Preoperative Anatomy Parameters in Implantable Collamer Lenses

Mapping Intimacies ◽

10.21203/rs.3.rs-968382/v1 ◽

2021 ◽

Author(s):

Yanzhen Xue ◽

Yonghong Guo ◽

Ruibo Zhao

Keyword(s):

Regression Analysis ◽

Linear Regression ◽

Anterior Chamber ◽

Linear Regression Analysis ◽

Corneal Thickness ◽

Intraclass Correlation ◽

Anterior Segment ◽

Anterior Chamber Depth ◽

Case Series ◽

Significant Difference

Abstract Purpose: To determine patient preoperative anatomical features and the parameters of implantable collamer lenses (ICLs) relevant in explaining vault variability.Setting: Ophthalmology Xi’an Aier Gucheng Eye hospital , Xi’an China.Design: Retrospective case series.Methods:This study comprised 88 eyes of 45 patients implanted with myopic or toric ICLs between May 2021 and August 2021.Pentacam imaging was used for assessing white-to-white (WTW) diameter, central keratometry, anterior chamber depth(ACD), central corneal thickness and vault. Anterior-segment optical coherence tomography（AS-OCT） was used to measure the horizontal anterior chamber angle distance (ATA). Ultrasound biomicroscopy (UBM) was used to measure horizontal and vertical sulcus to sulcus(vSTS). According to different ACD,we divide ACD into shallow group(2.8 to 3.2 mm),medium group(3.2 to 3.5 mm),and deep group(＞3.5mm).Results: Linear regression analysis found significant correlation between WTW diameters and ATA diameters( y= 0.9605x+0.1491,R² = 0.9148),with a coefficient of determinant of 0.9148 (P＜0.01). Linear regression analysis found significant correlation between hSTS and vSTS（y=0.9855x-0.0178,R²=0.1979）,with a coefficient of determinant of 0.1979 (P＜0.01). WTW diameters showed statistically significant difference in shallow and medium ACD (t=-3.28,P＜0.01 ), significant difference in shallow and deep ACD (t=-4.69,P＜0.01 ),there was no correlation in medium and deep ACD(t=-1.41,P＞0.05 ). There was a statistically significant correlation between WTW diameters and hSTS diameters when the ACD was less than 3.5 mm (t=-0.451, P=0.000) (t=1.406, P=0.026),but weak correlation when the ACD was bigger than 3.5 mm(t=1.594, P=0.051). ATA and WTW with a mean difference close to zero(-0.66 mm). Despite the relatively high correlation (intraclass correlation co-efficient =0.689), the range of agreement is quite broad (1.33 mm).Conclusions:ATA measured with AS-OCT can not be used interchangeably with WTW obtained with Pentacam. WTW diameters and hSTS diameters have a statistically significant correlation when the ACD was less than 3.5 mm. WTW, ATA, hSTS and vSTS all should be considered during design the size of lens and regulating the vault after surgery.

Anatomical and Visual Effects of Implantable Phakic Contact Lens on Correction of Myopia

10.21203/rs.3.rs-1245764/v1 ◽

2022 ◽

Author(s):

Mahmoud Ekram ◽

Ahmed Mohamed Kamal Elshafei ◽

Asmaa Anwar Mohamed ◽

Mohamed Farouk Sayed Othman Abdelkader

Keyword(s):

