Transformations in Plasma Metabolic Profiles of Patients with Major Depression During Treatment: A Pilot Metabolomics Study

2021 ◽  
Author(s):  
Xixuan Li ◽  
Shufang Zhang ◽  
Jingxuan Tan ◽  
Ying Zhu ◽  
Xuejia Zhai ◽  
...  
Keyword(s):  
Major Depression ◽  
Large Scale ◽  
Mental Disease ◽  
Sample Size Calculation ◽  
Self Control ◽  
Metabolic Profiles ◽  
Healthy Controls ◽  
Physical And Mental Health ◽  
Variation Trend ◽  
Kegg Pathways

Abstract Background Major depression disorder (MDD) is a mental disease that seriously endangers human physical and mental health. The purpose of present study is to detect the differences of plasma metabolic profiles between MDD patients and healthy controls. Moreover, the hospitalization process of MDD patients was followed to explore the reversal of metabolic abnormalities in MDD patients by conventional treatment in the form of self-control.Methods Ultra-Performance Liquid Chromatography- Mass Spectrometry (UPLC-MS) was used to detect the metabolic profiles in 47 plasma samples from 12 controls and 12 MDD patients. Multivariate statistical analysis and K-means clustering were operated to search for significantly different metabolites (SDMs) between pair-comparison groups and specific metabolites (SMs) with ideal variation trend in relative content. Finally, the metabolites were integrated into Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways to preliminarily explore the potential mechanism of MDD disrupting the metabolic process.Results There were significant differences in plasma metabolic profiles between healthy controls and MDD patients. A total of 14 SDMs between untreated MDD patients and healthy controls were classified into the top ten KEGG pathways enrichment, among which the relative contents of 4 SMs, 9-HPODE, imidazoleacetic acid, thromboxane B2 (TXB2), and arachidonic acid (AA) showed a regular variation trend after MDD patients’ treatment. A new metabolite-pathway network containing 4 SMs and 8 pathways was accessed after further integration analysis. The sample size calculation showed that a verification set of 84-135 subjects (containing healthy controls and MDD paients) was desired to confirm the results of this study.Conclusion The results indicate that the transition in metabolic pathways during the occurrence and treatment process of MDD is mainly dominated by transformations in lipid metabolism and its relevant signaling pathway system. Additionally, histidine metabolism is also engaged. Subsequent large-scale validation study is acquired to evaluate whether the selected metabolites have the potential to diagnose and access the therapeutic effect of MDD, and to explore the probable mechanism of MDD in combination with other technologies.

GR-mediated FKBP5 RNA induction differentially influenced by weight in major depression and healthy controls

2013 ◽  
Vol 46 (06) ◽  
Author(s):  
A Menke ◽  
S Kloiber ◽  
J Best ◽  
M Rex-Haffner ◽  
M Uhr ◽  
...  
Keyword(s):  
Major Depression ◽  
Healthy Controls

Hippocampal and amygdala volume changes in patients with major depression and healthy controls during a three year follow-up

2005 ◽  
Vol 38 (05) ◽  
Author(s):  
TS Frodl ◽  
T Zetzsche ◽  
G Schmitt ◽  
T Schlossbauer ◽  
MW Jäger ◽  
...  
Keyword(s):  
Major Depression ◽  
Healthy Controls ◽  
Volume Changes ◽  
Amygdala Volume

scholarly journals The Effects of COVID-19 Pandemic on Stress Vulnerability of Nursing Students According to Labour Market Status

Healthcare ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 633
Author(s):  
Mihaela Simionescu ◽  
Angelo Pellegrini ◽  
Elena-Nicoleta Bordea
Keyword(s):  
Nursing Students ◽  
Self Control ◽  
Stress Factors ◽  
Physical And Mental Health ◽  
Coping With Stress ◽  
Spiritual Dimension ◽  
Stressful Environment ◽  
Stress Vulnerability ◽  
Market Status ◽  
Labour Market Status

Nursing has always been a stressful job affecting the physical and mental health of the nurses, but the new medical context of the COVID-19 pandemic has enhanced this issue. The objective of this paper is to study differences between non-employed and employed nursing students in the medical system of Romania before and during the epidemic using matching methods and a sample of 526 nursing students. Stressors and strategies for coping with stress were also identified during the pandemic. The results indicated that employed students were more vulnerable to stress compared to non-employed ones before and during the pandemic. Females registered significantly higher stress scores compared to males in the period of the epidemic. The analysis of the overall sample suggested that gender and environment were significant stress factors during the pandemic, but living conditions were not relevant. The most effective coping strategies against stress for nurses during the COVID-19 crisis were based on self-control and the spiritual dimension, unlike the previous period when other colleagues’ support helped most nurses to overcome difficult working conditions. The implications of this study might help medical management in ensuring a less stressful environment for nurses during the epidemic.

