scholarly journals Evaluation of Factors Affecting the Expression of Anti-HBs in Children in Hunan Province

Author(s):  
Shan Tan ◽  
Shizhou Li ◽  
Jianxiang Dong ◽  
Hongmei Dai ◽  
Minghua Yang ◽  
...  

Abstract Background and objectives Vaccine is the most essential avenue to prevent hepatitis B infection in infants and preschool children in China, with the largest populations carrying hepatitis B virus in the world. This study aimed to evaluate the factors affecting the response level of anti-HBs in children, with a view to provide instructions for hepatitis B prevention clinically. MethodsThe children taking physical examinations in the Third Xiangya Hospital from January 2013 to April 2020 were recruited. Telephone follow-up were adopted to collect further information. Univariate logistic regression was used to analyse the relationship between age and anti-HBs expression. After grouping by age and anti-HBs expression, we used chi-square test and T test to compare the difference between positive and negative antibody expression in each age subgroup. The meaningful variables (P<0.10) in chi-square test and T test were assessed with collinearity and chosen for univariate and multivariate logistic regression analysis by the stepwise backward maximum likelihood method (αin=0.05, αout=0.10).ResultsA total of 5838 samples (3362 males, 57.6%) were enrolled. The outcomes showed that the expression of anti-HBs was associated with age [OR=1.037(1.022-1.051)] in whole sample. Anemia[OR=0.392(0.185-0.835)], age[OR=2.542(1.961-3.295)] and Vit D[OR=0.977(0.969-0.984)] in 0.5-2.99 years subgroup, Zinc deficiency[OR=0.713(0.551-0.923] and age[OR=1.151(1.028-1.289)] in 3-5.99 years subgroup, Vit D[OR=0.983(0.971-0.995)] in 12-18 years subgroup had significant effect on the expression of anti-HBs. Conclusions This retrospective study illustrated that age, anaemia status, zinc deficiency and vitamin D were associated with the expression of anti-HBs in different age groups children, which could serve as a reference for the prevention of hepatitis.

2019 ◽  
Vol 8 (3) ◽  
pp. 18-30
Author(s):  
Amit Kumar Arora ◽  
M.S.S. Raju

The present article is an attempt to analyze the various factors affecting the adoption of an activity-based costing (ABC) system in selected manufacturing units in India. The following seven factors are considered: firm size, diversity of the product, percentage of overhead cost in total cost, listing of the company, cost audit compulsion, separate cost accounting department and the method of accounting. Logistic regression and a Chi Square test are applied to these factors and the use of an ABC system. On the basis of 72 sample units, the study found the size of the firm, percentage of overhead cost in total cost, cost audit compulsion and the method of accounting are statistically significant for the adoption of ABC system. While factors such as diversity of the product, separate cost accounting department and the listing of the company are found to not be statistically significant for the adoption of ABC system. The study has provided additional insights into areas relating to the factors affecting the implementation of ABC systems.


Author(s):  
Ismet Boz

This study was initiated to evaluate the effects of agri-environment program implemented in the Sultan reeds area of Kayseri province, Turkey. The specific objectives of the study were to compare the farmers who enrolled in the program with those who didn’t enroll regarding their application of different sustainable agricultural practices, and to determine factors affecting their enrolment in the program. The main comparative indicators were selected from different sustainable agricultural practices either promoted by the agri-environmental program or not promoted but considered very useful for the locality. Two stratified samples of farmers (enrolled and not enrolled) were selected based on their farm size. Chi-square tests of independence were used to compare farmers on the selected sustainable agricultural practices. Logistic regression model was used to determine factors affecting the enrolment of the agri-environment program. The findings of the chi-square test showed that enrolled farmers use grow more forage legumes, are more conscious about pesticides use and chemical applications, and they use more pressurized irrigation systems. Findings of the logistic regression model sowed that using rental land negatively, but contacts with extension personnel, and using long term loans for farming investments positively influenced the enrolment of the agri-environment program. Governmental effort must concentrate on these issues when promoting agri-environmental programs in the region.


2020 ◽  
Author(s):  
Yanli Gu ◽  
Donghui Wang ◽  
Cen Chen ◽  
Wanjun Lu ◽  
Hongbing Liu ◽  
...  

