scholarly journals Multifocal EBV-Associated and CMV-Correlated Post-Transplant Smooth Muscle Tumor: A Case After Liver Transplantation

2021 ◽  
Author(s):  
Mohammad Hossein Anbardar ◽  
Neda Soleimani ◽  
Dornaz Safavi ◽  
Ahad Eshraghian ◽  
Abbas Ayoub
Keyword(s):  
Liver Transplantation ◽  
Smooth Muscle ◽  
Spindle Cell ◽  
Smooth Muscle Tumor ◽  
Cmv Infection ◽  
Post Transplant ◽  
Smooth Muscle Tumors ◽  
Microscopic Evaluation ◽  
Paraffin Block ◽  
Muscle Tumor

Abstract IntroductionImmunodeficient patients, including the recipients of solid organs, exhibit an increase in the incidence of neoplasms. Post-transplant smooth muscle tumor (PTSMT) is a distinct and infrequent entity of these groups of neoplasms. Epstein–Barr virus (EBV) is considered to be involved in the etiology of this neoplasm.Case reportA 28-year-old man who underwent liver transplantation presented with abdominal pain and diarrhea for several months. He had a history of resistant systemic cytomegalovirus (CMV) infection after transplantation. On physical examination, he had mild abdominal tenderness. Spiral chest and abdominopelvic CT scan with contrast showed a liver lesion with ring enhancement; furthermore, it showed a solid lesion in the spleen and multiple small lesions in lower lobes of both lungs. Colonoscopy revealed multiple small raised polypoid lesions throughout the rectum and colon. Microscopic evaluation of colon mucosa biopsy using IHC study was in favor of spindle cell neoplasm with high proliferative index. He underwent a right hemicolectomy. A microscopic study showed spindle cell proliferation with mild atypia and a mild increase in mitotic rate without any necrosis, with features of smooth muscle tumor. Trucut biopsy of liver mass was also in favor of smooth muscle tumor. According to transplantation history and considering the possibility of EBV-associated smooth muscle tumor, EBV encoded RNA (EBER) chromogenic in-situ hybridization (CISH) study on paraffin block of colon lesions was requested, which demonstrated EBV RNA in tumor cell nuclei and immunoblasts of the adjacent lymph node, suggesting EBV-associated smooth muscle tumor. In addition, PCR for CMV was requested on paraffin block of the colon lesions, which also showed a positive result. PCR for EBV and CMV viremia were negative. The dosage of immunosuppressive agents was reduced, and currently, he is being followed, with slow expansion in the size of the lesions.Conclusion Although the incidence of post-transplant smooth muscle tumors (PTSMTs) is low, it should be remained in the differential diagnosis in post-transplantation patients, especially dealing with multifocal tumors. As strong stimulant for smooth muscle tumors, close follow-up and screening for EBV and CMV infection and early treatment at the time of diagnosis are recommended to avoid these virus-induced tumors.

scholarly journals Multifocal EBV-associated smooth muscle tumors in a patient with cytomegalovirus infection after liver transplantation: a case report from Shiraz, Iran

2022 ◽  
Vol 17 (1) ◽  
Author(s):  
Mohammad Hossein Anbardar ◽  
Neda Soleimani ◽  
Dornaz Safavi ◽  
Ahad Eshraghian ◽  
Abbas Ayoub
Keyword(s):  
Liver Transplantation ◽  
Smooth Muscle ◽  
Case Report ◽  
Immunosuppressive Agents ◽  
Smooth Muscle Tumor ◽  
Cmv Infection ◽  
Post Transplant ◽  
Smooth Muscle Tumors ◽  
Spindle Cell Proliferation ◽  
Muscle Tumor