Visual Acuity ◽

Anterior Chamber ◽

Contact Lens ◽

Anterior Segment ◽

Anterior Chamber Depth ◽

Case Series ◽

Care Group ◽

Case Series Study ◽

Significant Difference ◽

The Mean

Abstract Purpose: To evaluate the anatomical effects of implantable phakic contact lens (IPCL) (Care Group, India) on anterior segment and its visual outcomes .Patients and methods: In a prospective interventional case series study, 60 highly myopic eyes of 32 patients were subjected to IPCL implantation in the Ophthalmology Department of Minia University Hospital, Egypt from January 2019 to June 2021. All patients had complete ophthalmic examination and were followed up for 1 year. Pentacam was used for preoperative and postoperative estimation of anterior chamber depth (ACD), anterior chamber angle (ACA), anterior chamber volume (ACV) and IPCL vault in the 1st, 3rd, and 12th months. Assessment of corneal endothelium was done using specular microscope preoperatively and after 12 months. Preoperative and postoperative refraction and visual acuity were measured. Results: There was a statistically significant decrease in ACD, ACA, and ACV. There was no significant difference between preoperative and postoperative mean intraocular pressure (IOP) by the 12th month (P=0.163). The mean preoperative endothelial cell count (ECD) was significantly reduced from 2929.3±248 cells/mm2 to 2737.9±303 cells/mm2 at the 12th month (P<0.001). with a statistically highly significant improvement of mean Log Mar uncorrected visual acuity (UCVA) from 1.48±0.19 preoperatively to 0.46±0.11 by the end of follow up (P<0.001) with insignificant difference between preoperative best corrected visual acuity (BCVA) and postoperative UCVA (P=0.209). In the 12th month, the mean vault was 240±540 μm. No sight threatening complications occurred.Conclusion: Although IPCL induced anatomical changes, it was safe and effective for correction of high myopia.

Comparison of Anterior Ocular Biometric Measurements Using Swept-Source and Time-Domain Optical Coherence Tomography

Journal of Ophthalmology ◽

10.1155/2020/9739878 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

Sisi Chen ◽

Rongrong Gao ◽

Colm McAlinden ◽

Junming Ye ◽

Yiran Wang ◽

...

Keyword(s):

Time Domain ◽

Corneal Thickness ◽

Intraclass Correlation ◽

Anterior Segment ◽

Anterior Chamber Depth ◽

Correlation Coefficients ◽

Random Order ◽

Optical Coherence ◽

Swept Source ◽

Significant Difference

Purpose. To compare central corneal thickness (CCT), aqueous depth (AQD), and anterior chamber depth (ACD) measurements using the swept-source (CASIA SS-1000, Tomey, Japan) and time-domain (Visante, Carl Zeiss Meditec, USA) anterior segment optical coherence tomographers (OCT) in normal eyes. Methods. Sixty-eight eyes of 68 subjects were included. Three consecutive scans of each subject were obtained using both devices in a random order by one experienced operator. Standard deviation (Sw), coefficient of repeatability (CoR), coefficients of variation (CoV), and intraclass correlation coefficients (ICC) were used to evaluate the intraoperator repeatability. Agreement was assessed using the Bland–Altman plots and 95% limits of agreement (LoA). Results. All measurements of the swept-source OCT (SS-OCT) and time-domain OCT (TD-OCT) showed high repeatability with low CoR (CCT: 2.34 μm and 6.16 μm; AQD: 0.05 mm and 0.09 mm; ACD: 0.06 mm and 0.09 mm), low CoV (CCT: 0.16% and 0.42%; AQD: 0.61% and 0.97%; ACD: 0.53% and 0.83%), and high ICC (>0.98). The mean CCT with SS-OCT was slightly thicker than the results with TD-OCT (difference = 4.55 ± 2.62 μm, P<0.001). There was no statistically significant difference in AQD or ACD measurements between the two devices (0.01 ± 0.05 mm, P=0.111; 0.02 ± 0.05 mm, P=0.022, respectively). The 95% LoA between the SS-OCT and TD-OCT were −0.59 to 9.69 μm for CCT, −0.10 to 0.12 mm for AQD, and −0.09 to 0.12 mm for ACD. Conclusions. High levels of repeatability and agreement were found between the two devices for all three parameters, suggesting interchangeability. SS-OCT demonstrated superior repeatability compared with TD-OCT.