Autoantibody reactivity in serum of patients with major depression, schizophrenia and healthy controls

2008 ◽  
Vol 158 (1) ◽  
pp. 83-86 ◽  
Author(s):  
Christoph Laske ◽  
Meta Zank ◽  
Reinhild Klein ◽  
Elke Stransky ◽  
Anil Batra ◽  
...  
Keyword(s):  
Major Depression ◽  
Healthy Controls

scholarly journals Symptoms of Depression, Anxiety, and Stress and Prevalence of Major Depression and Its Predictors in Female University Students

2021 ◽  
Vol 18 (11) ◽  
pp. 5845
Author(s):  
Vanessa Blanco ◽  
Mar Salmerón ◽  
Patricia Otero ◽  
Fernando L. Vázquez
Keyword(s):  
Major Depression ◽  
University Students ◽  
Cross Sectional Study ◽  
Physical And Mental Health ◽  
Cross Sectional ◽  
Academic Characteristics ◽  
Santiago De Compostela ◽  
University Women ◽  
Symptoms Of Depression ◽  
Life Engagement

Depression, anxiety and stress are increasingly concerning phenomena in our society, with serious consequences on physical and mental health. The repercussions may be particularly devastating in particular population subgroups, such as female university students. The purpose of this study was to determine the levels of depression, anxiety, and stress and the prevalence of depression and associated factors, in Spanish university women. A cross-sectional study was conducted with a random sample of 871 students from the Santiago de Compostela University (mean age 20.7 years, SD = 2.8). Information was collected on sociodemographic and academic characteristics; symptoms of depression, anxiety, and stress; diagnosis of major depression; optimism, resilience, social support, life engagement, and five personality domains, using validated instruments. Of the participants, 18.1%, 22.8% and 13.5% presented with severe/very severe levels of depression, anxiety and stress, respectively. A total of 12.9% had major depression. Higher life engagement was associated with lower risk of depression (OR = 0.92, 95% CI 0.87–0.98), while higher levels of neuroticism (OR = 1.20, 95% CI, 1.12–1.28) and openness to experience (OR = 1.08, 95% CI, 1.02–1.14) were associated with greater risk. These findings reveal an alarming percentage of female university students who experience major depression and severe/very severe stress.

scholarly journals Mitigating the global health threat of violent conflict: a preventive framework

2020 ◽  
pp. bmjnph-2020-000114
Author(s):  
Daniel Shapiro ◽  
Catherine Hua
Keyword(s):  
Global Health ◽  
Large Scale ◽  
Warning Signs ◽  
Violent Conflict ◽  
Physical And Mental Health ◽  
Educational Support ◽  
Early Warning Signs ◽  
Health Community ◽  
Practice Based Research ◽  
Preventive Role

Objective To examine the problem of large-scale violent conflict and the unique preventive role that the global health community can play.Methods We conducted a comprehensive literature review and extrapolated insights from practice-based research and consultation with leaders and grassroot organisations confronting emergent and ongoing large-scale conflict.Results The field of global health has thoroughly investigated the physical and mental health consequences of violent conflict, yet there is a dire need for preventive research and action.Conclusions Global health scholars and practitioners are well-positioned to track early warning signs of violence, construct predictive models of its outbreak, lobby for policy reform to address the structural roots of conflict, and provide mediation and educational support to mitigate emerging conflict.

scholarly journals The Sense of Smell and Aging: What We Have Learned From Population Studies

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 810-811
Author(s):  
Jayant Pinto
Keyword(s):  
Mental Health ◽  
Older Adults ◽  
Social Life ◽  
Large Scale ◽  
Population Studies ◽  
Vital Role ◽  
Sensory Function ◽  
Physical And Mental Health ◽  
Sense Of Smell ◽  
Health Aging

Abstract Decline of the sense of smell with age causes a marked impact on older adults, markedly reducing quality of life. Olfactory dysfunction impairs nutrition, decreases the ability to experience pleasure, and results in depression, among other burdens. Large-scale population studies have identified impaired olfaction as a key heath indicator that predicts the development of decreased physical and mental health, reduced physical activity, weight loss, mild cognitive impairment and dementia, and mortality itself. These data have been generated via analyses of data from several aging cohorts, including the National Social Life, Health, and Aging Project (NSHAP); the Beaver Dam cohort; the Atherosclerosis Risk in Communities project; the Rush Memory and Aging Project; the Health, Aging, and Body Composition project; the Washington Heights/Inwood Columbia Aging Project; among others. In this presentation, we will review the close connection between olfaction, health, aging, including discussion of insights from these studies. We will also discuss emerging data from NSHAP on the effects of sensory function on cognition, mental health, and social interaction, which demonstrate that sensory function plays a vital role in the lives of older adults. Part of a symposium sponsored by Sensory Health Interest Group.

