Postoperative delirium in children in undergoing treatment of congenital septal heart defects

The objective: to establish the prevalence of postoperative delirium (POD) and the influence of various factors in intra- and postoperative periods on its occurrence in children with septal congenital defects requiring surgical interventions with cardiopulmonary bypass (CPB).Subjects and methods: 40 children from 6 to 36 months and weighing from 7.5 to 15 kg were enrolled in the study; they underwent planned radical surgery of septal CHD with cardiopulmonary bypass. In the postoperative period, all patients were tested using the Cornell Assessment for Pediatric Delirium validated for children of this age. Cerebral damage was also assessed using three specific serum markers: protein S-100-ß, neuron-specific enolase (NSE) and glial fibrillar acidic protein (GFAP) before the surgery, upon bypass completion, and in 16 hours after the operation.Results. The study revealed the incidence of delirium in 22.5%. When analyzing many factors of the intra- and postoperative period, it was found that the use of donor blood components in the primary volume of CPB filling was statistically significantly more often observed in patients with established delirium: 7 (78%) and 13 (42%) (p = 0.049). Also, it was found that levels of S-100-ß, NSE, and GFAP were significantly higher in patients with confirmed POD.The study described the incidence of POD in children after surgical treatment of congenital heart disease under cardiopulmonary bypass and showed that intraoperative transfusion was a risk factor for the development of delirium. The role of markers of cerebral damage in the diagnosis of POD was also proven.

Download Full-text

Cardiopulmonary bypass strategy without donor blood components as a method for preventing brain damage in children

Complex Issues of Cardiovascular Diseases ◽

10.17802/2306-1278-2021-10-2s-21-26 ◽

2021 ◽

Vol 10 (2) ◽

pp. 21-26

Author(s):

A. A. Ivkin ◽

D. V. Borisenko ◽

E. V. Grigoriev

Keyword(s):

Cardiopulmonary Bypass ◽

Interleukin 1 ◽

Neuron Specific Enolase ◽

Protein S ◽

Clinical Analysis ◽

Cerebral Injury ◽

Blood Components ◽

Donor Blood ◽

Surgical Interventions ◽

S 100

Aim. To establish the role of donor blood components which are used in the intraoperative period in children with septal congenital heart disease (CHD) who need surgical interventions with cardiopulmonary bypass (CPB) for the prevention of cerebral injury in the postoperative period.Methods. 40 children of 14 months old on average and 8.8 kg of weight were under the study. All patients underwent radical correction of the septal CHD with the use of CPB. The patients were divided into 2 groups according to the donated blood components used. Cerebral damage was assessed with the help of three specific markers: protein S-100-ß, neuron-specific enolase (NSE) and glial fibrillar acidic protein (GFAP). The severity of the systemic inflammatory response was defined by the level of the following markers: interleukin 1, 6 and 10 in serum before operations, after the completion of IC and 16 hours after surgery. The clinical analysis of cerebral injury was performed via the Cornell Assessment for Pediatric Delirium.Results. Statistically the concentration of all three markers of cerebral injury was significantly higher in the transfusion group after the end of CPB. Similar dynamics was observed in the concentrations of interleukins. In addition, the values for GFAP were higher in the transfusion group and 16 hours after surgery.Conclusion. The safety and effectiveness of the strategy on refusal of intraoperative transfusion in order to prevent cerebral injury in children during the correction of septal CHD has been demonstrated.

Download Full-text

Protein S-100 and neuron-specific enolase serum levels remain unaffected by electroconvulsive therapy in patients with depression

Journal of Neural Transmission ◽

10.1007/s00702-014-1228-9 ◽

2014 ◽

Vol 121 (11) ◽

pp. 1411-1415 ◽

Cited By ~ 8

Author(s):

Laura Kranaster ◽

Christoph Janke ◽

Sonani Mindt ◽

Michael Neumaier ◽

Alexander Sartorius

Keyword(s):

Electroconvulsive Therapy ◽

Neuron Specific Enolase ◽

Protein S ◽

Serum Levels ◽

S 100

Download Full-text

Role of endothelium dysfunction in starting immunopathologic response in chronic brain ischemia

Bulletin of Siberian Medicine ◽

10.20538/1682-0363-2008-5-2-470-474 ◽

2008 ◽

Vol 7 (5-2) ◽

pp. 470-474

Author(s):

G. I. Shumakher ◽

Ye. N. Vorobiyova ◽

Ye. V. Nechounayeva ◽

M. A. Khoreva ◽

R. I. Vorobiyov ◽

...