Evaluation of Anterior Segment’s Structures in Tilted Disc Syndrome

Journal of Ophthalmology ◽

10.1155/2016/5185207 ◽

2016 ◽

Vol 2016 ◽

pp. 1-4 ◽

Cited By ~ 3

Author(s):

Ercan Ozsoy ◽

Abuzer Gunduz ◽

Ersin Ersan Demirel ◽

Tongabay Cumurcu

Keyword(s):

Anterior Chamber ◽

Axial Length ◽

Corneal Thickness ◽

Anterior Segment ◽

Anterior Chamber Depth ◽

Control Group ◽

Tilted Disc Syndrome ◽

Chamber Volume ◽

Significant Difference ◽

Tilted Disc

Purpose. To evaluate anterior segment’s structures by Pentacam in patients with tilted disc syndrome (TDS).Methods. Group 1 included forty-six eyes of forty-six patients who have the TDS. Group 2 including forty-six eyes of forty-six cases was the control group which was equal to the study group in age, gender, and refraction. A complete ophthalmic examination was performed in both groups. All cases were evaluated by Pentacam. The axial length (AL) of eyes was measured by ultrasound. Quantitative data obtained from these measurements were compared between two groups.Results. There was no statistically significant difference for age, gender, axial length, and spherical equivalent measurements between two groups (p=0.625,p=0.830,p=0.234, andp=0.850). There was a statistically significant difference for central corneal thickness (CCT), corneal volume (CV), anterior chamber angle (ACA), and pupil size measurements between two groups (p=0.001,p=0.0001,p=0.003, andp=0.001). Also, there was no statistically significant difference for anterior chamber depth (ACD), anterior chamber volume (ACV), and lens thickness (LT) measurements between two groups (p=0.130,p=0.910, andp=0.057).Conclusion. We determined that CCT was thinner, CV was less, and ACA was narrower in patients with TDS. There are some changes in the anterior segment of the eyes with tilted disc.

Agreement between anterior segment Optical Coherence Tomography, Lenstar and Ultrasound Biomicroscopy measurements of anterior segment parameters

10.21203/rs.2.427/v1 ◽

2019 ◽

Author(s):

Ziyan Yu ◽

Ting Huang ◽

Qiao Yu ◽

Jun Kong ◽

Bo Qu

Keyword(s):

Optical Coherence Tomography ◽

Anterior Chamber ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Anterior Segment ◽

Anterior Chamber Depth ◽

Ultrasound Biomicroscopy ◽

Optical Coherence ◽

Significant Difference ◽

Medical University

Abstract Purpose To compare anterior chamber depth (ACD) and central corneal thickness (CCT) measurements by anterior segment optical coherence tomography (AS-OCT), Lenstar and ultrasound biomicroscopy (UBM). Methods A retrospective cross section study. A total of 83 eyes from 54 patients were included. Central corneal thickness (CCT) and anterior chamber depth (ACD) values obtained from three devices (AS-OCT, Lenstar and UBM) were recorded. All patients were collected from Oct. 2015 to Aug. 2016 in the Fourth Affiliated Hospital of China Medical University. Differences of these three devices (ACD and CCT) were statistically analyzed by randomized blocks analysis. Pearson correlative analysis and Bland-Altman analysis were used to compare the correlation and agreement. Results There’s no significant difference in measuring ACD by Lenstar and UBM (P>0.05), but there were significant differences in other two groups (AS-OCT and UBM, AS-OCT and Lenstar) (P<0.05). There were significant differences in the mean CCT measured by the three devices (P<0.05). There were high correlation in measuring ACD (all P<0.001, r1=0.928,r2=0.982,r3=0.932, respectively), and CCT(all P<0.001,r1=0.957,r2=0.949,r3=0.928, respectively). Conclusion AS-OCT, Lenstar and UBM yielded comparable results and are all can be used interchangeably for anterior segment measurements.

The Effects of Ramadan Fasting on Anterior Segment Parameters, Visual Acuity and Intraocular Pressures of the Eye

The Open Ophthalmology Journal ◽

10.2174/1874364101711010152 ◽

2017 ◽

Vol 11 (1) ◽

pp. 152-155 ◽

Cited By ~ 2

Author(s):

Ozlem Barut Selver ◽

Melis Palamar ◽

Kevser Gerceker ◽

Sait Egrilmez ◽

Ayse Yagci

Keyword(s):

