scholarly journals Experimental research on the evaluation of left ventricular systolic function by layered speckle tracking before and after berberine treatment in a cardiac hypertrophy rat model

2021 ◽  
Author(s):  
haorou Luo ◽  
Tuli Kou ◽  
Ye Su ◽  
Lixue Yin
Keyword(s):  
Cardiac Hypertrophy ◽  
Myocardial Hypertrophy ◽  
Systolic Function ◽  
Left Ventricular Systolic Function ◽  
Left Ventricular ◽  
Control Group ◽  
Intragastric Administration ◽  
Ventricular Systolic Function ◽  
Group A ◽  
Group B

Abstract Background We aimed to detect the cardiac dysfunction in the early myocardial hypertrophy rat model by layered strain and to evaluate the effect of berberine on the left ventricular systolic function of myocardial hypertrophy rats. Methods 80 healthy SD rats were randomly divided into 4 groups. The last three groups(ISO group) were injected with isoproterenol intraperitoneally to establish a model of myocardial hypertrophy;After successful modeling, group A and group B were given berberine hydrochloride intragastric administration (5mg/kg; 10mg/kg), and group C was given the same amount of normal saline by intragastric administration. The left ventricular systolic function was performed at the end of each trial using the layered strain technique. The myocardial tissue of rats was taken for pathological examination, and Masson trichrome staining and hematoxylin-eosin staining were performed. The myocardial interstitial fibrosis was evaluated and the correlation analysis was performed. Results The GCS, GSCendo and GSCmid of the ISO group were lower than those of the control group, and the difference was statistically significant (− 20.46% −29.57% −19.39% vs. −15.71% −20.11% −15.35%; P < 0.05). After berberine treatment, the GSCendo in group A (5mg/kg) and group B (10mg/kg) was higher than that in group C (− 24.49% vs.−26.87% vs.−20.09%; P < 0.001); The improvement in group B was more significant (− 24.49% vs.−26.87%; P < 0.001). Pathological results showed that, compared with the control group, fibrosis was significantly increased in the ISO group. After 7 days of berberine intragastric intervention, compared with group C without intervention, the fibrosis deposition in group A and B was reduced, and the fibrosis deposition in group B was more obvious. Spearman rank correlation analysis showed that Gscendo was positively correlated with the percentage of myocardial interstitial fiber deposition. Conclusion Persistent cardiac hypertrophy leads to marked myocardial fibrosis and necrosis. Berberine can inhibit the progression of myocardial fibrosis after the formation of cardiac hypertrophy. The stratified strain technique can identify early myocardial systolic dysfunction in patients with cardiac hypertrophy and evaluate the efficacy of short-term drug intervention, which is expected to be a new method for clinical quantitative evaluation of left ventricular systolic dysfunction.

Assessment of Left Ventricular Systolic Function After Revascularization in Patients with ST Segment Elevation Myocardial Infarction by Stratified Strain Technique

2020 ◽  
Author(s):  
Yi Liang ◽  
Xinxin Chen ◽  
Liangjie Xu ◽  
Cuicui Zhou ◽  
Tingpan Fan ◽  
...  
Keyword(s):  
Longitudinal Strain ◽  
Systolic Function ◽  
Left Ventricular Systolic Function ◽  
Left Ventricular ◽  
Ventricular Systolic Function ◽  
St Segment Elevation ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment ◽  
Group A ◽  
Group B

