Early Cumulus Cell Removal Increases Cumulative Live Birth Rate While Having No Negative Effect on the Malformation Rate in in Vitro Fertilization: A Propensity Score-Matched Cohort Study

2021 ◽  
Author(s):  
Li Juan Sun ◽  
Shan Shan Liang ◽  
Min Hao Liu ◽  
Jia Ping Pan ◽  
Mei Yuan Huang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Rate ◽  
Cumulus Cell ◽  
Live Birth Rate ◽  
Matched Cohort ◽  
Cumulative Live Birth Rate ◽  
Vitro Fertilization ◽  
Cumulative Live Birth ◽  
Negative Effect

O-137 Salpingectomy versus neosalpingostomy in women with hydrosalpinx: a prospective cohort study with long-term follow-up

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
L Yan ◽  
C Zhu ◽  
G Liang ◽  
C He ◽  
Y Liang ◽  
...  
Keyword(s):  
Cohort Study ◽  
In Vitro Fertilization ◽  
Live Birth ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Cumulative Live Birth Rate ◽  
Vitro Fertilization ◽  
Cumulative Live Birth ◽  
Natural Conception

Abstract Study question What is the comparative effectiveness between salpingectomy and neosalpingostomy in the treatment of bilateral severe hydrosalpinx? Summary answer In women with bilateral severe hydrosalpinx, salpingectomy combined with In Vitro Fertilization (IVF) treatment resulted in a higher cumulative live birth rate than neosalpingostomy. What is known already Hydrosalpinx accounts for 25% to 35% of female subfertility and has a negative effect on pregnancy rates in women who undergo IVF. So far salpingectomy before in vitro fertilization treatment has been suggested for the treatment of hydrosalpinx in order to improve the chance of a live birth. Previous studies have reported a pooled live birth rate of 25% through natural conception after neosalpingostomy and an ongoing pregnancy rate of 55.8% after salpingectomy with IVF. Direct comparison of the cumulative live birth rate after salpingectomy versus neosalpingostomy, both followed by IVF is lacking. Study design, size, duration We performed a single center, prospective comparative cohort study in the International Peace Maternity and Child Health Hospital affiliated to Shanghai Jiao Tong University School of Medicine, China. We studied women diagnosed with tubal subfertility with bilateral hydrosalpinx between January 2005 and December 2012. Based on a shared decision approach, they had bilateral salpingectomy or neosalpingostomy followed by IVF. They were annually followed up until July 2020 for the occurrence of live birth. Participants/materials, setting, methods Out of 113 women, 55 had bilateral salpingectomy and 58 had bilateral neosalpingostomy. Primary outcome was cumulative live birth rate, defined as the cumulative birth rate of the first living neonate through either natural conception or in vitro fertilization. Both intention-to-treat (ITT) and per-protocol (PP) analysis were processed. Cox proportional hazards regression model with potential variables was performed to identify predictors of successful live birth. Main results and the role of chance Baseline characteristics were comparable between two groups. There were 42 live births in the salpingectomy and 36 in the neosalpingostomy group. When the result of IVF was incorporated (55/55 in salpingectomy group and 25/58 in neosalpingostomy group underwent IVF), salpingectomy resulted in a higher cumulative live birth rate (85.3% vs 76.0%; hazard ratio of the whole survival curve, 2.18; 95% CI, 1.37 - 3.45; P = 0.001), a lower risk of ectopic pregnancy (1.8% vs 20.7%; risk ratio, 0.07; 95% CI, 0.01 - 0.57; P = 0.013), and a shorter time to live birth (19 [14,27] versus 36 [17,76] months, P = 0.001).The number of live birth rates after natural conception was 0% (0/55) in the salpingectomy group and 28% (16/58) in neosalpingostomy group.The results of PP analyses were comparable with the ITT analyses apart from the biochemical pregnancy rate and the overall live birth rate, they were higher (the former: 76% (42/55) versus 58% (29/50), P = 0.045; the latter: 76% (42/55) versus 56% (28/50), P = 0.027) in salpingectomy group. Limitations, reasons for caution This is an observational study. The small sample size along with the data was obtained from a cohort study in a single center. Wider implications of the findings In women with confirmed bilateral severe hydrosalpinx, salpingectomy followed by IVF results in a higher cumulative live birth rate and decreases the risk of EP as compared to neosalpingostomy. However, neosalpingostomy is the only option to achieve a live birth by natural conception that should be discussed with patients preoperatively. Trial registration number not applicable

scholarly journals Prediction of cumulative live birth rate in women aged 40 years and over undergoing In vitro fertilization/intracytoplasmic sperm injectiona