Statistical methods for unidirectional switch designs: Past, present, and future

2017 ◽  
Vol 27 (9) ◽  
pp. 2872-2882 ◽  
Author(s):  
Zhuozhao Zhan ◽  
Geertruida H de Bock ◽  
Edwin R van den Heuvel
Keyword(s):  
Statistical Methods ◽  
Large Scale ◽  
Sample Size Calculation ◽  
Complex Interventions ◽  
New Drugs ◽  
Control Treatment ◽  
Future Research ◽  
Control Group ◽  
Unified Framework ◽  
New Treatment

Clinical trials may apply or use a sequential introduction of a new treatment to determine its efficacy or effectiveness with respect to a control treatment. The reasons for choosing a particular switch design have different origins. For instance, they may be implemented for ethical or logistic reasons or for studying disease-modifying effects. Large-scale pragmatic trials with complex interventions often use stepped wedge designs (SWDs), where all participants start at the control group, and during the trial, the control treatment is switched to the new intervention at different moments. They typically use cross-sectional data and cluster randomization. On the other hand, new drugs for inhibition of cognitive decline in Alzheimer’s or Parkinson’s disease typically use delayed start designs (DSDs). Here, participants start in a parallel group design and at a certain moment in the trial, (part of) the control group switches to the new treatment. The studies are longitudinal in nature, and individuals are being randomized. Statistical methods for these unidirectional switch designs (USD) are quite complex and incomparable, and they have been developed by various authors under different terminologies, model specifications, and assumptions. This imposes unnecessary barriers for researchers to compare results or choose the most appropriate method for their own needs. This paper provides an overview of past and current statistical developments for the USDs (SWD and DSD). All designs are formulated in a unified framework of treatment patterns to make comparisons between switch designs easier. The focus is primarily on statistical models, methods of estimation, sample size calculation, and optimal designs for estimation of the treatment effect. Other relevant open issues are being discussed as well to provide suggestions for future research in USDs.

The citalopram challenge test in patients with major depression and in healthy controls

1999 ◽  
Vol 88 (2) ◽  
pp. 75-88 ◽  
Author(s):  
Thomas Kapitany ◽  
Monika Schindl ◽  
Shird D Schindler ◽  
Barbara Heßelmann ◽  
Thomas Füreder ◽  
...  
Keyword(s):  
Major Depression ◽  
Challenge Test ◽  
Healthy Controls

Research Progress of Essential Oil as a New Complementary Therapy in the Treatment of Depression

2021 ◽  
Vol 21 ◽  
Author(s):  
Xinli Liang ◽  
Xinli Wang ◽  
Guowei Zhao ◽  
Xiaoying Huang ◽  
Xiqiang Xu ◽  
...  
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Mental Disease ◽  
Complementary Therapy ◽  
Scientific Basis ◽  
Research Progress ◽  
Chemical Components ◽  
Physical And Mental Health ◽  
Plant Essential Oils ◽  
Treatment Of Depression

: Depression is a mood disorder or affective disorder disease with depression as the main symptom. It has become a kind of mental disease that cannot be ignored in the world that seriously endangers human physical and mental health. Antidepressants commonly used in clinics generally have some defects including slow action, unremarkable effects and large side-effects. Therefore, there has a huge developing space for the research of new and effective therapeutic drugs to supplement or replace traditional drugs. Essential oil has obvious advantages in the treatment of depression and other emotional diseases, its aromatic odor can directly stimulate the olfactory nerves, and the lipophilic small- molecular compounds can cross the blood-brain barrier easily, to play its regulatory role of releasing of neurotransmitters and hormones related to depression, or adjusting the expression of brain-derived neurotrophic factor and proinflammatory cytokines. The pathogenesis of depression and the problems in traditional medication was illustrated, the research on the antidepressant effects and mechanism of essential oils in recent years was summarized and the antidepressant chemical components in plant essential oils were reviewed in this article. It could provide scientific basis for essential oil to be a new choice for relieving depression and treating depression.

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