HOMA-IR Mean Values in Healthy Individuals: A Population Based Study in Iranian Subjects
Abstract Aims HOMA-IR considers as the valid index for estimation of insulin sensitivity (IS) and insulin resistance (IR) in different pathological conditions. Few studies have evaluated the relation of IR with a broad group of health related-outcomes in population-based human subjects. In this population-based investigation, we sought to report the mean value of HOMA-IR in different subgroups of a large population-based database in Iranian healthy subjects. Methods This population-based study recruited adult healthy individuals between the ages of 18 to 70 years old who referred to Massoud Medical Laboratory, Tehran, Iran. Fasting insulin was measured by using the Electro chemiluminescence method using Roche Cobas 6000 e601/602 instrument. Results The mean value of HOMA-IR of the entire population was 2.11 ± 0.99. It was observed that the HOMA-IR index tended to be higher in age subgroups of 18–25 (839 individuals), 40–45 (642 individuals) and 35–40 (1179 individuals), HOMA-IR values of 2.17 ± 0.98, 2.19 ± 1.01, and 2.16 ± 1.01 respectively. Conclusion Our findings showed the mean value of 2.11 ± 0.99 HOMA-IR in the Iranian healthy population. Considering the large sample size in our study, more clinical investigations in terms of ethnicity should be done to provide a precise standardized HOMA-IR index in the Iranian population.