Visual Acuity ◽

Anterior Chamber ◽

Corneal Thickness ◽

Anterior Segment ◽

Anterior Chamber Depth ◽

Ophthalmological Examination ◽

Significant Difference ◽

Before And After ◽

Group 2 ◽

Group 1

Objective: It is aimed to determine whether fasting during Ramadan has any significant effect on anterior chamber parameters, visual acuity and intraocular pressures. Methods: 31 fasting (Group 1) and 30 non-fasting healthy volunteers (Group 2) were enrolled. All cases underwent an ophthalmological examination and anterior segment parameter evaluation (central corneal thickness (CCT), anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA), pupil size) with Pentacam before and after the breaking of the Ramadan fast in Group 1, before and after dinner in Group 2. Results: The mean age was 43.35 ± 13.20 in Group 1, 43.17 ± 12.90 in Group 2 (p= 0.955). No significant difference was detected in any of the parameters in both groups. Conclusion: There is a need for more detailed and associated studies to understand better about the influence of Ramadan fast on various ocular parameters.

Short-Term Effects of Two Types of Goggles On Intraocular Pressure and Anterior Eye Segment Biometrics

10.21203/rs.3.rs-1069603/v1 ◽

2021 ◽

Author(s):

Xu Zhang ◽

Huixian Wang ◽

Yuan Nie ◽

Wenjing Li

Keyword(s):

Intraocular Pressure ◽

Anterior Chamber ◽

Corneal Thickness ◽

Anterior Segment ◽

Anterior Chamber Depth ◽

Cross Sectional Study ◽

Cross Sectional ◽

Chamber Volume ◽

Significant Difference ◽

Anterior Eye Segment

Abstract Background: To evaluate and compare the changes in intraocular pressure and anterior eye segment biometrics,during and after wearing two types of commonly used swimming goggles.Methods: In a cross-sectional study, a total of 40 healthy adults aged between 18 and 60 years old were selected to wear two kinds of common swimming goggles (ocular socket and orbital goggles). Intraocular pressure and anterior segment biometry were evaluated before wearing, at 2 and 5 minutes of wearing, and at 5 minutes after removing the goggles. Intraocular pressure (IOP), corneal front keratometry values (K1, K2, Km), central corneal thickness (CCT), central anterior chamber depth (ACD), anterior chamber volume (ACV), and anterior chamber angle (ACA) were measured.Results: The IOP at 2 minutes (21.0±2.2 mmHg) and 5 minutes (21.2±2.3 mmHg) was significantly higher than before wearing goggles (17.7± 2.1 mmHg). The IOP after the goggles were removed and at 5 minutes after the goggles were removed was 18.4±2.3 mmHg and 17.7±2.1 mmHg, respectively. ACV, ACD, and ACA values all decreased while the googles were worn. After the goggles were removed, these changes gradually returned to baseline values, with no significant difference in the values before and after.Conclusion: This study proves that wearing orbital goggles can lead to an acute increase in IOP and a slight decrease in ACV, ACD, and ACA. However, once the goggles are removed, these indicators return to baseline levels, showing that wearing orbital goggles has no significant lasting effect on IOP and anterior segment parameters.

Effect of platelet-rich plasma on the degenerative rotator cuff tendinopathy according to the compositions

Journal of Orthopaedic Surgery and Research ◽

10.1186/s13018-019-1406-4 ◽

2019 ◽

Vol 14 (1) ◽

Cited By ~ 3

Author(s):

Sang Jun Kim ◽

Seung Mi Yeo ◽

Soo Jin Noh ◽

Chul-Won Ha ◽

Byung Chan Lee ◽

...

