scholarly journals Squamous cell carcinoma transformed from the prostatic adenocarcinoma with endocrine therapy: a case report and literature review

2021 ◽  
Author(s):  
Shizhang Song ◽  
Bo Jiang ◽  
Sichuan Hou ◽  
Xingang Huang ◽  
Chunmei Li ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Endocrine Therapy ◽  
Squamous Cell ◽  
Histopathological Examination ◽  
Specific Antigen ◽  
Prostatic Adenocarcinoma ◽  
Gleason Grading ◽  
Adenocarcinoma Of The Prostate ◽  
Multiple Treatments

Abstract BackgroundSquamous cell carcinoma (SCC) of the prostate is a very rare and highly aggressive tumor, which is insensitive to multiple treatments, prone to metastasis, and has a worse prognosis than adenocarcinoma of the prostate. However, a transformation of prostatic adenocarcinoma into squamous cell carcinoma is rarer and may occur after endocrine or radiotherapy. By now, there are few cases in the world about the transformation from adenocarcinoma into squamous cell carcinoma after treatment. To our knowledge, our case is the first reported in China.Case presentationA 67-year-old man with metastatic adenocarcinoma of the prostate for 2 years, was not suitable for radical prostatectomy due to the disease classified T4N1M1. Endocrine therapy using Luteinizing Hormone-Releasing Hormone (LHRH) analog (leuprorelin) and antiandrogen agent (bicalutamide) was started, and serum prostate-specific antigen (PSA) level gradually decreased to a nadir of 0.04ng/ml. 2 years after treatment, he complained of worsening of lower urinary tract symptoms, and then he underwent transurethral resection of the prostate (TURP). Histopathological examination confirmed most of the tissue areas were accompanied by poorly differentiated keratinizing squamous cell carcinoma. Now, the patient started docetaxel treatment. He has received 2 times of systemic chemotherapy. The patient's current general condition is fair.ConclusionsProstatic adenocarcinoma transformed into squamous cell carcinoma after endocrine therapy is very rare. However, the serum PSA of this tumor is probably normal, PSA and the Gleason grading system are of limited value in the diagnosis of SCC, histopathological can help its diagnosis. The transformation is silent and we cannot know it. The question of whether prostatic adenocarcinoma or SCC of the prostate requires more definitive research to answer.

scholarly journals Carcinoma of Vagina in Utero-Vaginal Prolapse: A Rare Presentation

2012 ◽  
Vol 52 (186) ◽  
Author(s):  
S Acharya ◽  
DK Uprety
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Histopathological Examination ◽  
Large Cell ◽  
Uterovaginal Prolapse ◽  
Rare Entity ◽  
Rare Presentation ◽  
Vaginal Carcinoma ◽  
Keywords Squamous Cell Carcinoma

Primary vaginal carcinoma in uterovaginal prolapse is a rare entity. We report a case of an 84-years-old lady, who presented with long standing vaginal ulcer in association with third degree uterovaginal prolapse. Incisional biopsy was taken from the ulcer. Histopathological examination showed a large cell keratinizing squamous cell carcinoma. Keywords: Squamous cell carcinoma, uterovaginal prolapse, vaginal carcinoma.

scholarly journals A case report of an unusual caecal metastatic location of a primary cervical squamous cell carcinoma

2020 ◽  
Vol 2020 (10) ◽  
Author(s):  
Obed Rockson ◽  
Christine Kora ◽  
Abdelbassir Ramdani ◽  
Badr Serji ◽  
Tijani El Harroudi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Histopathological Examination ◽  
Management Strategies ◽  
Cervical Squamous Cell Carcinoma ◽  
Right Hemicolectomy ◽  
Secondary Lesion ◽  
The Right ◽  
Metastatic Location

Abstract Squamous cell carcinoma (SCC) of the colon is a rare malignant tumor occurring as either a primary or secondary lesion. Few cases of metastatic or secondary colonic SCC have been published. We report an unusual case of a 59-year-old female patient who was treated by Wertheim hysterectomy and adjuvant chemoradiation for stage IIB SCC of the uterine cervix. Two years later, she developed a metastatic location in the caecum causing an acute intestinal obstruction. She underwent an emergency open right hemicolectomy with ileocolic anastomosis and resection of two nodules of the umbilicus and the right parietal peritoneum. Histopathological examination confirmed a triple metastatic location of SCC. She is disease-free 11 months after surgery. We discuss the clinicopathological features, management strategies, and the prognosis of this rare entity.

scholarly journals Two different clinical forms of squamous cell carcinoma (SCC) in the perineum and vulva of two mares

2020 ◽  
Vol 16 (1) ◽  
Author(s):  
Andrzej Raś ◽  
Iwona Otrocka-Domagała ◽  
Małgorzata Raś-Noryńska
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Ultrasound Examination ◽  
Histopathological Examination ◽  
Reproductive Organs ◽  
Malignant Neoplasms ◽  
Surgical Removal ◽  
Chemotherapy Treatment ◽  
Case Presentation

Abstract Background Genital malignant neoplasms in mares are relatively rare. The treatment involve surgical removal of the tumour masses, chemotherapy or both. Case presentation Two elderly warmblood mares, aged 16 and 20 were presented in University Clinic with the lumpy lesions at the region of perineum and left labia. Surgical removals of tumour masses were performed on standing animals. Removed tissues were subjected to histopathological examination which confirmed SCC. Conclusions Clinical and ultrasound examination of reproductive organs in both mares showed no inflammatory or neoplastic changes. Both mares healed within 2 weeks after surgery and showed no signs of tumour recurrence for the following year despite no chemotherapy treatment.

