Magnetic Digital Microfluidics for Point-of-Care Testing: Where Are We Now?

2020 ◽  
Vol 27 ◽  
Author(s):  
Yi Zhang
Keyword(s):  
System Integration ◽  
Diagnostic Tests ◽  
Point Of Care ◽  
Digital Microfluidics ◽  
Controlled Environment ◽  
Point Of Care Testing ◽  
Microfluidic Platforms ◽  
Interface System ◽  
Technical Issues ◽  
Sample System

: Point-of-care (POC) testing decentralizes the diagnostic tests to the sites near the patient. Many POC tests rely microfluidic platforms for sample-to-answer analysis. Compared to other microfluidic systems, magnetic digital microfluidics demonstrate compelling advantages for POC diagnostics. In this review, we have examined the capability of magnetic digital microfluidics-based POC diagnostic platforms. More importantly, we have categorized POC settings into three classes based on “where is the point”, “who to care” and “how to test”, and evaluated the suitability of magnetic digital microfluidics in various POC settings. Furthermore, we have addressed other technical issues associated with POC testing such as controlled environment, sample-system interface, system integration and information connectivity. We hope this review would provide a guideline for the future development of magnetic digital microfluidics-based platforms for POC testing.

scholarly journals Disposable Voltammetric Immunosensors Integrated with Microfluidic Platforms for Biomedical, Agricultural and Food Analyses: A Review

Sensors ◽  
2018 ◽  
Vol 18 (12) ◽  
pp. 4124 ◽  
Author(s):  
Fabiana Felix ◽  
Alexandre Baccaro ◽  
Lúcio Angnes
Keyword(s):  
Quality Management ◽  
Signal Amplification ◽  
Screen Printing ◽  
Point Of Care ◽  
Microfluidic Devices ◽  
Strong Interactions ◽  
Point Of Care Testing ◽  
Microfluidic Platforms ◽  
Broad Variety ◽  
Interesting Alternative

Disposable immunosensors are analytical devices used for the quantification of a broad variety of analytes in different areas such as clinical, environmental, agricultural and food quality management. They detect the analytes by means of the strong interactions between antibodies and antigens, which provide concentration-dependent signals. For the herein highlighted voltammetric immunosensors, the analytical measurements are due to changes in the electrical signals on the surface of the transducers. The possibility of using disposable and miniaturized immunoassays is a very interesting alternative for voltammetric analyses, mainly, when associated with screen-printing technologies (screen-printed electrodes, SPEs), and microfluidic platforms. The aim of this paper is to discuss a carefully selected literature about different examples of SPEs-based immunosensors associated with microfluidic technologies for diseases, food, agricultural and environmental analysis. Technological aspects of the development of the voltammetric immunoassays such as the signal amplification, construction of paper-based microfluidic platforms and the utilization of microfluidic devices for point-of-care testing will be presented as well.

Innovations in point of care testing for bacterial infections: The Longitude Prize with Daniel Berman

2020 ◽  
Author(s):  
Daniel Berman
Keyword(s):  
Antimicrobial Resistance ◽  
Diagnostic Tests ◽  
Bacterial Infections ◽  
Point Of Care ◽  
Rapid Diagnostic Tests ◽  
Public Healthcare ◽  
Point Of Care Testing ◽  
Set Up ◽  
Insight Into

Antimicrobial resistance (AMR) is one of the most serious clinical and public healthcare challenges. In this video Daniel Berman,  Nesta Challenges, provides an overview of the Longitude Prize, why the prize was set up and what the prize hopes to achieve. Daniel also provides insight into some of the rapid diagnostic tests currently in the running for the £8 million prize.

scholarly journals Call to action for health systems integration of point-of-care testing to mitigate the transmission and burden of sexually transmitted infections

2020 ◽  
Vol 96 (5) ◽  
pp. 342-347 ◽  
Author(s):  
Igor Toskin ◽  
Veloshnee Govender ◽  
Karel Blondeel ◽  
Maurine Murtagh ◽  
Magnus Unemo ◽  
...  
Keyword(s):  
Health Systems ◽  
Low Income ◽  
System Integration ◽  
Policy Design ◽  
Point Of Care ◽  
Health Coverage ◽  
Point Of Care Testing ◽  
Programme Implementation ◽  
Correct Treatment ◽  
Middle Income

ObjectivesIn 2016, WHO estimated 376 million new cases of the four main curable STIs: gonorrhoea, chlamydia, trichomoniasis and syphilis. Further, an estimated 290 million women are infected with human papillomavirus. STIs may lead to severe reproductive health sequelae. Low-income and middle-income countries carry the highest global burden of STIs. A large proportion of urogenital and the vast majority of extragenital non-viral STI cases are asymptomatic. Screening key populations and early and accurate diagnosis are important to provide correct treatment and to control the spread of STIs. This article paints a picture of the state of technology of STI point-of-care testing (POCT) and its implications for health system integration.MethodsThe material for the STI POCT landscape was gathered from publicly available information, published and unpublished reports and prospectuses, and interviews with developers and manufacturers.ResultsThe development of STI POCT is moving rapidly, and there are much more tests in the pipeline than in 2014, when the first STI POCT landscape analysis was published on the website of WHO. Several of the available tests need to be evaluated independently both in the laboratory and, of particular importance, in different points of care.ConclusionThis article reiterates the importance of accurate, rapid and affordable POCT to reach universal health coverage. While highlighting the rapid technical advances in this area, we argue that insufficient attention is being paid to health systems capacity and conditions to ensure the swift and rapid integration of current and future STI POCT. Unless the complexity of health systems, including context, institutions, adoption systems and problem perception, are recognised and mapped, simplistic approaches to policy design and programme implementation will result in poor realisation of intended outcomes and impact.

