scholarly journals Tuberculosis Situation in Volga Federal District in 2016-2020

2022 ◽  
Vol 99 (12) ◽  
pp. 22-26
Author(s):  
M. M. Yunusbaeva ◽  
L. Ya. Borodina ◽  
R. A. Sharipov ◽  
E. S. Bilalov ◽  
M. M. Аzamatova ◽  
...  
Keyword(s):  
Federal District ◽  
Multiple Drug ◽  
Maximum Increase ◽  
Resistant Tuberculosis ◽  
Hiv Coinfection ◽  
Multiple Drug Resistant ◽  
Republic Of Bashkortostan ◽  
Mdr Tb ◽  
The Russian Federation ◽  
The Republic

The objective of the study: to assess changes in the incidence and prevalence of multiple drug resistant tuberculosis (MDR TB) and TB/HIV coinfection (TB/HIV) in Volga Federal District (VFD) and its regions during 2016-2020.Subjects and Methods. Data from FGSN Forms No. 8, 33, and 61, and analytical reviews of main statistical TB rates in the Russian Federation have been studied. The number of those died is presented as per the Rosstat data.Results. An increase in the incidence and prevalence of MDR TB and TB/HIV coinfection has been detected in certain region of Volga Federal District. Perm Region, the Republic of Bashkortostan, the Republic of Udmurtia, and Orenburg and Samara Regions have the highest prevalence of MDR TB and TB/HIV coinfection. In 2020, the Republic of Bashkortostan was the only region where the incidence and prevalence of MDR TB were growing (164.7% and 47.3%, respectively). The highest incidence and prevalence of TB/HIV coinfection was reported in the Republic of Bashkortostan, Perm Kray, Orenburg Region, the Chuvash and Udmurt Republics. Over the last 5 years, the maximum increase in TB/HIV incidence and prevalence was observed in the Republic of Bashkortostan (38.8% and 41.3%, respectively).

Synthesis and Anti-mycobacterium Study on Halo-substituted 2-aryl oxyacetohydrazones

2020 ◽  
Vol 16 (5) ◽  
pp. 618-628 ◽  
Author(s):  
Vijay J. Desale ◽  
Suraj N. Mali ◽  
Hemchandra K. Chaudhari ◽  
Maya C. Mali ◽  
Bapu R. Thorat ◽  
...  
Keyword(s):  
Uv Spectroscopy ◽  
Health Concern ◽  
Multiple Drug ◽  
Resistant Tuberculosis ◽  
Multiple Drug Resistant ◽  
H37rv Strain ◽  
Mdr Tb ◽  
Drug Regimens ◽  
Ft Ir ◽  
Mycobacteria Tuberculosis

Background: The treatment of multiple-drug-resistant tuberculosis (MDR-TB) with currently available marketed drugs remains a global health concern. The cases of resistant tuberculosis patients are increasing day by day. Objective: The objective of this study is to highlight the need of developing shorter, simpler and tolerable drug regimens. Methods: In the present study, we synthesized various halo-substituted 2-aryloxyacetohydrazones via a series of reactions from halo-substituted phenols. All the compounds were characterized by using various spectroscopic methods, such as NMR, FT-IR, UV spectroscopy, etc. Results: All the synthesized hydrazones showed theoretically good interactions with enzyme enoyl reductase (pdb id: 4tzk). All the synthesized compounds (5a-5o) showed moderate to good activity (3.125-100 μg/mL) against Mycobacteria tuberculosis, H37RV strain. Conclusion: Our results would pave a new way for the development of more effective Anti-TB agents in the future.

