scholarly journals The Possible Ameliorative Effect of Hesperidin Administration in Aluminum Phosphide Induced Acute Nephrotoxicity in Adult Albino Rats

2022 ◽  
Vol 38 (1) ◽  
pp. 46-56
Author(s):  
Sahar Moustafa ◽  
Rania Hashish ◽  
Rehab Abdel-Karim
Keyword(s):  
Albino Rats ◽  
Aluminum Phosphide ◽  
Ameliorative Effect

Ameliorative Effect of Withaferin A on Ageing-Mediated Impairment in the Dopamine System and Its Associated Behavior of Wistar Albino Rat

Pharmacology ◽  
2018 ◽  
Vol 103 (3-4) ◽  
pp. 114-119 ◽  
Author(s):  
Mohammad Raziya Banu ◽  
Muhammed Ibrahim ◽  
K. Prabhu ◽  
Srinivasagam Rajasankar
Keyword(s):  
Protective Efficacy ◽  
Motor Impairment ◽  
Withaferin A ◽  
Albino Rats ◽  
Aged Rats ◽  
Albino Rat ◽  
Aged Rat ◽  
Group Iii ◽  
Group I ◽  
Ameliorative Effect

Withaferin A (WA) was evaluated for its neuro-protective efficacy on ageing induced striatal dopamine (DA) and behavioural changes in aged rats. Wistar albino rats were divided into group I – young (3 months), Group II – aged (24 months), Group III – aged rats supplemented with WA (50 mg/kg b.w once in a day for 30 days) and Group IV – young rats supplemented with WA (50 mg/kg b.w). The HPLC assay revealed significant decline in the levels of DA and homovanillic acid (HVA) in substantia nigra (SN) and striatum (ST) of aged rat. A marked decline in motor activity of aged rat was observed through open field, beam walking and grid walking motor experiments. These results indicate that ageing reduces nigro-striatal activity as well as nigro-striatal DA levels. Interestingly, the administration of WA (50 mg\kg b.w) resulted in a substantial resurge of DA and HVA in SN and ST and a significant reversal of motor impairment in aged rats. This study is the first report that evidently determines the neuro-protective efficacy of WA on dopaminergic system of SN and ST in aged rats.

scholarly journals Ameliorative effect of Cubeba Officinalis dried fruits against Tacrolimus induced nephrotoxicity in Wistar albino rats

2020 ◽  
Vol 11 (1) ◽  
pp. 596-602
Author(s):  
Suman S ◽  
Hayagreeva Dinakar Y ◽  
Suhas reddy P V ◽  
Sai Sudha Yadav B ◽  
Venkateshwar Reddy V
Keyword(s):  
Ethanolic Extract ◽  
Albino Rats ◽  
Local Market ◽  
Sodium Potassium ◽  
Dried Fruits ◽  
Main Adverse Effect ◽  
Ameliorative Effect ◽  
Nephroprotective Activity ◽  
Wistar Albino Rats ◽  
Histopathological Studies

Cubeba Officinalis is traditionally effective in the treatment of various kidney ailments, and the main adverse effect of tacrolimus is nephrotoxicity. There is no documented evidence about the ameliorative potential of Cubeba Officinalis in tacrolimus induced nephrotoxicity. The main endeavor of the study was to determine the nephroprotective activity of ethanolic extract of Cubeba Officinalis dried fruits against tacrolimus induced nephrotoxicity in Wistar albino rats. The Cubeba Officinalis dried fruits were collected from the local market, and Male albino rats weighing 200-250 g were used for the study. The dose of is lower 200mg/kg, higher dose 400 mg/kg of test drug (EECO) was used, and silymarin is used as the standard at the dose of 20 mg/kg. The animals were divided into five groups, six animals each, which is started prior to oral administration of tacrolimus and continued with the fourteen days tacrolimus treatment. After the whole period of study, the rats were sacrificed, and histopathological studies and biochemical estimations were carried out. The BUN values  were decreased from 33.60±3.84 in nephrotoxic rats to 28.27±2.48 (200mg/kg) and 20.70±0.81 (400mg/kg),creatinine levels from 1.645±0.21 to 0.926±0.19 (200mg/kg) and 0.638±0.07(400 mg/kg),uric acid levels from 1.822±0.249 to 1.092±0.306 (200 mg/kg) and 0.806±0.181 (400 mg/kg) sodium, potassium and chloride levels from 1.607± 0.091, 2.548± 0.293 and 259.8±6.42 to 1.302± 0.169 , 1.023±0.174 and 134.7±9.138 (200mg/kg of EECO) and 0.586±0.092 , 0.831±0.174 and 130.2±2.29 (400mg/kg of EECO). The Ethanolic extract of cubeba officinalis was found to be effective in treating the nephrotoxicity in tacrolimus induced nephrotoxicity.

