scholarly journals Laryngopharyngeal reflux diagnostics: review article

2021 ◽  
pp. 48-57
Author(s):  
I. B. Angotoeva ◽  
A. K. Aylarov ◽  
S. Ya. Kosyakov ◽  
I. D. Loranskaya ◽  
E. E. Rumyantseva
Keyword(s):  
Laryngopharyngeal Reflux ◽  
Direct Action ◽  
Abdominal Ultrasound ◽  
Placebo Treatment ◽  
Upper Esophageal Sphincter ◽  
Diagnostic Methods ◽  
Response To Treatment ◽  
Modern Problem ◽  
Ph Metry

Laryngopharyngeal reflux (LPR) is an actual, modern problem for the practice of an ENT doctor, because majority of complaints lead the patient, first of all, to an otorhinolaryngologist. LPR is an extraesophageal manifestation of gastroesophageal reflux disease (GERD), which leads to a recurrent course of symptoms resulting from the direct action of gastric contents on the mucous membrane of the laryngopharynx when ingested through the upper esophageal sphincter, as well as a decrease in the quality of life. Patients with LPR represent 4% to 10% of outpatients visiting an ENT physician. The main problem of diagnosing of LPR is that there are not any exact researches for this disease, such as PCR-test or biopsy. GERD diagnostic methods performed by gastroenterologists include: assessment of complaints, esophagogastroduodenoscopy (EGDS), intraesophageal pH-metry, esophageal manometry, impedance-pH-metry with the placement of 2 probes in the esophagus and pharynx, gastrointestinal fluoroscopy (GI) with barium, gastroesophageal scintigraphy, abdominal ultrasound (abdominal ultrasound), and pepsin test. All these tests are widely using for diagnosis and sometimes helps us. But the question remains: do all these research methods allow to establish the presence of LPR? Interpretation of existing studies is difficult due to the ambiguous diagnostic criteria for LPR, varying rates of response to treatment, and the significant effect of placebo treatment. Therefore, diagnostic methods for LFR require further study and development.

scholarly journals Сapabilitу of 24-hour esophageal pH-impedance monitoring in the diagnosis of GERD-associated laryngeal diseases

2020 ◽  
pp. 62-72
Author(s):  
S. V. Starostina ◽  
V. M. Makhov ◽  
O. A. Storonova ◽  
A. V. Bolshakov ◽  
I. V. Kuprina ◽  
...  
Keyword(s):  
Ph Value ◽  
Laryngopharyngeal Reflux ◽  
Morphological Changes ◽  
Upper Esophageal Sphincter ◽  
Diagnostic Methods ◽  
Laryngeal Diseases ◽  
Esophageal Clearance ◽  
Pharyngeal Muscles ◽  
Reflux Laryngitis ◽  
Impedance Monitoring

Extraesophageal manifestations of gastroesophageal reflux disease (GERD), despite the improvement of methods of diagnosis and treatment of patients with this pathology, still remain an urgent problem of medicine and cause increased attention of clinicians and researchers. In some cases, patients with GERD do not present typical complaints of heartburn, regurgitation; the disease may manifest extraesophageal manifestations, such as chronic cough, hoarseness, reflux laryngitis, and others caused by the presence of laryngopharyngeal reflux (LFR) – inflammation of the mucous membrane of the upper digestive and respiratory tracts with possible morphological changes associated with direct and indirect (reflex) exposure to gastroduodenal reflux. The occurrence of LFR is possible due to a violation of the motor function of the esophagus and insufficiency of the upper esophageal sphincter, as well as a decrease in the tone of the pharyngeal muscles. The most accessible methods of diagnosis of LFR are registration of complaints according to the questionnaire “index of reflux symptoms”, assessment of the clinical and functional state of the larynx using a visually analog “scale of reflux signs”. A positive response to the empirical use of proton pump inhibitors in combination with procinetics and determination of pepsin content in saliva can also be alternative diagnostic methods. To date, 24-hour pH-impedance monitoring is a method that allows the most accurate diagnosis of all types of reflux, regardless of the pH value, to verify high reflux in combination with its physical properties, as well as to estimate the time of chemical and volumetric esophageal clearance. In addition to performing esophagogastroduodenoscopy, the use of this method is indicated in patients with suspected extraesophageal manifestations of GERD. The article presents clinical examples of patients with extraesophageal manifestations of GERD, describes the possibilities of 24-hour pH-impedance monitoring of the esophagus in the diagnosis of LFR and reflux-associated diseases of the larynx.