Keyword(s):

Laboratory Investigation ◽

Brain Ischemia ◽

Neuron Specific Enolase ◽

Protein S ◽

Circulating Endothelial Cells ◽

Control Group ◽

Laboratory Diagnostics ◽

Endothelium Dysfunction ◽

S 100 ◽

Chronic Brain Ischemia

The paper presents results of clinical and laboratory investigation of 106 patients with chronic brain ischemia (CBI) I-II stages (44 males and 62 females). The age of examined patients varied from 38 to 67 years (mean age was 55,6 ± 2,2). The diagnosis of CBI was estimated according to the generally accepted criteria. Results of laboratory investigation of 22 practically healthy people (10 males and 12 females) served as control. The age of control group varied from 35 to 64 years (mean age was 53,2 ± 2,1). Laboratory diagnostics included detection levels of circulating endothelial cells, autoantibodies to encephalitogenic protein, neuron-specific enolase and protein S-100. Reliable changes of immune status as well as signs of endothelium dysfunction was revealed. These indices are expressed in patients with CBI II stage. Direct correlation between intensity of endothelium dysfunction and activity of autoimmune aggression in brain was revealed.

Download Full-text

Prediction of cognitive dysfunction after resuscitation from out-of-hospital cardiac arrest using serum neuron-specific enolase and protein S-100

Heart ◽

10.1136/hrt.2006.091314 ◽

2007 ◽

Vol 93 (10) ◽

pp. 1268-1273 ◽

Cited By ~ 56

Author(s):

N. R Grubb ◽

C. Simpson ◽

R. A Sherwood ◽

H. D Abraha ◽

S. M Cobbe ◽

...

Keyword(s):

Cardiac Arrest ◽

Cognitive Dysfunction ◽

Neuron Specific Enolase ◽

Protein S ◽

S 100 ◽

Hospital Cardiac Arrest ◽

Serum Neuron Specific Enolase

Download Full-text

Outcome after cardiac arrest: predictive values and limitations of the neuroproteins neuron-specific enolase and protein S-100 and the Glasgow Coma Scale

Resuscitation ◽

10.1016/j.resuscitation.2004.10.011 ◽

2005 ◽

Vol 65 (1) ◽

pp. 49-55 ◽

Cited By ~ 87

Author(s):

Rüdiger Pfeifer ◽

Angelika Börner ◽

Andreas Krack ◽

Holger H. Sigusch ◽

Ralf Surber ◽

...

Keyword(s):

Cardiac Arrest ◽

Glasgow Coma Scale ◽

Neuron Specific Enolase ◽

Protein S ◽

Predictive Values ◽

Coma Scale ◽

S 100

Download Full-text

Relation between electroconvulsive therapy, cognitive side effects, neuron specific enolase, and protein S-100

Journal of Neurology Neurosurgery & Psychiatry ◽

10.1136/jnnp.71.3.394 ◽

2001 ◽

Vol 71 (3) ◽

pp. 394-396 ◽

Cited By ~ 46

Author(s):

M W Agelink

Keyword(s):

Side Effects ◽

Electroconvulsive Therapy ◽

Neuron Specific Enolase ◽

Protein S ◽

S 100 ◽

Cognitive Side Effects

Download Full-text

Neurone-specific enolase and Sangtec 100 assays during cardiac surgery: part III - does haemolysis affect their accuracy?

Perfusion ◽

10.1177/026765919701200305 ◽

1997 ◽

Vol 12 (3) ◽

pp. 171-177 ◽

Cited By ~ 30

Author(s):

F Gao ◽

D N F Harris ◽

S Sapsed-Byrne ◽

S Sharp

Keyword(s):

Cardiac Surgery ◽

Cardiopulmonary Bypass ◽

Neuronal Damage ◽

Red Cells ◽

Cerebral Damage ◽

Correction Formula ◽

S 100 ◽

Serial Dilutions

Neurone-specific enolase (NSE) and Sangtec 100 (S-100) are useful for detecting cerebral damage during cardiopulmonary bypass (CPB). However, red cells contain NSE, and the haemolysis frequently caused by CPB could produce a false rise in NSE; S-100 is not found in red cells and should not be affected. We, therefore, compared the effects of haemolysis on NSE and S-100 to see if correction was necessary and possible. From seven patients, serial dilutions of haemolysed red cells were added to plasma (1/64-1/2048), measured for absorption at 540 nm and assayed for NSE and S-100. S-100 concentrations showed no change with haemolysis. Measured NSE increased significantly with haemolysis >1/512 (an increase of 6.6 μg/ml): a correction formula is presented. In 39/48 patients after CPB, mean haemolysis was <1/256 and would not need any correction. NSE and S-100 assay can, therefore, be used throughout CPB, which allows both glial and neuronal damage to be studied.

Download Full-text