Identification and Characterization of Novel Nematode Cell Death Genes and Their Mammalian Homologs.

1998 ◽  
Author(s):  
Michael Hengartner
Keyword(s):  
Cell Death ◽  
Cell Death Genes ◽  
Death Genes ◽  
Identification And Characterization

Functional characterization of calliphorid cell death genes and cellularization gene promoters for controlling gene expression and cell viability in early embryos

2014 ◽  
Vol 24 (1) ◽  
pp. 58-70 ◽  
Author(s):  
R. M. Edman ◽  
R. J. Linger ◽  
E. J. Belikoff ◽  
F. Li ◽  
S.-H. Sze ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Death ◽  
Cell Viability ◽  
Functional Characterization ◽  
Gene Promoters ◽  
Early Embryos ◽  
Cell Death Genes ◽  
Death Genes

Expression of cell death genes during human preimplantation embryo development

1998 ◽  
Vol 5 (1) ◽  
pp. 149A-149A
Author(s):  
A JURISICOVA ◽  
S VARMUZA ◽  
N MACLUSKY ◽  
R CASPER
Keyword(s):  
Cell Death ◽  
Embryo Development ◽  
Preimplantation Embryo ◽  
Preimplantation Embryo Development ◽  
Cell Death Genes ◽  
Death Genes

scholarly journals Network Analysis Identifies Drug Targets and Small Molecules to Modulate Apoptosis Resistant Cancers

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 851
Author(s):  
Samreen Fathima ◽  
Swati Sinha ◽  
Sainitin Donakonda
Keyword(s):  
Cell Death ◽  
Small Molecules ◽  
Drug Targets ◽  
Apoptotic Cell ◽  
Colon Adenocarcinoma ◽  
Interaction Networks ◽  
Small Cell Lung ◽  
Protein Protein Interaction ◽  
Cell Death Genes ◽  
Death Genes

Programed cell death or apoptosis fails to induce cell death in many recalcitrant cancers. Thus, there is an emerging need to activate the alternate cell death pathways in such cancers. In this study, we analyzed the apoptosis-resistant colon adenocarcinoma, glioblastoma multiforme, and small cell lung cancers transcriptome profiles. We extracted clusters of non-apoptotic cell death genes from each cancer to understand functional networks affected by these genes and their role in the induction of cell death when apoptosis fails. We identified transcription factors regulating cell death genes and protein–protein interaction networks to understand their role in regulating cell death mechanisms. Topological analysis of networks yielded FANCD2 (ferroptosis, negative regulator, down), NCOA4 (ferroptosis, up), IKBKB (alkaliptosis, down), and RHOA (entotic cell death, down) as potential drug targets in colon adenocarcinoma, glioblastoma multiforme, small cell lung cancer phenotypes respectively. We also assessed the miRNA association with the drug targets. We identified tumor growth-related interacting partners based on the pathway information of drug-target interaction networks. The protein–protein interaction binding site between the drug targets and their interacting proteins provided an opportunity to identify small molecules that can modulate the activity of functional cell death interactions in each cancer. Overall, our systematic screening of non-apoptotic cell death-related genes uncovered targets helpful for cancer therapy.

scholarly journals 1779 Cell Death Genes are Induced Immediately after Hypoxia-Reoxygenation (HR) in the Newborn Mouse Lung

2012 ◽  
Vol 97 (Suppl 2) ◽  
pp. A503-A503
Author(s):  
E. Wollen ◽  
A. Rognlien ◽  
M. Atneosen-Asegg ◽  
M. Wright ◽  
M. Bjoras ◽  
...  
Keyword(s):  
Cell Death ◽  
Mouse Lung ◽  
Newborn Mouse ◽  
Cell Death Genes ◽  
Death Genes ◽  
Hypoxia Reoxygenation

Interleukin-1α-converting enzyme (ICE) and related cell death genes ICErel-II and ICErel-III map to the same PAC clone at band 11q22.2-22.3

1997 ◽  
Vol 8 (8) ◽  
pp. 611-613 ◽  
Author(s):  
Jamal Nasir ◽  
Jane L. Theilmann ◽  
John P. Vaillancourt ◽  
Neil A. Munday ◽  
Ambereen Ali ◽  
...  
Keyword(s):  
Cell Death ◽  
Converting Enzyme ◽  
Related Cell ◽  
Interleukin 1Α ◽  
Cell Death Genes ◽  
Death Genes

scholarly journals Native cell-death genes as candidates for developing wilt resistance in transgenic banana plants

AoB Plants ◽  
2014 ◽  
Vol 6 (0) ◽  
pp. plu037-plu037 ◽  
Author(s):  
S. B. Ghag ◽  
U. K. S. Shekhawat ◽  
T. R. Ganapathi
Keyword(s):  
Cell Death ◽  
Wilt Resistance ◽  
Native Cell ◽  
Transgenic Banana ◽  
Cell Death Genes ◽  
Death Genes

Transient Transfection Assay of Cell Death Genes

2000 ◽  
pp. 480-492 ◽  
Author(s):  
Masayuki Miura ◽  
Junying Yuan
Keyword(s):  
Cell Death ◽  
Transient Transfection ◽  
Transient Transfection Assay ◽  
Cell Death Genes ◽  
Death Genes ◽  
Transfection Assay

Cell Death Genes May Hold Clues to Preserving Fertility After Chemotherapy

1999 ◽  
Vol 91 (8) ◽  
pp. 664-666 ◽  
Author(s):  
T. Reynolds
Keyword(s):  
Cell Death ◽  
Cell Death Genes ◽  
Death Genes
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