DIAGNOSING QUALITY OF FRICTION SYSTEMS OF MECHANISMS OF DEVICES

2019 ◽  
Vol 1 (7) ◽  
pp. 10-13
Author(s):  
D. Yu. Ershov ◽  
I. N. Lukyanenko ◽  
E. E. Aman
Keyword(s):  
Surface Defects ◽  
Diagnostic Methods ◽  
Design Parameters ◽  
Diagnostic Model ◽  
Mechanical Assemblies ◽  
Local Defects ◽  
Relationship Of ◽  
The Relationship ◽  
Production And Operation

The article shows the need to develop diagnostic methods for monitoring the quality of lubrication systems, which makes it possible to study the dynamic processes of contacting elements of the friction systems of instrument mechanisms, taking into account roughness parameters, the presence of local surface defects of elements and the bearing capacity of a lubricant. In the present article, a modern diagnostic model has been developed to control the quality of the processes of production and operation of friction systems of instrument assemblies. With the help of the developed model, it becomes possible to establish the relationship of diagnostic and design parameters of the mechanical system, as well as the appearance of possible local defects and lubricant state, which characterize the quality of friction systems used in many mechanical assemblies of the mechanisms of devices. The research results are shown in the form of nomograms to assess the defects of the elements of friction mechanisms of the mechanisms of the devices.

scholarly journals Advances in Plant Disease Detection and Monitoring: From Traditional Assays to In-Field Diagnostics

Sensors ◽  
2021 ◽  
Vol 21 (6) ◽  
pp. 2129 ◽  
Author(s):  
Ilaria Buja ◽  
Erika Sabella ◽  
Anna Grazia Monteduro ◽  
Maria Serena Chiriacò ◽  
Luigi De Bellis ◽  
...  
Keyword(s):  
Emerging Diseases ◽  
Diagnostic Methods ◽  
Preventive Actions ◽  
Initial Symptoms ◽  
New Frontier ◽  
Information And Communication ◽  
Instruments And Techniques ◽  
The Difference ◽  
Asymptomatic Individuals

Human activities significantly contribute to worldwide spread of phytopathological adversities. Pathogen-related food losses are today responsible for a reduction in quantity and quality of yield and decrease value and financial returns. As a result, “early detection” in combination with “fast, accurate, and cheap” diagnostics have also become the new mantra in plant pathology, especially for emerging diseases or challenging pathogens that spread thanks to asymptomatic individuals with subtle initial symptoms but are then difficult to face. Furthermore, in a globalized market sensitive to epidemics, innovative tools suitable for field-use represent the new frontier with respect to diagnostic laboratories, ensuring that the instruments and techniques used are suitable for the operational contexts. In this framework, portable systems and interconnection with Internet of Things (IoT) play a pivotal role. Here we review innovative diagnostic methods based on nanotechnologies and new perspectives concerning information and communication technology (ICT) in agriculture, resulting in an improvement in agricultural and rural development and in the ability to revolutionize the concept of “preventive actions”, making the difference in fighting against phytopathogens, all over the world.

