scholarly journals Clinical efficacy of anti-ige-therapy in adult patients with severe uncontrolled bronchial asthma in real clinical practice

2018 ◽  
pp. 54-58
Author(s):  
G. L. Ignatova ◽  
E. V. Blinova ◽  
O. L. Minakina
Keyword(s):  
Quality Of Life ◽  
Clinical Practice ◽  
Bronchial Asthma ◽  
Allergic Diseases ◽  
Adult Patients ◽  
Asthma Exacerbations ◽  
Ige Mediated ◽  
Real Clinical Practice

The article presents the results of comprehensive assessment of the efficacy of anti-IgE therapy in adult patients with severe IgE-mediated uncontrolled bronchial asthma in real clinical practice. Omalizumab added to the background anti-inflammatory therapy allowed to reduce the incidence of asthma exacerbations, achieve stable positive dynamics during severe asthma and associated allergic diseases, increase control of the disease, and improve the patients’ quality of life. The drug has a wellcharacterized long-term use safety profile.

scholarly journals QL4 - ASSESSMENT OF QUALITY OF LIFE IN PATIENTS WITH METASTATIC MELANOMA IN REAL CLINICAL PRACTICE IN FRANCE

2018 ◽  
Vol 21 ◽  
pp. S13
Author(s):  
M. Kandel ◽  
C. Allayous ◽  
S. Dalle ◽  
L. Mortier ◽  
S. Dalac ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Practice ◽  
Metastatic Melanoma ◽  
Real Clinical Practice

scholarly journals The assessment of quality of life in clinical practice in patients with schizophrenia

2014 ◽  
Vol 16 (2) ◽  
pp. 185-195 ◽  
Keyword(s):  
Quality Of Life ◽  
Clinical Practice ◽  
Negative Symptoms ◽  
Future Research ◽  
Cross Sectional ◽  
Affective Symptoms ◽  
Outcome Criterion ◽  
Pubmed Search

The aim of the present article is to review QoL scales used in studies investigating patients with schizophrenia over the past 5 years, and to summarize the results of QoL assessment in clinical practice in these patients. Literature available from January 2009 to December 2013 was identified in a PubMed search using the key words "quality of life" and "schizophrenia" and in a cross-reference search for articles that were particularly relevant. A total of n=432 studies used 35 different standardized generic and specific QoL scales in patients with schizophrenia. Affective symptoms were major obstacles for QoL improvement in patients with schizophrenia. Though positive symptoms, negative symptoms, and cognitive functioning may be seen as largely independent parameters from subjective QoL, especially in cross-sectional trials, long-term studies confirmed a critical impact of early QoL improvement on long-term symptomatic and functional remission, as well as of early symptomatic response on long-term QoL. Results of the present review suggest that QoL is a valid and useful outcome criterion in patients with schizophrenia. As such, it should be consistently applied in clinical trials. Understanding the relationship between symptoms and functioning with QoL is important because interventions that focus on symptoms of psychosis or functioning alone may fail to improve subjective QoL to the same level. However, the lack of consensus on QoL scales hampers research on its predictive validity. Future research needs to find a consensus on the concept and measures of QoL and to test whether QoL predicts better outcomes with respect to remission and recovery under consideration of different treatment approaches in patients with schizophrenia.

scholarly journals Assessment of quality of life in patients with metastatic melanoma in real clinical practice in France

2018 ◽  
Vol 29 ◽  
pp. viii460
Author(s):  
M. Kandel ◽  
C. Allayous ◽  
S. Dalle ◽  
L. Mortier ◽  
S. Dalac Rat ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Practice ◽  
Metastatic Melanoma ◽  
Real Clinical Practice

Long-term outcome and quality of life in adult patients after the Fontan operation

2004 ◽  
Vol 93 (9) ◽  
pp. 1141-1145 ◽  
Author(s):  
Annemien E van den Bosch ◽  
Jolien W Roos-Hesselink ◽  
Ron van Domburg ◽  
Ad J.J.C Bogers ◽  
Maarten L Simoons ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Fontan Operation ◽  
Adult Patients ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals AB1095 Long-term impact of juvenile idiopathic arthritis on quality of life of adult patients in greece