Keyword(s):

Regression Analysis ◽

Rotator Cuff ◽

Linear Regression ◽

Platelet Rich Plasma ◽

Linear Regression Analysis ◽

Significant Group ◽

Meaningful Improvement ◽

Cutoff Value ◽

Significant Difference ◽

Tgf Β1

Abstract Background There are controversies about platelet-rich plasma (PRP) as an established treatment option for rotator cuff (RC) tendinopathy. The purpose of the study was to find the relation of cellular component with clinical efficacy in RC tendinopathy and to find the composition of PRP in treating RC tendinopathy. Methods A total 30 patients were recruited and divided into PRP and control groups. In the PRP group, 2 ml of PRP solution was injected to the hypoechoic lesion of degenerative supraspinatus via 22-gauge syringe with peppering technique. Patients in the control group were taught rotator cuff strengthening exercises. American Shoulder and Elbow Surgeons (ASES), Constant-Murley score, and numeric rating scale (NRS) were measured before, 6 weeks after, 12 weeks after, and 24 weeks after the procedure. PRP compositions were analyzed using the 1 ml of PRP solution. Results Linear regression analysis showed no significant difference of ASES and Constant-Murley scores between the groups at 6 weeks (P = 0.582 and 0.258) and at 12 weeks (P = 0.969 and 0.795) but showed a significant difference at 24 weeks (P = 0.050 and 0.048). Independent t test showed significant group difference of NRS at 6 weeks (P = 0.031) but not at 12 and 24 weeks (P = 0.147 and 0.935). 5.19 pg/ml in IL-1β and 61.79 μg/ml in TGF-β1 were acquired as cutoff values to predict meaningful improvement. The PRP subgroup above IL-1β or TGF-β1 cutoff value showed significant differences in all clinical outcomes compared with the exercise group while the PRP subgroup below the cutoff value showed no significant differences in linear regression analysis. Conclusions Our study can help to find the optimal PRP condition and to enhance the effect of PRP on RC tendinopathy. Trial registration All the patients were registered in our Institutional Ethics Committee (approval number 2014-05-009).

Distribution of White-to-White Corneal Diameter and Anterior Chamber Depth in Chinese Myopic Patients

Frontiers in Medicine ◽

10.3389/fmed.2021.732719 ◽

2021 ◽

Vol 8 ◽

Author(s):

Guihua Xu ◽

Guanrong Wu ◽

Zijing Du ◽

Shanqing Zhu ◽

Yunxiang Guo ◽

...

Keyword(s):

Anterior Chamber ◽

Age Groups ◽

Anterior Segment ◽

Anterior Chamber Depth ◽

Distribution Patterns ◽

Normal Range ◽

Cross Sectional ◽

Significant Difference ◽

Study Population ◽

Corneal Diameter

Purpose: To investigate the distribution of white-to-white (WTW) corneal diameter and anterior chamber depth (ACD) in Chinese myopia patients.Methods: This was a cross-sectional observational study conducted at five ophthalmic centers. Anterior segment biometry was performed in 7,893 eyes of the 7,893 myopic patients using Pentacam, and the WTW and ACD were recorded. The distribution patterns of WTW and ACD were evaluated and the correlation between WTW and ACD was analyzed statistically.Results: There were 4416 (55.95%) males and 3477 (44.05%) females. The age of the study population was 25.14 ± 5.41 years. Distribution of WTW was slightly positively skewed (Skewness = 0.0076, Kurtosis = 0.3944, KS P = 0.020) with a mean of 11.65 ± 0.38 mm and a 95% normal range of 10.91–12.39 mm. A significant difference in WTW was found among different myopia groups (P < 0.001). The ACD was normally distributed (Skewness = 0.899, Kurtosis = 0.027, KS P = 0.086). The mean ACD was 3.25 ± 0.26 mm and the 95% normal range of was 2.74–3.75 mm. A significant difference in ACD was also found among different myopia groups (P = 0.030). There was a significant correlation between WTW and ACD (r = 0.460, P < 0.001).Conclusions: In our study, 95% of the Chinese myopic patients had a WTW within 10.91–12.39 mm and an ACD within 2.74–3.75 mm. ACD and WTW were significantly different among different myopia, gender and age groups. WTW was positively correlated with ACD.

