scholarly journals In Situ Gene Therapy Rescues Doxorubicin-induced Ovarian Damage via Adenovirus Mediated Sirt1 and Tgfbr2

2021 ◽  
Author(s):  
Lingwei Ma ◽  
Huan Lu ◽  
Yanzhi Feng ◽  
Yan Li ◽  
Su Zhou ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Gene Therapy ◽  
Cancer Patients ◽  
Female Cancer Patients ◽  
Key Genes ◽  
Ovarian Damage ◽  
Negative Impacts ◽  
Human And Mouse

Abstract Chemotherapy-induced ovarian damage and fertility loss have negative impacts on the quality of life for female cancer patients worldwide. Thus, we aimed to explore the feasibility and safety of gene therapy for prevention of such damage. First, we validated doxorubicin-induced ovarian damage in human and mouse ovarian tissues and identified two key genes (Sirt1 and Tgfbr2). Next, we generated AdV-Sirt1 and AdV-Tgfbr2 after vectors screening (AdV,AAV and LV) for their ability to transduce mouse ovaries. Finally, we conducted in situ ovarian injection of AdV-Sirt1 and AdV-Tgfbr2 in doxorubicin-treated mice and assessed their ovarian functions and reserves. The interventions dramatically alleviated doxorubicin-induced ovarian damage without apparently influencing the health status of their offspring. Together, our results indicate that AdV-Sirt1 and AdV-Tgfbr2 can serve as effective and safe agents for reducing doxorubicin-induced ovarian damage and also suggest that they may be potentially applicable for post-chemotherapy protection in female cancer patients.

Anger, Coping, and Quality of Life in Female Cancer Patients

2013 ◽  
Vol 41 (1) ◽  
pp. 135-142 ◽  
Author(s):  
Karolina Barinková ◽  
Margita Mesároová
Keyword(s):  
Quality Of Life ◽  
Cancer Patients ◽  
Psychological Intervention ◽  
Cognitive Strategies ◽  
Mood States ◽  
Profile Of Mood States ◽  
Brief Cope ◽  
Adult Cancer Survivors ◽  
Female Cancer Patients

The purpose of this study was to examine the relationships among anger, coping, and quality of life (QoL) in female cancer patients. We asked 144 female cancer patients with either a malignant or a benign diagnosis to complete the Profile of Mood States (POMS; McNair, Lorr, & Droppleman, 1971), the Brief COPE questionnaire (Carver, 1997), and the Quality of Life in Adult Cancer Survivors (QLACS; Avis et al., 2005) questionnaire. The total score indicating a low level of anger was significantly negatively associated with adaptive cognitive strategies and significantly positively associated with maladaptive coping strategies. Correlation analysis showed that there was a relationship between QoL factors and low anger scores. This knowledge may be incorporated in psychological intervention in the form of recognition and understanding of anger in cancer patients.

The impact of tailored nutrition intervention and dietary counseling on body weight in female cancer cachexia patients in India.

2014 ◽  
Vol 32 (31_suppl) ◽  
pp. 67-67
Author(s):  
Neha Kapoor ◽  
Ihab Tewfik ◽  
Jane Naufahu ◽  
Sundus Tewfik ◽  
Rakesh Garg ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Palliative Care ◽  
Body Weight ◽  
Cancer Patients ◽  
Muscle Mass ◽  
Cancer Cachexia ◽  
Intervention Group ◽  
Nutritional Counseling ◽  
Female Cancer Patients

67 Background: The prevalence of malnutrition, amongst cancer palliative patients, is 81%. As cancer progresses, patients’ develop malnutrition owing to metabolic changes and ill-effects of treatment. The aim of this study was to improve nutritional status of female cancer patients and their quality of life by counseling and providing nutrient rich natural food (IAtta). Methods: Female cancer patients (n=45) attending palliative care clinic (AIIMS, New Delhi); with symptoms of cachexia were randomly distributed into control (Group one, n=23) and intervention group (Group two, n=22). Both groups were provided with nutritional counseling while the intervention group also received 100grams of IAtta, to be consumed daily for three months. Anthropometric measurements [weight, muscle mass, percentage body fat (%BF) and mid upper arm circumference (MUAC)], dietary intake (two day dietary recall) and quality of life (European Organisation for Research and Treatment of Cancer-Quality of Life C30 Questionnaire) were assessed at baseline and after three months. Data was analysed using paired t-test and Wilcoxon signed-rank test on the variables assessed. P-value < 0.05 was considered statistically significant at 95% confidence interval. Results: Patients in group one had significantly decreased body weight (p= 0.001), muscle mass (p= 0.021), MUAC (p= 0.005) and %BF (p= 0.001) by end of three months. While patients in group two reported significant improvement in fatigue (p= 0.001) and appetite loss score (p= 0.002) under quality of life domains. Conclusions: Nutritional counseling along with IAtta food supplementation helps in stabilising weight and improves quality of life of cancer cachexia patients undergoing palliative care treatment. Clinical trial information: RP- 02/17.06.2013. [Table: see text]

Prospective Assessment of Quality of Life of Female Cancer Patients

2002 ◽  
Vol 85 (1) ◽  
pp. 140-147 ◽  
Author(s):  
E. Greimel ◽  
I. Thiel ◽  
F. Peintinger ◽  
I. Cegnar ◽  
E. Pongratz
Keyword(s):  
Quality Of Life ◽  
Cancer Patients ◽  
Female Cancer Patients ◽  
Prospective Assessment

scholarly journals IMPACT OF CANCER ON QUALITY OF LIFE & DEPRESSION AMONG CAREGIVERS

2022 ◽  
Vol 71 (6) ◽  
pp. 2216-19
Author(s):  
Mahwash Zulfiqar Khan ◽  
Nusrat Qamar ◽  
Shahbaz Ahmad ◽  
AbuBakar Siddique
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
Negative Impact ◽  
Breast Cancer Patients ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Female Cancer Patients ◽  
The Impact

Objective: To determine the impact of cancer on quality of life and depression among caregivers. Study Design: Cross-sectional survey. Place and Duration of Study: Anmol Hospital, Lahore, from Jul 2019 to Jan 2020. Methodology: Data collected from caregivers of female cancer patients by purposive sampling technique using Standardized Questionnaire of Caregiver Assistance Scale and emotional distress was assessed by the Profile of Mood States. Data were entered into Statistical Package for Social Sciences for statistical analysis. Results: Among 110 participants (caregivers of female cancer patients) 28 (25.5%) were female while 82 (74.5%) were male caregivers. Patients other than breast cancer were 79 (71.8%), while breast cancer patients were 31 (28.2%). There was a significant association between caregiver health, quality of life and level of depression, one year ago, and at current with p-values= 0.001, 0.001 and 0.01 respectively. Conclusion: There was a negative impact on the health and quality of life of caregivers. Their health was better in the beginning but with time, their lives became more difficult.

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