2018 ◽  
Author(s):  
G.C. Paskalis ◽  
D. Dimopoulou ◽  
M. Trachana ◽  
C.C. Theocharidou ◽  
P. Pratsidou-Gertsi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Juvenile Idiopathic Arthritis ◽  
Adult Patients ◽  
Long Term Impact

scholarly journals Emotional distress and quality of life in allergic diseases

2020 ◽  
Vol 73 (2) ◽  
pp. 370-373
Author(s):  
Marcin Jarosz ◽  
Sadia Syed ◽  
Michał Błachut ◽  
Karina Badura Brzoza
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Anxiety Disorders ◽  
Mood Disorders ◽  
Emotional Disorders ◽  
Behavioral Disorders ◽  
Bronchial Asthma ◽  
Allergic Diseases ◽  
Increased Risk

Emotional disorders accompany many somatic diseases, especially ones with severe or chronic course, and such are allergic diseases. Long-term course of the disease, the need for chronic treatment and repeated exacerbations as well as symptoms of depression or anxiety have a significant impact on the quality of life of patients, constituting a serious burden both from the point of view of the individual and the society. The data evaluating emotional disturbances and their impact on the quality of life in three atopic diseases: bronchial asthma, atopic dermatitis and seasonal rhinitis were analysed. Mood disorders as well as mental and behavioral disorders due to alcohol abuse are the most common psychiatric disorders observed in patients with bronchial asthma. There are data indicating a relationship between the occurrence of allergic rhinitis and mood disorders, anxiety disorders and suicidal tendencies. Atopic dermatitis is associated with an increased risk of depressive and anxiety disorders and sleep disorders, and in children with more prevalence of behavioral disorders. Most studies highlighted the relationship between emotional disorders and quality of life in the above-mentioned patient groups. In addition to physical ailments, patients suffering from allergic diseases also report emotional problems that can adversely affect the course of the disease, the treatment process, and reduce quality of life. Therefore, these patients require a holistic approach with a more accurate assessment of emotional disorders.

scholarly journals Clinical aspects of the use of ribociclib

2020 ◽  
pp. 44-56
Author(s):  
A. A. Markovich ◽  
M. V. Kalugin ◽  
O. О. Gordeeva ◽  
M. Zh. Yakoobova
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Clinical Practice ◽  
Endocrine Therapy ◽  
Phase Iii ◽  
Clinical Aspects ◽  
Short Term Treatment ◽  
Secondary Resistance

Luminal metastatic HER2-negative breast cancer remains one of the most common cancers in oncological practice. This disease still remains incurable. Endocrine therapy remained the standard therapy of choice for disseminated patients for a long time. The search for new effective drugs, development of strategies that can overcome primary and secondary resistance to endocrinotherapy has shown that the CDK4/6-inhibitors group can improve not only the short-term treatment outcomes, but also affect the overall survival of patients, which has been demonstrated in a number of phase III studies. Along with that, the use of CDK4/6 inhibitors maintains a good quality of life, allows patients to maintain professional and social activities, which is of great importance for long-term prospects. Given that the endocrine therapy combined with CDK4/6-inhibitors today is the new standard of therapy in patients with luminal HER2- negative breast cancer, knowing how to use this therapy in daily clinical practice is crucial. Know and apply innovative drugs in clinical practice and the management of regimen toxicity always my work demands close application. This article provides an overview of the data on the efficacy of ribociclib based on phase III registration studies. It also presents its own clinical experience demonstrating the feasibility of using a new group of drugs in patients both in pre- and postmenopausal women. The authors discussed the issues related to the modification of the regimen due to the toxicity of therapy, in particular, neutropenia and hepatotoxicity. They also showed the possibility of managing adverse events with the preservation of a long-term effect with no loss in quality of life.

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