scholarly journals Effect of Total Glucosides of Paeony on Imiquimod-Induced Psoriatic Skin Lesions by Regulating VEGF

2021 ◽  
Vol Volume 14 ◽  
pp. 1889-1897
Author(s):  
Yuan Zhang ◽  
Xuan Zhou ◽  
Ledong Sun
Keyword(s):  
Skin Lesions ◽  
Psoriatic Skin ◽  
Total Glucosides Of Paeony

Activated and cycling lymphocytes in benign dermal lymphocytic infiltrates including psoriatic skin lesions

1985 ◽  
Vol 278 (2) ◽  
pp. 92-96 ◽  
Author(s):  
G. Lange Wantzin ◽  
J. K. Larsen ◽  
I. J. Christensen ◽  
E. Ralfkiaer ◽  
M. Tjalve ◽  
...  
Keyword(s):  
Skin Lesions ◽  
Psoriatic Skin ◽  
Lymphocytic Infiltrates

Psoriatic skin lesions induced by abatacept: Case report and review of the published work

2016 ◽  
Vol 44 (7) ◽  
pp. 845-846 ◽  
Author(s):  
Ikuko Ueda-Hayakawa ◽  
Chuyen Nguyen Thi Hong ◽  
Yoko Ueki ◽  
Naotomo Kambe ◽  
Hiroyuki Okamoto
Keyword(s):  
Case Report ◽  
Skin Lesions ◽  
Psoriatic Skin

Ankylosing spondylitis, other spondyloarthritides, and related conditions

2010 ◽  
pp. 3603-3616 ◽  
Author(s):  
J. Braun ◽  
J. Sieper
Keyword(s):  
Rheumatoid Arthritis ◽  
Back Pain ◽  
Ankylosing Spondylitis ◽  
Gastrointestinal Tract ◽  
Rheumatic Diseases ◽  
Skin Lesions ◽  
Inflammatory Back Pain ◽  
Psoriatic Skin ◽  
Inflammatory Rheumatic Diseases ◽  
History Of

The spondyloarthritides are a group of inflammatory rheumatic diseases with predominant involvement of axial and peripheral joints and entheses, together with other characteristic clinical features, including inflammatory back pain, sacroiliitis, peripheral arthritis (mainly in the legs), enthesitis, dactylitis, preceding infection of the urogenital/gastrointestinal tract, psoriatic skin lesions, Crohn-like gut lesions, anterior uveitis, and a family history of Spondyloarthritis. They are the second most frequent inflammatory rheumatic diseases after rheumatoid arthritis....

scholarly journals Changes in Proteome of Fibroblasts Isolated from Psoriatic Skin Lesions

2020 ◽  
Vol 21 (15) ◽  
pp. 5363
Author(s):  
Agnieszka Gęgotek ◽  
Pedro Domingues ◽  
Adam Wroński ◽  
Elżbieta Skrzydlewska
Keyword(s):  
Signal Transduction ◽  
Skin Lesions ◽  
Dermal Fibroblasts ◽  
Metabolic Effects ◽  
Psoriatic Skin ◽  
Proteomic Profile ◽  
Intercellular Signaling ◽  
Antioxidant Proteins ◽  
Skin Epidermis ◽  
Proinflammatory Factors

The dermal fibroblasts are in constant contact with the cells of the immune system and skin epidermis. Therefore, they are essential for the development of lesions in psoriasis. The aim of this study was to assess the changes in the proteomic profile of fibroblasts in the dermis of psoriasis patients, and to discuss the most significant changes and their potential consequences. The proteomic results indicate that fibroblast dysfunction arises from the upregulation of proinflammatory factors and antioxidant proteins, as well as those involved in signal transduction and participating in proteolytic processes. Moreover, downregulated proteins in psoriatic fibroblasts are mainly responsible for the transcription/translation processes, glycolysis/ adenosine triphosphate synthesis and structural molecules. These changes can directly affect intercellular signaling and promote the hyperproliferation of epidermal cells. A better understanding of the metabolic effects of the proteomic changes observed could guide the development of new pharmacotherapies for psoriasis.

