A Novel Fluorescent c-Met Targeted Imaging Agent for Intra-Operative Colonic Tumour Mapping: Translation from the Laboratory into a Clinical Trial

2021 ◽  
Author(s):  
Gemma Ruth Armstrong ◽  
Mohammed Ibrahim Khot ◽  
Christophe Portal ◽  
Nick P. West ◽  
Sarah L. Perry ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Imaging Agent ◽  
Targeted Imaging ◽  
Colonic Tumour

A novel fluorescent c-met targeted imaging agent for intra-operative colonic tumour mapping: Translation from the laboratory into a clinical trial

2021 ◽  
pp. 101679
Author(s):  
Gemma R. Armstrong ◽  
Mohammed I. Khot ◽  
Christophe Portal ◽  
Nick P. West ◽  
Sarah L. Perry ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Imaging Agent ◽  
Targeted Imaging ◽  
Colonic Tumour

scholarly journals In vivo delivery of a fluorescent FPR2/ALX-targeted probe using focused ultrasound and microbubbles to image activated microglia

2020 ◽  
Vol 1 (5) ◽  
pp. 385-389
Author(s):  
Sophie V. Morse ◽  
Tamara Boltersdorf ◽  
Tiffany G. Chan ◽  
Felicity N. E. Gavins ◽  
James J. Choi ◽  
...  
Keyword(s):  
Neurological Disorders ◽  
Focused Ultrasound ◽  
Imaging Agent ◽  
Targeted Imaging ◽  
Activated Microglia ◽  
The Brain ◽  
In Vivo Delivery

Targeted imaging agent labels activated microglia when delivered into the brain with focused ultrasound and microbubbles – a tool to investigate inflammation in neurological disorders.

scholarly journals Advance of Molecular Imaging Technology and Targeted Imaging Agent in Imaging and Therapy

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Zhi-Yi Chen ◽  
Yi-Xiang Wang ◽  
Yan Lin ◽  
Jin-Shan Zhang ◽  
Feng Yang ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Living Organism ◽  
Pathological Process ◽  
Imaging Agent ◽  
Imaging Agents ◽  
Therapeutic Drug ◽  
Targeted Imaging ◽  
Imaging Technology ◽  
Or Gene ◽  
Theranostic Applications

Molecular imaging is an emerging field that integrates advanced imaging technology with cellular and molecular biology. It can realize noninvasive and real time visualization, measurement of physiological or pathological process in the living organism at the cellular and molecular level, providing an effective method of information acquiring for diagnosis, therapy, and drug development and evaluating treatment of efficacy. Molecular imaging requires high resolution and high sensitive instruments and specific imaging agents that link the imaging signal with molecular event. Recently, the application of new emerging chemical technology and nanotechnology has stimulated the development of imaging agents. Nanoparticles modified with small molecule, peptide, antibody, and aptamer have been extensively applied for preclinical studies. Therapeutic drug or gene is incorporated into nanoparticles to construct multifunctional imaging agents which allow for theranostic applications. In this review, we will discuss the characteristics of molecular imaging, the novel imaging agent including targeted imaging agent and multifunctional imaging agent, as well as cite some examples of their application in molecular imaging and therapy.

Phase I clinical trial of 99mTc-etarfolatide, an imaging agent for folate receptor in healthy Japanese adults

2015 ◽  
Vol 29 (9) ◽  
pp. 792-798 ◽  
Author(s):  
Yoshinori Yamada ◽  
Hiroshi Nakatani ◽  
Hisashi Yanaihara ◽  
Masahiro Omote
Keyword(s):  
Clinical Trial ◽  
Phase I ◽  
Folate Receptor ◽  
Phase I Clinical Trial ◽  
Imaging Agent ◽  
Japanese Adults

99mTechnetium-HYNIC(tricine/TPPTS)-Aca-Bombesin(7–14) as a Targeted Imaging Agent with MicroSPECT in a PC-3 Prostate Cancer Xenograft Model

2011 ◽  
Vol 8 (4) ◽  
pp. 1165-1173 ◽  
Author(s):  
Hildo J. K. Ananias ◽  
Zilin Yu ◽  
Rudi A. Dierckx ◽  
Christophe van der Wiele ◽  
Wijnand Helfrich ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Xenograft Model ◽  
Imaging Agent ◽  
Targeted Imaging

scholarly journals Optoacoustic Detection of Early Therapy-Induced Tumor Cell Death Using a Targeted Imaging Agent

2017 ◽  
Vol 23 (22) ◽  
pp. 6893-6903 ◽  
Author(s):  
Bangwen Xie ◽  
Michal R. Tomaszewski ◽  
André A. Neves ◽  
Susana Ros ◽  
De-En Hu ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Cell ◽  
Imaging Agent ◽  
Targeted Imaging ◽  
Tumor Cell Death ◽  
Early Therapy
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