The Development of an Antimicrobial Contact Lens – From the Laboratory to the Clinic

2020 ◽  
Vol 21 (4) ◽  
pp. 357-368 ◽  
Author(s):  
Mark D.P. Willcox ◽  
R. Chen ◽  
P. Kalaiselvan ◽  
M. Yasir ◽  
R. Rasul ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Contact Lens ◽  
Ocular Surface ◽  
Contact Lenses ◽  
Research Progress ◽  
Clinical Testing ◽  
Contact Lens Wear ◽  
Loss Of Vision ◽  
Infection And Inflammation ◽  
Lens Wear

Contact lens wear is generally safe and provides excellent vision. However, contact lens wear is often associated with the risk of developing ocular surface infection and inflammation, and in severe cases, the infection can result in loss of vision. Antimicrobial peptide-coated contact lenses have been made to help reduce the incidence of infection and inflammation. This paper reviews the research progress from conception, through the laboratory and preclinical tests to the latest information on clinical testing of an antimicrobial contact lens. We provide insights into the pathways followed and pitfalls that have been encountered. The journey has not always been linear or smooth, but has resulted in some of the first published clinical testing of antimicrobial peptide-coated contact lenses in humans. We hope this may help lead to the development and commercialisation of antimicrobial contact lenses in the future.

scholarly journals Immunology of the ocular surface and contact lens wear: theoretical fundamentals

2013 ◽  
Vol 2 ◽  
pp. 254-259 ◽  
Author(s):  
Piotr Skopiński ◽  
Piotr Krawczyk ◽  
Anna M. Ambroziak
Keyword(s):  
Contact Lens ◽  
Ocular Surface ◽  
Contact Lens Wear ◽  
Lens Wear

scholarly journals Clinical implications of the immunity of the ocular surface: the effect of extended contact lens wear

2013 ◽  
Vol 2 ◽  
pp. 260-264
Author(s):  
Anna M. Ambroziak ◽  
Piotr Krawczyk ◽  
Kamil Szulborski ◽  
Piotr Skopiński
Keyword(s):  
Contact Lens ◽  
Ocular Surface ◽  
Clinical Implications ◽  
Contact Lens Wear ◽  
Extended Contact ◽  
Lens Wear

scholarly journals Preliminary Clinical Exploration of Scleral Lens Performance on Normal Eyes

2018 ◽  
Vol 2 (2) ◽  
pp. e14-e21
Author(s):  
Melissa Barnett ◽  
Jonathon Ross ◽  
Blythe Durbin-Johnson
Keyword(s):  
Visual Acuity ◽  
Contact Lens ◽  
Healthy Subjects ◽  
Contact Lenses ◽  
Front Surface ◽  
Contact Lens Wear ◽  
Factors Associated ◽  
Rigid Contact ◽  
Lens Wear ◽  
Spectacle Correction

Abstract Objectives: The purpose of this study was to evaluate the performance (i.e. vision, comfort and fit) of spherical and front-surface toric scleral lenses in subjects with regular, healthy corneas. Methods: Scleral lenses were fitin the eyes (n = 16) of healthy subjects (n = 9) with regular corneas, absent of pathology, and studied using an observational, multi-visit design. Lens fit was objectively evaluatedby an experienced practitioner.Following 1 month of successful lens wear, participants completedsubjective satisfaction surveys regarding the scleral lens wearing experience. Results:  According to participant surveys, scleral lenses were subjectively preferred over soft toric or gas permeable contact lenses in 88% of eyes, including in all eyes fit with a front-surface toric scleral lens (n = 3). Seventy-five percent (75%) of eyes achieved visual acuity of 0.1 logMAR or better, while all eyes with prior spectacle wear achieved visual acuity with a scleral lens within 1 Snellen line of spectacle correction. Seventy-five percent (75%) of eyes achieved good subjective comfort with a scleral lens. No participants reported poor subjective vision and/or comfort. Conclusions:  Our findings suggest that subjects preferred the performance of a scleral lens (spherical or front-surface toric) compared to a soft toric or gas permeable contact lens. Moreover, scleral lenses may provide a viable, alternative contact lens modality option for patients considering discontinuation of traditional soft toric and/or rigid contact lens wear; so long as the factors associated with hypoxia remain minimized. Key Words:  scleral lens; scleral contact lens; front-surface toric scleral lens; lens performance; normal eyes; healthy eyes

Tribological classification of contact lenses – From coefficient of friction to sliding work: Can contact lens wear help you burn calories?