Analisis of budget costs with different treatment efficiencies of newly diagnosed tuberculosis patients with multiple drug resistant pathogen

2021 ◽  
Vol 9 (3) ◽  
pp. 5-10
Author(s):  
N.V. Kuznetsov ◽  
A.S. Lesonen ◽  
U.M. Markelov ◽  
E.D. Mikhailova
Keyword(s):  
Drug Resistance ◽  
Rapid Determination ◽  
Multiple Drug Resistance ◽  
Multiple Drug ◽  
Multiple Drug Resistant ◽  
Treatment Gaps ◽  
Mdr Tb ◽  
Polymerase Chain ◽  
The Republic

The article presents the results of predicting the dynamics of the spread of new cases of tuberculosis (TB) with multiple drug resistance (MDR) in the Republic of Karelia, as well as the costs of treating patients with tuberculosis, considering the different effectiveness of treatment. It has been demonstrated that while enhancing efficiency of treatment, due to the rapid determination of drug resistance by the method of polymerase chain reaction and a decrease in treatment gaps (using food kits), the effectiveness of treatment is significantly increased and the prevalence of MDR-TB decreases, which leads to significant budget savings.

scholarly journals Risk factors for multiple drug resistant tuberculosis relapses

2020 ◽  
Vol 98 (11) ◽  
pp. 21-26
Author(s):  
А. S. Аlliluev ◽  
O. V. Filinyuk ◽  
E. E. Shnayder ◽  
P. N. Golubchikov ◽  
D. E. Аmichba
Keyword(s):  
Risk Factors ◽  
Medical Center ◽  
Multiple Drug ◽  
Sputum Smear ◽  
Smear Microscopy ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Resistant Tuberculosis ◽  
Multiple Drug Resistant ◽  
Mdr Tb

The objective of the study: to identify risk factors for relapses in patients after the effective course of chemotherapy for multiple drug resistant tuberculosis (MDR TB). Subjects and methods. Medical files of 346 adult MDR TB patients were analyzed, they all had the effective treatment as per regimen IV in Tomsk Phthisiopulmonology Medical Center in 2009-2011. They were divided into 2 groups: Group 1 included 35 patients who developed a relapse of tuberculosis over the next 5 years; Group 2 consisted of 311 patients who had no relapse of the disease over the next 5 years. Results. The relapse rate in effectively treated MDR TB patients made 10.1% (35/346 patients). The following social factors contributed to higher chances of the relapse: retirement age (p = 0.045; OR = 2.86 [1.14-7.20]) and disability due to somatic diseases (p < 0.001; OR = 4.82 [2.13-10.90]); while biomedical factors were the following: HIV infection (OR = 19.19 [5.29-69.56]), mental illness (OR = 5.85 [2.27-15.03]), tobacco smoking (OR = 3.16 [1.08-9.20]). People with history of tuberculosis relapses (OR = 12.17 [4.19-35.34]) have higher chances of relapse, as well as those having the following characteristics of the tuberculosis disease during the effective chemotherapy course: destruction of lung tissue (OR = 7.48 [1.76-31.80]), positive results of sputum smear microscopy (OR = 2.91 [1.28-6.61]), persisting bacterial excretion (by culture) after 2 months of chemotherapy (OR = 4.98 [2.41-10.29]).

scholarly journals Machine Learning for Prediction of Relapses in Multiple Drug Resistant Tuberculosis Patients

2021 ◽  
Vol 99 (11) ◽  
pp. 27-34
Author(s):  
A. S. Аlliluev ◽  
O. V. Filinyuk ◽  
E. E. Shnаyder ◽  
S. V. Аksenov
Keyword(s):  
Machine Learning ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Gradient Boosting ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Resistant Tuberculosis ◽  
Multiple Drug Resistant ◽  
Mdr Tb

The objective of the study: to evaluate the possibility of using machine learning algorithms for prediction of relapses in multiple drug resistant tuberculosis (MDR TB) patients.Subjects and Methods. Сlinical, epidemiological, gender, sex, social, biomedical parameters and chemotherapy parameters were analyzed in 346 cured MDR TB patients. The tools of the scikit-learn library, Version 0.24.2 in the Google Colaboratory interactive cloud environment were used to build forecasting models.Results. Analysis of the characteristics of relapse prediction models in cured MDR TB patients using machine learning algorithms including decision tree, random forest, gradient boosting, and logistic regression using K-block stratified validation revealed high sensitivity (0.74 ± 0.167; 0.91 ± 0.17; 0.91 ± 0.14; 0.91 ± 0.16, respectively) and specificity (0.97 ± 0.03; 0.98 ± 0.02; 0.98 ± 0.02; 0.98 ± 0.02, respectively).Five main predictors of relapse in cured MDR-TB patients were identified: repeated courses of chemotherapy; length of history of tuberculosis; destructive process in the lungs; total duration of treatment less than 22 months; and use of less than five effective anti-TB drugs in the regimen of chemotherapy.

