scholarly journals Combined effect of Ilizarov technique, low-intensity pulsed ultrasound, and teriparatide for limb reconstruction of Gustilo–Anderson type IIIc open tibial fracture with a large bone defect in elderly patients with severe osteoporosis: A case report

2021 ◽  
Author(s):  
Koji Nozaka ◽  
Naohisa Miyakoshi ◽  
Motoki Mita ◽  
Yoichi Shimada
Keyword(s):  
Elderly Patients ◽  
Weight Bearing ◽  
Pulsed Ultrasound ◽  
Severe Osteoporosis ◽  
Limb Reconstruction ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Large Bone ◽  
Large Bone Defects ◽  
Type Iiic

Abstract Background Gustilo–Anderson type IIIc tibial open fracture with large bone defects in severely osteoporotic elderly patients is a rare injury that may be a challenging clinical scenario.Case presentation This study presents the case of a 68-year-old man who sustained a Gustilo–Anderson type IIIc open tibial fracture with a large bone defect. The patient had severe osteoporosis and the bone was contaminated; therefore, we determined that the bone could not be returned to the tibia. The patient underwent acute limb shortening and gradual lengthening with an Ilizarov external fixator combined with low-intensity pulsed ultrasound and teriparatide administration for limb reconstruction, which allowed immediate full weight-bearing capacity. The fixator was removed at 12 months postoperatively, and by this time, the fracture had completely healed. At the most recent 5-year follow-up after the injury, the patient reported fully weight-bearing capacity without walking aids and had full knee and ankle range of motion.Conclusions To the best of our knowledge, this is the first study to report the use of combined Ilizarov technique, low-intensity pulsed ultrasound, and teriparatide for limb reconstruction of Gustilo–Anderson type IIIc open tibial fractures with large bone defects in elderly patients with severe osteoporosis.

scholarly journals Low intensity pulsed ultrasound information technology intervention in diagnosis and prediction of Muscle Atrophy

2021 ◽  
Vol 37 (6-WIT) ◽  
Author(s):  
Zhijun Sun
Keyword(s):  
Information Technology ◽  
Body Weight ◽  
Muscle Atrophy ◽  
Gastrocnemius Muscle ◽  
Weight Bearing ◽  
Good Effect ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Technology Intervention

Objective: To discuss the effects and function of LIPUS on muscle atrophy (MA), analysis from various aspects through the study of low-intensity pulsed ultrasound (LIPUS) information technology intervention (ITI) in diagnosis and the prediction of muscle atrophy.. Method: In this study conducted in our university, 74 healthy female SD rats aged three months, weighing 100-200g were selected. All rats were placed in sterile cages from June 2020 to September 2020. They were divided into three groups. In the OVO group and OVE group, the mice are treated with LIPUS, Finally, the changes of body weight, grasping power, biochemical indexes and glycogen content of gastrocnemius muscle were analyzed and recorded to explore the effect and value of LIPUS ITI combined with intermittent weight-bearing exercise in the treatment of MA Results: After weight-bearing running, the body weight of model (OVO) group, exercise (OVE) group and NC group had significant statistical significance (P<0.01). It was found that the weight of OVE group was much more as compared to OVO group. There was significant difference in body weight between OVO group and NC group (P<0.05). After LIPUS treatment, it was found that the weight of OVO group, OVE group, LIPUS group and OVE +LIPUS group increased. Compared with the NC group, there was significant statistical difference (P<0.01). Conclusion: Low intensity pulsed ultrasound ITI has a good effect on improving MA, so as to effectively improve the weight of gastrocnemius muscle. The combined application of the two is better for the improvement of muscular atrophy. doi: https://doi.org/10.12669/pjms.37.6-WIT.4839 How to cite this:Sun Z. Low intensity pulsed ultrasound information technology intervention in diagnosis and prediction of Muscle Atrophy. Pak J Med Sci. 2021;37(6):1569-1573. doi: https://doi.org/10.12669/pjms.37.6-WIT.4839 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Improved activity of MC3T3-E1 cells by the exciting piezoelectric BaTiO3/TC4 using low-intensity pulsed ultrasound

2021 ◽  
Vol 6 (11) ◽  
pp. 4073-4082
Author(s):  
Kunzhan Cai ◽  
Yilai Jiao ◽  
Quan Quan ◽  
Yulin Hao ◽  
Jie Liu ◽  
...  
Keyword(s):  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity

scholarly journals Osteocytes as main responders to low-intensity pulsed ultrasound treatment during fracture healing

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tatsuya Shimizu ◽  
Naomasa Fujita ◽  
Kiyomi Tsuji-Tamura ◽  
Yoshimasa Kitagawa ◽  
Toshiaki Fujisawa ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Transcriptional Control ◽  
Target Genes ◽  
Pulsed Ultrasound ◽  
Activated T Cells ◽  
In Vivo Models ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Ultrasound Stimulation

AbstractUltrasound stimulation is a type of mechanical stress, and low-intensity pulsed ultrasound (LIPUS) devices have been used clinically to promote fracture healing. However, it remains unclear which skeletal cells, in particular osteocytes or osteoblasts, primarily respond to LIPUS stimulation and how they contribute to fracture healing. To examine this, we utilized medaka, whose bone lacks osteocytes, and zebrafish, whose bone has osteocytes, as in vivo models. Fracture healing was accelerated by ultrasound stimulation in zebrafish, but not in medaka. To examine the molecular events induced by LIPUS stimulation in osteocytes, we performed RNA sequencing of a murine osteocytic cell line exposed to LIPUS. 179 genes reacted to LIPUS stimulation, and functional cluster analysis identified among them several molecular signatures related to immunity, secretion, and transcription. Notably, most of the isolated transcription-related genes were also modulated by LIPUS in vivo in zebrafish. However, expression levels of early growth response protein 1 and 2 (Egr1, 2), JunB, forkhead box Q1 (FoxQ1), and nuclear factor of activated T cells c1 (NFATc1) were not altered by LIPUS in medaka, suggesting that these genes are key transcriptional regulators of LIPUS-dependent fracture healing via osteocytes. We therefore show that bone-embedded osteocytes are necessary for LIPUS-induced promotion of fracture healing via transcriptional control of target genes, which presumably activates neighboring cells involved in fracture healing processes.

Low-intensity pulsed ultrasound affects RUNX2 immunopositive osteogenic cells in delayed clinical fracture healing

Bone ◽  
2009 ◽  
Vol 45 (5) ◽  
pp. 862-869 ◽  
Author(s):  
Sjoerd Rutten ◽  
Peter A. Nolte ◽  
Clara M. Korstjens ◽  
Jenneke Klein-Nulend
Keyword(s):  
Fracture Healing ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Osteogenic Cells ◽  
Low Intensity ◽  
Clinical Fracture

scholarly journals The effect of low intensity pulsed ultrasound on mandibular condylar growth in young adult rats

Bone Reports ◽  
2021 ◽  
pp. 101122
Author(s):  
Yasamin Hadaegh ◽  
Hasan Uludag ◽  
Douglas Dederich ◽  
Tarek H. El-Bialy
Keyword(s):  
Young Adult ◽  
Pulsed Ultrasound ◽  
Adult Rats ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity
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