Phlegmonous gastritis in 2 yearling horses

2022 ◽  
pp. 104063872110650
Author(s):  
Julie B. Engiles ◽  
Francisco A. Uzal ◽  
Mauricio A. Navarro ◽  
Virginia B. Reef ◽  
Susan J. Bender
Keyword(s):  
Clinical Signs ◽  
Poor Response ◽  
Abdominal Ultrasound ◽  
Mucosal Injury ◽  
Response To Treatment ◽  
Bacterial Populations ◽  
Proliferative Enteropathy ◽  
Mucosal Involvement ◽  
Phlegmonous Gastritis ◽  
History Of

Phlegmonous gastritis was diagnosed in 2 yearling fillies that were presented with a 1-wk history of fever, lethargy, and hypoproteinemia, associated with a previous diagnosis of equine proliferative enteropathy based on clinical signs and PCR assay detection of Lawsonia intracellularis in fecal samples. Abdominal ultrasound revealed enlargement of the stomach and expansion of its submucosal layer with hypoechoic fluid, as well as thickened hypomotile small intestinal segments. Given the poor prognosis and poor response to treatment, both horses were euthanized, one on the day of presentation and the other after 3 wk of intensive medical management including a combination of antimicrobials, analgesics, and intravenous colloids. At autopsy, acute mural gastritis characterized by severe submucosal edema with suppurative inflammation (i.e., phlegmonous gastritis) and necroulcerative enteritis compatible with the necrotizing form of equine proliferative enteropathy were identified in both horses. The gastric inflammation was associated with thrombosis and mixed bacterial populations, including Clostridium perfringens, that were confined to the submucosa without evidence of mucosal involvement; toxin genes compatible with C. perfringens type C were identified in one case. Human phlegmonous gastritis is an uncommon, often-fatal pyogenic infection that is often associated with mucosal injury, bacteremia, or immunocompromise. Our finding of this unusual gastric lesion in 2 horses with similar signalment, clinical disease, and spectrum of postmortem lesions suggests a similar etiopathogenesis that possibly involves local, regional, or distant hematogenous origin, and should be considered a potential complication of gastrointestinal mucosal compromise in horses.

Adenomyosis – its possible effect on endometrial function and receptivity

2021 ◽  
Vol 86 (3) ◽  
pp. 205-209
Author(s):  
Karel Crha ◽  
◽  
Michal Ješeta ◽  
Radovan Pilka ◽  
Pavel Ventruba ◽  
...  
Keyword(s):  
Epithelial Mesenchymal Transition ◽  
Current Knowledge ◽  
Histopathological Examination ◽  
Transvaginal Ultrasound ◽  
Embryo Implantation ◽  
Diagnostic Methods ◽  
Mesenchymal Transition ◽  
New Information

Summary Objective: There have been many studies on adenomyosis, which can impair the quality of life of a woman. There are various kinds of opinions on the pathogenesis, diagnostics and treatment of adenomyosis. The goal of this article is to present the current knowledge of adenomyosis and its impact on the endometrial function and receptivity. Methods: PubMed/Medline, Web of Sciences and Scopus were searched for the articles in English indexed until February 2021 with terms of: adenomyosis, endometrial receptivity, and infertility. Results: Recent studies on angiogenesis and epithelial-mesenchymal transition in the endometrium bring new information on the ethiology and pathogenesis of adenomyosis. In clinical practice, the main diagnostic methods of adenomyosis include transvaginal ultrasound, magnetic resonance imaging or hysteroscopy, although the definitive confirmation is set by histopathological examination. The rules of #Enzian classification of endometriosis should be applied for the classification of adenomyosis. The treatment of adenomyosis should consider individual clinical presentation and reproductive plans of a patient and should be performed in centers for the treatment of endometriosis. Conclusion: Adenomyosis affects endometrial vascularisation and epithelial-mesenchymal transition/mesenchymal-epithelial transition; thus, it can be the cause of irregular uterine bleeding or embryo implantation failure. The research and analysis of endometrial proteome could lead to the new ways of adenomyosis treatment.

Usefulness of Matrix Metalloproteinase-7 in Saliva as a Diagnostic Biomarker for Laryngopharyngeal Reflux Disease.