scholarly journals Treatment of multiple drug-resistant tuberculosis (MDR-TB) in Iran

2005 ◽  
Vol 9 (6) ◽  
pp. 317-322 ◽  
Author(s):  
Seyed Mehdi Mirsaeidi ◽  
Payam Tabarsi ◽  
Kaveh Khoshnood ◽  
Majid Valiollah Pooramiri ◽  
Ali Rowhani-Rahbar ◽  
...  
Keyword(s):  
Multiple Drug ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Resistant Tuberculosis ◽  
Multiple Drug Resistant ◽  
Mdr Tb

scholarly journals Effect of moxifloxacin on oxidative stress, paraoxonase-1 (PON1) activity and efficacy of treatment in patients with multiple drug-resistant tuberculosis

2017 ◽  
Vol 16 (10) ◽  
pp. 2515-2520 ◽  
Author(s):  
Hongguo Yang ◽  
Yanyan Zhao ◽  
Yunbo Ma ◽  
Qiang Wen ◽  
Minghui Zhang
Keyword(s):  
Oxidative Stress ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Control Group ◽  
Multiple Drug ◽  
Observation Group ◽  
Drug Resistant ◽  
Resistant Tuberculosis ◽  
Multiple Drug Resistant ◽  
Mdr Tb

Purpose: To investigate the effect of moxifloxacin on paraoxonase-1 (PON1)  activity, and serum oxidative stress in patients with multiple drug-resistant tuberculosis (MDR-TB).Methods: A total ofof 130 MDR-TB patients who were treated with moxifloxacin from October 2014 to October 2010 in Eastern Medical District of Linyi People's Hospital of Shandong Province, China were randomly divided into an observation group (65 cases, moxifloxacin group) and control group (65 cases, non-moxifloxacin group). Total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), PON1 levels and treatment efficacy for groups were determined.Results: Compared with pre-treatment levels, TOS (23.3 ± 4.7 vs 13.9 ± 3.3 umol H2O2 Eq/L, t = 13.20, p = 0.00) and OSI (17.4 ± 4.8 vs 5.7 ± 1.4 U, t = 18.87, p = 0.00) of the observation group significantly decreased, while TAS (1.4 ± 0.5 vs 3.5 ± 0.7 umol Trolox Eq/L, t = 19.68, p = 0.00) and PON1 (15.5 ± 6.9 vs 31.1 ± 8.3 U/L, t = 11.65, p = 0.00) significantly increased. TOS (23.3 ± 4.7 vs 13.9 ± 3.3 umol H2O2 Eq/L, t = 7.73, p < 0.05) and OSI (16.9 ± 5.5 vs 7.4 ± 3.2U, t = 12.04, p = 0.05) reduced significantly in the control group. Moxifloxacin correlated positively with △TAS (r = 0.697, p = 0. 04) and △PON1 (r = 0.785, p = 0.01), but correlation with △TOS (r = -0.625, p = 0.01) was negative. Efficacy was significantly higher in the observation group than that in the control group (81.54 % vs 56.92 %, p =0.00).Conclusion: Oxidative stress injury in MDR-TB patients may be effectively managed by combination of moxifloxacin with anti-TB treatmentKeywords: Multiple drug-resistant TB, Moxifloxacin, Paraoxonase, Oxidative stress

scholarly journals Clinical and economic aspects of enhanced treatment efficacy of multiple drug resistant tuberculosis

