scholarly journals CEST MRI Provides Amides/amines Surrogate Biomarkers for Treatment-naïve Glioma Sub-typing

2021 ◽  
Author(s):  
Laura Mancini ◽  
Stefano Casagranda ◽  
Guillaume Gautier ◽  
Philippe Peter ◽  
Bruno Lopez ◽  
...  
Keyword(s):  
Patient Management ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Idh Mutation ◽  
Saturation Transfer ◽  
Magnetisation Transfer Ratio ◽  
Clinical Value ◽  
Cest Mri ◽  
Treatment Naïve ◽  
Glioma Classification

Abstract PurposeAccurate gliomas classification affects patient management and is challenging on non- or low-enhancing gliomas. This study investigated the clinical value of different Chemical Exchange Saturation Transfer (CEST) metrics for glioma classification and assessed the diagnostic effect of the presence of abundant fluid in gliomas subpopulations.MethodsForty-five treatment-naïve glioma patients with known isocitrate dehydrogenase (IDH) mutation and 1p/19q codeletion status received CEST MRI at 3T. Magnetisation transfer ratio asymmetry and CEST metrics (amides: offset range 3-4ppm, amines: 1.5-2.5ppm, amides/amines ratio) were calculated with two models: ‘asymmetry-based’ (AB) and ‘fluid-suppressed’ (FS). Presence of T2/FLAIR mismatch was noted.ResultsIDH-wildtype had higher amides/amines ratio than IDH-mutant_1p/19qcodel (p<0.022). Amides/amines ratio and amines levels differentiated IDH-wildtype from IDH-mutant (p<0.0045) and from IDH-mutant_1p/19qret (p<0.021). IDH-mutant_1p/19qret had higher amides and amines than IDH-mutant_1p/19qcodel (p<0.035). IDH-mutant_1p/19qret with AB/FS mismatch had higher amines than IDH-mutant_1p/19qret without AB/FS mismatch (p<0.016). In IDH-mutant_1p/19qret, the presence of AB/FS mismatch was closely related to the presence of T2/FLAIR mismatch (p=0.014).ConclusionsCEST-derived biomarkers for amides, amines and their ratio can help with histomolecular staging in gliomas without intense contrast enhancement. T2/FLAIR mismatch is reflected in the presence of AB/FS CEST mismatch. The AB/FS CEST mismatch identifies glioma sub-groups that may have prognostic and clinical relevance.

scholarly journals CEST MRI provides amide/amine surrogate biomarkers for treatment-naïve glioma sub-typing

2022 ◽  
Author(s):  
Laura Mancini ◽  
Stefano Casagranda ◽  
Guillaume Gautier ◽  
Philippe Peter ◽  
Bruno Lopez ◽  
...  
Keyword(s):  
Chemical Exchange ◽  
Magnetization Transfer ◽  
Chemical Exchange Saturation Transfer ◽  
Magnetization Transfer Ratio ◽  
Saturation Transfer ◽  
Wild Type ◽  
Clinical Value ◽  
Cest Mri ◽  
Treatment Naïve ◽  
Glioma Classification

Abstract Purpose Accurate glioma classification affects patient management and is challenging on non- or low-enhancing gliomas. This study investigated the clinical value of different chemical exchange saturation transfer (CEST) metrics for glioma classification and assessed the diagnostic effect of the presence of abundant fluid in glioma subpopulations. Methods Forty-five treatment-naïve glioma patients with known isocitrate dehydrogenase (IDH) mutation and 1p/19q codeletion status received CEST MRI (B1rms = 2μT, Tsat = 3.5 s) at 3 T. Magnetization transfer ratio asymmetry and CEST metrics (amides: offset range 3–4 ppm, amines: 1.5–2.5 ppm, amide/amine ratio) were calculated with two models: ‘asymmetry-based’ (AB) and ‘fluid-suppressed’ (FS). The presence of T2/FLAIR mismatch was noted. Results IDH-wild type had higher amide/amine ratio than IDH-mutant_1p/19qcodel (p < 0.022). Amide/amine ratio and amine levels differentiated IDH-wild type from IDH-mutant (p < 0.0045) and from IDH-mutant_1p/19qret (p < 0.021). IDH-mutant_1p/19qret had higher amides and amines than IDH-mutant_1p/19qcodel (p < 0.035). IDH-mutant_1p/19qret with AB/FS mismatch had higher amines than IDH-mutant_1p/19qret without AB/FS mismatch ( < 0.016). In IDH-mutant_1p/19qret, the presence of AB/FS mismatch was closely related to the presence of T2/FLAIR mismatch (p = 0.014). Conclusions CEST-derived biomarkers for amides, amines, and their ratio can help with histomolecular staging in gliomas without intense contrast enhancement. T2/FLAIR mismatch is reflected in the presence of AB/FS CEST mismatch. The AB/FS CEST mismatch identifies glioma subgroups that may have prognostic and clinical relevance.

scholarly journals A generalized ratiometric chemical exchange saturation transfer (CEST) MRI approach for mapping renal pH using iopamidol

2017 ◽  
Vol 79 (3) ◽  
pp. 1553-1558 ◽  
Author(s):  
Yin Wu ◽  
Iris Y. Zhou ◽  
Takahiro Igarashi ◽  
Dario L. Longo ◽  
Silvio Aime ◽  
...  
Keyword(s):  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Cest Mri

scholarly journals Renal pH Imaging Using Chemical Exchange Saturation Transfer (CEST) MRI: Basic Concept

2021 ◽  
pp. 241-256
Author(s):  
Dario Livio Longo ◽  
Pietro Irrera ◽  
Lorena Consolino ◽  
Phillip Zhe Sun ◽  
Michael T. McMahon
Keyword(s):  
Chemical Exchange ◽  
Kidney Diseases ◽  
Chemical Exchange Saturation Transfer ◽  
Functional Information ◽  
Saturation Transfer ◽  
Ph Changes ◽  
Ph Imaging ◽  
Cest Mri ◽  
Magnetic Resonance Imaging Mri ◽  
Renal Mri

AbstractMagnetic Resonance Imaging (MRI) has been actively explored in the last several decades for assessing renal function by providing several physiological information, including glomerular filtration rate, renal plasma flow, tissue oxygenation and water diffusion. Within MRI, the developing field of chemical exchange saturation transfer (CEST) has potential to provide further functional information for diagnosing kidney diseases. Both endogenous produced molecules as well as exogenously administered CEST agents have been exploited for providing functional information related to kidney diseases in preclinical studies. In particular, CEST MRI has been exploited for assessing the acid-base homeostasis in the kidney and for monitoring pH changes in several disease models. This review summarizes several CEST MRI procedures for assessing kidney functionality and pH, for monitoring renal pH changes in different kidney injury models and for evaluating renal allograft rejection.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction chapter is complemented by two separate chapters describing the experimental procedure and data analysis.

scholarly journals A method for accurate pH mapping with chemical exchange saturation transfer (CEST) MRI

2015 ◽  
Vol 11 (3) ◽  
pp. 195-202 ◽  
Author(s):  
Phillip Zhe Sun ◽  
Gang Xiao ◽  
Iris Yuwen Zhou ◽  
Yingkun Guo ◽  
Renhua Wu
Keyword(s):  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Cest Mri
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