Comparison of [18F] NaF PET/CT Analysis Methods and Derivation of a Semi-population Input Function for Site Specific Measurements of Bone Formation in a Population With Chronic Kidney Disease Mineral and Bone Disorder

10.21203/rs.3.rs-641228/v1 ◽

2021 ◽

Author(s):

Marie Houmaa Vrist ◽

Jesper Nørgaard Bech ◽

Thomas Guldager Lauridsen ◽

Claire Anne Fynbo ◽

Jørn Theil

Keyword(s):

Regression Analysis ◽

Linear Regression ◽

Linear Regression Analysis ◽

Input Function ◽

Mineral And Bone Disorder ◽

Pet Ct ◽

Significant Difference ◽

Bone Disorder ◽

Non Linear ◽

Patlak Analysis

Abstract PurposeImplementation and comparison of non-invasive dynamic and static whole-body (WB) [18F]NaF PET/CT scan methods to replace invasive bone biopsy, used for quantitative analysis of bone clearance in patients with chronic kidney disease - mineral and bone disorder (CKD-MBD).MethodsSeventeen patients with CKD-MBD underwent a 60-minute dynamic scan followed by a 30-minute static WB scan. Tracer kinetics in four thoracic vertebrae were analyzed using non-linear regression and Patlak analysis using image-derived arterial input functions. We validated the use of a semi-population input function in this population.ResultsSkeletal plasma clearance (Ki) from Patlak analyses correlated well with non-linear regression analysis, but Ki-results using Patlak analysis were lower compared to Ki-results using non-linear regression analysis. However, no significant difference was found between Ki obtained by static WB scans and Ki obtained by dynamic scans using non-linear regression analysis (p=0.29). ConclusionOur results show good correlation between dynamic and static analysis of skeletal plasma clearance with no significant difference between the Ki-results obtained by non-linear regression analysis and the more clinically suitable static scan analysis method. We found lower Ki-results when Patlak analysis was applied. Thus, WB [18F]NaF PET/CT scans can be applied in future studies to measure Ki in CKD-BMD patients, but the results should not be compared uncritically with results obtained by dynamic scans analysis.

Peripheral Anterior Chamber Depth and Angle Measurements Using Pentacam After Implantation of Toric and Non-toric Implantable Collamer Lenses

Frontiers in Medicine ◽

10.3389/fmed.2021.610590 ◽

2021 ◽

Vol 8 ◽

Author(s):

Jiao Zhao ◽

Jing Zhao ◽

Wen Yang ◽

Huamao Miao ◽

Lingling Niu ◽

...

Keyword(s):

Anterior Chamber ◽

Anterior Chamber Depth ◽

Case Series ◽

Angle Measurements ◽

Significant Difference ◽

Group A ◽

Icl V4c ◽

Contralateral Eye ◽

Group B ◽

Safety Indices

Purpose: To evaluate the characteristics of peripheral anterior chamber measurements by Pentacam after posterior implantable collamer lenses (ICL) and toric ICL (TICL) with central hole (V4c) implantation.Methods: Prospective, non-randomized consecutive case series. Forty-six patients undergoing ICL implantation in one eye (Group A) and identically sized TICL in the contralateral eye (Group B) in the Refractive Surgery Center of Eye and ENT Hospital of Fudan University were prospectively included. According to ICL/TICL size, these eyes were further divided into four subgroups. Peripheral anterior chamber depth (PACD) and angle (ACA) in nasal and temporal sides were measured using Pentacam pre-operatively and 12-month post-operatively.Results: The safety indices were 1.34 ± 0.32 and 1.25 ± 0.16 and the efficacy indices were 1.20 ± 0.24 and 1.19 ± 0.19 for ICL and TICL groups, respectively. There was no significant difference in pre-operative PACD or ACA between the two groups. Post-operative PACD and ACA were significantly lower than pre-operative values. Variations of PACD and ACA of TICL group were significantly larger than those of ICL group. The change of ACA for 13.2 mm lenses was significantly larger than that of 12.6 mm lenses. Pre-operative CACD and vault were significantly associated with post-operative PACD, while pre-operative ACA and vault were significantly associated with post-operative ACA.Conclusions: Variations of PACD and ACA were greater in eyes after TICL (V4c) implantation compared with identically sized ICL (V4c) implantation and with larger size than smaller size lens implantation. Pre-operative anterior chamber structure and vault affect post-operative PACD and ACA.