Effect of Decaffeinated Green Tea Polyphenols on Body Weight and Precocious Puberty in Obese Girls: A Randomized Controlled Trial

2020 ◽  
Author(s):  
Luyao Xie ◽  
Qingya Tang ◽  
Qiuyun Gu ◽  
Hao Zheng ◽  
Xiaodi Wang ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Body Weight ◽  
Green Tea ◽  
Precocious Puberty ◽  
Controlled Trial ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Randomized Controlled

scholarly journals Effect of Decaffeinated Green Tea Polyphenols on Body Fat and Precocious Puberty in Obese Girls: A Randomized Controlled Trial

2021 ◽  
Vol 12 ◽  
Author(s):  
Luyao Xie ◽  
Qingya Tang ◽  
Die Yao ◽  
Qiuyun Gu ◽  
Hao Zheng ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Green Tea ◽  
Body Fat ◽  
Precocious Puberty ◽  
Sexual Development ◽  
Controlled Trial ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Control Group ◽  
Randomized Controlled

BackgroundObesity has been reported to be an important contributing factor for precocious puberty, especially in girls. The effect of green tea polyphenols on weight reduction in adult population has been shown, but few related studies have been conducted in children. This study was performed to examine the effectiveness and safety of decaffeinated green tea polyphenols (DGTP) on ameliorating obesity and early sexual development in girls with obesity.DesignThis is a double-blinded randomized controlled trial. Girls with obesity aged 6–10 years old were randomly assigned to receive 400 mg/day DGTP or isodose placebo orally for 12 weeks. During this period, all participants received the same instruction on diet and exercise from trained dietitians. Anthropometric measurements, secondary sexual characteristics, B-scan ultrasonography of uterus, ovaries and breast tissues, and related biochemical parameters were examined and assessed pre- and post-treatment.ResultsBetween August 2018 and January 2020, 62 girls with obesity (DGTP group n = 31, control group n = 31) completed the intervention and were included in analysis. After the intervention, body mass index, waist circumference, and waist-to-hip ratio significantly decreased in both groups, but the percentage of body fat (PBF), serum uric acid (UA), and the volumes of ovaries decreased significantly only within the DGTP group. After controlling confounders, DGTP showed a significantly decreased effect on the change of PBF (β = 2.932, 95% CI: 0.214 to 5.650), serum UA (β = 52.601, 95% CI: 2.520 to 102.681), and ovarian volumes (right: β = 1.881, 95% CI: 0.062 to 3.699, left: β = 0.971, 95% CI: 0.019 to 1.923) in girls with obesity. No side effect was reported in both groups during the whole period.ConclusionDGTP have shown beneficial effects of ameliorated obesity and postponed early sexual development in girls with obesity without any adverse effects. Clinical Trial Registration[https://clinicaltrials.gov/ct2/show/NCT03628937], identifier [NCT03628937].

scholarly journals Subcutaneous Oxyntomodulin Reduces Body Weight in Overweight and Obese Subjects: A Double-Blind, Randomized, Controlled Trial

Diabetes ◽  
2005 ◽  
Vol 54 (8) ◽  
pp. 2390-2395 ◽  
Author(s):  
K. Wynne ◽  
A. J. Park ◽  
C. J. Small ◽  
M. Patterson ◽  
S. M. Ellis ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Body Weight ◽  
Controlled Trial ◽  
Double Blind ◽  
Randomized Controlled ◽  
Obese Subjects

scholarly journals The effect of a hiding box on stress levels and body weight in Dutch shelter cats; a randomized controlled trial

PLoS ONE ◽  
2019 ◽  
Vol 14 (10) ◽  
pp. e0223492 ◽  
Author(s):  
W. J. R. van der Leij ◽  
L. D. A. M. Selman ◽  
J. C. M. Vernooij ◽  
C. M. Vinke
Keyword(s):  
Randomized Controlled Trial ◽  
Body Weight ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Stress Levels
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