Point‐of‐care testing in cattle practice: reliability of cow‐side diagnostic tests

In Practice ◽  
2016 ◽  
Vol 38 (6) ◽  
pp. 293-302 ◽  
Author(s):  
Ángel Abuelo ◽  
Victor Alves‐Nores
Keyword(s):  
Diagnostic Tests ◽  
Point Of Care ◽  
Point Of Care Testing

scholarly journals Paper-Based Point-of-Care Testing of SARS-CoV-2

2021 ◽  
Vol 9 ◽  
Author(s):  
Yuan Jia ◽  
Hao Sun ◽  
Jinpeng Tian ◽  
Qiuming Song ◽  
Wenwei Zhang
Keyword(s):  
Diagnostic Tests ◽  
State Of The Art ◽  
Point Of Care ◽  
Low Cost ◽  
The State ◽  
Detection Methods ◽  
Point Of Care Testing ◽  
Research Opportunities ◽  
Acute Infections ◽  
Reliable Detection

The COVID-19 pandemic has resulted in significant global social and economic disruption. The highly transmissive nature of the disease makes rapid and reliable detection critically important. Point-of-care (POC) tests involve performing diagnostic tests outside of a laboratory that produce a rapid and reliable result. It therefore allows the diagnostics of diseases at or near the patient site. Paper-based POC tests have been gaining interest in recent years as they allow rapid, low-cost detection without the need for external instruments. In this review, we focus on the development of paper-based POC devices for the detection of SARS-CoV-2. The review first introduces the principles of detection methods that are available to paper-based devices. It then summarizes the state-of-the-art paper devices and their analytical performances. The advantages and drawbacks among methods are also discussed. Finally, limitations of the existing devices are discussed, and prospects are given with the hope to identify research opportunities and directions in the field. We hope this review will be helpful for researchers to develop a clinically useful and economically efficient paper-based platform that can be used for rapid, accurate on-site diagnosis to aid in identifying acute infections and eventually contain the COVID-19 pandemic.

Point-of-care blood coagulation assay enabled by printed circuit board-based digital microfluidics

Lab on a Chip ◽  
2022 ◽  
Author(s):  
Donghao Li ◽  
Xinyu Liu ◽  
Yujuan Chai ◽  
Jieying Shan ◽  
Yihan Xie ◽  
...  
Keyword(s):  
Printed Circuit Board ◽  
Point Of Care ◽  
Digital Microfluidics ◽  
Circuit Board ◽  
Clinical Settings ◽  
Point Of Care Testing ◽  
Printed Circuit ◽  
Coagulation Assays ◽  
Coagulation Function ◽  
Coagulation Assay

The monitoring of coagulation function has great implications in many clinical settings. However, existing coagulation assays are simplex, sample-consuming, and slow in turnaround, making them less suitable for point-of-care testing....

scholarly journals Application of Microfluidics in Immunoassay: Recent Advancements

2021 ◽  
Vol 2021 ◽  
pp. 1-24
Author(s):  
Yuxing Shi ◽  
Peng Ye ◽  
Kuojun Yang ◽  
Jie Meng ◽  
Jiuchuan Guo ◽  
...  
Keyword(s):  
Performance Improvement ◽  
Biochemical Analysis ◽  
Driving Forces ◽  
State Of The Art ◽  
Point Of Care ◽  
Digital Microfluidics ◽  
Microfluidic Chips ◽  
Point Of Care Testing ◽  
Microfluidic Platform ◽  
The Past

In recent years, point-of-care testing has played an important role in immunoassay, biochemical analysis, and molecular diagnosis, especially in low-resource settings. Among various point-of-care-testing platforms, microfluidic chips have many outstanding advantages. Microfluidic chip applies the technology of miniaturizing conventional laboratory which enables the whole biochemical process including reagent loading, reaction, separation, and detection on the microchip. As a result, microfluidic platform has become a hotspot of research in the fields of food safety, health care, and environmental monitoring in the past few decades. Here, the state-of-the-art application of microfluidics in immunoassay in the past decade will be reviewed. According to different driving forces of fluid, microfluidic platform is divided into two parts: passive manipulation and active manipulation. In passive manipulation, we focus on the capillary-driven microfluidics, while in active manipulation, we introduce pressure microfluidics, centrifugal microfluidics, electric microfluidics, optofluidics, magnetic microfluidics, and digital microfluidics. Additionally, within the introduction of each platform, innovation of the methods used and their corresponding performance improvement will be discussed. Ultimately, the shortcomings of different platforms and approaches for improvement will be proposed.

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