Squamous cell carcinoma of the vagina and cervix in sheep — Case report

2011 ◽  
Vol 59 (1) ◽  
pp. 123-127 ◽  
Author(s):  
Luis Ferrer ◽  
Delia Lacasta ◽  
Juan Ramos ◽  
Jose Jalón ◽  
Marta Ruiz De Arcaute ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Mononuclear Cells ◽  
Histopathological Examination ◽  
Basal Membrane ◽  
Vaginal Wall ◽  
Isolated Cells ◽  
Gynaecological Malignancy ◽  
The World

This report describes the clinical and histopathological characteristics of a squamous cell carcinoma infiltrating the cervix and the vaginal wall, producing reproductive symptoms and subnormal fertility in an adult ewe. Necropsy showed a large (15-cm-long) neoplastic mass infiltrating the vaginal wall and the cervix. Histopathological examination revealed atypical squamous epithelial cords invading the basal membrane and dermis, round anaplastic cells, focal areas of necrosis, keratinisation of isolated cells, and pronounced infiltration by mononuclear cells around the cords. No squamous cell carcinoma of such localisation has been reported from sheep before. In humans, this tumour is the most common gynaecological malignancy in the world.

scholarly journals Abdominal lymph node metastasis from prostatic adenocarcinoma in a patient with esophageal squamous cell carcinoma

2009 ◽  
Vol 17 (1) ◽  
pp. 29-31
Author(s):  
Kentaro Yamaguchi ◽  
Yoshihiko Naritaka ◽  
Shinichi Asaka ◽  
Noriyuki Isohata ◽  
Takeshi Shimakawa ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prostatic Adenocarcinoma ◽  
Abdominal Lymph Node ◽  
Node Metastasis

scholarly journals Adenosquamous and squamous cell carcinoma of the pancreas: two histopathological variants of ductal adenocarcinoma

2021 ◽  
Vol 67 (3) ◽  
pp. 173-176
Author(s):  
Tiberiu-Bogdan Szekely ◽  
Cornelia Toganel ◽  
Zoltan Kadar ◽  
Alexandra Daniela Sava ◽  
Tivadar Bara ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Adenosquamous Carcinoma ◽  
Histopathological Examination ◽  
Pancreatic Head ◽  
Ductal Adenocarcinoma ◽  
Mesenchymal Transition ◽  
Carcinoma Of The Pancreas ◽  
First Case

Abstract Introduction: Primary squamous cell carcinoma (SCC) and adenosquamous carcinoma of the pancreas are rare malignancies for which diagnostic and treatment strategy are challenging. In this paper we present a literature review of these tumors based on two case reports. Case presentation: In the first case, a 55-year-old male presented with an inoperable pancreatic head/body junction tumor. Endoscopic ultrasound-guided fine needle aspiration was practiced, and histopathological examination revealed a squamous cell carcinoma of the pancreas. After exclusion of any another tumor, the diagnosis of cT4N0M0-staged primary pancreatic SCC was made. The patient is under treatment with gemcitabine and oxaliplatin. The second case is represented by a 73-year-old patient in which imagistic examinations highlighted a cystic mass of the pancreatic body. Following coporeo-caudal splenic-pancreatectomy and histopathological-proved diagnosis of adenosquamous carcinoma, the patient started chemotherapy but died at 11 months after surgery. Both tumor components displayed positivity for markers which prove ductal (cytokeratin19, maspin) and squamous differentiation (p63, cytokeratin5/6) same as vimentin, as indicator of epithelial mesenchymal transition (EMT). Conclusions: SCC and adenosquamous carcinoma of the pancreas are aggressive malignancies which prognosis remains highly reserved. These tumors might be variants of ductal adenocarcinomas which are dedifferentiated through EMT phenomenon.

scholarly journals Rare presentation of gingival squamous cell carcinoma of maxillary posterior region mimicking pyogenic granuloma in a non-smoker – A case report

2021 ◽  
Vol 6 (3) ◽  
pp. 174-178
Author(s):  
R. Reshmaa ◽  
R. Kadhiresan ◽  
U. Arunmozhi ◽  
R. Shanmugapriya
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Histopathological Examination ◽  
Malignant Neoplasm ◽  
Pyogenic Granuloma ◽  
Oral Carcinoma ◽  
Rare Presentation ◽  
Gingival Squamous Cell Carcinoma

Gingival Squamous cell carcinoma (GSCC) in maxilla is a rare malignant neoplasm especially when compared with mandible. The most common sites of oral carcinoma are being the lateral border of the tongue and the floor of the mouth which is followed by palate, buccal mucosa and rarely in gingiva. The clinical picture of oral carcinoma can be misguided for gingival overgrowth, desquamative lesions, traumatic ulcers or even pyogenic granuloma. Maxillary oral gingival carcinoma is a rare entity especially in a non-smoker. In this case report, a 70-year-old male patient presented with a gingival lesion in maxilla 24,25 region mimicking pyogenic granuloma without having a tobacco history. A thorough clinical, radiographical and histopathological examination was done and led to the diagnosis of GSCC and the treatment was initiated.Creating awareness among practitioners about gingival squamous cell carcinoma mimicking pyogenic granuloma in dental practice.

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