scholarly journals Is it necessary to monitor the serum luteinizing hormone(LH) concentration on the human chorionic gonadotropin (HCG) day among young women during the follicular-phase long protocol? ：A retrospective cohort study

2021 ◽  
Author(s):  
Wenjuan Zhang ◽  
Zhaozhao Liu ◽  
Manman Liu ◽  
Jiaheng Li ◽  
Yichun Guan
Keyword(s):  
Cohort Study ◽  
Young Women ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Follicular Phase ◽  
Preimplantation Genetic Testing ◽  
Vitro Fertilization ◽  
Significant Difference ◽  
Long Protocol

Abstract Background The normal physiological function of LH requires a certain concentration range, but because of pituitary desensitization, even on the HCG day, endogenous levels of LH are low in the follicular-phase long protocol. So our study aimed to determine whether it is necessary to monitor serum LH concentrations and to determine whether there is an optimal LH range to achieve the desired clinical outcome. Methods A retrospective cohort study included 4503 cycles of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) units from January 1, 2016, to June 30, 2019, in a single department. The main outcome measures included retrieved eggs, available embryos, live birth rate. Results Divided the LHHCG into five groups: Group A (LH ≤ 0.5), Group B (0.5 IU/L < LH ≤ 1.2 IU/L), Group C (1.2 IU/L < LH ≤ 2.0 IU/L), Group D (2.0 IU/L < LH ≤ 5.0 IU/L), Group E (LH > 5 IU/L). In terms of the numbers of retrieved eggs, embryos, high-quality embryos and diploid fertilized oocytes, an increase of the LHHCG level showed a trend of a gradual decrease. However, there was no significant difference in clinical outcomes among the groups.By adjusting for confounding factors, with an increase in LHHCG, the number of retrieved eggs decreased. Conclusion In the follicular-phase long protocol among young women, monitoring of LHHCG are recommended in the clinical guidelines. What’s more, those who undergo Preimplantation Genetic Testing(PGT) may benefit more when the LH level is controlled within a certain range.

scholarly journals Miscarriage Rates due to Endometriosis: A Retrospective Cohort Study

2020 ◽  
pp. 1
Author(s):  
Pinar Calis ◽  
Gizem Isik ◽  
Dilara Duygulu ◽  
Nuray Bozkurt ◽  
Deniz Karcaaltincaba
Keyword(s):  
Cohort Study ◽  
In Vitro Fertilization ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Control Group ◽  
Pathology Report ◽  
Miscarriage Rate ◽  
Vitro Fertilization ◽  
Significant Difference

<p><strong>OBJECTIVE:</strong> To find the differences of miscarriage rates between pregnant patients with and without endometriosis. </p><p><strong>STUDY DESIGN:</strong> The retrospective cohort study was conducted in the Department of Obstetrics and Gynecology, School of Medicine, Gazi University between January-2015 and December-2018. Patients were divided into two groups; endometriosis and non-endometriosis according to their pathology report and ultrasound examination. In both groups, miscarriage rates and in vitro fertilization pregnancy ratios were analyzed. Miscarriage rates in in vitro fertilization pregnancies and in endometriosis group who had and didn't have surgery also analyzed.</p><p><strong>RESULTS:</strong> Sixty-two patients in the study group and 65 patients in the control group were included. There was no significant difference in miscarriage rates between endometriosis and non-endometriosis group (20/62 (32%) and 13/65 (20%), respectively, p=0.124). There was a statistically significant difference in miscarriage rates between in vitro fertilization and non-in vitro fertilization group (p=0.004). Apart from that, in in vitro fertilization group, the miscarriage rate was higher in the endometrioma subgroup than non-endometrioma (p=0.008).</p><p><strong>CONCLUSION:</strong> There was an only significant difference in miscarriage rate in the in vitro fertilization group between endometrioma and non-endometrioma patients. In the future, there should be more studies to define the actual pathophysiology for miscarriage with endometriosis.</p>

Effect of Advanced Paternal Age on Reproductive Outcomes in IVF Cycles of Nonmale Factor Infertility: a Retrospective Cohort Study

2021 ◽  
Author(s):  
Xinmei Lu ◽  
Yubing Liu ◽  
Xiang Cao ◽  
Doudou Zhang ◽  
Tiancheng Zhang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Multiple Pregnancy ◽  
Age Groups ◽  
Paternal Age ◽  
Semen Parameters ◽  
Miscarriage Rate ◽  
Vitro Fertilization

Abstract Background: Female age over 35 years has been considered a determinant factor and increases the risk of infertility. However, paternal age has been virtually ignored, and its potential role is still poorly investigated. There is no current consensus on the effects of paternal age on assisted reproductive technology（ART）outcomes. Methods: In total, 381 in vitro fertilization (IVF) cycles of nonmale factor infertility (paternal age <35 y in 261 cycles, 35– 39 y in 72 cycles and ≥ 40 y in 48 cycles) were involved in this retrospective cohort study. Maternal age was controlled at under 35 years old. Embryo quality, clinical and neonatal outcomes were compared.Results: Among different paternal age groups, fertilization rate and high-quality embryos were not significantly different (P> 0.05). Compared with the <35 y group, pregnancy rate was not significantly different in the 35–39 y group (P> 0.05), but significantly lower in the ≥ 40 y group(P < 0.05). Additionally, we found a statistically significantly lower implantation rate for men aged ≥40 years (18.8%) compared to the group of men aged <35 years (31.1%) and men aged 35-39 years (30.0%) (P <0.05). A declining trend in the live birth rate (30.6%, 21.7%, and 19.6%) was noted in the subgroups of paternal age (<35 y, 35-39 y, and ≥40 y) (P >0.05). The miscarriage rate was significantly higher in the 35–39 y (44.8%) than that in the <35 y group (21.0%)(P <0.05). While in the oldest group of paternal age ≥ 40 y, although miscarriage rate increased but not significantly different (P >0.05). There were no significant differences in the preterm birth or multiple pregnancy rates among the different paternal age groups (P >0.05). Ectopic pregnancy was only found in the paternal age <35 y group. There was no abnormality in the birth weight of newborns among the different male age groups. Conclusion: Paternal age over 40 years is a key risk factor that influences the ART success rate even with good semen parameters, though has no impact on embryo development.

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