scholarly journals The Effect of Apolipoprotein E Gene Polymorphism and Lp (a) Levels on Coronary Artery Disease with Atrial Fibrillation

2021 ◽  
Author(s):  
Yong Li ◽  
Lei Chen ◽  
Min Zhang ◽  
Wensu Chen
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Apolipoprotein E ◽  
Blood Lipid ◽  
E Gene ◽  
Apolipoprotein E Gene ◽  
Independent Risk Factors ◽  
Artery Disease

Abstract Background This study is the first to explore the influence of the apolipoprotein E gene (APOE) and blood lipid metabolism on coronary artery disease (CAD) with atrial fibrillation.Methods In this study, there were a total of 2048 participants, including 400 patients in the control group (CAD- AF-), 126 AF patients without CAD (CAD- AF+), 1294 CAD patients without AF (CAD+ AF-) and 228 CAD patients with AF (CAD+ AF+). Blood lipid levels and APOE genotypes were determined by collecting blood samples from the patients.Results Compared with CAD patients without AF, the age and Lp (a) levels of CAD patients with AF were significantly higher. Among CAD patients, the frequencies of E3/E3 and ε3 genotypes in patients with AF were significantly lower than those in patients without AF, and the frequencies of E4/E4 and ε4 genotypes were significantly increased. Spearman correlation analysis showed that in CAD patients, Lp(a) levels in the ε4 group were significantly higher than those in the group of patients without ε4, and there was a significant correlation between ε4 and Lp (a) levels (p<0.001, r=0.106). Multivariate logistic regression analysis found that the increase in Lp (a) levels (p=0.023) and age (p=0.01) were independent risk factors for CAD patients who develop AF.Conclusion Patients with AF had increased age, ε4 frequencies and Lp (a) levels among CAD patients, age and Lp (a) levels may be independent risk factors for CAD patients to develop AF.

scholarly journals Apolipoprotein E gene polymorphism: effects on plasma lipids and risk of type 2 diabetes and coronary artery disease

2012 ◽  
Vol 11 (1) ◽  
pp. 36 ◽  
Author(s):  
Rajesh Chaudhary ◽  
Atip Likidlilid ◽  
Thavatchai Peerapatdit ◽  
Damras Tresukosol ◽  
Sorachai Srisuma ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Polymorphism ◽  
Apolipoprotein E ◽  
Plasma Lipids ◽  
E Gene ◽  
Apolipoprotein E Gene ◽  
Artery Disease

Relationship between severity of coronary artery disease and apolipoprotein E gene polymorphism

2010 ◽  
Vol 10 (3) ◽  
pp. 202-208 ◽  
Author(s):  
F. Demet Arslan Ince ◽  
Aysenur Atay ◽  
Mehmet Koseoglu ◽  
Murat Yesil ◽  
Erdal Deveci
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Polymorphism ◽  
Apolipoprotein E ◽  
E Gene ◽  
Apolipoprotein E Gene ◽  
Artery Disease

Relevance of Apolipoprotein E Polymorphism for Coronary Artery Disease in the Saudi Population

1999 ◽  
Vol 123 (12) ◽  
pp. 1241-1245
Author(s):  
Nduna Dzimiri ◽  
Brian F. Meyer ◽  
Syed S. Hussain ◽  
Chona Basco ◽  
Barima Afrane ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Apolipoprotein E ◽  
Elevated Serum ◽  
Serum Triglycerides ◽  
Increased Risk ◽  
Apolipoprotein E Polymorphism ◽  
Independent Risk Factors ◽  
Artery Disease

Abstract Background.—The apolipoprotein E alleles ε2 and ε4 have been reported as independent risk factors for coronary artery disease (CAD) and as predictors for the development of atherosclerosis. Methods and Results.—We determined by polymerase chain reaction the distribution of apolipoprotein E polymorphism in 320 Saudi blood donors (BD), 96 CAD patients, and 40 control subjects who had undergone angiography. Compared to controls, only ε4 was elevated in CAD patients. More than 61% (P &lt; .0001) of the patients had angina, and 52.1% (P &lt; .05) were diabetic; both of these factors were strongly associated with the presence of allele ε2. The ε2 allele was also associated with hypertension, elevated serum triglycerides, and total cholesterol. On the other hand, the allele ε4 appeared to be associated with increased risk of CAD and was also associated with hypertension, 3-vessel disease, and restenosis. Conclusions.—Accordingly, ε4 may be associated with increased risk of CAD, whereas ε2 appears to be a predictor of several risk factors for atherosclerosis.

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