scholarly journals Effects of Systemic Interleukin-10 Therapy on Psoriatic Skin Lesions: Histologic, Immunohistologic, and Molecular Biology Findings

2001 ◽  
Vol 116 (5) ◽  
pp. 721-727 ◽  
Author(s):  
Khusru Asadullah ◽  
Markus Friedrich ◽  
Sandra Hanneken ◽  
Christoph Rohrbach ◽  
Heike Audring ◽  
...  
Keyword(s):  
Molecular Biology ◽  
Skin Lesions ◽  
Interleukin 10 ◽  
Psoriatic Skin

scholarly journals Asymmetric stem-cell division ensures sustained keratinocyte hyperproliferation in psoriatic skin lesions

2015 ◽  
Vol 37 (2) ◽  
pp. 359-368 ◽  
Author(s):  
HAI-YAN JIA ◽  
YING SHI ◽  
LONG-FEI LUO ◽  
GUAN JIANG ◽  
QIONG ZHOU ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Division ◽  
Skin Lesions ◽  
Psoriatic Skin ◽  
Stem Cell Division

scholarly journals UCHL1/PGP 9.5 Dynamic in Neuro-Immune-Cutaneous Milieu: Focusing on Axonal Nerve Terminals and Epidermal Keratinocytes in Psoriatic Itch

2018 ◽  
Vol 2018 ◽  
pp. 1-13
Author(s):  
Piotr Kupczyk ◽  
Adam Reich ◽  
Mariusz Gajda ◽  
Marcin Hołysz ◽  
Edyta Wysokińska ◽  
...  
Keyword(s):  
Endocrine Cells ◽  
Protein Gene ◽  
Skin Lesions ◽  
Psoriatic Skin ◽  
Epidermal Keratinocytes ◽  
Nerve Terminals ◽  
Pgp 9.5 ◽  
Protein Gene Product ◽  
C Fibers ◽  
Suprabasal Keratinocytes

Psoriasis is an immunogenetic skin disease manifesting as plaque lesions on the skin. Patients with psoriasis frequently suffer from itch, an unpleasant sensation causing a desire to scratch. Psoriatic itch is mainly transmitted by unmyelinated C-fibers; however, the exact molecular mechanism of psoriatic itch is still unexplained. Protein gene product 9.5 (PGP 9.5) is a panneurological marker commonly used for analysis of peripheral peptidergic and nonpeptidergic nerves and identification of cutaneous neuro-immune-endocrine cells. However, some studies suggested that nonneuronal cells, like keratinocytes, may also express PGP 9.5. This phenomenon might be linked with impaired axonal transport, keratinocyte injury, or dysfunctions of neuro-immune-cutaneous connections. The aim of this study was to analyze the expression of PGP 9.5 in psoriatic skin. We observed significantly altered density of PGP 9.5-positive axonal nerve terminals in pruritic lesional (p=0.04) and nonlesional psoriatic skin (p>0.001) compared with controls. In contrast, no significant differences were observed between psoriatic skin without itch and controls. Furthermore, PGP 9.5 expression by suprabasal keratinocytes (SBKs) was significantly increased in itchy skin lesions (p=0.007) compared to skin without itch, and a positive correlation was observed between PGP 9.5 expression and itch intensity (r=0.64; p=0.02). Our findings indicate changes in peripheral innervations and psoriatic keratinocytes, which may influence neuro-immune-cutaneous homeostasis and modulate itch transmission.

The use of Laser Doppler to Classify Psoriatic Skin Lesions

2008 ◽  
Vol 37 (2) ◽  
pp. 63-71 ◽  
Author(s):  
G. F. Sudha ◽  
M. Santosh Kumar ◽  
V. Swetha ◽  
N. Gobinath
Keyword(s):  
Skin Lesions ◽  
Laser Doppler ◽  
Psoriatic Skin
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