scholarly journals 1P405 Study of Cellular Communication of Suprachiasmatic Nucleus through Synaptic Connections(16. Cell-cell communication,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

2006 ◽  
Vol 46 (supplement2) ◽  
pp. S248
Author(s):  
Yoshihiro Sugio ◽  
Hideyuki Terazono ◽  
Ikurou Suzuki ◽  
Akihiro Hattori ◽  
Tomoyuki Kaneko ◽  
...  
2006 ◽  
Vol 46 (supplement2) ◽  
pp. S248
Author(s):  
Miao_Hsia Lin ◽  
Yu_Liang Yang ◽  
Mao_Yuan Chen ◽  
Guang_Huey Lin ◽  
San_San Tsay ◽  
...  

2016 ◽  
Vol 32 (1) ◽  
pp. 35-47 ◽  
Author(s):  
Stephanie R. Taylor ◽  
Thomas J. Wang ◽  
Daniel Granados-Fuentes ◽  
Erik D. Herzog

Although the suprachiasmatic nucleus (SCN) has long been considered the master circadian clock in mammals, the topology of the connections that synchronize daily rhythms among SCN cells is not well understood. We combined experimental and computational methods to infer the directed interactions that mediate circadian synchrony between regions of the SCN. We analyzed PERIOD2 (PER2) expression from SCN slices during and after treatment with tetrodotoxin, allowing us to map connections as cells resynchronized their daily cycling following blockade and restoration of cell-cell communication. Using automated analyses, we found that cells in the dorsal SCN stabilized their periods slower than those in the ventral SCN. A phase-amplitude computational model of the SCN revealed that, to reproduce the experimental results: (1) the ventral SCN had to be more densely connected than the dorsal SCN and (2) the ventral SCN needed strong connections to the dorsal SCN. Taken together, these results provide direct evidence that the ventral SCN entrains the dorsal SCN in constant conditions.


2022 ◽  
Vol 8 ◽  
Author(s):  
Jefferson M. Smith ◽  
Razia Chowdhry ◽  
Michael J. Booth

Synthetic cells, which mimic cellular function within a minimal compartment, are finding wide application, for instance in studying cellular communication and as delivery devices to living cells. However, to fully realise the potential of synthetic cells, control of their function is vital. An array of tools has already been developed to control the communication of synthetic cells to neighbouring synthetic cells or living cells. These tools use either chemical inputs, such as small molecules, or physical inputs, such as light. Here, we examine these current methods of controlling synthetic cell communication and consider alternative mechanisms for future use.


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