scholarly journals Ameliorative effect of acetyl-l-carnitine in valproic acid induced autistic albino rats: Prenatal model

2019 ◽  
Vol 405 ◽  
pp. 116-117
Author(s):  
S. Geethakrishnan ◽  
V. Bakshi ◽  
S. Katta ◽  
P. Gandhamalla ◽  
M. Kaluwala ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Albino Rats ◽  
Ameliorative Effect

scholarly journals AMELIORATIVE EFFECT OF CAROB AQUEOUS EXTRACT ON WATER PIPE SMOKE INDUCED-TOXICITY IN ADULT MALE ALBINO RATS

2016 ◽  
Vol 9 (1) ◽  
pp. 246
Author(s):  
Mona Abdel Rahman ◽  
Fatma Elzahraa H. Salem ◽  
Amira A. Bauomy ◽  
Mona Ahmed Khalifa
Keyword(s):  
Aqueous Extract ◽  
Post Treatment ◽  
Tissue Homogenate ◽  
Albino Rats ◽  
Water Pipe ◽  
Treatment Groups ◽  
Ameliorative Effect ◽  
Liver And Kidney ◽  
Lung Tissue Homogenate ◽  
Kidney Functions

<p><strong>Objective: </strong>The aim of the present study was to investigate the daily effect of pre and post treatment of carob aqueous extract (600 mg/kg b. wt.); on rats exposed to were exposed to water pipe smoke (10 mg/kg; 15 minutes) for 2, 4, 6 and 8 w.</p><p><strong>Methods: </strong>Rats were divided into 6 groups; 1<sup>st</sup> group was served as a control. Rats of the 2<sup>nd</sup> group were administered amiodarone (an antiarrhythmic medication used as a model for lung toxicity) at a dose level of 30 mg/kg. The rats of 3<sup>rd</sup> and 4<sup>th</sup> groups were exposed to water pipe smoke and treated with carob extract respectively. However, the two remaining groups (5<sup>th</sup> and 6<sup>th</sup>) were the pre-and post-treatment groups with carob extract respectively.</p><p><strong>Results: </strong>Amiodarone and water pipe smoke induced a significant increase in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP); on the contrary, induced a significant decrease in serum total protein and albumin. In addition; serum creatinine and urea showed a significant increase; as well as; amiodarone and water pipe smoke increased the oxidative stress (malondialdehyde/glutathione; MDA/GSH) in lung tissue homogenate. While; carob extract gavage showed protective and curative effects in liver and kidney functions; in addition; it decreased MDA level and increased GSH level significantly.</p><p><strong>Conclusion: </strong>Finally, we can conclude that the carob aqueous extract treatment revealed ameliorative effects on rats were exposed to water pipe smoke.</p>

scholarly journals Anti-diabetic effect of Stachytarpheta jamaicensis on low dose streptozotocin-induced diabetic rats fed on a high-fat diet

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Mac Donald Idu ◽  
Owen – Obaseki Edehia ◽  
Benjamin Ogunma Gabriel
Keyword(s):  
High Fat Diet ◽  
Blood Glucose Concentration ◽  
Ethanol Extract ◽  
Scientific Basis ◽  
Negative Control ◽  
Diabetic Rats ◽  
Albino Rats ◽  
High Fat ◽  
Ameliorative Effect ◽  
Different Doses

