tunnel ◽

Case Control Study ◽

Anatomical Variation ◽

Case Control ◽

Transverse Carpal Ligament ◽

Large Variability ◽

Tunnel Syndrome ◽

Control Study

Abstract Background The etiology of carpal tunnel syndrome (CTS) is multifactorial. Static mechanical characteristics of CTS have been described, but dynamic (muscular) parameters remain obscure. We believe that musculature overlying the transverse carpal ligament may have an effect on carpal tunnel pressure and may explain the prevalence of CTS in manual workers. Questions/Purposes To utilize magnetic resonance imaging (MRI) imaging to estimate the amount of muscle crossing the area of the carpal tunnel and to compare these MRI measurements in patients with and without documented CTS. Methods A case–control study of wrist MRI scans between January 1, 2018, and December 1, 2019, was performed. Patients with a diagnosis of CTS were matched by age and gender with controls without a diagnosis of CTS. Axial MRI cuts at the level of the hook of the hamate were used to measure the thenar and hypothenar muscle depth overlying the carpal tunnel. Muscle depth was quantified in millimeters at three points: midcapitate, capitate–hamate border, capitate–trapezoid border. Average depth was calculated by dividing the cross-sectional area (CSA) by the transverse carpal ligament width. Statistical analysis included Student's t-test, chi-square test, and Pearson's correlation coefficient calculation. Results A total of 21 cases and 21 controls met the inclusion criteria for the study. There were no significant differences in demographics between case and control groups. The location and depth of the musculature crossing the carpal tunnel were highly variable in all areas evaluated. A significantly positive correlation was found between proximal median nerve CSA and muscle depth in the capitate–hamate area (correlation coefficient = 0.375; p = 0.014). CSA was not significantly associated with chart documented CTS. Conclusions We found large variability in our measurements. This likely reflects true anatomical variation. The significance of our findings depends on the location of the muscles and the line of pull and their effect on the mechanics of the transverse carpal ligament. Future research will focus on refining measurement methodology and understanding the mechanical effect of the muscular structure and insertions on carpal tunnel pressure. Level of Evidence This is a Level 3, case–control study.

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