Abstract Aims: To identify the risk factors of mortality for coronavirus disease 19 (COVID-19) patients admitted to intensive care units (ICU), we conducted a retrospective analysis.Methods: The demographic characteristics, laboratory findings and chest X-ray data of COVID-19 patients admitted to ICU of Huoshenshan Hospital from February 10 to April 10, 2020 were retrospectively analyzed. Student's t test and chi-square test were used to compare continuous variables, categorical variables respectively. Logistic regression model was used to seek risk factors of mortality.Results: A total of 57 patients (38 males and 19 females) were included in this retrospective study, including 20 patients in deceased group and 37 patients in surviving group. Leukocyte count, neutrophil count, lymphocyte count, eosinophil count, neutrophil-to-lymphocyte ratio (NLR), urea nitrogen, lactate dehydrogenase (LDH), interleukin-6 (IL-6), C-reactive protein (CRP), arterial partial pressure of oxygen/oxygen concentration (PaO2/FiO2) and imaging findings were statistically different between the two groups. The multivariate logistic regression analysis identified IL-6 and PaO2/FiO2 as independent risk factors of mortality. The area of under curves (AUC) of IL-6 and PaO2/FiO2 were 0.9 (95%CI:0.823-0.977, p<0.0001) and 0.865 (95%CI:0.774-0.956, p<0.0001) respectively. The cut-off value of IL-6 was 25.69 pg/mL, the sensitivity was 95% and the specificity was 75.7%, while the cut-off value of PaO2/FiO2 was 167.79 mmHg, the sensitivity was 75.7% and the specificity was 85%.Conclusion: Clinicians should pay enough attention to IL-6 and PaO2/FiO2, especially when IL-6>25.69 pg/ml and PaO2/FiO2<167.79 mmHg, and take active intervention measures as early as possible.


2021 ◽  
Vol 4 (1) ◽  
pp. 25-30
Author(s):  
Lisnawati . ◽  
Sri Hani Purwati

Introduction: Every year Hepatitis B has experienced a very rapid increase from <1% up to now reaching 5%, it is estimated that worldwide has a history of Hepatitis B and has Hepatitis B up to 2 billion people. Pregnant women have a high risk of transmitting infections around 1.5 to 2.5% of pregnant women worldwide who have Hepatitis B. Areas with the highest risk include the Mediterranean, Middle East (Gulf countries, Saudi Arabia and Turkey), Pakistan, Central, and North Asia namely Japan, Taiwan, Greenland and Africa, the Amazon basin and certain regions of the Indonesia Pacific. This study aims to determine the effect of leaflets versus power points on the knowledge and attitudes of pregnant women about Hepatitis B. Methods: analytical research with Quasi-experiment technique with pretest and posttest Two Group Design designs taken with accidental sampling technique obtained a sample of 20 people in the leaflet group and 20 people in the powerpoint group. The instrument used was a questionnaire created by researchers who had tested the validity and reliability. The analysis used in the knowledge variable uses the Wilcoxon test and in the attitude, variable use the Mcnemar test. To know the comparison of knowledge using the Independent t-test and the attitude using the Chi-square test. Results: the results of the independent t-test were used to find out the comparison between the leaflet group and the PowerPoint group, the p-value was 0.206, and the chi-square test between the leaflet group and the PowerPoint group obtained a p-value of 1,000. Conclusion: there was no difference in the effect of using leaflets compared to power points on the knowledge and attitudes of pregnant women about Hepatitis B in UPTD Puskesmas Kedokan Bunder Indramayu Regency in 2020.


