scholarly journals Placental Changes in Anemia, Gestational Diabetes and Pregnancy Induced Hypertension

2020 ◽  
Vol 6 (2) ◽  
pp. 86-91
Author(s):  
Mithil Potuganti ◽  
B. R. Zambare

Background: To assess the changes occurring in the placenta due to anemia, pregnancy induced hypertension (PIH), Gestational Diabetes Mellitus (GDM) and whether these changes were reversible with treatment when they were diagnosed in early stages. Subjects and Methods: The study is conducted in the Department of Obstetrics and Gynecology, DVVPF’s Medical College, Ahmednagar on 200 anemic patients, 180 PIH patients and 650 GDM patients. Placentae were collected, stored in a 10% formalin solution. Morphological changes in respect to shape, weight, diameter, thickness, number of cotyledons and site of insertion of the cord are observed and documented. Results: In anemic patients who has undergone treatment, there were a smaller number of irregular (37/100) and round (63/100) round placentae were seen, whereas in the untreated anemic group, round (09/100) round and irregular (91/100) irregular placentae were seen. In PIH group with treatment, round (57/90) placentae and irregular (33/90) placentae were seen, whereas, in the untreated group, 13/100 round/oval placentae were observed and 77/100 irregular placentae were seen. Conclusion: Morphology of placenta is on error mode in untreated anemia, PIH and GDM. Diagnosis in the first trimester and on consequent treatment till the delivery is resulting in decreasing of irregular morphology of placenta and wellbeing of newborns.

2021 ◽  
Author(s):  
Dan DIAO ◽  
DIAO Fang ◽  
XIAO Bin ◽  
Ning LIU ◽  
Fengjuan LI ◽  
...  

Abstract Both gestational diabetes mellitus(GDM) and pregnancy induced hypertension (PIH) would influence the gestation significantly. However, the causation between these two symptoms remains speculative. 16,404 pregnant women were identified in Harbin, China in this study. We investigated the evaluate the causal effect of GMD on PIH based on the statistic inference theory. The statistical results indicated that GDM might cause PIH. Also, this case study demonstrated that the decrease temperature might also cause hypertension during pregnancy, and the prevalence rate of GDM increased with age. However, the prevalence of diabetes did not show a remarkable difference in varied areas and ages. This study could provide some essential information that will help to investigate the mechanism for GDM and PIH.


2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Yunhui Wang ◽  
Xiaomiao Zhao ◽  
Huidan Zhao ◽  
Hong Ding ◽  
Jianping Tan ◽  
...  

Objectives. To evaluate pregnancy outcomes and its determinants in women with polycystic ovary syndrome (PCOS).Methods. Two-hundred and twenty pregnant PCOS and 594 healthy women were followed from early pregnancy. Incidences of gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), preterm birth, twinning, and fetal growth restriction (FGR) were determined.Results. The incidence of GDM was notably higher among all PCOS combined (54.9%; OR: 2.9, 95% CI: 2.0–4.1) and PCOS subgroups, whether they conceived spontaneously (51.5%; OR: 3.3, 95% CI: 2.0–5.4), or via IVF-ET or ovarian stimulation, compared with controls (14.3%;P<0.001). The incidence of PIH was also higher among all PCOS (10.4%; OR: 2.2, 95% CI: 1.1–4.4) and the subgroup conceiving spontaneously (11.8%; OR: 2.6, 95% CI: 1.1–6.2;P<0.001) but not for those conceiving with IVF-ET (9.1%) or ovarian stimulation (9.4%). Lean women with PCOS (BMI<24kg/m2) had higher incidences of GDM (51.1% versus 14.5%; OR: 5.6, 95% CI: 3.4–9.0) and PIH (8.9% versus 3.2%; OR: 3.0, 95% CI: 1.3–7.1) than lean controls. PCOS woemn with normal glucose tolerance had higher risk for PIH than their comparable control group (OR: 4.0, 95% CI: 1.3–11.7).Conclusion. This study suggested that PCOS is an independent risk factor for the development of GDM and PIH. This trial is registered withChiCTR-RCC-11001824.


2015 ◽  
Vol 4 (11) ◽  
pp. 453-456 ◽  
Author(s):  
Sajida Perveen ◽  
Qaiser Jabeen ◽  
Muhammad Zahid Iqbal

Pregnancy-induced hypertension (PIH) and gestational diabetes mellitus (GDM) both have no adequate classification in addition to nomenclature that creates difficulties for researchers to find link between them. Aim of this work was to review the most recent data available on PIH and GDM and find the association between both conditions during gestation. Epidemeologies and whole studies which have done till now days, could not satisfy that what is association between PIH and GDM. The main issue to solve is how to find the association between GDM and PIH. Very limited data and research studies are available, creating hindrance to find any association. The one way to find the association now, can be that it should be checked the level of hypertension before, during and after gestation. According to the available data and research, it could be deduced that insulin resistance, present in non-insulin dependent diabetes mellitus (NIDDM), may provide association more frequently. However, no direct evidential data is available for this link.Perveen et al., International Current Pharmaceutical Journal, October 2015, 4(11): 453-456


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