Abstract Introduction Immunodeficient patients, including the recipients of solid organs, exhibit an increase in the incidence of neoplasms. Post-transplant smooth muscle tumor (PTSMT) is a distinct and infrequent entity of these groups of neoplasms. Epstein–Barr virus (EBV) is considered to be involved in the etiology of this neoplasm. Case report A 28-year-old man who underwent liver transplantation presented with abdominal pain and diarrhea for several months. He had a history of resistant systemic cytomegalovirus (CMV) infection after transplantation. Radiologic evaluation and colonoscopy revealed multiple liver, spleen, lung, and colon lesions. Microscopic assessment of colon and liver lesions using IHC study were in favor of spindle cell proliferation with mild atypia and a mild increase in mitotic rate without any necrosis, with features of smooth muscle tumor. Considering the transplantation history, EBER chromogenic in situ hybridization (CISH) study on paraffin blocks was requested, which demonstrated EBV RNA in tumor cell nuclei, suggesting EBV-associated smooth muscle tumor. In addition, PCR for CMV on paraffin blocks was positive. PCR for EBV and CMV viremia were negative. The dosage of immunosuppressive agents was reduced, and currently, he is being followed, with slow expansion in the size of the lesions. Conclusion Although the incidence of post-transplant smooth muscle tumors (PTSMTs) is low, it should be remained in the differential diagnosis in post-transplantation patients, especially dealing with multifocal tumors. As strong stimulant for smooth muscle tumors, close follow-up and screening for EBV and CMV infection and early treatment at the time of diagnosis are recommended to avoid these virus-induced tumors.

Epstein-Barr Virus–Associated Smooth Muscle Tumor of the Iris in a Patient With Transplant: A Case Report and Review of the Literature

2009 ◽  
Vol 133 (8) ◽  
pp. 1238-1241
Author(s):  
Le Yu ◽  
Anthony J. Aldave ◽  
Ben J. Glasgow
Keyword(s):  
Smooth Muscle ◽  
Virus Infection ◽  
Epstein Barr Virus ◽  
Smooth Muscle Tumor ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Smooth Muscle Tumors ◽  
Epstein Barr ◽  
Barr Virus Infection ◽  
Muscle Tumor

Abstract Epstein-Barr virus infection has been linked to the development of smooth muscle tumors in immunocompromised patients with organ transplants and acquired immunodeficiency syndrome. A 52-year-old female recipient of a renal transplant presented with enlarging masses of the left iris. Incisional biopsy of the mass revealed a smooth muscle tumor of the iris. Epstein-Barr virus infection was confirmed by in situ hybridization for Epstein-Barr virus–encoded, small RNA in tumor cells. Eight months after total iridectomy the patient was free of disease. Although the prognosis and classification of Epstein-Barr virus–associated smooth muscle tumors are controversial, mortalities caused by these tumors are rare.

Multicentric intracranial smooth-muscle tumor in a woman with human immunodeficiency virus

2000 ◽  
Vol 93 (4) ◽  
pp. 701-703 ◽  
Author(s):  
Jonathan S. Citow ◽  
Leonard Kranzler
Keyword(s):  
Human Immunodeficiency Virus ◽  
Smooth Muscle ◽  
Smooth Muscle Tumor ◽  
Content Type ◽  
Parasellar Region ◽  
Smooth Muscle Tumors ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Muscle Tumor

✓ A 31-year-old woman with acquired immunodeficiency syndrome (AIDS) was found to harbor both a pulmonary smooth-muscle tumor and an intracranial extraaxial smooth-muscle tumor of the parasellar region. The frequency of smooth-muscle tumors (leiomyoma and leiomyosarcoma) has increased with AIDS, but much more so in children than in adults. Only nine cases of human immunodeficiency virus—related smooth-muscle tumors have been previously reported in adults, and only one of these was located intracranially.