2014 ◽  
Author(s):  
Μαρουδιά Κρίνη

Σκοπός της παρούσας διδακτορικής διατριβής ήταν να διερευνήσει την κατανομή των HLA-DRB1, DQA1 και DQB1 αλληλομόρφων γονιδίων, των απλοτύπων και γονοτύπων στον ελληνικό παιδιατρικό πληθυσμό με κοιλιοκάκη, σε σύγκριση με τους υγιείς μάρτυρες, και να αξιολογήσει την επίδραση των HLA τάξης ΙΙ γονιδίων στην επιδεκτικότητα της νόσου. Παράλληλα, αναζητήθηκαν συσχετίσεις του HLA-γενετικού υποστρώματος των ασθενών με τα κλινικά, επιδημιολογικά, ορολογικά και ιστολογικά χαρακτηριστικά της νόσου.Μελετήθηκαν 118 παιδιά με κοιλιοκάκη ελληνικής καταγωγής. Oι συμπτωματικοί ασθενείς ταξινομήθηκαν σε 3 ομάδες ως εξής: ομάδα Α = DQB1*02 ομοζυγώτες, ομάδα Β = DQB1*02 ετεροζυγώτες και ομάδα Γ = DQB1*02 αρνητικοί ασθενείς. Ως ομάδα ελέγχου, για τη σύγκριση των αποτελεσμάτων της HLA τυποποίησης των ασθενών, χρησίμευσε η HLA τυποποίηση 120 υγιών ατόμων, δοτών αίματος και μυελού των οστών, μη συγγενών μεταξύ τους, ελληνικής καταγωγής και εθνικότητας. Η γονιδιακή HLA τυποποίηση πραγματοποιήθηκε με τις μεθόδους PCR-SSP και PCR-SSO. Η στατιστική ανάλυση περιελάμβανε τα Pearson’s Chi-Square test, Fisher’s exact test, Student’s t-test, Mann-Whitney και Kruskal-Wallis test. Ο βαθμός τη σχέσης ελέγχθηκε με ακριβή λογιστική παλινδρόμηση (exact logistic regression) και παρουσιάστηκε ως λόγος σχετικών πιθανοτήτων (odds ratios, OR). Tα αποτελέσματα έδειξαν στατιστικά αυξημένη συχνότητα των HLA-DQB1*02:01, DQB1*02:02, DQA1*02:01, DQA1*05:01, DRB1*03 και DRB1*07 και στατιστικά μειωμένη συχνότητα των HLA-DQB1*03:01, DQB1*05:01, DQB1*05:02, DQA1*01:01, DQA1*01:02, DQA1*01:04, DQA1*05:05, DRB1*01 και DRB1*16 στους ασθενείς σε σύγκριση με τους υγιείς μάρτυρες. Σε επίπεδο απλοτύπων, ο κύριος συσχετιζόμενος με την κοιλιοκάκη απλότυπος ήταν ο DR3-DQ2 και ακολούθησε ο DR7-DQ2. Το 95,8% των ασθενών με κοιλιοκάκη εκφράζει το DQ2 ή/και το DQ8 μόριο. Μόνο ένας στους 118 ασθενείς, που αντιστοιχεί σε πιθανότητα 0,8%, δεν εκφράζει κανένα από τα συσχετιζόμενα με την κοιλιοκάκη αλλήλια και είναι DQ2/DQ8/DQA1*05/DQB1*02 - αρνητικός. Τα αποτελέσματα της μελέτης έδειξαν μια στατιστικά σημαντική διαφορά στον τίτλο των ΕΜΑ αντισωμάτων μεταξύ των ομάδων Α και Γ. Αναλυτικά, οι τίτλοι των ΕΜΑ αντισωμάτων είναι σημαντικά υψηλότεροι στους HLA-DQB1*02 ομοζυγώτες σε σχέση με τους HLA-DQB1*02 αρνητικούς ασθενείς, γεγονός που πιθανόν να αντανακλά μια HLA-DQB1*02 δοσοεξαρτώμενη επίδραση στον τίτλο των ΕΜΑ αντισωμάτων.Συμπερασματικά, η παρούσα διατριβή περιγράφει για πρώτη φορά στον ελληνικό παιδιατρικό πληθυσμό τη συχνότητα εμφάνισης των HLA τάξης ΙΙ αλληλομόρφων γονιδίων, απλοτύπων και γονοτύπων, και επιβεβαιώνει τη συμβολή των HLA τάξης ΙΙ γονιδίων στη γενετική προδιάθεση της νόσου. Επιπλέον, παρέχει στοιχεία που υποδηλώνουν μια πιθανή HLΑ-DQB1*02 δοσοεξαρτώμενη επίδραση στον τίτλο των ΕΜΑ αντισωμάτων.


2020 ◽  
Vol 1 ◽  
pp. 30-34
Author(s):  
Muhammad Rafi Fathurrohman ◽  
Sri Suparti

Nausea and vomiting should be further checked and prevented, because these conditions can be a cause or complication during hemodialysis patients. Electrolyte and water imbalance (dehydration) can be considered as the main complication of nausea and vomiting itself. The aim of this study was to determine the factors that influence the severity of nausea and vomiting in patients undergoing hemodialysis. This type of research is quantitative with analytic descriptive method, with an approach using a retrospective cohort research design. The sampling technique in this study was a total sampling technique with a total sample of 57 patients. The research instrument used questionnaires and observations, data analysis using the Chi Square test and simple logistic regression analysis. The location of the study was the hemodialysis therapy site at the Islamic Hospital in Purwokerto in January-February 2020. The results showed that most of the respondents with the severity of nausea and vomiting, the patient's diet was not balanced (61.4%), the excess fluid had edema (63.2%), the gender was male (59.6%), female (40.4%). %), age 18-65 (57.9%), duration of HD <12 months (64.9%) and 58 respondents> 12 months (35.1). The results of bivariate analysis using logistic regression, obtained p value of the patient's diet 0.009, excess fluid, age and sex 0.001 and the duration of HD 0.003. From this analysis, there are 5 factors that can cause the severity of nausea and vomiting, namely the patient's diet, excess fluidity, gender, age, and duration of HD.