Abstract Objective: Stratified strain was used to evaluate the local stratified strain and the overall longitudinal strain of the left ventricle of the affected myocardium after revascularization in patients with ST-segment elevation myocardial infarction (STEMI).Methods: 120 patients diagnosed as STEMI in the Affiliated Hospital of Jiangsu University from July 2017 to August 2018 were selected. According to the time from symptom onset to balloon dilation (S-TO-B), 120 patients were divided into group A (S-TO-B≤6h) and group B (6h<S-TO-B <12h) .The changes of left ventricular global longitudinal strain (GLS), local partial layer strain (TLSendo, TLS-mid, TLSepi) and LVEF were compared between the two groups immediately after operation, 3 hours ,24 hours and 1 week after operation. The incidence of major adverse cardiovascular events (MACE) and LVEF were followed up during hospitalization and one month after operation.Results: In group A, TLSendo, TLSmid, TLSepi and GLS increased gradually at each time after vascular opening; in group B, TLSendo, TLSmid, TLSepi and GLS decreased immediately after vascular opening 3 hours after surgery, with obvious TLSendo and gradually increased, but the increase was smaller than that in group A. TLSendo,TLSmid, TLSepi and GLS increased in all patients one week after operation, but TLSendo and TLSepi increased more significantly than TLSmid, and GLS changed less. TlSendo increase of 4.50% is the most accurate parameter to predict the significant improvement of left ventricular systolic function in patients with STEMI one month after operation, with an AUC area of 0.87, sensitivity and specificity of 80.0% and 86.0%, respectively.Conclusions: Layered strain technique can be used to evaluate the myocardial strain in patients with STEMI, and recognize the effect of S-TO-B on the prognosis of STEMI, which has important clinical application value.

scholarly journals Speckle Tracking Imaging Combined With Myocardial Comprehensive Index to Evaluate Left Ventricular Function Changes in Patients With Systemic Lupus Erythematosus

2021 ◽  
Author(s):  
Jia Feng ◽  
zijing Zhai ◽  
zhen Wang ◽  
lei Huang ◽  
shanshan Dong ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Speckle Tracking ◽  
Systolic Function ◽  
Left Ventricular Systolic Function ◽  
Left Ventricular ◽  
Control Group ◽  
Speckle Tracking Imaging ◽  
Systemic Lupus ◽  
Ventricular Systolic Function ◽  
Comprehensive Index

Abstract ObjectiveTo evaluate left ventricular systolic function in patients with systemic lupus erythematosus (SLE) using three-dimensional speckle tracking imaging (3D-STI). MethodsThirty patients with SLE (SLE group) and 30 healthy people (control group) were examined using 3D-STI, and their clinical characteristics were collected. The following conventional 3D parameters were obtained: left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular ejection fraction (LVEF), spherical index (SPI), left ventricular end-diastolic mass (LV EDmass), and left ventricular end-systolic mass (LV ESmass). The following 3D-STI strain parameters were obtained: global longitudinal strain (GLS), global circumferential strain (GCS), left ventricular twist angle (LVtw), torque (Tor), peak strain dispersion (PSD), and myocardial comprehensive index (MCI). Statistical analysis was used to analyze the differences in the above indicators among the groups and their correlations. ResultsLVEDV and LVEF decreased; LV EDmass and LV ESmass increased; GLS, GCS, LVtw, Tor, and MCI decreased; and PSD increased in the SLE group compared with the control group (P < 0.05). The receiver operating characteristic curve showed that the area under the curve of the MCI was the highest (0.940), the sensitivity of the Tor and MCI was the highest (90.00%), and the specificity of the Tor was the highest (93.33%). Correlation analysis showed that there was a good correlation between the MCI and hs-TropT. ConclusionThe systolic function of the left ventricle is decreased in patients with SLE. 3D-STI technology can detect abnormal left ventricular systolic function in patients with SLE in the early stage.

scholarly journals Evaluation of left ventricular systolic function in patients with different types of ischemic heart disease by two-dimensional speckle tracking imaging

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Xing Xing ◽  
Dan Li ◽  
Shaomin Chen ◽  
Lingli Wang ◽  
Zhaoping Li ◽  
...  
Keyword(s):  
Systolic Function ◽  
Left Ventricular Systolic Function ◽  
Left Ventricular ◽  
Structure And Function ◽  
Control Group ◽  
Speckle Tracking Imaging ◽  
Ventricular Systolic Function ◽  
Different Types ◽  
And Function ◽  
Conventional Echocardiography