Epstein-Barr virus-associated post-transplant primary smooth muscle tumor of the liver: Report of an autopsy case

1996 ◽  
Vol 46 (8) ◽  
pp. 601-604 ◽  
Author(s):  
Yoshito Sadahira ◽  
Takuya Moriya ◽  
Teruo Shirabe ◽  
Tsuyoshi Matsuno ◽  
Toshiaki Manabe
Keyword(s):  
Smooth Muscle ◽  
Epstein Barr Virus ◽  
Smooth Muscle Tumor ◽  
Autopsy Case ◽  
Post Transplant ◽  
Barr Virus ◽  
Epstein Barr ◽  
Muscle Tumor

Epstein-Barr Virus-Associated Smooth Muscle Tumor of the Basal Ganglia in an HIV+ Child: Case Report and Review of the Literature

2004 ◽  
Vol 7 (2) ◽  
pp. 198-203 ◽  
Author(s):  
Shimareet Kumar ◽  
Mariarita Santi ◽  
Gilbert Vezina ◽  
Tena Rosser ◽  
Roma S. Chandra ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Basal Ganglia ◽  
Epstein Barr Virus ◽  
Smooth Muscle Tumor ◽  
Barr Virus ◽  
Smooth Muscle Tumors ◽  
Immunodeficiency Virus ◽  
Epstein Barr ◽  
Mass Lesions ◽  
Muscle Tumor

We describe the clinicopathologic features of an Epstein-Barr virus (EBV)-associated smooth muscle tumor arising in the basal ganglia of a 10-year-old human immunodeficiency virus (HIV)-positive child. Only a few cases of intracranial smooth muscle tumors are reported in the literature and virtually all of these have been extra-axial, involving the dura or sinuses in HIV+ adults. Our case underscores the need to include an EBV-associated smooth muscle tumor in the differential diagnosis when evaluating intracranial mass lesions in immunodeficient children.

Smooth Muscle Tumors of the Breast: Clinicopathologic Features of Two Cases

1994 ◽  
Vol 80 (3) ◽  
pp. 241-245 ◽  
Author(s):  
Amedeo Boscaino ◽  
Gerardo Ferrara ◽  
Pasquale Orabona ◽  
Vittoria Donofrio ◽  
Stefania Staibano ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Tumor ◽  
Mitotic Rate ◽  
Grey Zone ◽  
High Tendency ◽  
Smooth Muscle Tumors ◽  
Eosinophilic Cytoplasm ◽  
The Common ◽  
Ancillary Features ◽  
Muscle Tumor

Two cases of smooth muscle tumor of the breast with high tendency to local relapses are reported. The common cytohistologic feature of these infrequent neoplasms is interfacing bundles with spindle-shaped cells showing eosinophilic cytoplasm and blunt-ended nuclei. In estimating the prognosis of these lesions, the mitotic index must be evaluated together with evidence of necrosis and hypercellularity. The present cases suggest that, in the absence of the ancillary features, a mitotic rate of 1-3 × 10 HPF might define a “grey zone” in the spectrum of lesions between leiomyomas and leiomyosarcomas: the smooth muscle tumors of indeterminate prognosis (low risk lesions).

scholarly journals Smooth Muscle Tumor Originating in the Pleura: A Case Report and Updated Literature Review

2016 ◽  
Vol 2016 ◽  
pp. 1-6
Author(s):  
Santiago Fabián Moscoso Martínez ◽  
Vadim Zarubin ◽  
Geethapriya Rajasekaran Rathnakumar ◽  
Alireza Zarineh
Keyword(s):  
Computed Tomography ◽  
Smooth Muscle ◽  
Thoracoscopic Surgery ◽  
Smooth Muscle Tumor ◽  
Malignant Potential ◽  
Definitive Diagnosis ◽  
Pleuritic Chest Pain ◽  
Smooth Muscle Tumors ◽  
Video Assisted Thoracoscopic Surgery ◽  
Muscle Tumor

Smooth muscle tumors (SMTs) of the pleura are exceptionally rare. At present and to the best of these authors’ knowledge, there are only 17 cases reported in the literature. We describe a case of a 51-year-old woman who complained of left sided pleuritic chest pain. Further, computed tomography (CT) revealed a left sided localized pleural-based mass involving the 9th rib. She underwent an interventional radiology guided percutaneous core biopsy of the lesion, which disclosed a “Smooth Muscle Tumor of Undetermined Malignant Potential (SMT-UMP).” A video-assisted thoracoscopic surgery (VATS) was performed for diagnosis and treatment purposes. Resections of the pleural-based mass and 9th rib were performed. SMT-UMP was the definitive diagnosis.

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