2021 ◽  
Author(s):  
Nu-Ri Im ◽  
Byoungjae Kim ◽  
Kwang-Yoon Jung ◽  
Seung-Kuk Baek
Keyword(s):  
Matrix Metalloproteinase ◽  
Sensitivity And Specificity ◽  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Diagnostic Methods ◽  
Reflux Symptom Index ◽  
Enzyme Activity Assay ◽  
Symptom Index ◽  
Laryngopharyngeal Reflux Disease ◽  
Matrix Metalloproteinase 7

Abstract Introduction Several diagnostic methods are currently being used to diagnose LPRD (laryngopharyngeal reflux disease), but have the disadvantage of being invasive, subjective, or expensive. Objectives Our purpose in this study was to investigate the correlation between pepsin and MMP-7 (Matrix Metalloproteinase-7) in pharyngeal secretions of subjects according to RSI (Reflux Symptom Index) score to find out the diagnostic value of MMP-7. Method We recruited 173 subjects aged between 19 and 85 years who completed the RSI scale. All samples were taken after waking up, and the amount of the pepsin and MMP-7 in saliva were measured by means of an enzyme activity assay. Results There was a significant increase of pepsin and MMP-7 activity in the study group with an RSI score of 13 or higher. The sensitivity and specificity of MMP-7 for predicting the possibility of an RSI of 13 or more was higher than that of pepsin. When MMP-7 and pepsin were combined, this sensitivity and specificity increased. Conclusion An enzyme assay of MMP-7 in saliva may be a noninvasive and easy technique for diagnosing LPRD.

Ocular Tuberculosis: Clinics, Diagnosis and Treatment (Literature Review)

The Eye ◽  
2021 ◽  
Vol 23 (2) ◽  
pp. 41-45
Author(s):  
O. E. Russkikh ◽  
N. Y. Nikolenko
Keyword(s):  
Literature Review ◽  
Diagnostic Methods ◽  
Diagnosis And Treatment ◽  
Ocular Tuberculosis ◽  
Treatment Regimens ◽  
The Russian Federation ◽  
Serious Disease ◽  
Suggested Classification

Ocular tuberculosis is a serious disease with a long recurrent course, often leading to a significant decrease in the visual functions and quality of life of patients as well as disability. In recent years, the incidence rate of the ocular tuberculosis in the Russian Federation has been declining: in 2016, according to a number of authors, its incidence amounted to 5.2%.Purpose. To systematize literature data on the topic of ocular tuberculosis.Materials and methods. We reviewed literature available on elibrary.ru, cyberleninka.ru websites and in “Clinical Ophthalmology” journal. Results. We suggested classification of the ocular tuberculosis lesions, analyzed modern diagnostic methods and treatment regimens and evaluated their effectiveness.Conclusions. Literature review revealed that in order to improve the quality of detection, diagnosis and treatment of ocular tuberculosis, joint efforts of ophthalmologists and phthisiologists as well as use of modern methods of tuberculinodiagnosis are essential.

scholarly journals Diagnostic methods of detecting defects within the material with the use of active infrared thermovision

2017 ◽  
Vol 37 (1) ◽  
pp. 41-44
Author(s):  
Karol Grochalski ◽  
Katarzyna Peta
Keyword(s):  
Control Process ◽  
Optical Excitation ◽  
Pulse Method ◽  
Active Surface ◽  
Diagnostic Methods ◽  
Adhesion Forces ◽  
Structure Defects ◽  
Unit Step ◽  
Quality Control Process

Abstract Article presents the methods of detecting defects within material with the use of active infrared thermovision. During the study ABS and PVC samples were used inside which internal structure defects and defects of glue conjunction between components were modeled. During combining composite materials with the use of glue joints, there is a problem with homogenous distribution of the glue layer on the surface of an element, which results in the creation of defects in joint structure and the decline of active surface of adhesion forces on the combined materials. It is then necessary to control the quality of the conjunction between the glued surfaces. The use of non-contact diagnostic methods allows to analyze a larger surface which conditions in more efficient quality control process. In the study, external heat excitation was used - optical excitation with periodic variable signal (LockIn method) and unit step excitation (Pulse method). The methods of analysis of the obtained thermograms are presented.

scholarly journals ECOLOGICALLY BASED DISEASE MANAGEMENT TECHNIQUES IN BARLEY CULTIVATION IN THE CENTRAL BLACK SOIL REGION