Abstract Background The purpose of this study was to evaluate left ventricular systolic function in patients with different types of ischemic heart disease using two-dimensional speckle tracking imaging (2D-STI). Methods We retrospectively studied patients who were admitted to Peking University Third Hospital from January 2011 to December 2017 due to chest tightness and chest pain. Two hundred forty-two patients were divided into control group, CMD group and obstructive CAD group. The main coronary artery stenosis was confirmed by coronary angiography or coronary computed tomography and coronary flow reserve (CFR) in patients was measured by transthoracic Doppler echocardiography. Left ventricular strain and strain rate (SR) measured by 2D-STI. Cardiac structure and function were measured by conventional echocardiography. Results Conventional echocardiography showed that there was no significant difference in cardiac structure and function among the three groups (P > 0.05). Moreover, the longitudinal strain (LS) of each ventricular wall in CMD group was notably lower than that in control group (P < 0.01). In addition, global longitudinal SR and longitudinal SR in CMD group and obstructive CAD group were obviously lower than those in control group (P < 0.01). GLS, endocardial LS and epicardial LS were negatively correlated with CFR (P < 0.01). Conclusions Early left ventricular systolic dysfunction was found in patients with CMD and patients with obstructive CAD, with similar degree. CFR is an independent influencing factor of GLS. GLS and stratified LS have certain diagnostic value for CMD.

Automated Quantitative Technique of 3D Cardiac Anatomical Model for Evaluating Left Ventricular Systolic Function in Patients with Myocardial Infarction

2020 ◽  
Vol 10 (8) ◽  
pp. 1143-1148
Author(s):  
Yuanyuan Xing ◽  
Hongyuan Xue ◽  
Yuquan Ye
Keyword(s):  
Myocardial Infarction ◽  
Systolic Function ◽  
Left Ventricular Systolic Function ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Control Group ◽  
Case Group ◽  
Ventricular Systolic Function ◽  
Anatomical Model ◽  
Quantitative Technique

This study intends to use 3D cardiac anatomical model automatic quantitative technique Heart Model (HM) to assess left ventricular systolic function in patients with myocardial infarction. Thirty patients with myocardial infarction (case group) and 32 healthy individuals (control group) were enrolled in this study.M-mode echocardiography (MME), two-dimensional echocardiography (2DE), 3D cardiac anatomical model (HM) and real-time 3D echocardiography (3DE) were used to collect echocardiographic images. Left ventricular systolic function parameters (LVEDV), left ventricular end-systolic volume (LVESV), and left ventricular ejection fraction (LVEF) were obtained from two post-surgical analysis of more than 5 years of experience. Compared to control group, MME, 2DE, HM, and 3DE were significantly higher in the LVEDV and LVESV cases and lower in the LVEF (P < 0 05). MME, 2DE, HM and 3DE were correlated and best correlation as found between HM and 3DE (P < 0 05). For the consistency of MME, 2DE, HM and 3DE, the best consistency was observed in the LVEF of HM and 3DE, and case group was lower than control (P < 0 05). In terms of repeatability of MME, 2DE, HM and 3DE, HM showed the best repeatability followed by MME. In comparison of the time of MME, 2DE, HM and 3DE, HM had shortest time (< 0 05). HM automatic quantitative technique can evaluate left ventricular systolic function in myocardial infarction patients, and it is simple, rapid and reproducible.

scholarly journals Correlation of N-terminal pro-B-type natriuretic peptide with clinical parameters in patients with hypertension

2013 ◽  
Vol 70 (8) ◽  
pp. 728-734
Author(s):  
Janko Pejovic ◽  
Svetlana Ignjatovic ◽  
Marijana Dajak ◽  
Nada Majkic-Singh ◽  
Zarko Vucinic ◽  
...  
Keyword(s):  
Heart Failure ◽  
Systolic Function ◽  
Nyha Class ◽  
Left Ventricular Systolic Function ◽  
Left Ventricular ◽  
Control Group ◽  
Ventricular Systolic Function ◽  
Function Group ◽  
Group 2 ◽  
Group 1