2018 ◽  
Vol 41 ◽  
pp. S41
Author(s):  
Samuele Tosatti ◽  
Olof Sterner ◽  
Rudolf Aeschlimann ◽  
Stefan Zuercher ◽  
Charles Scales ◽  
...  
Keyword(s):  
Coefficient Of Friction ◽  
Contact Lens ◽  
Contact Lenses ◽  
Contact Lens Wear ◽  
Lens Wear

scholarly journals Personal hygiene risk factors for contact lens-related microbial keratitis

2020 ◽  
Vol 5 (1) ◽  
pp. e000476
Author(s):  
Anna Stellwagen ◽  
Cheryl MacGregor ◽  
Roger Kung ◽  
Aristides Konstantopoulos ◽  
Parwez Hossain
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Contact Lens ◽  
Contact Lenses ◽  
Healthcare Services ◽  
University Hospital ◽  
Personal Hygiene ◽  
Microbial Keratitis ◽  
Contact Lens Wear ◽  
Lens Wear

ObjectiveMicrobial keratitis is a sight-threatening complication of contact lens wear, which affects thousands of patients and causes a significant burden on healthcare services. This study aims to identify compliance with contact lens care recommendations and identify personal hygiene risk factors in patients who develop contact lens-related microbial keratitis.Methods and analysisA case–control study was conducted at the University Hospital Southampton Eye Casualty from October to December 2015. Two participant groups were recruited: cases were contact lens wearers presenting with microbial keratitis and controls were contact lens wearers without infection. Participants underwent face-to-face interviews to identify lens wear practices, including lens type, hours of wear, personal hygiene and sleeping and showering in lenses. Univariate and multivariate regression models were used to compare groups.Results37 cases and 41 controls were identified. Showering in contact lenses was identified as the greatest risk factor (OR, 3.1; 95% CI, 1.2 to 8.5; p=0.03), with showering daily in lenses compared with never, increasing the risk of microbial keratitis by over seven times (OR, 7.1; 95% CI, 2.1 to 24.6; p=0.002). Other risks included sleeping in lenses (OR, 3.1; 95% CI, 1.1 to 8.6; p=0.026), and being aged 25–39 (OR, 6.38; 95% CI, 1.56 to 26.10; p=0.010) and 40–54 (OR, 4.00; 95% CI 0.96 to 16.61; p=0.056).ConclusionThe greatest personal hygiene risk factor for contact lens-related microbial keratitis was showering while wearing lenses, with an OR of 3.1, which increased to 7.1 if patients showered daily in lenses. The OR for sleeping in lenses was 3.1, and the most at-risk age group was 25–54.

The effect of contact lens wear on dynamic ocular surface temperature

2005 ◽  
Vol 28 (1) ◽  
pp. 29-36 ◽  
Author(s):  
Christine Purslow ◽  
James S. Wolffsohn ◽  
Jacinto Santodomingo-Rubido
Keyword(s):  
Surface Temperature ◽  
Contact Lens ◽  
Ocular Surface ◽  
Contact Lens Wear ◽  
Lens Wear

scholarly journals Impact of Rigid Gas Permeable Contact Lenses Removal on Anterior and Posterior Corneal Surfaces in Keratoconus Patients

2019 ◽  
Author(s):  
Motohiro Itoi ◽  
Koji Kitazawa ◽  
Hisayo Higashihara ◽  
Chie Sotozono
Keyword(s):  
Contact Lens ◽  
Contact Lenses ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Corneal Surface ◽  
Contact Lens Wear ◽  
Surface Areas ◽  
The Impact ◽  
Lens Wear ◽  
Anterior Posterior

AbstractPurposeTo evaluate the impact of removal of rigid gas-permeable (RGP) contact lenses on the anterior and posterior cornea surfaces of eyes with keratoconus.MethodsEight eyes of 8 patients with keratoconus (KC) (age 34.3 ± 15.3 years; range 19–60 years) were enrolled. Anterior segment optical coherence tomography (AS-OCT) was performed at 1, 5, 10, 20, and 60 minutes after the patients removed their RGP contact lenses. Measurements included anterior and posterior best-fit sphere (BFS); elevation values and corneal surface areas; corneal thickness at the thinnest point; and the anterior-posterior ratio of the corneal surface (As/Ps) between 1 minute and 60 minutes after RGP contact lens removal.ResultsAnterior and posterior elevation values and corneal surface areas showed significant increases, whereas anterior and posterior BFS and central corneal thickness decreased significantly (P < 0.01) between 1 minute and 60 minutes after RGP contact lens removal. No statistically significant differences were found in the As/Ps ratio during the first hour after suspending RGP contact lens wear.ConclusionsWe found that the patients with keratoconus experienced significant changes in both the anterior and posterior corneal shape for 60 minutes after removal of RGP contact lenses.

scholarly journals Subclinical Inflammation of the Ocular Surface in Soft Contact Lens Wear

Cornea ◽  
2020 ◽  
Vol 39 (2) ◽  
pp. 146-154
Author(s):  
Noor Haziq Saliman ◽  
Philip B. Morgan ◽  
Andrew S. MacDonald ◽  
Carole Maldonado-Codina
Keyword(s):  
Contact Lens ◽  
Ocular Surface ◽  
Subclinical Inflammation ◽  
Soft Contact ◽  
Contact Lens Wear ◽  
Soft Contact Lens ◽  
Lens Wear
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