2018 ◽  
Vol 19 (5) ◽  
pp. 1345-1362
Author(s):  
Bishnu Mohan Dash ◽  
Lokender Prashad ◽  
Mili Dutta

The article highlights the situation of child labour using the Census data of Government of India from 1971 to 2011. This study has also utilized the National Sample Survey Organization 68th round data on employment and unemployment of child labour in India. In this study, bivariate and multivariate analysis has been carried out. The chi-square test has been used to study the association between child labour and various socio-economic characteristics. The multiple logistic regression technique has been used to find out the factors affecting child labour. All the analysis has been carried out in SPSS and STATA software. The article has highlighted the growth rate of child labour and its distribution with socio- economic characteristics and work participation rate of child labour in India. Using the logistic regression, the study has projected the estimates of child labour in India. Besides that, the article recommended various suggestions for the abolition and regulation of the incidences of child labour in India.


2019 ◽  
Vol 7 (6) ◽  
pp. 107-119
Author(s):  
Ma. Lourdes C. Alvarez

This study aimed to determine and describe the conceptual understanding in chemical equilibrium among selected freshman students who were classified as surface and deep learners. Data were gathered utilizing study process questionnaire and conceptual understanding test. This study involved two intact classes of 58 engineering students enrolled in General Chemistry II and was conducted for three weeks. Using the study process questionnaire, students were classified as either surface or deep learners. After the lesson on chemical equilibrium, conceptual understanding test was given to the students. Students were then grouped into six based on their learning approaches and level of conceptual understanding. The findings of the study revealed that majority of the class (53%) are deep learners while 47% are surface learners. Using t-test analysis, surface and deep learners differ in the scores they obtained on concepts about factors affecting equilibrium. Chi square test of independence also showed that surface and deep learners significantly differ from each other in terms of their level of conceptual understanding on factors affecting equilibrium concepts. The results of t-test and chi-square test revealed that there could be times that differences between surface and deep learners could only be seen when tested across different concepts within a certain topic.


2022 ◽  
Vol 7 (1) ◽  
pp. 345
Author(s):  
Safina Fairuz Salwaa ◽  
Taufiq Hidayat ◽  
I Gde Rurus Suryawan

Congenital heart disease (CHD) is a congenital condition caused by a lack of heart development during the fetal stage. There is a notion that children with CHD have low nutritional status due to their condition. Nutritional input, energy requirements, dietary components, and prenatal circumstances impact a person's nutritional status. An analytical observational design with a cross-sectional approach was used in this research. Data were obtained via medical records and questionnaires posed to the patients' guardians who had provided informed consent. The Chi-square test and multivariate logistic regression analysis were used to analyze the data. The study was conducted on 62 subjects. There were 74.19% of subjects with acyanotic CHD and 25.81% with cyanotic CHD. 61.29 % of the subjects were exclusively breastfed for the first six months. The Chi-Square test revealed a relationship between breastfeeding and the nutritional status of children with CHD, with p = 0.0001 (p<0.05). The multivariate logistic regression analysis showed the significance of the type of CHD suffered by the subjects was 0.003 (p<0.05). There is a significant association between breastfeeding for the first six months and the type of CHD suffered by children with their nutritional status at Dr. Soetomo General Hospital.


Author(s):  
Hasna Ibadurrahmi ◽  
Silvia Veronica ◽  
Nunuk Nugrohowati

Scabies is a skin disease caused by mite infestation and sensitization Sarcoptes scabiei variety hominis. Every student who live in dormitories boarding school has the same opportunities for the occurrence of scabies. Students and environmental characteristics of the rooms thought to contribute to the incidence of scabies. Tis study aims to determine what factors most influence on the incidence of scabies disease at boarding Qotrun Nada Cipayung Depok academic year 2015/2016. Tis research was observational analytic with cross sectional design. The subjects were 258 students of MTs and MA Boarding school of Qotrun Nada academic year 2015/2016. Data analysis was based on the incidence of disease scabies using Chi-square test (p < 0,05) and followed by multivariate logistic regression. Chi-Square test results showed that there was influence among knowledge, attitudes, student behavior, density of occupant, humidity, lighting, temperature, and room ventilation students with the incidence of scabies disease at boarding Qotrun Nada Cipayung, Depok. Results of multivariate logistic regression analysis showed the most influences characteristics were student attitude and density of occupant.


Sign in / Sign up

Export Citation Format

Share Document