Background/Aim. Identification of patients with arterial hypertension and a possible onset of heart failure by determining the concentration of N-terminal pro-B-type natriuretic peptide (NT-proBNP) enables timely intensification of treatment and allows clinicians to prescribe and implement optimal and appropriate care. The aim of this study was to evaluate NT-proBNP in patients with longstanding hypertension and in patients with signs of hypertensive cardiomyopathy. Methods. The study involved 3 groups, with 50 subjects each: ?healthy? persons (control group), patients with hypertension and normal left ventricular systolic function (group 1) and patients with longstanding hypertension and signs of hypertensive cardiomyopathy with impaired left ventricular systolic function (group 2). We measured levels of NT-proBNP, Creactive protein and creatinine according to the manufacturer?s instructions. All the patients were clinically examined including physical examination of the heart with blood pressure, pulse rate, electrocardiogram (ECG) and echocardiogram. Results. Our results showed that the determined parameters generally differed significantly (Student?s t-test) among the groups. The mean (? SD) values of NT-proBNP in the control group, group 1 and group 2 were: 2.794 (? 1.515) pmol/L, 9.575 (? 5.449) pmol/L and 204.60 (84,93) pmol/L, respectively. NTproBNP correlated significantly with the determined parameters both in the group 1 and the group 2. In the group 1, the highest correlation was obtained with Creactive protein (r = 0.8424). In the group 2, the highest correlation was obtained with ejection fraction (r = - 0.9111). NT-proBNP showed progressive increase in proportion to the New York Heart Association (NYHA) classification. The patients in thegroup 2 who belonged to the II and III NYHA class had significantly higher levels of NTproBNP than those in the NYHA class I (ANOVA test, p = 0.001). Conclusion. The obtained results suggest that NTproBNP is a useful biomarker in the treatment of patients with longstanding hypertension who are at risk for heart failure.

scholarly journals Speckle tracking imaging combined with myocardial comprehensive index to evaluate left ventricular function changes in patients with systemic lupus erythematosus

2021 ◽  
Author(s):  
Jia Feng ◽  
Zijing Zhai ◽  
Zhen Wang ◽  
Lei Huang ◽  
Shanshan Dong ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Speckle Tracking ◽  
Systolic Function ◽  
Left Ventricular Systolic Function ◽  
Left Ventricular ◽  
Control Group ◽  
Speckle Tracking Imaging ◽  
Systemic Lupus ◽  
Ventricular Systolic Function ◽  
Severe Group

Objective: To evaluate early changes in left ventricular systolic function in patients with systemic lupus erythematosus (SLE) using three-dimensional speckle tracking imaging (3D-STI). Methods: Thirty SLE patients and 30 healthy people (control group) were selected, the patients were further divided into subgroups according to their Safety of Estrogens in Lupus Erythematosus National Assessment version of the SLE Disease Activity Index (SELENA-SLEDAI) score: SELENA-SLEDAI ≤ 12 (mild-to-moderate group), SELENA-SLEDAI > 12 (severe group). Blood samples were obtained from patients and laboratory investigations were performed. All participants were examined using 3D-STI, the 3D conventional and strain parameters were obtained. The above parameters were compared in the three studied groups. Receiver operating curves (ROC) were prepared for above parameters and analyzed to identify correlations among LVEF, GLS, GCS, LVtw, Tor, MCI and hs-TropT. Results: Compared with the control group, the absolute values of LVEDV, LVEF, GLS, GCS, LVtw, Tor and MCI decreased, LV EDmass, LV ESmass and PSD increased in the mild-to-moderate and the severe groups (P2 < 0.05, P3 < 0.05). There was statistically significant difference in terms of strain parameters between the mild-to-moderate group and the severe group (P1 < 0.05). The highest area under the ROC for MCI was 0.909, the highest sensitivity for MCI was 90.00%, and the highest specificity for Tor was 86.67%. Correlation analysis showed that there was a good correlation between the MCI and hs-TropT (r = − 0.677). Conclusion: 3D-STI technology may help detect early changes in left ventricular systolic function in patients with SLE

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