AGROFOR ◽  
2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Alexey Lukin ◽  
Alexander Yeprintsev ◽  
Dmitry Fedorin ◽  
Olga Maraeva ◽  
Sergey Selyavkin
Keyword(s):  
Local Environment ◽  
Black Soil ◽  
Diagnostic Methods ◽  
Disease Spread ◽  
Soil Productivity ◽  
Biological Products ◽  
Healthy Environment ◽  
Black Soil Region ◽  
Species Specific

At present, there are microbiological Bacillus-based products used to preservevaluable micro biota and improving the level of biological soil productivity as wellas sustaining the local environment. The research focuses on discovering how someparticular biological products and autochthonous microorganisms influence theyield capacity of barley grown in the Black-Earth region of Russia. The researchobjectives included a search for autochthonous strains of microorganisms thatimprove resistance to diseases, estimation of how biological products contribute tothe quality of barley seeds, biological products effect on the spread and diseaseresistance and estimation of how biological products enhance the yield capacity ofbarley. The paper describes the results of identification of an autochthonousBacillus strains. PCR diagnostic methods were used to confirm the strain specificorigin of two sample cells extracted from soil (S1 and S2). The study involved theanalysis of micro biota of leached chernozem, which revealed the autochthonousstrain of Bacillus S1 having a germicidal effect. The S1 strain revealed Bacillussubtilis and Bacillus сеreus, while S2 revealed only Bacillus subtilis, as detected bythe method of molecular diagnostics based on using species-specific primers.Biological treatment of the seeds improved their sowing qualities, namely,germination readiness and germination capacity. In addition, it was found out thatsuch treatment improves the resistance to disease affection and spread. Bacillus S1,in particular, reduces the disease affection by 16,5 % and the disease spread 3,5 asmuch. Finally, the experiment demonstrated that biological treatment cancontribute to sustaining healthy environment for the plants and thus increase theiryield capacity.

scholarly journals Consistency and Homogeneity of Atmospheric Energy, Moisture, and Mass Budgets in ERA5

2021 ◽  
pp. 1-69
Author(s):  
Johannes Mayer ◽  
Michael Mayer ◽  
Leopold Haimberger
Keyword(s):  
Moisture Transport ◽  
Energy Transport ◽  
Diagnostic Methods ◽  
Moisture Budget ◽  
Energy Fluxes ◽  
Atmospheric Energy ◽  
Fifth Generation ◽  
Freshwater Fluxes ◽  
Better Than

AbstractThis study uses advanced numerical and diagnostic methods are used to evaluate the atmospheric energy budget with the fifth generation European Re-Analysis (ERA5) in combination with observed and reconstructed top-of-the-atmosphere (TOA) energy fluxes for the period 1985–2018. We assess the meridional as well as ocean-to-land energy transport and perform internal consistency checks using mass-balanced data. Furthermore, the moisture and mass budgets in ERA5 are examined and compared with previous budget evaluations using ERA-Interim as well as observation-based estimates. Results show that peak annual mean meridional atmospheric energy transports in ERA5 (4.58±0.07 PW in the northern hemisphere) are weaker compared to ERA-Interim (4.74±0.09 PW), where the higher spatial and temporal resolution of ERA5 can be excluded as possible reason. The ocean-to-land energy transport in ERA5 is reliable at least from 2000 onwards (∼2.5 PW) such that the imbalance between net TOA fluxes and lateral energy fluxes over land are on the order of ∼1W m-2. Spin-up/-down effects as revealed from inconsistencies between analyses and forecasts are generally smaller and temporally less variable in ERA5 compared to ERA-Interim. Evaluation of the moisture budget shows that the ocean-to-land moisture transport and parameterized freshwater fluxes agree well in ERA5, while there are large inconsistencies in ERA-Interim. Overall, the quality of the budgets derived from ERA5 is demonstrably better than estimates from ERA-Interim. Still some particularly sensitive budget quantities (e.g., precipitation, evaporation, and ocean-land energy transport) show apparent inhomogeneities, especially in the late 1990s, which warrant further investigation and need to be considered in studies of interannual variability and trends.

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