2020 ◽  
Vol 98 (9) ◽  
pp. 50-54
Author(s):  
Yu. M. Markelov ◽  
A. S. Lesonen
Keyword(s):  
Treatment Efficacy ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Sensitivity Testing ◽  
Drug Resistant Tuberculosis ◽  
Tuberculosis Patients ◽  
Resistant Tuberculosis ◽  
Multiple Drug Resistant ◽  
Economic Efficacy ◽  
The Republic

The objective of the study: To evaluate the clinical and economic efficacy of chemotherapy in patients with newly diagnosed multiple drug resistant tuberculosis (MDR).Subjects and methods. The number and structure of MDR tuberculosis patients living on the territory of the Republic of Karelia from 2008 to 2017 were studied. The clinical and economic efficacy of treatment of MDR tuberculosis patients was assessed.Results. In 2011-2017, decrease in the number of MDR patients in the Republic of Karelia was mainly due to enhanced treatment efficacy of new MDR tuberculosis cases. The introduction of social support methods (food parsels) and express drug sensitivity testing to rifampicin using the Gene Xpert MTB/RIF was associated with higher treatment efficacy – from 37.2% (2013) to 58% (2014), the lower rate of treatment defaults, and significant decrease in mortality, as well as reduction of costs for curing of one MDR tuberculosis patient from1.68 million rubles in 2012 up to 0.77 million rubles in 2014. 

scholarly journals OTOTOXICITY IN MDR-TB PATIENTS ON CATEGORY-4 REGIMEN: A CASE REPORT

2020 ◽  
Vol 7 (2) ◽  
pp. 257-259
Author(s):  
Tanish Baqar ◽  
Sharique Ahmad ◽  
Silky Rai
Keyword(s):  
Case Report ◽  
Large Scale ◽  
Multiple Drug Resistance ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Medical Progress ◽  
Resistant Tuberculosis ◽  
Multiple Drug Resistant ◽  
Mdr Tb

Multiple drug-resistant tuberculosis (MDR-TB) is a critical situation affecting adults as properly as children across the globe (1). To determine the incidence and risk factors associated with Multiple Drug Resistant Tuberculosis (MDR-TB) (2), we studied Ototoxicity on 18 culture confirmed MDR-TB patients in Eras' Lucknow Medical College and Hospital, Lucknow from September, 2019 to January, 2020. This case follows a well documented report of a patient describing an unusual and novel occurrence of ototoxicity when undergoing treatment concerning multiple drug resistance tuberculosis along with symptoms, signs, diagnosis, treatment and follow-up (3). For descriptive convenience, the patient will be classified as patient 1. The following case is the cornerstones of medical progress and provides many new ideas in medicine. Containing an extensive review of the relevant literature on the topic, the case report is a rapid short communication between busy clinicians who may not have time or resources to conduct large scale research.(4)

scholarly journals Forest fires in Volga federal district of the Russian Federation (2000-2020 years)

2021 ◽  
Vol 244 ◽  
pp. 01014
Author(s):  
Alsu Fazylova ◽  
Elina Nasyrova ◽  
Liana Faritova ◽  
Alexey Elizaryev
Keyword(s):  
Initial Data ◽  
Russian Federation ◽  
Forest Fires ◽  
Statistical Data ◽  
Strong Dependence ◽  
Federal District ◽  
Republic Of Bashkortostan ◽  
Minimum Number ◽  
The Russian Federation ◽  
The Republic

Using statistical data, the dynamics of forest fires in the Volga federal district of the Russian Federation from 2000 to 2020 years is analyzed. The number and area of forest fires were considered as the initial data. At the same time, the total area of forest fire and of burned forests were taken into account separately. It was found that during the period under review, the minimum number of fires was recorded in 2000, and the maximum in 2018. Out of 14 subjects included in the Volga federal district, forest fires in the Republic of Bashkortostan were studied in detail. The dependence of the number of fires by season is established. Using correlation analysis of the statistical data for 2000-2020, the fact of strong dependence between the number of fires in the Volga federal district and forest area covered by fire was established.

Sign in / Sign up

Export Citation Format

Share Document