Abstract Introduction This study evaluates the anti-diabetic effect of ethanol extract of Stachytarpheta jamaicensis leaf on streptozotocin (STZ) - induced diabetic rats fed on high-fat diet (HFD). Methods Sets of male albino rats of the Wistar strain weighing between 180 and 250 g were exposed to high fat diet (margarine and oil from vegetable sources in a ratio of 2:1 w/v) for 3 weeks. Then the animals were fasted overnight; hyperglycemic state was induced using reduced dose of streptozotocin (35 mg/kg) and animals were randomly divided into five groups (n = 7); group A received the HFD + STZ (35 mg/kg i.p.); group B received HFD + STZ + gliberclamide (10 mg/kg; i.p); groups C, D and E were administered the HFD + streptozotocin with different doses of the ethanol extract (30, 35 and 100 mg/kg p.o., respectively). Results Results showed significant (p < 0.05) decrease in blood glucose concentration of the rats treated with different doses of S. jamaicensis extract and those treated with gliberclamide compared to the untreated diabetic rats (negative control). Significant (p < 0.05) reductions in activities of serum AST, ALP, total protein and bilirubin were noticed in the groups in contrast to the control. Levels of urea, creatinine, potassium and chloride were considerably (p < 0.05) low while sodium and bicarbonate levels were high in the groups except the control. Lipid profile revealed significant (p < 0.05) reduction in total cholesterol, triacylglycerol, LDL, VLDL while HDL levels were high in the groups compared to the control. The extract significantly (p < 0.05) ameliorated weight loss. Histopathology of the liver, kidney and pancreas showed ameliorative effect of the extract against the deleterious changes occasioned by the HFD and STZ induced diabetic state. Conclusion These findings have provided scientific basis for the use of S. jamaicensis in the treatment of diabetes mellitus in ethnomedicinal practices in Nigeria.

scholarly journals Ameliorative effect of Albizzia procera leaves extract against experimentally induced gastric ulcer models in Wistar albino rats

2021 ◽  
Vol 13 (1) ◽  
pp. 308-315
Author(s):  
Vivek Srivastava ◽  
Santosh Kumar Verma ◽  
Neha Mathur ◽  
Kapil Kumar Goel
Keyword(s):  
Gastric Ulcer ◽  
Ethanolic Extract ◽  
Gastric Fluid ◽  
Gastric Ulcers ◽  
Albino Rats ◽  
Traditional Medicines ◽  
Pylorus Ligation ◽  
Ameliorative Effect ◽  
Wistar Albino Rats ◽  
Experimentally Induced

Albizzia procera belongs to family Fabaceae and has several phytoconstituents like flavonoids, terpenes, alkaloids, saponins etc. The plant is commonly used in traditional medicines. The objective of the present study was to assess the ameliorative effect of A. procera leaves extract against an experimentally induced gastric ulcer in albino rats. The antiulcer, antisecretory and cytoprotective properties of an ethanolic extract prepared from the leaves was evaluated. When given in a 200 mg/kg oral (per. os) dose, the extract produced 74% and 85% protection index in ethanol-induced ulcer model and pylorus ligation model, respectively.  Additionally, the extract also prohibited the formation of haemorrhage and edema, significantly lessened catalase activity (p<0.0001) and the lipid peroxidation level (p<0.0001) in the glandular tissue of Wistar albino rats. Furthermore, the extract also significantly diminished the total acidity(p<0.0001) of the gastric fluid by increasing its pH (p<0.0001). The occupancy of different phytoconstituents in the extract, such as flavonoids and tannins were identified that may be responsible for its gastro-protective activity. All these results provide a basis explaining the antiulcer ability of A. procera being useful in the management of gastric ulcers.

Sign in / Sign up

Export Citation Format

Share Document