2020 ◽  
Vol 4 (4) ◽  
pp. 233
Author(s):  
Cong Fang ◽  
Lei Jia ◽  
Pan-Yu Chen ◽  
Ying-Chun Guo ◽  
Zhi-Qiang Zhang ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Live Birth ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Cumulative Live Birth Rate ◽  
Vitro Fertilization ◽  
Cumulative Live Birth

No impact of treated hyperprolactinemia on cumulative live birth rate and perinatal outcomes in in vitro fertilization‐embryo transfer

2019 ◽  
Vol 45 (7) ◽  
pp. 1236-1244
Author(s):  
Yuwei Duan ◽  
Xinyan Liu ◽  
Wenhui Hou ◽  
Mingfen Deng ◽  
Jun Gao ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Embryo Transfer ◽  
Live Birth ◽  
Birth Rate ◽  
Perinatal Outcomes ◽  
Live Birth Rate ◽  
Cumulative Live Birth Rate ◽  
Vitro Fertilization ◽  
Cumulative Live Birth

scholarly journals Predicting cumulative live birth rate for the first cycle of in vitro fertilization

2019 ◽  
Vol 112 (3) ◽  
pp. e182-e183
Author(s):  
Yao Lu ◽  
Guiquan Wang ◽  
Steven R. Lindheim ◽  
Yun Sun
Keyword(s):  
In Vitro Fertilization ◽  
Live Birth ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Cumulative Live Birth Rate ◽  
Vitro Fertilization ◽  
Cumulative Live Birth

scholarly journals Gonadotropin receptor variants are linked to cumulative live birth rate after in vitro fertilization

2018 ◽  
Vol 36 (1) ◽  
pp. 29-38 ◽  
Author(s):  
I. Lindgren ◽  
H. Nenonen ◽  
E. Henic ◽  
L. Bungum ◽  
A. Prahl ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Live Birth ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Cumulative Live Birth Rate ◽  
Vitro Fertilization ◽  
Cumulative Live Birth ◽  
Gonadotropin Receptor

scholarly journals Cumulative live birth rates over multiple complete cycles of in vitro fertilisation cycles: ten-year cohort study of 20687 women following freeze-all strategy

2020 ◽  
Author(s):  
Qianqian Zhu ◽  
Bian Wang ◽  
Jiaying Lin ◽  
Mingru Yin ◽  
yun Wang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Live Birth ◽  
Birth Rate ◽  
Prediction Models ◽  
Live Birth Rate ◽  
In Vitro Fertilisation ◽  
Cumulative Live Birth Rate ◽  
Complete Cycle ◽  
Cumulative Live Birth

Abstract Background For patients embarking on in vitro fertilization (IVF) or Intracytoplasmic sperm injection (ICSI), one of the most concerned problems is their chance of a live-birth. The cumulative live birth rate (CLBR) after IVF has been reported in recent years; however these studies were all about conventional IVF strategy, the CLBRs following freeze-all strategy has not been reported. Methods This was a retrospective cohort study. A total of 20687 women undergoing their first and following IVF cycles during the period from January 1, 2007 through March 31, 2016 were included in this study. The primary Outcomes of the present study were presented in three types: the live birth rate per complete cycle, the conservative CLBR and the optimal CLBR. Results The CLBR increased from 50.74% for the first complete cycle to 64.41% after seven complete cycles,and varied by age category. The CLBR after five complete cycles declined from 77.11% for women younger than 31 years, to 8.63% for women older than 40 years. The predictors of live birth over multiple complete cycles for patients embarking on IVF following freeze-all strategy were women’s age and causes of infertility. In the model constructed for patients finishing the first complete cycle, the number of oocyte retrieved at complete cycle one also played an important predictive role. Conclusions Among women undergoing IVF following freeze-all strategy, the CLBR after seven complete IVF cycles was 84.77% if there were no barriers to continue the IVF treatment, with variation by age. Two prediction models were developed to estimate their probability of having a baby over multiple complete IVF cycles with freeze-all strategy among patients before starting IVF and patients after the first complete cycle, which is critical for patients to make treatment decisions and preparations physically, emotionally and financially.

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